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Items: 1 to 50 of 129

1.

Noncompetitive antagonists induce cooperative AMPA receptor channel gating.

Shi EY, Yuan CL, Sipple MT, Srinivasan J, Ptak CP, Oswald RE, Nowak LM.

J Gen Physiol. 2019 Jan 8. pii: jgp.201812209. doi: 10.1085/jgp.201812209. [Epub ahead of print]

PMID:
30622133
2.

Comparative screening of recombinant antigen thermostability for improved leptospirosis vaccine design.

Ptak CP, Akif M, Hsieh CL, Devarajan A, He P, Xu Y, Oswald RE, Chang YF.

Biotechnol Bioeng. 2019 Feb;116(2):260-271. doi: 10.1002/bit.26864. Epub 2018 Dec 5.

PMID:
30418677
3.

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency.

Goffin E, Drapier T, Larsen AP, Geubelle P, Ptak CP, Laulumaa S, Rovinskaja K, Gilissen J, Tullio P, Olsen L, Frydenvang K, Pirotte B, Hanson J, Oswald RE, Kastrup JS, Francotte P.

J Med Chem. 2018 Jan 11;61(1):251-264. doi: 10.1021/acs.jmedchem.7b01323. Epub 2017 Dec 19.

4.

Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design.

Hsieh CL, Ptak CP, Tseng A, Suguiura IMS, McDonough SP, Sritrakul T, Li T, Lin YP, Gillilan RE, Oswald RE, Chang YF.

Elife. 2017 Dec 6;6. pii: e30051. doi: 10.7554/eLife.30051.

5.

New Insights into the Mechanism of Ca2+-Dependent Inactivation of NMDA Receptors.

Oswald RE.

Biophys J. 2017 Nov 21;113(10):2131-2132. doi: 10.1016/j.bpj.2017.10.008. Epub 2017 Nov 5. No abstract available.

6.

Long-term impacts of unconventional drilling operations on human and animal health.

Bamberger M, Oswald RE.

J Environ Sci Health A Tox Hazard Subst Environ Eng. 2015;50(5):447-59. doi: 10.1080/10934529.2015.992655.

PMID:
25734821
7.

NMR solution structure of the terminal immunoglobulin-like domain from the leptospira host-interacting outer membrane protein, LigB.

Ptak CP, Hsieh CL, Lin YP, Maltsev AS, Raman R, Sharma Y, Oswald RE, Chang YF.

Biochemistry. 2014 Aug 19;53(32):5249-60. doi: 10.1021/bi500669u. Epub 2014 Aug 4.

8.

Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development.

Martinez M, Ahmed AH, Loh AP, Oswald RE.

Biochemistry. 2014 Jun 17;53(23):3790-5. doi: 10.1021/bi500511m. Epub 2014 Jun 5.

9.

Unconventional oil and gas extraction and animal health.

Bamberger M, Oswald RE.

Environ Sci Process Impacts. 2014 Aug;16(8):1860-5. doi: 10.1039/c4em00150h.

PMID:
24816999
10.

Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840.

Jenkins MA, Wells G, Bachman J, Snyder JP, Jenkins A, Huganir RL, Oswald RE, Traynelis SF.

Mol Pharmacol. 2014 Apr;85(4):618-29. doi: 10.1124/mol.113.091488. Epub 2014 Jan 22.

11.

Role of stoichiometry in the dimer-stabilizing effect of AMPA receptor allosteric modulators.

Ptak CP, Hsieh CL, Weiland GA, Oswald RE.

ACS Chem Biol. 2014 Jan 17;9(1):128-33. doi: 10.1021/cb4007166. Epub 2013 Nov 1.

12.

Dynamics of cleft closure of the GluA2 ligand-binding domain in the presence of full and partial agonists revealed by hydrogen-deuterium exchange.

Ahmed AH, Ptak CP, Fenwick MK, Hsieh CL, Weiland GA, Oswald RE.

J Biol Chem. 2013 Sep 20;288(38):27658-66. doi: 10.1074/jbc.M113.495564. Epub 2013 Aug 12.

13.

The perturbation of tryptophan fluorescence by phenylalanine to alanine mutations identifies the hydrophobic core in a subset of bacterial Ig-like domains.

Raman R, Ptak CP, Hsieh CL, Oswald RE, Chang YF, Sharma Y.

