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Items: 45


Diverse Injury Pathways Induce Alveolar Epithelial Cell CCL2/12 Which Promotes Lung Fibrosis.

Yang J, Agarwal M, Ling S, Teitz-Tennenbaum S, Zemans RL, Osterholzer JJ, Sisson TH, Kim KK.

Am J Respir Cell Mol Biol. 2020 Jan 10. doi: 10.1165/rcmb.2019-0297OC. [Epub ahead of print]


Epigenetic stabilization of DC and DC precursor classical activation by TNFα contributes to protective T cell polarization.

Eastman AJ, Xu J, Bermik J, Potchen N, den Dekker A, Neal LM, Zhao G, Malachowski A, Schaller M, Kunkel S, Osterholzer JJ, Kryczek I, Olszewski MA.

Sci Adv. 2019 Dec 4;5(12):eaaw9051. doi: 10.1126/sciadv.aaw9051. eCollection 2019 Dec.


Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis.

Horowitz JC, Tschumperlin DJ, Kim KK, Osterholzer JJ, Subbotina N, Ajayi IO, Teitz-Tennenbaum S, Virk A, Dotson M, Liu F, Sicard D, Jia S, Sisson TH.

Thromb Haemost. 2019 Dec;119(12):1968-1980. doi: 10.1055/s-0039-1697953. Epub 2019 Nov 8.


Efferocytosis of apoptotic alveolar epithelial cells is sufficient to initiate lung fibrosis.

Kim KK, Dotson MR, Agarwal M, Yang J, Bradley PB, Subbotina N, Osterholzer JJ, Sisson TH.

Cell Death Dis. 2018 Oct 17;9(11):1056. doi: 10.1038/s41419-018-1074-z.


Autocrine IL-10 Signaling Promotes Dendritic Cell Type-2 Activation and Persistence of Murine Cryptococcal Lung Infection.

Teitz-Tennenbaum S, Viglianti SP, Roussey JA, Levitz SM, Olszewski MA, Osterholzer JJ.

J Immunol. 2018 Oct 1;201(7):2004-2015. doi: 10.4049/jimmunol.1800070. Epub 2018 Aug 10.


Erratum for Xu et al., "Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection".

Xu J, Eastman AJ, Flaczyk A, Neal LM, Zhao G, Carolan J, Malachowski AN, Stolberg VR, Yosri M, Chensue SW, Curtis JL, Osterholzer JJ, Olszewski MA.

mBio. 2018 May 29;9(3). pii: e01039-18. doi: 10.1128/mBio.01039-18. No abstract available.


CD4+ T Cells Orchestrate Lethal Immune Pathology despite Fungal Clearance during Cryptococcus neoformans Meningoencephalitis.

Neal LM, Xing E, Xu J, Kolbe JL, Osterholzer JJ, Segal BM, Williamson PR, Olszewski MA.

mBio. 2017 Nov 21;8(6). pii: e01415-17. doi: 10.1128/mBio.01415-17.


Anti-PD-1 Antibody Treatment Promotes Clearance of Persistent Cryptococcal Lung Infection in Mice.

Roussey JA, Viglianti SP, Teitz-Tennenbaum S, Olszewski MA, Osterholzer JJ.

J Immunol. 2017 Nov 15;199(10):3535-3546. doi: 10.4049/jimmunol.1700840. Epub 2017 Oct 16.


Exploitation of Scavenger Receptor, Macrophage Receptor with Collagenous Structure, by Cryptococcus neoformans Promotes Alternative Activation of Pulmonary Lymph Node CD11b+ Conventional Dendritic Cells and Non-Protective Th2 Bias.

Xu J, Flaczyk A, Neal LM, Fa Z, Cheng D, Ivey M, Moore BB, Curtis JL, Osterholzer JJ, Olszewski MA.

Front Immunol. 2017 Sep 28;8:1231. doi: 10.3389/fimmu.2017.01231. eCollection 2017.


T Cell-Restricted Notch Signaling Contributes to Pulmonary Th1 and Th2 Immunity during Cryptococcus neoformans Infection.

Neal LM, Qiu Y, Chung J, Xing E, Cho W, Malachowski AN, Sandy-Sloat AR, Osterholzer JJ, Maillard I, Olszewski MA.

J Immunol. 2017 Jul 15;199(2):643-655. doi: 10.4049/jimmunol.1601715. Epub 2017 Jun 14.


