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Items: 1 to 50 of 84

1.

Role of Proinsulin Self-Association in Mutant INS gene-induced Diabetes of Youth.

Sun J, Xiong Y, Li X, Haataja L, Chen W, Mir SA, Lv L, Madley R, Larkin D, Anjum A, Dhayalan B, Rege N, Wickramasinghe ND, Weiss MA, Itkin-Ansari P, Kaufman RJ, Ostrov DA, Arvan P, Liu M.

Diabetes. 2020 Mar 5. pii: db191106. doi: 10.2337/db19-1106. [Epub ahead of print]

PMID:
32139596
2.

A Novel Small Molecule Inhibits Intrahepatocellular Accumulation of Z-Variant Alpha 1-Antitrypsin In Vitro and In Vivo.

Zhang X, Pham K, Li D, Schutte RJ, Gonzalo DH, Zhang P, Oshins R, Tan W, Brantly M, Liu C, Ostrov DA.

Cells. 2019 Dec 6;8(12). pii: E1586. doi: 10.3390/cells8121586.

3.

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated with Carbonic Anhydrase Inhibitors: Epidemiology, Genetics, and Insights into Mechanisms.

Trubiano JA, Ostrov DA, Phillips EJ.

J Allergy Clin Immunol Pract. 2019 Nov - Dec;7(8):2854-2856. doi: 10.1016/j.jaip.2019.07.013. No abstract available.

PMID:
31706497
4.

Identification of drug-specific public TCR driving severe cutaneous adverse reactions.

Pan RY, Chu MT, Wang CW, Lee YS, Lemonnier F, Michels AW, Schutte R, Ostrov DA, Chen CB, Phillips EJ, Mallal SA, Mockenhaupt M, Bellón T, Tassaneeyakul W, White KD, Roujeau JC, Chung WH, Hung SI.

Nat Commun. 2019 Aug 8;10(1):3569. doi: 10.1038/s41467-019-11396-2.

5.

Interleukin-8 blockade prevents activated endothelial cell mediated proliferation and chemoresistance of acute myeloid leukemia.

Vijay V, Miller R, Vue GS, Pezeshkian MB, Maywood M, Ast AM, Drusbosky LM, Pompeu Y, Salgado AD, Lipten SD, Geddes T, Blenc AM, Ge Y, Ostrov DA, Cogle CR, Madlambayan GJ.

Leuk Res. 2019 Sep;84:106180. doi: 10.1016/j.leukres.2019.106180. Epub 2019 Jul 3.

PMID:
31299413
6.

Targeting the site encoded by SERPINA1*E342K for treating alpha-1 antitrypsin deficiency-associated liver diseases.

Zhang X, Pham K, Li D, Schutte RJ, Brantly M, Liu C, Ostrov DA.

FEBS Lett. 2019 Jul;593(14):1849-1862. doi: 10.1002/1873-3468.13452. Epub 2019 Jun 6.

PMID:
31116417
7.

Molecular docking predictions of fragrance binding to human leukocyte antigen molecules.

Schutte RJ, Zhang X, An N, Ostrov DA, Vukmanović S.

Contact Dermatitis. 2019 Sep;81(3):174-183. doi: 10.1111/cod.13283. Epub 2019 Jul 9.

PMID:
30957232
8.

Dapsone- and nitroso dapsone-specific activation of T cells from hypersensitive patients expressing the risk allele HLA-B*13:01.

Zhao Q, Alhilali K, Alzahrani A, Almutairi M, Amjad J, Liu H, Sun Y, Sun L, Zhang H, Meng X, Gibson A, Ogese MO, Kevin Park B, Liu J, Ostrov DA, Zhang F, Naisbitt DJ.

Allergy. 2019 Aug;74(8):1533-1548. doi: 10.1111/all.13769. Epub 2019 Apr 15.

9.

HLA-A*32:01 is strongly associated with vancomycin-induced drug reaction with eosinophilia and systemic symptoms.

Konvinse KC, Trubiano JA, Pavlos R, James I, Shaffer CM, Bejan CA, Schutte RJ, Ostrov DA, Pilkinton MA, Rosenbach M, Zwerner JP, Williams KB, Bourke J, Martinez P, Rwandamuriye F, Chopra A, Watson M, Redwood AJ, White KD, Mallal SA, Phillips EJ.

