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Author Correction: Sensory primary cilium is a responsive cAMP microdomain in renal epithelia.

Sherpa RT, Mohieldin AM, Pala R, Wachten D, Ostrom RS, Nauli SM.

Sci Rep. 2020 Jan 29;10(1):1731. doi: 10.1038/s41598-020-58754-5.


Glucocorticoids rapidly activate cAMP production via Gαs to initiate non-genomic signaling that contributes to one-third of their canonical genomic effects.

Nuñez FJ, Johnstone TB, Corpuz ML, Kazarian AG, Mohajer NN, Tliba O, Panettieri RA Jr, Koziol-White C, Roosan MR, Ostrom RS.

FASEB J. 2020 Feb;34(2):2882-2895. doi: 10.1096/fj.201902521R. Epub 2019 Dec 27.


Agonist-specific desensitization of PGE2-stimulated cAMP signaling due to upregulated phosphodiesterase expression in human lung fibroblasts.

Nunez FJ, Schulte NA, Fogel DM, Michalski J, Rennard SI, Penn RB, Toews ML, Ostrom RS.

Naunyn Schmiedebergs Arch Pharmacol. 2019 Dec 28. doi: 10.1007/s00210-019-01800-5. [Epub ahead of print]


Budesonide enhances agonist-induced bronchodilation in human small airways by increasing cAMP production in airway smooth muscle.

Koziol-White C, Johnstone TB, Corpuz ML, Cao G, Orfanos S, Parikh V, Deeney B, Tliba O, Ostrom RS, Dainty I, Panettieri RA Jr.

Am J Physiol Lung Cell Mol Physiol. 2020 Feb 1;318(2):L345-L355. doi: 10.1152/ajplung.00393.2019. Epub 2019 Nov 20.


Effect of Adenylyl Cyclase Type 6 on Localized Production of cAMP by β-2 Adrenoceptors in Human Airway Smooth-Muscle Cells.

Agarwal SR, Fiore C, Miyashiro K, Ostrom RS, Harvey RD.

J Pharmacol Exp Ther. 2019 Jul;370(1):104-110. doi: 10.1124/jpet.119.256594. Epub 2019 May 8.


Sensory primary cilium is a responsive cAMP microdomain in renal epithelia.

Sherpa RT, Mohieldin AM, Pala R, Wachten D, Ostrom RS, Nauli SM.

Sci Rep. 2019 Apr 25;9(1):6523. doi: 10.1038/s41598-019-43002-2. Erratum in: Sci Rep. 2020 Jan 29;10(1):1731.


Transforming Growth Factor-β1 Decreases β2-Agonist-induced Relaxation in Human Airway Smooth Muscle.

Ojiaku CA, Chung E, Parikh V, Williams JK, Schwab A, Fuentes AL, Corpuz ML, Lui V, Paek S, Bexiga NM, Narayan S, Nunez FJ, Ahn K, Ostrom RS, An SS, Panettieri RA Jr.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):209-218. doi: 10.1165/rcmb.2018-0301OC.


p53 Expression in Lung Fibroblasts Is Linked to Mitigation of Fibrotic Lung Remodeling.

Nagaraja MR, Tiwari N, Shetty SK, Marudamuthu AS, Fan L, Ostrom RS, Fu J, Gopu V, Radhakrishnan V, Idell S, Shetty S.

Am J Pathol. 2018 Oct;188(10):2207-2222. doi: 10.1016/j.ajpath.2018.07.005.


cAMP attenuates TGF-β's profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4.

Qadri MM, Jay GD, Ostrom RS, Zhang LX, Elsaid KA.

Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C432-C443. doi: 10.1152/ajpcell.00041.2018. Epub 2018 Jun 13.


PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6.

Johnstone TB, Smith KH, Koziol-White CJ, Li F, Kazarian AG, Corpuz ML, Shumyatcher M, Ehlert FJ, Himes BE, Panettieri RA Jr, Ostrom RS.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):530-541. doi: 10.1165/rcmb.2017-0294OC.


cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes.