Scavenger Receptor MARCO Orchestrates Early Defenses and Contributes to Fungal Containment during Cryptococcal Infection.

Xu J, Flaczyk A, Neal LM, Fa Z, Eastman AJ, Malachowski AN, Cheng D, Moore BB, Curtis JL, Osterholzer JJ, Olszewski MA.

J Immunol. 2017 May 1;198(9):3548-3557. doi: 10.4049/jimmunol.1700057. Epub 2017 Mar 15.


Immunoregulation in Fungal Diseases.

Roussey JA, Olszewski MA, Osterholzer JJ.

Microorganisms. 2016 Dec 10;4(4). pii: E47. Review.


Disruption of Early Tumor Necrosis Factor Alpha Signaling Prevents Classical Activation of Dendritic Cells in Lung-Associated Lymph Nodes and Development of Protective Immunity against Cryptococcal Infection.

Xu J, Eastman AJ, Flaczyk A, Neal LM, Zhao G, Carolan J, Malachowski AN, Stolberg VR, Yosri M, Chensue SW, Curtis JL, Osterholzer JJ, Olszewski MA.

mBio. 2016 Jul 12;7(4). pii: e00510-16. doi: 10.1128/mBio.00510-16. Erratum in: mBio. 2018 May 29;9(3):.


Late mortality after sepsis: propensity matched cohort study.

Prescott HC, Osterholzer JJ, Langa KM, Angus DC, Iwashyna TJ.

BMJ. 2016 May 17;353:i2375. doi: 10.1136/bmj.i2375.


"Scar-cinoma": viewing the fibrotic lung mesenchymal cell in the context of cancer biology.

Horowitz JC, Osterholzer JJ, Marazioti A, Stathopoulos GT.

Eur Respir J. 2016 Jun;47(6):1842-54. doi: 10.1183/13993003.01201-2015. Epub 2016 Mar 30.


Local GM-CSF-Dependent Differentiation and Activation of Pulmonary Dendritic Cells and Macrophages Protect against Progressive Cryptococcal Lung Infection in Mice.

Chen GH, Teitz-Tennenbaum S, Neal LM, Murdock BJ, Malachowski AN, Dils AJ, Olszewski MA, Osterholzer JJ.

J Immunol. 2016 Feb 15;196(4):1810-21. doi: 10.4049/jimmunol.1501512. Epub 2016 Jan 11.


Role of dendritic cell-pathogen interactions in the immune response to pulmonary cryptococcal infection.

Eastman AJ, Osterholzer JJ, Olszewski MA.

Future Microbiol. 2015;10(11):1837-57. doi: 10.2217/fmb.15.92. Review.


Cryptococcal heat shock protein 70 homolog Ssa1 contributes to pulmonary expansion of Cryptococcus neoformans during the afferent phase of the immune response by promoting macrophage M2 polarization.

Eastman AJ, He X, Qiu Y, Davis MJ, Vedula P, Lyons DM, Park YD, Hardison SE, Malachowski AN, Osterholzer JJ, Wormley FL Jr, Williamson PR, Olszewski MA.

J Immunol. 2015 Jun 15;194(12):5999-6010. doi: 10.4049/jimmunol.1402719. Epub 2015 May 13.


Local origin of mesenchymal cells in a murine orthotopic lung transplantation model of bronchiolitis obliterans.

Mimura T, Walker N, Aoki Y, Manning CM, Murdock BJ, Myers JL, Lagstein A, Osterholzer JJ, Lama VN.

Am J Pathol. 2015 Jun;185(6):1564-74. doi: 10.1016/j.ajpath.2015.03.002. Epub 2015 Apr 4.


Cryptococcus neoformans-induced macrophage lysosome damage crucially contributes to fungal virulence.

Davis MJ, Eastman AJ, Qiu Y, Gregorka B, Kozel TR, Osterholzer JJ, Curtis JL, Swanson JA, Olszewski MA.

J Immunol. 2015 Mar 1;194(5):2219-31. doi: 10.4049/jimmunol.1402376. Epub 2015 Jan 30.


Early or late IL-10 blockade enhances Th1 and Th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infection.

Murdock BJ, Teitz-Tennenbaum S, Chen GH, Dils AJ, Malachowski AN, Curtis JL, Olszewski MA, Osterholzer JJ.

J Immunol. 2014 Oct 15;193(8):4107-16. doi: 10.4049/jimmunol.1400650. Epub 2014 Sep 15.