Biochemistry. 2013 Jul 9;52(27):4589-91. doi: 10.1021/bi400128r. Epub 2013 Jun 28.

PMID:
23800025
14.

Science and politics of shale gas extraction.

Bamberger M, Oswald RE.

New Solut. 2013;23(1):7-12. doi: 10.2190/NS.23.1.b. No abstract available.

PMID:
23552645
15.

The structure of (-)-kaitocephalin bound to the ligand binding domain of the (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/glutamate receptor, GluA2.

Ahmed AH, Hamada M, Shinada T, Ohfune Y, Weerasinghe L, Garner PP, Oswald RE.

J Biol Chem. 2012 Nov 30;287(49):41007-13. doi: 10.1074/jbc.M112.416362. Epub 2012 Oct 17.

16.

The loss of an electrostatic contact unique to AMPA receptor ligand binding domain 2 slows channel activation.

Holley SM, Ahmed AH, Srinivasan J, Murthy SE, Weiland GA, Oswald RE, Nowak LM.

Biochemistry. 2012 May 15;51(19):4015-27. doi: 10.1021/bi3001837. Epub 2012 May 2.

17.

Impacts of gas drilling on human and animal health.

Bamberger M, Oswald RE.

New Solut. 2012;22(1):51-77. doi: 10.2190/NS.22.1.e.

PMID:
22446060
18.

Identification of formation of initial native structure in onconase from an unfolded state.

Gahl RF, Oswald RE, Scheraga HA.

Biochemistry. 2012 Jan 10;51(1):521-32. doi: 10.1021/bi201168d. Epub 2011 Dec 14.

19.

Mechanism of AMPA receptor activation by partial agonists: disulfide trapping of closed lobe conformations.

Ahmed AH, Wang S, Chuang HH, Oswald RE.

J Biol Chem. 2011 Oct 7;286(40):35257-66. doi: 10.1074/jbc.M111.269001. Epub 2011 Aug 16.

20.

Mechanisms of modal activation of GluA3 receptors.

Poon K, Ahmed AH, Nowak LM, Oswald RE.

Mol Pharmacol. 2011 Jul;80(1):49-59. doi: 10.1124/mol.111.071688. Epub 2011 Apr 4.

21.

The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 via a PXVXL binding motif.

Xu X, Lee YJ, Holm JB, Terry MD, Oswald RE, Horne WA.

J Biol Chem. 2011 Mar 18;286(11):9677-87. doi: 10.1074/jbc.M110.187864. Epub 2011 Jan 10.

22.

Characterizing single-channel behavior of GluA3 receptors.

Poon K, Nowak LM, Oswald RE.

Biophys J. 2010 Sep 8;99(5):1437-46. doi: 10.1016/j.bpj.2010.06.058.

23.
24.
25.

Distinct modulations of human capsaicin receptor by protons and magnesium through different domains.

Wang S, Poon K, Oswald RE, Chuang HH.

J Biol Chem. 2010 Apr 9;285(15):11547-56. doi: 10.1074/jbc.M109.058727. Epub 2010 Feb 9.

26.

Hydrophobic side chain dynamics of a glutamate receptor ligand binding domain.

Maltsev AS, Oswald RE.

J Biol Chem. 2010 Mar 26;285(13):10154-62. doi: 10.1074/jbc.M109.088641. Epub 2010 Jan 28.

27.

On the mechanisms of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor binding to glutamate and kainate.

Fenwick MK, Oswald RE.

J Biol Chem. 2010 Apr 16;285(16):12334-43. doi: 10.1074/jbc.M109.086371. Epub 2010 Jan 28.

28.

Probing the allosteric modulator binding site of GluR2 with thiazide derivatives.

Ptak CP, Ahmed AH, Oswald RE.

Biochemistry. 2009 Sep 15;48(36):8594-602. doi: 10.1021/bi901127s.

29.

Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain.

Ahmed AH, Thompson MD, Fenwick MK, Romero B, Loh AP, Jane DE, Sondermann H, Oswald RE.

Biochemistry. 2009 May 12;48(18):3894-903. doi: 10.1021/bi900107m.

30.

Structure of the S1S2 glutamate binding domain of GLuR3.

Ahmed AH, Wang Q, Sondermann H, Oswald RE.

Proteins. 2009 May 15;75(3):628-37. doi: 10.1002/prot.22274.

