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Items: 43


Nuclear envelope-localized torsinA-LAP1 complex regulates hepatic VLDL secretion and steatosis.

Shin JY, Hernandez-Ono A, Fedotova T, Östlund C, Lee MJ, Gibeley SB, Liang CC, Dauer WT, Ginsberg HN, Worman HJ.

J Clin Invest. 2019 Aug 13;130:4885-4900. doi: 10.1172/JCI129769.


Pathogenic mutations in genes encoding nuclear envelope proteins and defective nucleocytoplasmic connections.

Östlund C, Chang W, Gundersen GG, Worman HJ.

Exp Biol Med (Maywood). 2019 Nov;244(15):1333-1344. doi: 10.1177/1535370219862243. Epub 2019 Jul 12. No abstract available.


Imbalanced nucleocytoskeletal connections create common polarity defects in progeria and physiological aging.

Chang W, Wang Y, Luxton GWG, Östlund C, Worman HJ, Gundersen GG.

Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3578-3583. doi: 10.1073/pnas.1809683116. Epub 2019 Feb 11.


A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.

Wang Y, Lichter-Konecki U, Anyane-Yeboa K, Shaw JE, Lu JT, Östlund C, Shin JY, Clark LN, Gundersen GG, Nagy PL, Worman HJ.

J Cell Sci. 2016 May 15;129(10):1975-80. doi: 10.1242/jcs.187302. Epub 2016 Mar 31.


Muscular Dystrophy Mutations Impair the Nuclear Envelope Emerin Self-assembly Properties.

Herrada I, Samson C, Velours C, Renault L, Östlund C, Chervy P, Puchkov D, Worman HJ, Buendia B, Zinn-Justin S.

ACS Chem Biol. 2015 Dec 18;10(12):2733-42. doi: 10.1021/acschembio.5b00648. Epub 2015 Oct 5.


Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts.

Chang W, Antoku S, Östlund C, Worman HJ, Gundersen GG.

Nucleus. 2015;6(1):77-88. doi: 10.1080/19491034.2015.1004947.


Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities.

Waterhouse DN, Sutherland BW, Santos ND, Masin D, Osooly M, Strutt D, Ostlund C, Anantha M, Harasym N, Manisali I, Wehbe M, Bally MB, Webb MS.

Invest New Drugs. 2014 Dec;32(6):1071-82. doi: 10.1007/s10637-014-0138-x. Epub 2014 Jul 27.


Inhibition of TGF-β signaling at the nuclear envelope: characterization of interactions between MAN1, Smad2 and Smad3, and PPM1A.

Bourgeois B, Gilquin B, Tellier-Lebègue C, Östlund C, Wu W, Pérez J, El Hage P, Lallemand F, Worman HJ, Zinn-Justin S.

Sci Signal. 2013 Jun 18;6(280):ra49. doi: 10.1126/scisignal.2003411.


Targeting carbonic anhydrase IX depletes breast cancer stem cells within the hypoxic niche.

Lock FE, McDonald PC, Lou Y, Serrano I, Chafe SC, Ostlund C, Aparicio S, Winum JY, Supuran CT, Dedhar S.

Oncogene. 2013 Oct 31;32(44):5210-9. doi: 10.1038/onc.2012.550. Epub 2012 Dec 3.


Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins.

Wang Y, Ostlund C, Choi JC, Swayne TC, Gundersen GG, Worman HJ.

Nucleus. 2012 Sep-Oct;3(5):452-62. doi: 10.4161/nucl.21675. Epub 2012 Aug 16.


Subcellular localization of SREBP1 depends on its interaction with the C-terminal region of wild-type and disease related A-type lamins.

Duband-Goulet I, Woerner S, Gasparini S, Attanda W, Kondé E, Tellier-Lebègue C, Craescu CT, Gombault A, Roussel P, Vadrot N, Vicart P, Ostlund C, Worman HJ, Zinn-Justin S, Buendia B.

Exp Cell Res. 2011 Dec 10;317(20):2800-13. doi: 10.1016/j.yexcr.2011.09.012. Epub 2011 Oct 4.


Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors.

Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, Kyle A, Auf dem Keller U, Leung S, Huntsman D, Clarke B, Sutherland BW, Waterhouse D, Bally M, Roskelley C, Overall CM, Minchinton A, Pacchiano F, Carta F, Scozzafava A, Touisni N, Winum JY, Supuran CT, Dedhar S.

Cancer Res. 2011 May 1;71(9):3364-76. doi: 10.1158/0008-5472.CAN-10-4261. Epub 2011 Mar 17. Erratum in: Cancer Res. 2011 Jul 1;71(13):4733. Cancer Res. 2011 Jun 15;71(12):4325.


Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement.

Folker ES, Ostlund C, Luxton GW, Worman HJ, Gundersen GG.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):131-6. doi: 10.1073/pnas.1000824108. Epub 2010 Dec 20.


Loss of a DNA binding site within the tail of prelamin A contributes to altered heterochromatin anchorage by progerin.

Bruston F, Delbarre E, Ostlund C, Worman HJ, Buendia B, Duband-Goulet I.

FEBS Lett. 2010 Jul 16;584(14):2999-3004. doi: 10.1016/j.febslet.2010.05.032. Epub 2010 May 24.


Diseases of the nuclear envelope.

Worman HJ, Ostlund C, Wang Y.

Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a000760. doi: 10.1101/cshperspect.a000760. Review.


Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins.

Ostlund C, Folker ES, Choi JC, Gomes ER, Gundersen GG, Worman HJ.

J Cell Sci. 2009 Nov 15;122(Pt 22):4099-108. doi: 10.1242/jcs.057075. Epub 2009 Oct 20.


Influence of surface topography on adhesive and long-range capillary forces between hydrophobic surfaces in water.

Wallqvist V, Claesson PM, Swerin A, Ostlund C, Schoelkopf J, Gane PA.

Langmuir. 2009 Aug 18;25(16):9197-207. doi: 10.1021/la900759e.


Reduction of a 4q35-encoded nuclear envelope protein in muscle differentiation.

Ostlund C, Guan T, Figlewicz DA, Hays AP, Worman HJ, Gerace L, Schirmer EC.

Biochem Biophys Res Commun. 2009 Nov 13;389(2):279-83. doi: 10.1016/j.bbrc.2009.08.133. Epub 2009 Aug 28.


The R439C mutation in LMNA causes lamin oligomerization and susceptibility to oxidative stress.

Verstraeten VL, Caputo S, van Steensel MA, Duband-Goulet I, Zinn-Justin S, Kamps M, Kuijpers HJ, Ostlund C, Worman HJ, Briedé JJ, Le Dour C, Marcelis CL, van Geel M, Steijlen PM, van den Wijngaard A, Ramaekers FC, Broers JL.

J Cell Mol Med. 2009 May;13(5):959-71. doi: 10.1111/j.1582-4934.2009.00690.x. Epub 2009 Feb 11.


The arginine methyltransferase Rmt2 is enriched in the nucleus and co-purifies with the nuclear porins Nup49, Nup57 and Nup100.

Olsson I, Berrez JM, Leipus A, Ostlund C, Mutvei A.

Exp Cell Res. 2007 May 15;313(9):1778-89. Epub 2007 Mar 15.


Dependence of diffusional mobility of integral inner nuclear membrane proteins on A-type lamins.

Ostlund C, Sullivan T, Stewart CL, Worman HJ.

Biochemistry. 2006 Feb 7;45(5):1374-82.


Both lamin A and lamin C mutations cause lamina instability as well as loss of internal nuclear lamin organization.

Broers JL, Kuijpers HJ, Ostlund C, Worman HJ, Endert J, Ramaekers FC.

Exp Cell Res. 2005 Apr 1;304(2):582-92. Epub 2004 Dec 20.


Intracellular trafficking and dynamics of double homeodomain proteins.

Ostlund C, Garcia-Carrasquillo RM, Belayew A, Worman HJ.

Biochemistry. 2005 Feb 22;44(7):2378-84.


Lamin-associated proteins.

Ostlund C, Worman HJ.

Methods Cell Biol. 2004;78:829-59. No abstract available.


Altered protein dynamics of disease-associated lamin A mutants.

