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Items: 1 to 50 of 165

1.

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): Rationale, Progress and Perspective.

Kuriyama S, Metoki H, Kikuya M, Obara T, Ishikuro M, Yamanaka C, Nagai M, Matsubara H, Kobayashi T, Sugawara J, Tamiya G, Hozawa A, Nakaya N, Tsuchiya N, Nakamura T, Narita A, Kogure M, Hirata T, Tsuji I, Nagami F, Fuse N, Arai T, Kawaguchi Y, Higuchi S, Sakaida M, Suzuki Y, Osumi N, Nakayama K, Ito K, Egawa S, Chida K, Kodama E, Kiyomoto H, Ishii T, Tsuboi A, Tomita H, Taki Y, Kawame H, Suzuki K, Ishii N, Ogishima S, Mizuno S, Takai-Igarashi T, Minegishi N, Yasuda J, Igarashi K, Shimizu R, Nagasaki M, Tanabe O, Koshiba S, Hashizume H, Motohashi H, Tominaga T, Ito S, Tanno K, Sakata K, Shimizu A, Hitomi J, Sasaki M, Kinoshita K, Tanaka H, Kobayashi T, Kure S, Yaegashi N, Yamamoto M; Tohoku Medical Megabank Project Study Group .

Int J Epidemiol. 2019 Aug 25. pii: dyz169. doi: 10.1093/ije/dyz169. [Epub ahead of print] No abstract available.

PMID:
31504573
2.

Structural and functional defects of the respiratory neural system in the medulla and spinal cord of Pax6 mutant rats.

Ikeda K, Onimaru H, Inada H, Tien Lin S, Arata S, Osumi N.

Brain Res Bull. 2019 Jul 10;152:107-116. doi: 10.1016/j.brainresbull.2019.07.007. [Epub ahead of print]

PMID:
31301380
3.

SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling.

Mochizuki K, Tando Y, Sekinaka T, Otsuka K, Hayashi Y, Kobayashi H, Kamio A, Ito-Matsuoka Y, Takehara A, Kono T, Osumi N, Matsui Y.

Development. 2018 Dec 3;145(23). pii: dev164160. doi: 10.1242/dev.164160.

4.

Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination.

Mochizuki K, Hayashi Y, Sekinaka T, Otsuka K, Ito-Matsuoka Y, Kobayashi H, Oki S, Takehara A, Kono T, Osumi N, Matsui Y.

Cell Rep. 2018 Sep 4;24(10):2682-2693.e6. doi: 10.1016/j.celrep.2018.07.108.

5.

Pax6-dependent regulation of the rat Fabp7 promoter activity.

Inada H, Numayama-Tsuruta K, Mochizuki K, Sasaki-Hoshino M, Osumi N.

Genes Cells. 2018 Jul 9. doi: 10.1111/gtc.12623. [Epub ahead of print]

6.

Risk of Neurodevelopmental Disease by Paternal Aging: A Possible Influence of Epigenetic Alteration in Sperm.

Kimura R, Yoshizaki K, Osumi N.

Adv Exp Med Biol. 2018;1012:75-81. doi: 10.1007/978-981-10-5526-3_8. Review.

PMID:
29956196
7.

Targeting the Brain with a Neuroprotective Omega-3 Fatty Acid to Enhance Neurogenesis in Hypoxic Condition in Culture.

Lo Van A, Sakayori N, Hachem M, Belkouch M, Picq M, Fourmaux B, Lagarde M, Osumi N, Bernoud-Hubac N.

Mol Neurobiol. 2019 Feb;56(2):986-999. doi: 10.1007/s12035-018-1139-0. Epub 2018 Jun 1.

PMID:
29858775
8.

Whole-brain low-intensity pulsed ultrasound therapy markedly improves cognitive dysfunctions in mouse models of dementia - Crucial roles of endothelial nitric oxide synthase.

Eguchi K, Shindo T, Ito K, Ogata T, Kurosawa R, Kagaya Y, Monma Y, Ichijo S, Kasukabe S, Miyata S, Yoshikawa T, Yanai K, Taki H, Kanai H, Osumi N, Shimokawa H.