J Allergy Clin Immunol. 2019 Jul;144(1):183-192. doi: 10.1016/j.jaci.2019.01.045. Epub 2019 Feb 16.

PMID:
30776417
10.

Rationally designed small molecules to prevent type 1 diabetes.

Ostrov DA, Gottlieb PA, Michels AW.

Curr Opin Endocrinol Diabetes Obes. 2019 Apr;26(2):90-95. doi: 10.1097/MED.0000000000000470. Review.

PMID:
30694829
11.

Human Leukocyte Antigen Associations in Drug Hypersensitivity Reactions.

Schutte RJ, Sun Y, Li D, Zhang F, Ostrov DA.

Clin Lab Med. 2018 Dec;38(4):669-677. doi: 10.1016/j.cll.2018.08.002. Review.

PMID:
30420060
12.

Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors.

Ratnayake WS, Apostolatos CA, Apostolatos AH, Schutte RJ, Huynh MA, Ostrov DA, Acevedo-Duncan M.

Cell Adh Migr. 2018;12(5):447-463. doi: 10.1080/19336918.2018.1471323. Epub 2018 May 21.

13.

Methyldopa blocks MHC class II binding to disease-specific antigens in autoimmune diabetes.

Ostrov DA, Alkanani A, McDaniel KA, Case S, Baschal EE, Pyle L, Ellis S, Pöllinger B, Seidl KJ, Shah VN, Garg SK, Atkinson MA, Gottlieb PA, Michels AW.

J Clin Invest. 2018 May 1;128(5):1888-1902. doi: 10.1172/JCI97739. Epub 2018 Apr 3.

14.

SJS/TEN 2017: Building Multidisciplinary Networks to Drive Science and Translation.

White KD, Abe R, Ardern-Jones M, Beachkofsky T, Bouchard C, Carleton B, Chodosh J, Cibotti R, Davis R, Denny JC, Dodiuk-Gad RP, Ergen EN, Goldman JL, Holmes JH 4th, Hung SI, Lacouture ME, Lehloenya RJ, Mallal S, Manolio TA, Micheletti RG, Mitchell CM, Mockenhaupt M, Ostrov DA, Pavlos R, Pirmohamed M, Pope E, Redwood A, Rosenbach M, Rosenblum MD, Roujeau JC, Saavedra AP, Saeed HN, Struewing JP, Sueki H, Sukasem C, Sung C, Trubiano JA, Weintraub J, Wheatley LM, Williams KB, Worley B, Chung WH, Shear NH, Phillips EJ.

J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):38-69. doi: 10.1016/j.jaip.2017.11.023. Review.

15.

Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis.

Ratnayake WS, Apostolatos AH, Ostrov DA, Acevedo-Duncan M.

Int J Oncol. 2017 Nov;51(5):1370-1382. doi: 10.3892/ijo.2017.4131. Epub 2017 Sep 22.

16.

Shared peptide binding of HLA Class I and II alleles associate with cutaneous nevirapine hypersensitivity and identify novel risk alleles.

Pavlos R, McKinnon EJ, Ostrov DA, Peters B, Buus S, Koelle D, Chopra A, Schutte R, Rive C, Redwood A, Restrepo S, Bracey A, Kaever T, Myers P, Speers E, Malaker SA, Shabanowitz J, Jing Y, Gaudieri S, Hunt DF, Carrington M, Haas DW, Mallal S, Phillips EJ.

Sci Rep. 2017 Aug 17;7(1):8653. doi: 10.1038/s41598-017-08876-0.

17.

Structural Elements Recognized by Abacavir-Induced T Cells.

Yerly D, Pompeu YA, Schutte RJ, Eriksson KK, Strhyn A, Bracey AW, Buus S, Ostrov DA.

Int J Mol Sci. 2017 Jul 7;18(7). pii: E1464. doi: 10.3390/ijms18071464.

18.

Association of the HLA-B*53:01 Allele With Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome During Treatment of HIV Infection With Raltegravir.

Thomas M, Hopkins C, Duffy E, Lee D, Loulergue P, Ripamonti D, Ostrov DA, Phillips E.

