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Items: 1 to 50 of 146

1.

Modeling Human Cancer-induced Cachexia.

Talbert EE, Cuitiño MC, Ladner KJ, Rajasekerea PV, Siebert M, Shakya R, Leone GW, Ostrowski MC, Paleo B, Weisleder N, Reiser PJ, Webb A, Timmers CD, Eiferman DS, Evans DC, Dillhoff ME, Schmidt CR, Guttridge DC.

Cell Rep. 2019 Aug 6;28(6):1612-1622.e4. doi: 10.1016/j.celrep.2019.07.016.

2.

Loss of PTEN Accelerates NKX3.1 Degradation to Promote Prostate Cancer Progression.

Bowen C, Ostrowski MC, Leone G, Gelmann EP.

Cancer Res. 2019 Aug 15;79(16):4124-4134. doi: 10.1158/0008-5472.CAN-18-4110. Epub 2019 Jun 18.

PMID:
31213464
3.

Two Distinct E2F Transcriptional Modules Drive Cell Cycles and Differentiation.

Cuitiño MC, Pécot T, Sun D, Kladney R, Okano-Uchida T, Shinde N, Saeed R, Perez-Castro AJ, Webb A, Liu T, Bae SI, Clijsters L, Selner N, Coppola V, Timmers C, Ostrowski MC, Pagano M, Leone G.

Cell Rep. 2019 Jun 18;27(12):3547-3560.e5. doi: 10.1016/j.celrep.2019.05.004. Epub 2019 May 23.

4.

Endothelial-specific deletion of Ets-1 attenuates Angiotensin II-induced cardiac fibrosis via suppression of endothelial-to-mesenchymal transition.

Xu L, Fu M, Chen D, Han W, Ostrowski MC, Grossfeld P, Gao P, Ye M.

BMB Rep. 2019 Jan 23. pii: 4423. [Epub ahead of print]

5.

Eomes partners with PU.1 and MITF to Regulate Transcription Factors Critical for osteoclast differentiation.

Carey HA, Hildreth BE 3rd, Samuvel DJ, Thies KA, Rosol TJ, Toribio RE, Charles JF, Ostrowski MC, Sharma SM.

iScience. 2019 Jan 25;11:238-245. doi: 10.1016/j.isci.2018.12.018. Epub 2018 Dec 27.

6.

Stromal PTEN Regulates Extracellular Matrix Organization in the Mammary Gland.

Jones CE, Hammer AM, Cho Y, Sizemore GM, Cukierman E, Yee LD, Ghadiali SN, Ostrowski MC, Leight JL.

Neoplasia. 2019 Jan;21(1):132-145. doi: 10.1016/j.neo.2018.10.010. Epub 2018 Dec 12.

7.

PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance.

Russell L, Swanner J, Jaime-Ramirez AC, Wang Y, Sprague A, Banasavadi-Siddegowda Y, Yoo JY, Sizemore GM, Kladney R, Zhang J, Lehman NL, Ostrowski MC, Hong B, Caligiuri M, Yu J, Kaur B.

Nat Commun. 2018 Nov 27;9(1):5006. doi: 10.1038/s41467-018-07344-1.

8.

Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth.

Pitarresi JR, Liu X, Avendano A, Thies KA, Sizemore GM, Hammer AM, Hildreth BE 3rd, Wang DJ, Steck SA, Donohue S, Cuitiño MC, Kladney RD, Mace TA, Chang JJ, Ennis CS, Li H, Reeves RH, Blackshaw S, Zhang J, Yu L, Fernandez SA, Frankel WL, Bloomston M, Rosol TJ, Lesinski GB, Konieczny SF, Guttridge DC, Rustgi AK, Leone G, Song JW, Wu J, Ostrowski MC.

Life Sci Alliance. 2018 Oct 26;1(5):e201800190. doi: 10.26508/lsa.201800190. eCollection 2018 Oct.

9.

Pyruvate kinase M2 regulates homologous recombination-mediated DNA double-strand break repair.

Sizemore ST, Zhang M, Cho JH, Sizemore GM, Hurwitz B, Kaur B, Lehman NL, Ostrowski MC, Robe PA, Miao W, Wang Y, Chakravarti A, Xia F.

Cell Res. 2018 Nov;28(11):1090-1102. doi: 10.1038/s41422-018-0086-7. Epub 2018 Oct 8.

10.

Stromal PTEN determines mammary epithelial response to radiotherapy.

Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC.

Nat Commun. 2018 Jul 17;9(1):2783. doi: 10.1038/s41467-018-05266-6.

11.

Fibroblast-derived CXCL12 promotes breast cancer metastasis by facilitating tumor cell intravasation.

Ahirwar DK, Nasser MW, Ouseph MM, Elbaz M, Cuitiño MC, Kladney RD, Varikuti S, Kaul K, Satoskar AR, Ramaswamy B, Zhang X, Ostrowski MC, Leone G, Ganju RK.

Oncogene. 2018 Aug;37(32):4428-4442. doi: 10.1038/s41388-018-0263-7. Epub 2018 May 3.

PMID:
29720724
12.

Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation.

Carey HA, Hildreth BE 3rd, Geisler JA, Nickel MC, Cabrera J, Ghosh S, Jiang Y, Yan J, Lee J, Makam S, Young NA, Valiente GR, Jarjour WN, Huang K, Rosol TJ, Toribio RE, Charles JF, Ostrowski MC, Sharma SM.

Bone Res. 2018 Mar 28;6:8. doi: 10.1038/s41413-018-0011-1. eCollection 2018.

13.

Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent.

Sizemore ST, Mohammad R, Sizemore GM, Nowsheen S, Yu H, Ostrowski MC, Chakravarti A, Xia F.

Mol Cancer Res. 2018 Jul;16(7):1092-1102. doi: 10.1158/1541-7786.MCR-18-0106. Epub 2018 Mar 28.

14.

A hedgehog pathway-dependent gene signature is associated with poor clinical outcomes in Luminal A breast cancer.

Rudolph M, Sizemore ST, Lu Y, Teng KY, Basree MM, Reinbolt R, Timmers CD, Leone G, Ostrowski MC, Majumder S, Ramaswamy B.

Breast Cancer Res Treat. 2018 Jun;169(3):457-467. doi: 10.1007/s10549-018-4718-x. Epub 2018 Feb 20.

PMID:
29464534
15.

Csf1r-mApple Transgene Expression and Ligand Binding In Vivo Reveal Dynamics of CSF1R Expression within the Mononuclear Phagocyte System.

Hawley CA, Rojo R, Raper A, Sauter KA, Lisowski ZM, Grabert K, Bain CC, Davis GM, Louwe PA, Ostrowski MC, Hume DA, Pridans C, Jenkins SJ.

J Immunol. 2018 Mar 15;200(6):2209-2223. doi: 10.4049/jimmunol.1701488. Epub 2018 Feb 12.

16.

Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1.

Sizemore GM, Balakrishnan S, Hammer AM, Thies KA, Trimboli AJ, Wallace JA, Sizemore ST, Kladney RD, Woelke SA, Yu L, Fernandez SA, Chakravarti A, Leone G, Ostrowski MC.

Oncogene. 2017 Nov 23;36(47):6658. doi: 10.1038/onc.2017.347. Epub 2017 Oct 16.

PMID:
29035387
17.

Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.

Pourebrahim R, Zhang Y, Liu B, Gao R, Xiong S, Lin PP, McArthur MJ, Ostrowski MC, Lozano G.

Genes Dev. 2017 Sep 15;31(18):1847-1857. doi: 10.1101/gad.304972.117. Epub 2017 Oct 11.

18.

Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele.

Wu J, Liu X, Nayak SG, Pitarresi JR, Cuitiño MC, Yu L, Hildreth BE 3rd, Thies KA, Schilling DJ, Fernandez SA, Leone G, Ostrowski MC.

PLoS One. 2017 Sep 21;12(9):e0184984. doi: 10.1371/journal.pone.0184984. eCollection 2017.

19.

IL-18 Drives ILC3 Proliferation and Promotes IL-22 Production via NF-κB.

Victor AR, Nalin AP, Dong W, McClory S, Wei M, Mao C, Kladney RD, Youssef Y, Chan WK, Briercheck EL, Hughes T, Scoville SD, Pitarresi JR, Chen C, Manz S, Wu LC, Zhang J, Ostrowski MC, Freud AG, Leone GW, Caligiuri MA, Yu J.

J Immunol. 2017 Oct 1;199(7):2333-2342. doi: 10.4049/jimmunol.1601554. Epub 2017 Aug 25.

20.

Discovery of Stromal Regulatory Networks that Suppress Ras-Sensitized Epithelial Cell Proliferation.