Brain Stimul. 2018 Sep - Oct;11(5):959-973. doi: 10.1016/j.brs.2018.05.012. Epub 2018 May 22.

9.

Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.

Yamashita W, Takahashi M, Kikkawa T, Gotoh H, Osumi N, Ono K, Nomura T.

Development. 2018 Apr 16;145(8). pii: dev159764. doi: 10.1242/dev.159764.

10.

[The effect of polyunsaturated fatty acids on neocortical development].

Sakayori N, Osumi N.

Seikagaku. 2017 Apr;89(2):269-72. Review. Japanese. No abstract available.

PMID:
29624995
11.

Calling rikejo.

Osumi N.

Nature. 2018 Mar 22;555(7697):S59. doi: 10.1038/d41586-018-02906-1. No abstract available.

PMID:
29565412
12.

Entrainment of the Circadian Clock in Neural Stem Cells by Epidermal Growth Factor is Closely Associated with ERK1/2-mediated Induction of Multiple Clock-related Genes.

Mogi A, Yomoda R, Kimura S, Tsushima C, Takouda J, Sawauchi M, Maekawa T, Ohta H, Nishino S, Kurita M, Mano N, Osumi N, Moriya T.

Neuroscience. 2018 May 21;379:45-66. doi: 10.1016/j.neuroscience.2018.02.045. Epub 2018 Mar 6.

PMID:
29518531
13.

The role of Pax6 in brain development and its impact on pathogenesis of autism spectrum disorder.

Kikkawa T, Casingal CR, Chun SH, Shinohara H, Hiraoka K, Osumi N.

Brain Res. 2019 Feb 15;1705:95-103. doi: 10.1016/j.brainres.2018.02.041. Epub 2018 Feb 27. Review.

PMID:
29499177
14.

Correction: Early postnatal vocalizations predict sociability and spatial memory in C57BL/6J mice: Individual differences in behavioral traits emerge early in development.

Yoshizaki K, Koike K, Kimura R, Osumi N.

PLoS One. 2018 Jan 19;13(1):e0191702. doi: 10.1371/journal.pone.0191702. eCollection 2018.

15.

Organizing activity of Fgf8 on the anterior telencephalon.

Sato T, Kikkawa T, Saito T, Itoi K, Osumi N.

Dev Growth Differ. 2017 Dec;59(9):701-712. doi: 10.1111/dgd.12411. Epub 2017 Nov 10.

PMID:
29124740
16.

Early postnatal vocalizations predict sociability and spatial memory in C57BL/6J mice: Individual differences in behavioral traits emerge early in development.

Yoshizaki K, Koike K, Kimura R, Osumi N.

PLoS One. 2017 Nov 1;12(11):e0186798. doi: 10.1371/journal.pone.0186798. eCollection 2017. Erratum in: PLoS One. 2018 Jan 19;13(1):e0191702.

17.

Dab1 contributes differently to the morphogenesis of the hippocampal subdivisions.

Blume M, Inoguchi F, Sugiyama T, Owada Y, Osumi N, Aimi Y, Taki K, Katsuyama Y.

Dev Growth Differ. 2017 Oct;59(8):657-673. doi: 10.1111/dgd.12393. Epub 2017 Sep 25.

PMID:
28945921
18.

Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes.

Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iwamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T.

Transl Psychiatry. 2017 Sep 5;7(9):e1229. doi: 10.1038/tp.2017.182.

19.

Induction of osteoblastic differentiation of neural crest-derived stem cells from hair follicles.

Urano-Morisawa E, Takami M, Suzawa T, Matsumoto A, Osumi N, Baba K, Kamijo R.

PLoS One. 2017 Apr 6;12(4):e0174940. doi: 10.1371/journal.pone.0174940. eCollection 2017.

20.

Electroporation in the Rodent Embryonic Brain Using Whole Embryo Culture System.

Kikkawa T, Takahashi M, Osumi N.

