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Items: 17


Lovastatin, not Simvastatin, Corrects Core Phenotypes in the Fragile X Mouse Model.

Muscas M, Louros SR, Osterweil EK.

eNeuro. 2019 Jun 12;6(3). pii: ENEURO.0097-19.2019. doi: 10.1523/ENEURO.0097-19.2019. Print 2019 May/Jun.


Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome.

Asiminas A, Jackson AD, Louros SR, Till SM, Spano T, Dando O, Bear MF, Chattarji S, Hardingham GE, Osterweil EK, Wyllie DJA, Wood ER, Kind PC.

Sci Transl Med. 2019 May 29;11(494). pii: eaao0498. doi: 10.1126/scitranslmed.aao0498.


Cell-Type-Specific Translation Profiling Reveals a Novel Strategy for Treating Fragile X Syndrome.

Thomson SR, Seo SS, Barnes SA, Louros SR, Muscas M, Dando O, Kirby C, Wyllie DJA, Hardingham GE, Kind PC, Osterweil EK.

Neuron. 2017 Aug 2;95(3):550-563.e5. doi: 10.1016/j.neuron.2017.07.013.


Negative Allosteric Modulation of mGluR5 Partially Corrects Pathophysiology in a Mouse Model of Rett Syndrome.

Tao J, Wu H, Coronado AA, de Laittre E, Osterweil EK, Zhang Y, Bear MF.

J Neurosci. 2016 Nov 23;36(47):11946-11958.


Perturbed proteostasis in autism spectrum disorders.

Louros SR, Osterweil EK.

J Neurochem. 2016 Dec;139(6):1081-1092. doi: 10.1111/jnc.13723. Epub 2016 Aug 4. Review.


Convergence of Hippocampal Pathophysiology in Syngap+/- and Fmr1-/y Mice.

Barnes SA, Wijetunge LS, Jackson AD, Katsanevaki D, Osterweil EK, Komiyama NH, Grant SG, Bear MF, Nägerl UV, Kind PC, Wyllie DJ.

J Neurosci. 2015 Nov 11;35(45):15073-81. doi: 10.1523/JNEUROSCI.1087-15.2015.


Metabotropic glutamate receptor signaling is required for NMDA receptor-dependent ocular dominance plasticity and LTD in visual cortex.

Sidorov MS, Kaplan ES, Osterweil EK, Lindemann L, Bear MF.

Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12852-7. doi: 10.1073/pnas.1512878112. Epub 2015 Sep 28.


Conserved hippocampal cellular pathophysiology but distinct behavioural deficits in a new rat model of FXS.

Till SM, Asiminas A, Jackson AD, Katsanevaki D, Barnes SA, Osterweil EK, Bear MF, Chattarji S, Wood ER, Wyllie DJ, Kind PC.

Hum Mol Genet. 2015 Nov 1;24(21):5977-84. doi: 10.1093/hmg/ddv299. Epub 2015 Aug 4.


Extinction of an instrumental response: a cognitive behavioral assay in Fmr1 knockout mice.

Sidorov MS, Krueger DD, Taylor M, Gisin E, Osterweil EK, Bear MF.

Genes Brain Behav. 2014 Jun;13(5):451-8. doi: 10.1111/gbb.12137. Epub 2014 Apr 30.


Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

Lohith TG, Osterweil EK, Fujita M, Jenko KJ, Bear MF, Innis RB.

Mol Autism. 2013 May 24;4(1):15. doi: 10.1186/2040-2392-4-15.


Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome.

Osterweil EK, Chuang SC, Chubykin AA, Sidorov M, Bianchi R, Wong RK, Bear MF.

Neuron. 2013 Jan 23;77(2):243-50. doi: 10.1016/j.neuron.2012.01.034.


Lifting the mood on treating fragile X.

Osterweil EK, Kind PC, Bear MF.

Biol Psychiatry. 2012 Dec 1;72(11):895-7. doi: 10.1016/j.biopsych.2012.09.017. No abstract available.


Mutations causing syndromic autism define an axis of synaptic pathophysiology.

Auerbach BD, Osterweil EK, Bear MF.

Nature. 2011 Nov 23;480(7375):63-8. doi: 10.1038/nature10658.


Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome.

Krueger DD, Osterweil EK, Chen SP, Tye LD, Bear MF.

Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2587-92. doi: 10.1073/pnas.1013855108. Epub 2011 Jan 24.


Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome.

Osterweil EK, Krueger DD, Reinhold K, Bear MF.

J Neurosci. 2010 Nov 17;30(46):15616-27. doi: 10.1523/JNEUROSCI.3888-10.2010.


Activation of mGluR5 induces rapid and long-lasting protein kinase D phosphorylation in hippocampal neurons.

Krueger DD, Osterweil EK, Bear MF.

J Mol Neurosci. 2010 Sep;42(1):1-8. doi: 10.1007/s12031-010-9338-9. Epub 2010 Feb 23.


Myosin 1E interacts with synaptojanin-1 and dynamin and is involved in endocytosis.

Krendel M, Osterweil EK, Mooseker MS.

FEBS Lett. 2007 Feb 20;581(4):644-50. Epub 2007 Jan 18.

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