Liu H, Dowdle JA, Khurshid S, Sullivan NJ, Bertos N, Rambani K, Mair M, Daniel P, Wheeler E, Tang X, Toth K, Lause M, Harrigan ME, Eiring K, Sullivan C, Sullivan MJ, Chang SW, Srivastava S, Conway JS, Kladney R, McElroy J, Bae S, Lu Y, Tofigh A, Saleh SMI, Fernandez SA, Parvin JD, Coppola V, Macrae ER, Majumder S, Shapiro CL, Yee LD, Ramaswamy B, Hallett M, Ostrowski MC, Park M, Chamberlin HM, Leone G.

Dev Cell. 2017 May 22;41(4):392-407.e6. doi: 10.1016/j.devcel.2017.04.024.

21.

Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth.

Hammer AM, Sizemore GM, Shukla VC, Avendano A, Sizemore ST, Chang JJ, Kladney RD, Cuitiño MC, Thies KA, Verfurth Q, Chakravarti A, Yee LD, Leone G, Song JW, Ghadiali SN, Ostrowski MC.

Neoplasia. 2017 Jun;19(6):496-508. doi: 10.1016/j.neo.2017.04.004. Epub 2017 May 11.

22.

Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo.

Komar HM, Serpa G, Kerscher C, Schwoegl E, Mace TA, Jin M, Yang MC, Chen CS, Bloomston M, Ostrowski MC, Hart PA, Conwell DL, Lesinski GB.

Sci Rep. 2017 May 11;7(1):1787. doi: 10.1038/s41598-017-01973-0.

23.

The ETS family of oncogenic transcription factors in solid tumours.

Sizemore GM, Pitarresi JR, Balakrishnan S, Ostrowski MC.

Nat Rev Cancer. 2017 Jun;17(6):337-351. doi: 10.1038/nrc.2017.20. Epub 2017 Apr 28. Review.

PMID:
28450705
24.

IL-6 and PD-L1 antibody blockade combination therapy reduces tumour progression in murine models of pancreatic cancer.

Mace TA, Shakya R, Pitarresi JR, Swanson B, McQuinn CW, Loftus S, Nordquist E, Cruz-Monserrate Z, Yu L, Young G, Zhong X, Zimmers TA, Ostrowski MC, Ludwig T, Bloomston M, Bekaii-Saab T, Lesinski GB.

Gut. 2018 Feb;67(2):320-332. doi: 10.1136/gutjnl-2016-311585. Epub 2016 Oct 21.

25.

Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1.

Sizemore GM, Balakrishnan S, Hammer AM, Thies KA, Trimboli AJ, Wallace JA, Sizemore ST, Kladney RD, Woelke SA, Yu L, Fernandez SA, Chakravarti A, Leone G, Ostrowski MC.

Oncogene. 2017 Apr 20;36(16):2297-2308. doi: 10.1038/onc.2016.383. Epub 2016 Oct 31. Erratum in: Oncogene. 2017 Oct 16;:.

26.

Stromal ETS2 Regulates Chemokine Production and Immune Cell Recruitment during Acinar-to-Ductal Metaplasia.

Pitarresi JR, Liu X, Sharma SM, Cuitiño MC, Kladney RD, Mace TA, Donohue S, Nayak SG, Qu C, Lee J, Woelke SA, Trela S, LaPak K, Yu L, McElroy J, Rosol TJ, Shakya R, Ludwig T, Lesinski GB, Fernandez SA, Konieczny SF, Leone G, Wu J, Ostrowski MC.

Neoplasia. 2016 Sep;18(9):541-52. doi: 10.1016/j.neo.2016.07.006.

27.

Genetic ablation of Smoothened in pancreatic fibroblasts increases acinar-ductal metaplasia.

Liu X, Pitarresi JR, Cuitiño MC, Kladney RD, Woelke SA, Sizemore GM, Nayak SG, Egriboz O, Schweickert PG, Yu L, Trela S, Schilling DJ, Halloran SK, Li M, Dutta S, Fernandez SA, Rosol TJ, Lesinski GB, Shakya R, Ludwig T, Konieczny SF, Leone G, Wu J, Ostrowski MC.

Genes Dev. 2016 Sep 1;30(17):1943-55. doi: 10.1101/gad.283499.116. Epub 2016 Sep 15.

28.

FGFR and PTEN signaling interact during lens development to regulate cell survival.

Chaffee BR, Hoang TV, Leonard MR, Bruney DG, Wagner BD, Dowd JR, Leone G, Ostrowski MC, Robinson ML.