Curr Protoc Neurosci. 2017 Jan 3;78:3.30.1-3.30.16. doi: 10.1002/cpns.21.

PMID:
28046204
21.

Gene tracing analysis reveals the contribution of neural crest-derived cells in pituitary development.

Ueharu H, Yoshida S, Kikkawa T, Kanno N, Higuchi M, Kato T, Osumi N, Kato Y.

J Anat. 2017 Mar;230(3):373-380. doi: 10.1111/joa.12572. Epub 2016 Dec 27.

22.

Long-Term Protection of Genetically Ablated Rabbit Retinal Degeneration by Sustained Transscleral Unoprostone Delivery.

Nagai N, Koyanagi E, Izumida Y, Liu J, Katsuyama A, Kaji H, Nishizawa M, Osumi N, Kondo M, Terasaki H, Mashima Y, Nakazawa T, Abe T.

Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6527-6538. doi: 10.1167/iovs.16-20453.

PMID:
27918826
23.

Paternal Aging Affects Behavior in Pax6 Mutant Mice: A Gene/Environment Interaction in Understanding Neurodevelopmental Disorders.

Yoshizaki K, Furuse T, Kimura R, Tucci V, Kaneda H, Wakana S, Osumi N.

PLoS One. 2016 Nov 17;11(11):e0166665. doi: 10.1371/journal.pone.0166665. eCollection 2016.

24.

Mechanisms of DHA transport to the brain and potential therapy to neurodegenerative diseases.

Lo Van A, Sakayori N, Hachem M, Belkouch M, Picq M, Lagarde M, Osumi N, Bernoud-Hubac N.

Biochimie. 2016 Nov;130:163-167. doi: 10.1016/j.biochi.2016.07.011. Epub 2016 Aug 2. Review.

PMID:
27496085
25.

Maternal Nutritional Imbalance between Linoleic Acid and Alpha-Linolenic Acid Increases Offspring's Anxious Behavior with a Sex-Dependent Manner in Mice.

Sakayori N, Tokuda H, Yoshizaki K, Kawashima H, Innis SM, Shibata H, Osumi N.

Tohoku J Exp Med. 2016 Sep;240(1):31-7. doi: 10.1620/tjem.240.31.

26.

The Tohoku Medical Megabank Project: Design and Mission.

Kuriyama S, Yaegashi N, Nagami F, Arai T, Kawaguchi Y, Osumi N, Sakaida M, Suzuki Y, Nakayama K, Hashizume H, Tamiya G, Kawame H, Suzuki K, Hozawa A, Nakaya N, Kikuya M, Metoki H, Tsuji I, Fuse N, Kiyomoto H, Sugawara J, Tsuboi A, Egawa S, Ito K, Chida K, Ishii T, Tomita H, Taki Y, Minegishi N, Ishii N, Yasuda J, Igarashi K, Shimizu R, Nagasaki M, Koshiba S, Kinoshita K, Ogishima S, Takai-Igarashi T, Tominaga T, Tanabe O, Ohuchi N, Shimosegawa T, Kure S, Tanaka H, Ito S, Hitomi J, Tanno K, Nakamura M, Ogasawara K, Kobayashi S, Sakata K, Satoh M, Shimizu A, Sasaki M, Endo R, Sobue K, Tohoku Medical Megabank Project Study Group T, Yamamoto M.

J Epidemiol. 2016 Sep 5;26(9):493-511. doi: 10.2188/jea.JE20150268. Epub 2016 Jul 2.

27.

Regional Volume Decreases in the Brain of Pax6 Heterozygous Mutant Rats: MRI Deformation-Based Morphometry.

Hiraoka K, Sumiyoshi A, Nonaka H, Kikkawa T, Kawashima R, Osumi N.

PLoS One. 2016 Jun 29;11(6):e0158153. doi: 10.1371/journal.pone.0158153. eCollection 2016.

28.

Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites.

Sakayori N, Kikkawa T, Tokuda H, Kiryu E, Yoshizaki K, Kawashima H, Yamada T, Arai H, Kang JX, Katagiri H, Shibata H, Innis SM, Arita M, Osumi N.