Clin Infect Dis. 2017 May 1;64(9):1198-1203. doi: 10.1093/cid/cix096.

19.

Sulfatide Preserves Insulin Crystals Not by Being Integrated in the Lattice but by Stabilizing Their Surface.

Buschard K, Bracey AW, McElroy DL, Magis AT, Osterbye T, Atkinson MA, Bailey KM, Posgai AL, Ostrov DA.

J Diabetes Res. 2016;2016:6179635. doi: 10.1155/2016/6179635. Epub 2016 Feb 14.

20.

Identification of a Small Molecule Inhibitor of RAD52 by Structure-Based Selection.

Sullivan K, Cramer-Morales K, McElroy DL, Ostrov DA, Haas K, Childers W, Hromas R, Skorski T.

PLoS One. 2016 Jan 19;11(1):e0147230. doi: 10.1371/journal.pone.0147230. eCollection 2016.

21.

Effects of type 1 diabetes-associated IFIH1 polymorphisms on MDA5 function and expression.

Looney BM, Xia CQ, Concannon P, Ostrov DA, Clare-Salzler MJ.

Curr Diab Rep. 2015 Nov;15(11):96. doi: 10.1007/s11892-015-0656-8. Review.

PMID:
26385483
22.

Report from the National Institute of Allergy and Infectious Diseases workshop on drug allergy.

Wheatley LM, Plaut M, Schwaninger JM, Banerji A, Castells M, Finkelman FD, Gleich GJ, Guttman-Yassky E, Mallal SA, Naisbitt DJ, Ostrov DA, Phillips EJ, Pichler WJ, Platts-Mills TA, Roujeau JC, Schwartz LB, Trepanier LA.

J Allergy Clin Immunol. 2015 Aug;136(2):262-71.e2. doi: 10.1016/j.jaci.2015.05.027.

23.

New approaches for predicting T cell-mediated drug reactions: A role for inducible and potentially preventable autoimmunity.

Michels AW, Ostrov DA.

J Allergy Clin Immunol. 2015 Aug;136(2):252-7. doi: 10.1016/j.jaci.2015.06.024. Review.

24.

New genetic findings lead the way to a better understanding of fundamental mechanisms of drug hypersensitivity.

Pirmohamed M, Ostrov DA, Park BK.

J Allergy Clin Immunol. 2015 Aug;136(2):236-44. doi: 10.1016/j.jaci.2015.06.022. Review.

25.

Acyclovir Has Low but Detectable Influence on HLA-B*57:01 Specificity without Inducing Hypersensitivity.

Metushi IG, Wriston A, Banerjee P, Gohlke BO, English AM, Lucas A, Moore C, Sidney J, Buus S, Ostrov DA, Mallal S, Phillips E, Shabanowitz J, Hunt DF, Preissner R, Peters B.

PLoS One. 2015 May 29;10(5):e0124878. doi: 10.1371/journal.pone.0124878. eCollection 2015.

26.

Abacavir-reactive memory T cells are present in drug naïve individuals.

Lucas A, Lucas M, Strhyn A, Keane NM, McKinnon E, Pavlos R, Moran EM, Meyer-Pannwitt V, Gaudieri S, D'Orsogna L, Kalams S, Ostrov DA, Buus S, Peters B, Mallal S, Phillips E.

PLoS One. 2015 Feb 12;10(2):e0117160. doi: 10.1371/journal.pone.0117160. eCollection 2015.

27.

Development of novel Asf1-H3/H4 inhibitors.

Miknis GF, Stevens SJ, Smith LE, Ostrov DA, Churchill ME.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):963-8. doi: 10.1016/j.bmcl.2014.11.067. Epub 2014 Dec 4.

28.

Defective hydrophobic sliding mechanism and active site expansion in HIV-1 protease drug resistant variant Gly48Thr/Leu89Met: mechanisms for the loss of saquinavir binding potency.

Goldfarb NE, Ohanessian M, Biswas S, McGee TD Jr, Mahon BP, Ostrov DA, Garcia J, Tang Y, McKenna R, Roitberg A, Dunn BM.

Biochemistry. 2015 Jan 20;54(2):422-33. doi: 10.1021/bi501088e. Epub 2015 Jan 7.