Johnstone TB, Agarwal SR, Harvey RD, Ostrom RS.

Mol Pharmacol. 2018 Apr;93(4):270-276. doi: 10.1124/mol.117.110825. Epub 2017 Dec 7. Review.


Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesis of myasthenia gravis.

Du A, Huang S, Zhao X, Feng K, Zhang S, Huang J, Miao X, Baggi F, Ostrom RS, Zhang Y, Chen X, Xu C.

Autophagy. 2017;13(11):1981-1994. doi: 10.1080/15548627.2017.1375633. Epub 2017 Sep 29.


Hsp90 inhibitor induces nuclear translocation of HSF1 predominantly in hippocampal CA1 region.

Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K, Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao FF.

Mol Psychiatry. 2017 Jul;22(7):935. doi: 10.1038/mp.2017.125. No abstract available.


Compartmentalized cAMP responses to prostaglandin EP2 receptor activation in human airway smooth muscle cells.

Agarwal SR, Miyashiro K, Latt H, Ostrom RS, Harvey RD.

Br J Pharmacol. 2017 Aug;174(16):2784-2796. doi: 10.1111/bph.13904. Epub 2017 Jul 12.


International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.

Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R.

Pharmacol Rev. 2017 Apr;69(2):93-139. doi: 10.1124/pr.116.013078. Review.


A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism.

Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K, Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao FF.

Mol Psychiatry. 2017 Jul;22(7):990-1001. doi: 10.1038/mp.2016.104. Epub 2016 Jul 26.


A new molecular target for blunting organ fibrosis. Focus on "Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention".

Ostrom RS.

Am J Physiol Cell Physiol. 2014 Mar 15;306(6):C527-8. doi: 10.1152/ajpcell.00020.2014. Epub 2014 Jan 22. No abstract available.


Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms.

Bogard AS, Birg AV, Ostrom RS.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Apr;387(4):329-39. doi: 10.1007/s00210-013-0950-4. Epub 2013 Dec 22.


Adenylyl cyclase 6 activation negatively regulates TLR4 signaling through lipid raft-mediated endocytosis.

Cai W, Du A, Feng K, Zhao X, Qian L, Ostrom RS, Xu C.

J Immunol. 2013 Dec 15;191(12):6093-100. doi: 10.4049/jimmunol.1301912. Epub 2013 Nov 11.


Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.

Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ.

J Pharmacol Exp Ther. 2013 Nov;347(2):276-87. doi: 10.1124/jpet.113.207449. Epub 2013 Sep 5.


Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle.

Bogard AS, Adris P, Ostrom RS.

J Pharmacol Exp Ther. 2012 Aug;342(2):586-95. doi: 10.1124/jpet.112.193425. Epub 2012 May 22.


Melatonin membrane receptors in peripheral tissues: distribution and functions.

Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT.

Mol Cell Endocrinol. 2012 Apr 4;351(2):152-66. doi: 10.1016/j.mce.2012.01.004. Epub 2012 Jan 8. Review.


Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps.

Ostrom RS, Bogard AS, Gros R, Feldman RD.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Jan;385(1):5-12. doi: 10.1007/s00210-011-0696-9. Epub 2011 Oct 20. Review.


Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.

Bogard AS, Xu C, Ostrom RS.

J Pharmacol Exp Ther. 2011 Apr;337(1):209-17. doi: 10.1124/jpet.110.177923. Epub 2011 Jan 12.


The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder.

Pak KJ, Ostrom RS, Matsui M, Ehlert FJ.

J Pharmacol Exp Ther. 2010 Oct;335(1):239-48. doi: 10.1124/jpet.110.169995. Epub 2010 Jul 12.


Impaired M3 and enhanced M2 muscarinic receptor contractile function in a streptozotocin model of mouse diabetic urinary bladder.

Pak KJ, Ostrom RS, Matsui M, Ehlert FJ.

Naunyn Schmiedebergs Arch Pharmacol. 2010 May;381(5):441-54. doi: 10.1007/s00210-010-0509-6. Epub 2010 Mar 27.