Resident alveolar macrophages suppress, whereas recruited monocytes promote, allergic lung inflammation in murine models of asthma.

Zasłona Z, Przybranowski S, Wilke C, van Rooijen N, Teitz-Tennenbaum S, Osterholzer JJ, Wilkinson JE, Moore BB, Peters-Golden M.

J Immunol. 2014 Oct 15;193(8):4245-53. doi: 10.4049/jimmunol.1400580. Epub 2014 Sep 15.


Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.

Ibrahim MK, Barnes JL, Osorio EY, Anstead GM, Jimenez F, Osterholzer JJ, Travi BL, Ahuja SS, White AC Jr, Melby PC.

Infect Immun. 2014 Aug;82(8):3098-112. doi: 10.1128/IAI.01778-14. Epub 2014 May 12.


Interleukin-17A enhances host defense against cryptococcal lung infection through effects mediated by leukocyte recruitment, activation, and gamma interferon production.

Murdock BJ, Huffnagle GB, Olszewski MA, Osterholzer JJ.

Infect Immun. 2014 Mar;82(3):937-48. doi: 10.1128/IAI.01477-13. Epub 2013 Dec 9.


Scavenger receptor A modulates the immune response to pulmonary Cryptococcus neoformans infection.

Qiu Y, Dayrit JK, Davis MJ, Carolan JF, Osterholzer JJ, Curtis JL, Olszewski MA.

J Immunol. 2013 Jul 1;191(1):238-48. doi: 10.4049/jimmunol.1203435. Epub 2013 Jun 3.


Implicating exudate macrophages and Ly-6C(high) monocytes in CCR2-dependent lung fibrosis following gene-targeted alveolar injury.

Osterholzer JJ, Olszewski MA, Murdock BJ, Chen GH, Erb-Downward JR, Subbotina N, Browning K, Lin Y, Morey RE, Dayrit JK, Horowitz JC, Simon RH, Sisson TH.

J Immunol. 2013 Apr 1;190(7):3447-57. doi: 10.4049/jimmunol.1200604. Epub 2013 Mar 6.


Immune modulation mediated by cryptococcal laccase promotes pulmonary growth and brain dissemination of virulent Cryptococcus neoformans in mice.

Qiu Y, Davis MJ, Dayrit JK, Hadd Z, Meister DL, Osterholzer JJ, Williamson PR, Olszewski MA.

PLoS One. 2012;7(10):e47853. doi: 10.1371/journal.pone.0047853. Epub 2012 Oct 22.


FMS-like tyrosine kinase 3 ligand treatment of mice aggravates acute lung injury in response to Streptococcus pneumoniae: role of pneumolysin.

Brumshagen C, Maus R, Bischof A, Ueberberg B, Bohling J, Osterholzer JJ, Ogunniyi AD, Paton JC, Welte T, Maus UA.

Infect Immun. 2012 Dec;80(12):4281-90. doi: 10.1128/IAI.00854-12. Epub 2012 Sep 24.


Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination.

He X, Lyons DM, Toffaletti DL, Wang F, Qiu Y, Davis MJ, Meister DL, Dayrit JK, Lee A, Osterholzer JJ, Perfect JR, Olszewski MA.

Am J Pathol. 2012 Oct;181(4):1356-66. doi: 10.1016/j.ajpath.2012.06.012. Epub 2012 Jul 28.


Macrophage dectin-1 expression is controlled by leukotriene B4 via a GM-CSF/PU.1 axis.

Serezani CH, Kane S, Collins L, Morato-Marques M, Osterholzer JJ, Peters-Golden M.

J Immunol. 2012 Jul 15;189(2):906-15. doi: 10.4049/jimmunol.1200257. Epub 2012 Jun 13.


Early induction of CCL7 downstream of TLR9 signaling promotes the development of robust immunity to cryptococcal infection.

Qiu Y, Zeltzer S, Zhang Y, Wang F, Chen GH, Dayrit J, Murdock BJ, Bhan U, Toews GB, Osterholzer JJ, Standiford TJ, Olszewski MA.

J Immunol. 2012 Apr 15;188(8):3940-8. doi: 10.4049/jimmunol.1103053. Epub 2012 Mar 14.


PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury.