29.

Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma.

Zhao X, Puszyk WM, Lu Z, Ostrov DA, George TJ, Robertson KD, Liu C.

Mol Cancer Ther. 2015 Jan;14(1):80-9. doi: 10.1158/1535-7163.MCT-14-0229. Epub 2014 Oct 24.

30.

HLA-DRA variants predict penicillin allergy in genome-wide fine-mapping genotyping.

Guéant JL, Romano A, Cornejo-Garcia JA, Oussalah A, Chery C, Blanca-López N, Guéant-Rodriguez RM, Gaeta F, Rouyer P, Josse T, Canto G, Carmona FD, Bossini-Castillo L, Martin J, Laguna JJ, Fernandez J, Feo F, Ostrov DA, Plasencia PC, Mayorga C, Torres MJ, Blanca M.

J Allergy Clin Immunol. 2015 Jan;135(1):253-9. doi: 10.1016/j.jaci.2014.07.047. Epub 2014 Sep 12.

PMID:
25224099
31.

Discovery of structure-based small molecular inhibitor of αB-crystallin against basal-like/triple-negative breast cancer development in vitro and in vivo.

Chen Z, Ruan Q, Han S, Xi L, Jiang W, Jiang H, Ostrov DA, Cai J.

Breast Cancer Res Treat. 2014 May;145(1):45-59. doi: 10.1007/s10549-014-2940-8. Epub 2014 Apr 8.

PMID:
24710637
32.

The effect of malnutrition on norovirus infection.

Hickman D, Jones MK, Zhu S, Kirkpatrick E, Ostrov DA, Wang X, Ukhanova M, Sun Y, Mai V, Salemi M, Karst SM.

mBio. 2014 Mar 4;5(2):e01032-13. doi: 10.1128/mBio.01032-13.

33.

Gabapentin hybrid peptides and bioconjugates.

Lebedyeva IO, Ostrov DA, Neubert J, Steel PJ, Patel K, Sileno SM, Goncalves K, Ibrahim MA, Alamry KA, Katritzky AR.

Bioorg Med Chem. 2014 Feb 15;22(4):1479-86. doi: 10.1016/j.bmc.2013.12.017. Epub 2013 Dec 12.

PMID:
24468631
34.

Identification of adenine nucleotide translocase 4 inhibitors by molecular docking.

Leung WY, Hamazaki T, Ostrov DA, Terada N.

J Mol Graph Model. 2013 Sep;45:173-9. doi: 10.1016/j.jmgm.2013.08.016. Epub 2013 Sep 4.

35.

Potent elastase inhibitors from cyanobacteria: structural basis and mechanisms mediating cytoprotective and anti-inflammatory effects in bronchial epithelial cells.

Salvador LA, Taori K, Biggs JS, Jakoncic J, Ostrov DA, Paul VJ, Luesch H.

J Med Chem. 2013 Feb 14;56(3):1276-90. doi: 10.1021/jm3017305. Epub 2013 Jan 28.

36.

Engineered AAV vector minimizes in vivo targeting of transduced hepatocytes by capsid-specific CD8+ T cells.

Martino AT, Basner-Tschakarjan E, Markusic DM, Finn JD, Hinderer C, Zhou S, Ostrov DA, Srivastava A, Ertl HC, Terhorst C, High KA, Mingozzi F, Herzog RW.

Blood. 2013 Mar 21;121(12):2224-33. doi: 10.1182/blood-2012-10-460733. Epub 2013 Jan 16.

37.

Immunology. A decorated virus cannot hide.

Herzog RW, Ostrov DA.

Science. 2012 Nov 9;338(6108):748-9. doi: 10.1126/science.1230342. No abstract available.

PMID:
23139318
38.

The structural basis of HLA-associated drug hypersensitivity syndromes.

Pompeu YA, Stewart JD, Mallal S, Phillips E, Peters B, Ostrov DA.

Immunol Rev. 2012 Nov;250(1):158-66. doi: 10.1111/j.1600-065X.2012.01163.x. Review.

PMID:
23046128
39.

Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.

