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Items: 1 to 50 of 142


Designing safer analgesics: a focus on μ-opioid receptor pathways.

Pergolizzi JV Jr, LeQuang JA, Taylor R Jr, Ossipov MH, Colucci D, Raffa RB.

Expert Opin Drug Discov. 2018 Oct;13(10):965-972. doi: 10.1080/17460441.2018.1511539. Epub 2018 Sep 3.


Discovery of "folded DNA" structures in human cells: Potential drug targets.

Raffa RB, Pergolizzi JV Jr, Taylor R Jr, Ossipov MH; NEMA Research Group.

J Clin Pharm Ther. 2019 Feb;44(1):125-128. doi: 10.1111/jcpt.12758. Epub 2018 Aug 25.


Differential effects of left and right neuropathy on opioid gene expression in lumbar spinal cord.

Kononenko O, Mityakina I, Galatenko V, Watanabe H, Bazov I, Gerashchenko A, Sarkisyan D, Iatsyshyna A, Yakovleva T, Tonevitsky A, Marklund N, Ossipov MH, Bakalkin G.

Brain Res. 2018 Sep 15;1695:78-83. doi: 10.1016/j.brainres.2018.05.043. Epub 2018 May 28.


Efficacy and safety of galcanezumab for the prevention of episodic migraine: Results of the EVOLVE-2 Phase 3 randomized controlled clinical trial.

Skljarevski V, Matharu M, Millen BA, Ossipov MH, Kim BK, Yang JY.

Cephalalgia. 2018 Jul;38(8):1442-1454. doi: 10.1177/0333102418779543. Epub 2018 May 31.


Indirect-acting strategy of opioid action instead of direct receptor activation: dual-acting enkephalinase inhibitors (DENKIs).

Raffa RB, Pergolizzi JV Jr, Taylor R Jr, Ossipov MH; By the NEMA Research Group.

J Clin Pharm Ther. 2018 Aug;43(4):443-449. doi: 10.1111/jcpt.12687. Epub 2018 May 2. Review.


Nature's first "atypical opioids": Kratom and mitragynines.

Raffa RB, Pergolizzi JV, Taylor R, Ossipov MH; NEMA Research Group.

J Clin Pharm Ther. 2018 Jun;43(3):437-441. doi: 10.1111/jcpt.12676. Epub 2018 Mar 8.


Assessment of direct analgesic effect of duloxetine for chronic low back pain: post hoc path analysis of double-blind, placebo-controlled studies.

Enomoto H, Fujikoshi S, Funai J, Sasaki N, Ossipov MH, Tsuji T, Alev L, Ushida T.

J Pain Res. 2017 Jun 1;10:1357-1368. doi: 10.2147/JPR.S133396. eCollection 2017.


Anti-nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery-induced pain.

Majuta LA, Guedon JG, Mitchell SA, Ossipov MH, Mantyh PW.

Pain. 2017 Apr;158(4):605-617. doi: 10.1097/j.pain.0000000000000799.


The role of calcitonin gene-related peptide in peripheral and central pain mechanisms including migraine.

Iyengar S, Ossipov MH, Johnson KW.

Pain. 2017 Apr;158(4):543-559. doi: 10.1097/j.pain.0000000000000831. Review.


A review of the efficacy of atomoxetine in the treatment of attention-deficit hyperactivity disorder in children and adult patients with common comorbidities.

Clemow DB, Bushe C, Mancini M, Ossipov MH, Upadhyaya H.

Neuropsychiatr Dis Treat. 2017 Feb 3;13:357-371. doi: 10.2147/NDT.S115707. eCollection 2017. Review.


Synergistic attenuation of chronic pain using mu opioid and cannabinoid receptor 2 agonists.

Grenald SA, Young MA, Wang Y, Ossipov MH, Ibrahim MM, Largent-Milnes TM, Vanderah TW.

Neuropharmacology. 2017 Apr;116:59-70. doi: 10.1016/j.neuropharm.2016.12.008. Epub 2016 Dec 20.