Dev Biol. 2016 Feb 15;410(2):150-163. doi: 10.1016/j.ydbio.2015.12.027. Epub 2016 Jan 5.

29.

Single agent BMS-911543 Jak2 inhibitor has distinct inhibitory effects on STAT5 signaling in genetically engineered mice with pancreatic cancer.

Mace TA, Shakya R, Elnaggar O, Wilson K, Komar HM, Yang J, Pitarresi JR, Young GS, Ostrowski MC, Ludwig T, Bekaii-Saab T, Bloomston M, Lesinski GB.

Oncotarget. 2015 Dec 29;6(42):44509-22. doi: 10.18632/oncotarget.6332.

30.

E2f3 in tumor macrophages promotes lung metastasis.

Trikha P, Sharma N, Pena C, Reyes A, Pécot T, Khurshid S, Rawahneh M, Moffitt J, Stephens JA, Fernandez SA, Ostrowski MC, Leone G.

Oncogene. 2016 Jul 14;35(28):3636-46. doi: 10.1038/onc.2015.429. Epub 2015 Nov 9.

31.

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo.

Caserta E, Egriboz O, Wang H, Martin C, Koivisto C, Pecót T, Kladney RD, Shen C, Shim KS, Pham T, Karikomi MK, Mauntel MJ, Majumder S, Cuitino MC, Tang X, Srivastava A, Yu L, Wallace J, Mo X, Park M, Fernandez SA, Pilarski R, La Perle KM, Rosol TJ, Coppola V, Castrillon DH, Timmers C, Cohn DE, O'Malley DM, Backes F, Suarez AA, Goodfellow P, Chamberlin HM, Macrae ER, Shapiro CL, Ostrowski MC, Leone G.

Genes Dev. 2015 Aug 15;29(16):1707-20. doi: 10.1101/gad.262568.115.

32.

Failure to Target RANKL Signaling Through p38-MAPK Results in Defective Osteoclastogenesis in the Microphthalmia Cloudy-Eyed Mutant.

Carey HA, Bronisz A, Cabrera J, Hildreth BE 3rd, Cuitiño M, Fu Q, Ahmad A, Toribio RE, Ostrowski MC, Sharma SM.

J Cell Physiol. 2016 Mar;231(3):630-40. doi: 10.1002/jcp.25108.

33.

Cry protein crystals: a novel platform for protein delivery.

Nair MS, Lee MM, Bonnegarde-Bernard A, Wallace JA, Dean DH, Ostrowski MC, Burry RW, Boyaka PN, Chan MK.

PLoS One. 2015 Jun 1;10(6):e0127669. doi: 10.1371/journal.pone.0127669. eCollection 2015.

34.

Changes in BAI1 and nestin expression are prognostic indicators for survival and metastases in breast cancer and provide opportunities for dual targeted therapies.

Meisen WH, Dubin S, Sizemore ST, Mathsyaraja H, Thies K, Lehman NL, Boyer P, Jaime-Ramirez AC, Elder JB, Powell K, Chakravarti A, Ostrowski MC, Kaur B.

Mol Cancer Ther. 2015 Jan;14(1):307-14. doi: 10.1158/1535-7163.MCT-14-0659. Epub 2014 Nov 5.

35.

CSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth.

Mathsyaraja H, Thies K, Taffany DA, Deighan C, Liu T, Yu L, Fernandez SA, Shapiro C, Otero J, Timmers C, Lustberg MB, Chalmers J, Leone G, Ostrowski MC.

Oncogene. 2015 Jul;34(28):3651-61. doi: 10.1038/onc.2014.294. Epub 2014 Sep 22.

36.

MicroRNA 17-92 cluster mediates ETS1 and ETS2-dependent RAS-oncogenic transformation.

Kabbout M, Dakhlallah D, Sharma S, Bronisz A, Srinivasan R, Piper M, Marsh CB, Ostrowski MC.

PLoS One. 2014 Jun 26;9(6):e100693. doi: 10.1371/journal.pone.0100693. eCollection 2014.

37.

Protein kinase C Beta in the tumor microenvironment promotes mammary tumorigenesis.

Wallace JA, Pitarresi JR, Sharma N, Palettas M, Cuitiño MC, Sizemore ST, Yu L, Sanderlin A, Rosol TJ, Mehta KD, Sizemore GM, Ostrowski MC.