Ucar DA, Kurenova E, Garrett TJ, Cance WG, Nyberg C, Cox A, Massoll N, Ostrov DA, Lawrence N, Sebti SM, Zajac-Kaye M, Hochwald SN.

Cell Cycle. 2012 Sep 1;11(17):3250-9. doi: 10.4161/cc.21611. Epub 2012 Aug 16.

40.

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire.

Ostrov DA, Grant BJ, Pompeu YA, Sidney J, Harndahl M, Southwood S, Oseroff C, Lu S, Jakoncic J, de Oliveira CA, Yang L, Mei H, Shi L, Shabanowitz J, English AM, Wriston A, Lucas A, Phillips E, Mallal S, Grey HM, Sette A, Hunt DF, Buus S, Peters B.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9959-64. doi: 10.1073/pnas.1207934109. Epub 2012 May 29.

41.

Enoxacin directly inhibits osteoclastogenesis without inducing apoptosis.

Toro EJ, Zuo J, Ostrov DA, Catalfamo D, Bradaschia-Correa V, Arana-Chavez V, Caridad AR, Neubert JK, Wronski TJ, Wallet SM, Holliday LS.

J Biol Chem. 2012 May 18;287(21):17894-904. doi: 10.1074/jbc.M111.280511. Epub 2012 Apr 2.

42.

Kinetic characterization of newly discovered inhibitors of various constructs of human T-cell leukemia virus-1 (HTLV-1) protease and their effect on HTLV-1-infected cells.

Demir A, Oguariri RM, Magis A, Ostrov DA, Imamichi T, Dunn BM.

Antivir Ther. 2012;17(5):883-92. doi: 10.3851/IMP2090. Epub 2012 Mar 21.

PMID:
22436331
43.

A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl)-3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo.

Golubovskaya VM, Figel S, Ho BT, Johnson CP, Yemma M, Huang G, Zheng M, Nyberg C, Magis A, Ostrov DA, Gelman IH, Cance WG.

Carcinogenesis. 2012 May;33(5):1004-13. doi: 10.1093/carcin/bgs120. Epub 2012 Mar 7.

44.

Genomic and functional characterization of the diverse immunoglobulin domain-containing protein (DICP) family.

Haire RN, Cannon JP, O'Driscoll ML, Ostrov DA, Mueller MG, Turner PM, Litman RT, Litman GW, Yoder JA.

Genomics. 2012 May;99(5):282-91. doi: 10.1016/j.ygeno.2012.02.004. Epub 2012 Feb 21.

45.

Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease.

Ezgimen M, Lai H, Mueller NH, Lee K, Cuny G, Ostrov DA, Padmanabhan R.

Antiviral Res. 2012 Apr;94(1):18-24. doi: 10.1016/j.antiviral.2012.02.003. Epub 2012 Feb 11.

46.

Rational identification of enoxacin as a novel V-ATPase-directed osteoclast inhibitor.

Toro EJ, Ostrov DA, Wronski TJ, Holliday LS.

Curr Protein Pept Sci. 2012 Mar;13(2):180-91. Review.

47.

Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentation.

Michels AW, Ostrov DA, Zhang L, Nakayama M, Fuse M, McDaniel K, Roep BO, Gottlieb PA, Atkinson MA, Eisenbarth GS.

J Immunol. 2011 Dec 1;187(11):5921-30. doi: 10.4049/jimmunol.1100746. Epub 2011 Oct 31.

48.

Molecular imaging of inflammation and carcinogenesis.

Ostrov DA, Contag CH.

Cancer Prev Res (Phila). 2011 Oct;4(10):1523-6. doi: 10.1158/1940-6207.CAPR-11-0418.

49.

Prediction of off-target effects on angiotensin-converting enzyme 2.

Kulemina LV, Ostrov DA.

J Biomol Screen. 2011 Sep;16(8):878-85. doi: 10.1177/1087057111413919. Epub 2011 Aug 22.

PMID:
21859683
50.

A novel small molecule inhibitor of FAK and IGF-1R protein interactions decreases growth of human esophageal carcinoma.

Ucar DA, Cox A, He DH, Ostrov DA, Kurenova E, Hochwald SN.

Anticancer Agents Med Chem. 2011 Sep;11(7):629-37.

PMID:
21707510

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