Cortical and subcortical modulation of pain.

De Felice M, Ossipov MH.

Pain Manag. 2016 Apr;6(2):111-20. doi: 10.2217/pmt.15.63. Epub 2016 Mar 17. Review.


Is duloxetine's effect on painful physical symptoms in depression an indirect result of improvement of depressive symptoms? Pooled analyses of three randomized controlled trials.

Harada E, Tokuoka H, Fujikoshi S, Funai J, Wohlreich MM, Ossipov MH, Iwata N.

Pain. 2016 Mar;157(3):577-84. doi: 10.1097/j.pain.0000000000000406.


Positive emotions and brain reward circuits in chronic pain.

Navratilova E, Morimura K, Xie JY, Atcherley CW, Ossipov MH, Porreca F.

J Comp Neurol. 2016 Jun 1;524(8):1646-52. doi: 10.1002/cne.23968. Epub 2016 Feb 3. Review.


Targeting TRP channels for novel migraine therapeutics.

Dussor G, Yan J, Xie JY, Ossipov MH, Dodick DW, Porreca F.

ACS Chem Neurosci. 2014 Nov 19;5(11):1085-96. doi: 10.1021/cn500083e. Epub 2014 Aug 29. Review.


Proteomics of neuropathic pain: proteins and signaling pathways affected in a rat model.

Sui P, Watanabe H, Ossipov MH, Bakalkin G, Artemenko K, Bergquist J.

J Proteome Res. 2014 Sep 5;13(9):3957-65. doi: 10.1021/pr500241q. Epub 2014 Jul 28.


Activation of mesocorticolimbic reward circuits for assessment of relief of ongoing pain: a potential biomarker of efficacy.

Xie JY, Qu C, Patwardhan A, Ossipov MH, Navratilova E, Becerra L, Borsook D, Porreca F.

Pain. 2014 Aug;155(8):1659-66. doi: 10.1016/j.pain.2014.05.018. Epub 2014 May 23.


Descending pain modulation and chronification of pain.

Ossipov MH, Morimura K, Porreca F.

Curr Opin Support Palliat Care. 2014 Jun;8(2):143-51. doi: 10.1097/SPC.0000000000000055. Review.


Increased susceptibility to cortical spreading depression in an animal model of medication-overuse headache.

Green AL, Gu P, De Felice M, Dodick D, Ossipov MH, Porreca F.

Cephalalgia. 2014 Jul;34(8):594-604. doi: 10.1177/0333102413515344. Epub 2013 Dec 11.


Artemin induced functional recovery and reinnervation after partial nerve injury.

Wang R, Rossomando A, Sah DW, Ossipov MH, King T, Porreca F.

Pain. 2014 Mar;155(3):476-84. doi: 10.1016/j.pain.2013.11.007. Epub 2013 Nov 21.


Opioid and noradrenergic contributions of tapentadol in experimental neuropathic pain.

Meske DS, Xie JY, Oyarzo J, Badghisi H, Ossipov MH, Porreca F.

Neurosci Lett. 2014 Mar 6;562:91-6. doi: 10.1016/j.neulet.2013.08.017. Epub 2013 Aug 19.


Capturing the aversive state of cephalic pain preclinically.

De Felice M, Eyde N, Dodick D, Dussor GO, Ossipov MH, Fields HL, Porreca F.

Ann Neurol. 2013 Aug;74(2):257-65. doi: 10.1002/ana.23922. Epub 2013 Sep 10.


Descending facilitation maintains long-term spontaneous neuropathic pain.

Wang R, King T, De Felice M, Guo W, Ossipov MH, Porreca F.

J Pain. 2013 Aug;14(8):845-53. doi: 10.1016/j.jpain.2013.02.011. Epub 2013 Apr 19.


Dimethyl-labeling-based protein quantification and pathway search: a novel method of spinal cord analysis applicable for neurological studies.

Sui P, Watanabe H, Ossipov MH, Porreca F, Bakalkin G, Bergquist J, Artemenko K.