Osterholzer JJ, Christensen PJ, Lama V, Horowitz JC, Hattori N, Subbotina N, Cunningham A, Lin Y, Murdock BJ, Morey RE, Olszewski MA, Lawrence DA, Simon RH, Sisson TH.

J Pathol. 2012 Oct;228(2):170-80. doi: 10.1002/path.3992. Epub 2012 Jun 6.


Chemokine receptor 2-mediated accumulation of fungicidal exudate macrophages in mice that clear cryptococcal lung infection.

Osterholzer JJ, Chen GH, Olszewski MA, Zhang YM, Curtis JL, Huffnagle GB, Toews GB.

Am J Pathol. 2011 Jan;178(1):198-211. doi: 10.1016/j.ajpath.2010.11.006. Epub 2010 Dec 23.


Coevolution of TH1, TH2, and TH17 responses during repeated pulmonary exposure to Aspergillus fumigatus conidia.

Murdock BJ, Shreiner AB, McDonald RA, Osterholzer JJ, White ES, Toews GB, Huffnagle GB.

Infect Immun. 2011 Jan;79(1):125-35. doi: 10.1128/IAI.00508-10. Epub 2010 Nov 1.


Dual roles of CD40 on microbial containment and the development of immunopathology in response to persistent fungal infection in the lung.

Chen GH, Osterholzer JJ, Choe MY, McDonald RA, Olszewski MA, Huffnagle GB, Toews GB.

Am J Pathol. 2010 Nov;177(5):2459-71. doi: 10.2353/ajpath.2010.100141. Epub 2010 Sep 23.


Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes.

Osterholzer JJ, Chen GH, Olszewski MA, Curtis JL, Huffnagle GB, Toews GB.

J Immunol. 2009 Dec 15;183(12):8044-53. doi: 10.4049/jimmunol.0902823.


Th2 but not Th1 immune bias results in altered lung functions in a murine model of pulmonary Cryptococcus neoformans infection.

Jain AV, Zhang Y, Fields WB, McNamara DA, Choe MY, Chen GH, Erb-Downward J, Osterholzer JJ, Toews GB, Huffnagle GB, Olszewski MA.

Infect Immun. 2009 Dec;77(12):5389-99. doi: 10.1128/IAI.00809-09. Epub 2009 Sep 14.


Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans.

Osterholzer JJ, Milam JE, Chen GH, Toews GB, Huffnagle GB, Olszewski MA.

Infect Immun. 2009 Sep;77(9):3749-58. doi: 10.1128/IAI.00454-09. Epub 2009 Jun 29.


Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake.

Curtis JL, Todt JC, Hu B, Osterholzer JJ, Freeman CM.

Front Biosci (Landmark Ed). 2009 Jan 1;14:2631-46. Review.


Cryptococcal urease promotes the accumulation of immature dendritic cells and a non-protective T2 immune response within the lung.

Osterholzer JJ, Surana R, Milam JE, Montano GT, Chen GH, Sonstein J, Curtis JL, Huffnagle GB, Toews GB, Olszewski MA.

Am J Pathol. 2009 Mar;174(3):932-43. doi: 10.2353/ajpath.2009.080673. Epub 2009 Feb 13.


TLR9 is required for protective innate immunity in Gram-negative bacterial pneumonia: role of dendritic cells.

Bhan U, Lukacs NW, Osterholzer JJ, Newstead MW, Zeng X, Moore TA, McMillan TR, Krieg AM, Akira S, Standiford TJ.

J Immunol. 2007 Sep 15;179(6):3937-46.


CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen.

Osterholzer JJ, Ames T, Polak T, Sonstein J, Moore BB, Chensue SW, Toews GB, Curtis JL.

J Immunol. 2005 Jul 15;175(2):874-83.


Tumour-induced polarization of tumour vaccine-draining lymph node T cells to a type 1 cytokine profile predicts inherent strong immunogenicity of the tumour and correlates with therapeutic efficacy in adoptive transfer studies.

Winter H, Hu HM, Poehlein CH, Huntzicker E, Osterholzer JJ, Bashy J, Lashley D, Lowe B, Yamada J, Alvord G, Urba WJ, Fox BA.

Immunology. 2003 Mar;108(3):409-19.


Comparative analysis of murine dendritic cells derived from spleen and bone marrow.

Fields RC, Osterholzer JJ, Fuller JA, Thomas EK, Geraghty PJ, Mulé JJ.

J Immunother. 1998 Sep;21(5):323-39.


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