Stem Cells. 2016 Feb;34(2):470-82. doi: 10.1002/stem.2246. Epub 2015 Nov 27.

29.

Identification of the neural crest-specific enhancer of Seraf gene in avian peripheral nervous system development.

Suzuki T, Osumi N, Wakamatsu Y.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):1103-9. doi: 10.1016/j.bbrc.2015.10.074. Epub 2015 Oct 19.

PMID:
26494297
30.

Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells.

Koh SH, Liang AC, Takahashi Y, Maki T, Shindo A, Osumi N, Zhao J, Lin H, Holder JC, Chuang TT, McNeish JD, Arai K, Lo EH.

PLoS One. 2015 Sep 25;10(9):e0138724. doi: 10.1371/journal.pone.0138724. eCollection 2015.

31.

Localization and osteoblastic differentiation potential of neural crest-derived cells in oral tissues of adult mice.

Ono M, Suzawa T, Takami M, Yamamoto G, Hosono T, Yamada A, Suzuki D, Yoshimura K, Watahiki J, Hayashi R, Arata S, Mishima K, Nishida K, Osumi N, Maki K, Kamijo R.

Biochem Biophys Res Commun. 2015 Sep 4;464(4):1209-1214. doi: 10.1016/j.bbrc.2015.07.106. Epub 2015 Jul 29.

PMID:
26225748
32.

Dynamic expression patterns of Pax6 during spermatogenesis in the mouse.

Kimura R, Yoshizaki K, Osumi N.

J Anat. 2015 Jul;227(1):1-9. doi: 10.1111/joa.12318. Epub 2015 Jun 1.

33.

Otic placode cell specification and proliferation are regulated by Notch signaling in avian development.

Shida H, Mende M, Takano-Yamamoto T, Osumi N, Streit A, Wakamatsu Y.

Dev Dyn. 2015 Jul;244(7):839-51. doi: 10.1002/dvdy.24291. Epub 2015 Jun 18.

34.

Horizontal Basal Cell-Specific Deletion of Pax6 Impedes Recovery of the Olfactory Neuroepithelium Following Severe Injury.

Suzuki J, Sakurai K, Yamazaki M, Abe M, Inada H, Sakimura K, Katori Y, Osumi N.

Stem Cells Dev. 2015 Aug 15;24(16):1923-33. doi: 10.1089/scd.2015.0011. Epub 2015 Apr 28.

35.

Neurogenesis and sensorimotor gating: bridging a microphenotype and an endophenotype.

Osumi N, Guo N, Matsumata M, Yoshizaki K.

Curr Mol Med. 2015;15(2):129-37. Review.

PMID:
25732150
36.

Neural crest and placode contributions to olfactory development.

Suzuki J, Osumi N.

Curr Top Dev Biol. 2015;111:351-74. doi: 10.1016/bs.ctdb.2014.11.010. Epub 2015 Jan 20. Review.

PMID:
25662265
37.

X-ray phase-contrast computed tomography visualizes the microstructure and degradation profile of implanted biodegradable scaffolds after spinal cord injury.

Takashima K, Hoshino M, Uesugi K, Yagi N, Matsuda S, Nakahira A, Osumi N, Kohzuki M, Onodera H.

J Synchrotron Radiat. 2015 Jan;22(1):136-42. doi: 10.1107/S160057751402270X. Epub 2015 Jan 1.

38.

p38 MAP kinase mediates transforming-growth factor-β1-induced upregulation of matrix metalloproteinase-9 but not -2 in human brain pericytes.

Takahashi Y, Maki T, Liang AC, Itoh K, Lok J, Osumi N, Arai K.

Brain Res. 2014 Dec 17;1593:1-8. doi: 10.1016/j.brainres.2014.10.029. Epub 2014 Oct 22.

39.

Fatty acid binding proteins and the nervous system: Their impact on mental conditions.

Matsumata M, Inada H, Osumi N.