J Proteome Res. 2013 May 3;12(5):2245-52. doi: 10.1021/pr4001064. Epub 2013 Apr 9.


Pain relief produces negative reinforcement through activation of mesolimbic reward-valuation circuitry.

Navratilova E, Xie JY, Okun A, Qu C, Eyde N, Ci S, Ossipov MH, King T, Fields HL, Porreca F.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20709-13. doi: 10.1073/pnas.1214605109. Epub 2012 Nov 26.


Mechanisms of Bv8-induced biphasic hyperalgesia: increased excitatory transmitter release and expression.

De Felice M, Melchiorri P, Ossipov MH, Vanderah TW, Porreca F, Negri L.

Neurosci Lett. 2012 Jul 11;521(1):40-5. doi: 10.1016/j.neulet.2012.05.055. Epub 2012 May 26.


Afferent drive elicits ongoing pain in a model of advanced osteoarthritis.

Okun A, Liu P, Davis P, Ren J, Remeniuk B, Brion T, Ossipov MH, Xie J, Dussor GO, King T, Porreca F.

Pain. 2012 Apr;153(4):924-33. doi: 10.1016/j.pain.2012.01.022. Epub 2012 Mar 2.


An experimental model of headache-related pain.

Edelmayer RM, Ossipov MH, Porreca F.

Methods Mol Biol. 2012;851:109-20. doi: 10.1007/978-1-61779-561-9_7.


The perception and endogenous modulation of pain.

Ossipov MH.

Scientifica (Cairo). 2012;2012:561761. doi: 10.6064/2012/561761. Epub 2012 Dec 25. Review.


Engagement of descending inhibition from the rostral ventromedial medulla protects against chronic neuropathic pain.

De Felice M, Sanoja R, Wang R, Vera-Portocarrero L, Oyarzo J, King T, Ossipov MH, Vanderah TW, Lai J, Dussor GO, Fields HL, Price TJ, Porreca F.

Pain. 2011 Dec;152(12):2701-9. doi: 10.1016/j.pain.2011.06.008. Epub 2011 Jul 13.


Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.

Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW.

Brain Res. 2011 Jun 13;1395:1-11. doi: 10.1016/j.brainres.2011.04.024. Epub 2011 Apr 20.


Persistent medication-induced neural adaptations, descending facilitation, and medication overuse headache.

De Felice M, Ossipov MH, Porreca F.

Curr Opin Neurol. 2011 Jun;24(3):193-6. doi: 10.1097/WCO.0b013e328346af25. Review.


Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies.

Meng ID, Dodick D, Ossipov MH, Porreca F.

Cephalalgia. 2011 May;31(7):851-60. doi: 10.1177/0333102411402367. Epub 2011 Mar 28. Review.


Descending facilitatory pathways from the rostroventromedial medulla mediate naloxone-precipitated withdrawal in morphine-dependent rats.

Vera-Portocarrero LP, Ossipov MH, Lai J, King T, Porreca F.

J Pain. 2011 Jun;12(6):667-76. doi: 10.1016/j.jpain.2010.12.007. Epub 2011 Feb 26.


Growth factors and neuropathic pain.

Ossipov MH.

Curr Pain Headache Rep. 2011 Jun;15(3):185-92. doi: 10.1007/s11916-011-0183-5. Review.


Ongoing pain in the MIA model of osteoarthritis.

Liu P, Okun A, Ren J, Guo RC, Ossipov MH, Xie J, King T, Porreca F.

Neurosci Lett. 2011 Apr 15;493(3):72-5. doi: 10.1016/j.neulet.2011.01.027. Epub 2011 Jan 15.


Update on medication-overuse headache.

De Felice M, Ossipov MH, Porreca F.

Curr Pain Headache Rep. 2011 Feb;15(1):79-83. doi: 10.1007/s11916-010-0155-1. Review.


Central modulation of pain.

Ossipov MH, Dussor GO, Porreca F.

J Clin Invest. 2010 Nov;120(11):3779-87. doi: 10.1172/JCI43766. Epub 2010 Nov 1. Review.