Fibroblast-specific expression of AC6 enhances beta-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis.

Liu X, Li F, Sun SQ, Thangavel M, Kaminsky J, Balazs L, Ostrom RS.

Am J Physiol Lung Cell Mol Physiol. 2010 Jun;298(6):L819-29. doi: 10.1152/ajplung.00429.2009. Epub 2010 Mar 26.


The guinea pig ileum lacks the direct, high-potency, M(2)-muscarinic, contractile mechanism characteristic of the mouse ileum.

Griffin MT, Matsui M, Ostrom RS, Ehlert FJ.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Oct;380(4):327-35. doi: 10.1007/s00210-009-0434-8. Epub 2009 Jul 7.


CD82 endocytosis and cholesterol-dependent reorganization of tetraspanin webs and lipid rafts.

Xu C, Zhang YH, Thangavel M, Richardson MM, Liu L, Zhou B, Zheng Y, Ostrom RS, Zhang XA.

FASEB J. 2009 Oct;23(10):3273-88. doi: 10.1096/fj.08-123414. Epub 2009 Jun 4.


The C1 and C2 domains target human type 6 adenylyl cyclase to lipid rafts and caveolae.

Thangavel M, Liu X, Sun SQ, Kaminsky J, Ostrom RS.

Cell Signal. 2009 Feb;21(2):301-8. doi: 10.1016/j.cellsig.2008.10.017. Epub 2008 Nov 5.


An orphan GPCR finds a home in the heart.

Patel HH, Ostrom RS.

Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H479-81. doi: 10.1152/ajpheart.00633.2008. Epub 2008 Jun 27. No abstract available.


Detergent and detergent-free methods to define lipid rafts and caveolae.

Ostrom RS, Liu X.

Methods Mol Biol. 2007;400:459-68. Review.


Adenylyl cyclase type 6 overexpression selectively enhances beta-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts.

Liu X, Thangavel M, Sun SQ, Kaminsky J, Mahautmr P, Stitham J, Hwa J, Ostrom RS.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jun;377(4-6):359-69. Epub 2007 Oct 13.


Caveolae and lipid rafts: G protein-coupled receptor signaling microdomains in cardiac myocytes.

Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang CM, Roth DM.

Ann N Y Acad Sci. 2005 Jun;1047:166-72. Review.


cAMP-elevating agents and adenylyl cyclase overexpression promote an antifibrotic phenotype in pulmonary fibroblasts.

Liu X, Ostrom RS, Insel PA.

Am J Physiol Cell Physiol. 2004 May;286(5):C1089-99. Epub 2004 Jan 7.


Nitric oxide inhibition of adenylyl cyclase type 6 activity is dependent upon lipid rafts and caveolin signaling complexes.

Ostrom RS, Bundey RA, Insel PA.

J Biol Chem. 2004 May 7;279(19):19846-53. Epub 2004 Mar 8.


Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.

Insel PA, Ostrom RS.

Cell Mol Neurobiol. 2003 Jun;23(3):305-14. Review.


Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts.

Ostrom RS, Naugle JE, Hase M, Gregorian C, Swaney JS, Insel PA, Brunton LL, Meszaros JG.

J Biol Chem. 2003 Jul 4;278(27):24461-8. Epub 2003 Apr 23.


Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation.

Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG.

J Biol Chem. 2003 Feb 14;278(7):4590-6. Epub 2002 Dec 2.


New determinants of receptor-effector coupling: trafficking and compartmentation in membrane microdomains.

Ostrom RS.

Mol Pharmacol. 2002 Mar;61(3):473-6. Review. No abstract available.


RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking.

Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG.

Science. 2001 Nov 30;294(5548):1939-42.


Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase.

Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, Insel PA.

J Biol Chem. 2001 Nov 9;276(45):42063-9. Epub 2001 Aug 31.


Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP.

Ostrom RS, Gregorian C, Drenan RM, Gabot K, Rana BK, Insel PA.

Am J Physiol Cell Physiol. 2001 Aug;281(2):C524-31.

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