31.

Mechanism of partial agonism at the GluR2 AMPA receptor: Measurements of lobe orientation in solution.

Maltsev AS, Ahmed AH, Fenwick MK, Jane DE, Oswald RE.

Biochemistry. 2008 Oct 7;47(40):10600-10. doi: 10.1021/bi800843c. Epub 2008 Sep 17.

32.

NMR spectroscopy of the ligand-binding core of ionotropic glutamate receptor 2 bound to 5-substituted willardiine partial agonists.

Fenwick MK, Oswald RE.

J Mol Biol. 2008 May 2;378(3):673-85. doi: 10.1016/j.jmb.2008.03.012. Epub 2008 Mar 14.

33.

Backbone chemical shift assignment of a glutamate receptor ligand binding domain in complexes with five partial agonists.

Fenwick MK, Oswald RE.

Biomol NMR Assign. 2007 Dec;1(2):241-3. doi: 10.1007/s12104-007-9067-3. Epub 2007 Nov 30.

PMID:
19636875
34.

NMR assignment of Cdc42(T35A), an active Switch I mutant of Cdc42.

Adams PD, Oswald RE.

Biomol NMR Assign. 2007 Dec;1(2):225-7. doi: 10.1007/s12104-007-9062-8. Epub 2007 Nov 13.

PMID:
19636871
35.

Flexibility of a glutamate-binding domain.

Oswald RE.

Structure. 2007 Oct;15(10):1157-8. No abstract available.

36.

Molecular properties of local anesthetics as predictors of affinity for nicotinic acetylcholine receptors.

Pagán OR, Sivaprakasam K, Oswald RE.

J Neurosci Res. 2007 Oct;85(13):2943-9.

PMID:
17600837
37.

Structure of glutamate receptors.

Oswald RE, Ahmed A, Fenwick MK, Loh AP.

Curr Drug Targets. 2007 May;8(5):573-82. Review.

PMID:
17504102
38.

Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of kainate receptor subtype 6.

Kornreich BG, Niu L, Roberson MS, Oswald RE.

Neuroscience. 2007 May 25;146(3):1158-68. Epub 2007 Mar 26.

39.

Dynamics of the S1S2 glutamate binding domain of GluR2 measured using 19F NMR spectroscopy.

Ahmed AH, Loh AP, Jane DE, Oswald RE.

J Biol Chem. 2007 Apr 27;282(17):12773-84. Epub 2007 Mar 2.

40.

Solution structure of an oncogenic mutant of Cdc42Hs.

Adams PD, Oswald RE.

Biochemistry. 2006 Feb 28;45(8):2577-83.

41.

Ionotropic glutamate receptor recognition and activation.

Oswald RE.

Adv Protein Chem. 2004;68:313-49. Review.

PMID:
15500865
42.

Backbone dynamics of an oncogenic mutant of Cdc42Hs shows increased flexibility at the nucleotide-binding site.

Adams PD, Loh AP, Oswald RE.

Biochemistry. 2004 Aug 10;43(31):9968-77.

PMID:
15287724
43.

Emerging structural explanations of ionotropic glutamate receptor function.

McFeeters RL, Oswald RE.

FASEB J. 2004 Mar;18(3):428-38. Review.

PMID:
15003989
44.

Channel-opening kinetics of GluR6 kainate receptor.

Li G, Oswald RE, Niu L.

Biochemistry. 2003 Oct 28;42(42):12367-75.

PMID:
14567698
45.
46.

Solution structure of peptide toxins that block mechanosensitive ion channels.

Oswald RE, Suchyna TM, McFeeters R, Gottlieb P, Sachs F.

J Biol Chem. 2002 Sep 13;277(37):34443-50. Epub 2002 Jun 24.

47.

Semi-automated backbone resonance assignments of the extracellular ligand-binding domain of an ionotropic glutamate receptor.

McFeeters RL, Swapna GV, Montelione GT, Oswald RE.

J Biomol NMR. 2002 Mar;22(3):297-8. No abstract available.

PMID:
11991359
49.

Specific activation of the alpha 7 nicotinic acetylcholine receptor by a quaternary analog of cocaine.

Francis MM, Cheng EY, Weiland GA, Oswald RE.

Mol Pharmacol. 2001 Jul;60(1):71-9.

50.

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