Opioid-induced latent sensitization in a model of non-inflammatory viscerosomatic hypersensitivity.

Lian B, Vera-Portocarrero L, King T, Ossipov MH, Porreca F.

Brain Res. 2010 Oct 28;1358:64-70. doi: 10.1016/j.brainres.2010.08.032. Epub 2010 Aug 19.


Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers.

De Felice M, Ossipov MH, Wang R, Dussor G, Lai J, Meng ID, Chichorro J, Andrews JS, Rakhit S, Maddaford S, Dodick D, Porreca F.

Brain. 2010 Aug;133(Pt 8):2475-88. doi: 10.1093/brain/awq159. Epub 2010 Jul 13.


Reversal of pancreatitis-induced pain by an orally available, small molecule interleukin-6 receptor antagonist.

Vardanyan M, Melemedjian OK, Price TJ, Ossipov MH, Lai J, Roberts E, Boos TL, Deschamps JR, Jacobson AE, Rice KC, Porreca F.

Pain. 2010 Nov;151(2):257-65. doi: 10.1016/j.pain.2010.05.022. Epub 2010 Jul 4.


Attenuation of persistent experimental pancreatitis pain by a bradykinin b2 receptor antagonist.

Chen Q, Vera-Portocarrero LP, Ossipov MH, Vardanyan M, Lai J, Porreca F.

Pancreas. 2010 Nov;39(8):1220-5. doi: 10.1097/MPA.0b013e3181df1c90.


Attenuation of pain and inflammation in adjuvant-induced arthritis by the proteasome inhibitor MG132.

Ahmed AS, Li J, Ahmed M, Hua L, Yakovleva T, Ossipov MH, Bakalkin G, Stark A.

Arthritis Rheum. 2010 Jul;62(7):2160-9. doi: 10.1002/art.27492.


Triptan-induced latent sensitization: a possible basis for medication overuse headache.

De Felice M, Ossipov MH, Wang R, Lai J, Chichorro J, Meng I, Dodick DW, Vanderah TW, Dussor G, Porreca F.

Ann Neurol. 2010 Mar;67(3):325-37. doi: 10.1002/ana.21897.


Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.

Asiedu M, Ossipov MH, Kaila K, Price TJ.

Pain. 2010 Feb;148(2):302-8. doi: 10.1016/j.pain.2009.11.015. Epub 2009 Dec 14.


Glial activation in the rostroventromedial medulla promotes descending facilitation to mediate inflammatory hypersensitivity.

Roberts J, Ossipov MH, Porreca F.

Eur J Neurosci. 2009 Jul;30(2):229-41. doi: 10.1111/j.1460-9568.2009.06813.x. Epub 2009 Jul 9.


Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors.

Dogrul A, Ossipov MH, Porreca F.

Brain Res. 2009 Jul 14;1280:52-9. doi: 10.1016/j.brainres.2009.05.001. Epub 2009 May 8.


Nausea and vomiting side effects with opioid analgesics during treatment of chronic pain: mechanisms, implications, and management options.

Porreca F, Ossipov MH.

Pain Med. 2009 May-Jun;10(4):654-62. doi: 10.1111/j.1526-4637.2009.00583.x. Epub 2009 Mar 19. Review.


Medullary pain facilitating neurons mediate allodynia in headache-related pain.

Edelmayer RM, Vanderah TW, Majuta L, Zhang ET, Fioravanti B, De Felice M, Chichorro JG, Ossipov MH, King T, Lai J, Kori SH, Nelsen AC, Cannon KE, Heinricher MM, Porreca F.

Ann Neurol. 2009 Feb;65(2):184-93. doi: 10.1002/ana.21537.


Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors.

Zhang W, Gardell S, Zhang D, Xie JY, Agnes RS, Badghisi H, Hruby VJ, Rance N, Ossipov MH, Vanderah TW, Porreca F, Lai J.

Brain. 2009 Mar;132(Pt 3):778-87. doi: 10.1093/brain/awn330. Epub 2008 Dec 2.

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