Front Oncol. 2014 Apr 23;4:87. doi: 10.3389/fonc.2014.00087. eCollection 2014.

38.

Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1.

Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari K, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J.

Cancer Res. 2014 Feb 1;74(3):738-750. doi: 10.1158/0008-5472.CAN-13-2650. Epub 2013 Dec 5.

39.

The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF).

Bronisz A, Carey HA, Godlewski J, Sif S, Ostrowski MC, Sharma SM.

J Biol Chem. 2014 Jan 3;289(1):326-34. doi: 10.1074/jbc.M113.493874. Epub 2013 Nov 20.

40.

Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer.

Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, Park M, Leone G, Ostrowski MC.

PLoS One. 2013 Aug 16;8(8):e71533. doi: 10.1371/journal.pone.0071533. eCollection 2013.

41.

Transcription factor ATF3 links host adaptive response to breast cancer metastasis.

Wolford CC, McConoughey SJ, Jalgaonkar SP, Leon M, Merchant AS, Dominick JL, Yin X, Chang Y, Zmuda EJ, O'Toole SA, Millar EK, Roller SL, Shapiro CL, Ostrowski MC, Sutherland RL, Hai T.

J Clin Invest. 2013 Jul;123(7):2893-906. doi: 10.1172/JCI64410. Epub 2013 Jun 10.

42.

MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells.

Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, Ostrowski MC, Chiocca EA, Godlewski J.

Neuro Oncol. 2013 Sep;15(9):1212-24. doi: 10.1093/neuonc/not055. Epub 2013 Jun 3.

43.

Systemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma.

Wojton J, Chu Z, Mathsyaraja H, Meisen WH, Denton N, Kwon CH, Chow LM, Palascak M, Franco R, Bourdeau T, Thornton S, Ostrowski MC, Kaur B, Qi X.

Mol Ther. 2013 Aug;21(8):1517-25. doi: 10.1038/mt.2013.114. Epub 2013 Jun 4.

44.

Setting Snail2's pace during EMT.

Mathsyaraja H, Ostrowski MC.

Nat Cell Biol. 2012 Nov;14(11):1122-3. doi: 10.1038/ncb2616.

PMID:
23131919
45.

Loss of fibroblast HIF-1α accelerates tumorigenesis.

Kim JW, Evans C, Weidemann A, Takeda N, Lee YS, Stockmann C, Branco-Price C, Brandberg F, Leone G, Ostrowski MC, Johnson RS.

Cancer Res. 2012 Jul 1;72(13):3187-95. doi: 10.1158/0008-5472.CAN-12-0534. Epub 2012 May 3.

46.

Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320.

Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srinivasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pécot T, Rosol TJ, Cory S, Hallett M, Park M, Piper MG, Marsh CB, Yee LD, Jimenez RE, Nuovo G, Lawler SE, Chiocca EA, Leone G, Ostrowski MC.

Nat Cell Biol. 2011 Dec 18;14(2):159-67. doi: 10.1038/ncb2396.

47.

NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model.

Connelly L, Barham W, Onishko HM, Chen L, Sherrill TP, Zabuawala T, Ostrowski MC, Blackwell TS, Yull FE.

Breast Cancer Res. 2011 Aug 31;13(4):R83. doi: 10.1186/bcr2935.

48.

NF-κB signaling in fetal lung macrophages disrupts airway morphogenesis.

Blackwell TS, Hipps AN, Yamamoto Y, Han W, Barham WJ, Ostrowski MC, Yull FE, Prince LS.

J Immunol. 2011 Sep 1;187(5):2740-7. doi: 10.4049/jimmunol.1101495. Epub 2011 Jul 20.

49.

Transcription factor ets-2 plays an important role in the pathogenesis of pulmonary fibrosis.

Baran CP, Fischer SN, Nuovo GJ, Kabbout MN, Hitchcock CL, Bringardner BD, McMaken S, Newland CA, Cantemir-Stone CZ, Phillips GS, Ostrowski MC, Marsh CB.

Am J Respir Cell Mol Biol. 2011 Nov;45(5):999-1006. doi: 10.1165/rcmb.2010-0490OC. Epub 2011 May 11.

50.

Pten in the breast tumor microenvironment: modeling tumor-stroma coevolution.

Wallace JA, Li F, Leone G, Ostrowski MC.

Cancer Res. 2011 Feb 15;71(4):1203-7. doi: 10.1158/0008-5472.CAN-10-3263. Epub 2011 Feb 8. Review.

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