Neurosci Res. 2016 Jan;102:47-55. doi: 10.1016/j.neures.2014.08.012. Epub 2014 Sep 6. Review.

PMID:
25205626
40.

Differential effect of arachidonic acid and docosahexaenoic acid on age-related decreases in hippocampal neurogenesis.

Tokuda H, Kontani M, Kawashima H, Kiso Y, Shibata H, Osumi N.

Neurosci Res. 2014 Nov;88:58-66. doi: 10.1016/j.neures.2014.08.002. Epub 2014 Aug 19.

PMID:
25149915
41.

Preparation of rat serum suitable for mammalian whole embryo culture.

Takahashi M, Makino S, Kikkawa T, Osumi N.

J Vis Exp. 2014 Aug 3;(90):e51969. doi: 10.3791/51969.

42.

Comparative gene expression analyses reveal heterochrony for Sox9 expression in the cranial neural crest during marsupial development.

Wakamatsu Y, Nomura T, Osumi N, Suzuki K.

Evol Dev. 2014 Jul-Aug;16(4):197-206. doi: 10.1111/ede.12083. Epub 2014 Jun 17.

PMID:
24934187
43.

Asymmetric inheritance of Cyclin D2 maintains proliferative neural stem/progenitor cells: a critical event in brain development and evolution.

Tsunekawa Y, Kikkawa T, Osumi N.

Dev Growth Differ. 2014 Jun;56(5):349-57. doi: 10.1111/dgd.12135. Epub 2014 May 17. Review.

PMID:
24835888
44.

A novel cell migratory zone in the developing hippocampal formation.

Sugiyama T, Osumi N, Katsuyama Y.

J Comp Neurol. 2014 Oct 15;522(15):3520-38. doi: 10.1002/cne.23621. Epub 2014 May 14.

PMID:
24771490
45.

A platform for controlled dual-drug delivery to the retina: protective effects against light-induced retinal damage in rats.

Nagai N, Kaji H, Onami H, Katsukura Y, Ishikawa Y, Nezhad ZK, Sampei K, Iwata S, Ito S, Nishizawa M, Nakazawa T, Osumi N, Mashima Y, Abe T.

Adv Healthc Mater. 2014 Oct;3(10):1555-60, 1524. doi: 10.1002/adhm.201400114. Epub 2014 Apr 19.

PMID:
24753450
46.

Identification of gene expression profile of neural crest-derived cells isolated from submandibular glands of adult mice.

Takahashi M, Suzawa T, Yamada A, Yamaguchi T, Mishima K, Osumi N, Maki K, Kamijo R.

Biochem Biophys Res Commun. 2014 Apr 4;446(2):481-6. doi: 10.1016/j.bbrc.2014.02.130. Epub 2014 Mar 12.

PMID:
24613842
47.

Preservation of cochlear function in Fabp3 (H-Fabp) knockout mice.

Suzuki J, Oshima T, Yoshida N, Kimura R, Takata Y, Owada Y, Kobayashi T, Katori Y, Osumi N.

Neurosci Res. 2014 Apr-May;81-82:64-8. doi: 10.1016/j.neures.2014.02.003. Epub 2014 Feb 18.

48.

Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells.

Hagiwara K, Obayashi T, Sakayori N, Yamanishi E, Hayashi R, Osumi N, Nakazawa T, Nishida K.

PLoS One. 2014 Jan 20;9(1):e84072. doi: 10.1371/journal.pone.0084072. eCollection 2014.

49.

Impact of lipid nutrition on neural stem/progenitor cells.

Sakayori N, Kimura R, Osumi N.

Stem Cells Int. 2013;2013:973508. doi: 10.1155/2013/973508. Epub 2013 Oct 23. Review.

50.

A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye.

Nagai N, Kaji H, Onami H, Ishikawa Y, Nishizawa M, Osumi N, Nakazawa T, Abe T.

Acta Biomater. 2014 Feb;10(2):680-7. doi: 10.1016/j.actbio.2013.11.004. Epub 2013 Nov 15.

PMID:
24239899

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