Gilchrist S, Gilbert N, Perry P, Ostlund C, Worman HJ, Bickmore WA.

BMC Cell Biol. 2004 Dec 13;5(1):46.


Effect of pathogenic mis-sense mutations in lamin A on its interaction with emerin in vivo.

Holt I, Ostlund C, Stewart CL, Man Nt, Worman HJ, Morris GE.

J Cell Sci. 2003 Jul 15;116(Pt 14):3027-35. Epub 2003 Jun 3.


The carboxyl-terminal region common to lamins A and C contains a DNA binding domain.

Stierlé V, Couprie J, Ostlund C, Krimm I, Zinn-Justin S, Hossenlopp P, Worman HJ, Courvalin JC, Duband-Goulet I.

Biochemistry. 2003 May 6;42(17):4819-28.


Nuclear envelope proteins and neuromuscular diseases.

Ostlund C, Worman HJ.

Muscle Nerve. 2003 Apr;27(4):393-406. Review.


Expression of lamin A mutated in the carboxyl-terminal tail generates an aberrant nuclear phenotype similar to that observed in cells from patients with Dunnigan-type partial lipodystrophy and Emery-Dreifuss muscular dystrophy.

Favreau C, Dubosclard E, Ostlund C, Vigouroux C, Capeau J, Wehnert M, Higuet D, Worman HJ, Courvalin JC, Buendia B.

Exp Cell Res. 2003 Jan 1;282(1):14-23.


The Ig-like structure of the C-terminal domain of lamin A/C, mutated in muscular dystrophies, cardiomyopathy, and partial lipodystrophy.

Krimm I, Ostlund C, Gilquin B, Couprie J, Hossenlopp P, Mornon JP, Bonne G, Courvalin JC, Worman HJ, Zinn-Justin S.

Structure. 2002 Jun;10(6):811-23.


1H, 13C and 15N resonance assignments of the C-terminal domain of human lamin A/C.

Krimm I, Couprie J, Ostlund C, Worman HJ, Zinn-Justin S.

J Biomol NMR. 2002 Apr;22(4):371-2. No abstract available.


Statistical analysis of hyperspectral data from two Swedish lakes.

Flink P, Lindell T, Ostlund C.

Sci Total Environ. 2001 Mar 14;268(1-3):155-69.


Mapping of the water quality of Lake Erken, Sweden, from imaging spectrometry and Landsat Thematic Mapper.

Ostlund C, Flink P, Strömbeck N, Pierson D, Lindell T.

Sci Total Environ. 2001 Mar 14;268(1-3):139-54.


Intracellular trafficking of emerin, the Emery-Dreifuss muscular dystrophy protein.

Ostlund C, Ellenberg J, Hallberg E, Lippincott-Schwartz J, Worman HJ.

J Cell Sci. 1999 Jun;112 ( Pt 11):1709-19.


Autoantibodies in human chronic graft-versus-host disease after hematopoietic cell transplantation.

Quaranta S, Shulman H, Ahmed A, Shoenfeld Y, Peter J, McDonald GB, Van de Water J, Coppel R, Ostlund C, Worman HJ, Rizzetto M, Tsuneyama K, Nakanuma Y, Ansari A, Locatelli F, Paganin S, Rosina F, Manns M, Gershwin ME.

Clin Immunol. 1999 Apr;91(1):106-16.


Process-scale purification from cell culture supernatants: monoclonal antibodies.

Ostlund C, Borwell P, Malm B.

Dev Biol Stand. 1987;66:367-75.


Iodinated fibroblast beta-glucuronidase as a ligand for receptor-mediated endocytosis.

Dean MF, Diment S, Ostlünd C, Jenne BM, Contractor S.

Biochem J. 1985 Jul 1;229(1):213-9.


Quantification of unscheduled DNA synthesis in mononuclear leukocytes of the horse.

Ostlund C, Pero RW, Johnson DB.

Comp Biochem Physiol B. 1985;81(3):787-92.


Reproducibility and the influence of age on interspecimen determinations of blood pressure in the horse.

Ostlund C, Pero RW, Olsson B.

Comp Biochem Physiol A Comp Physiol. 1983;74(1):11-20.


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