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Items: 10


A secondary wave of neutrophil infiltration causes necrosis and ulceration in lesions of experimental American cutaneous leishmaniasis.

Peniche AG, Bonilla DL, Palma GI, Melby PC, Travi BL, Osorio EY.

PLoS One. 2017 Jun 7;12(6):e0179084. doi: 10.1371/journal.pone.0179084. eCollection 2017.


Transcriptional Profiling in Experimental Visceral Leishmaniasis Reveals a Broad Splenic Inflammatory Environment that Conditions Macrophages toward a Disease-Promoting Phenotype.

Kong F, Saldarriaga OA, Spratt H, Osorio EY, Travi BL, Luxon BA, Melby PC.

PLoS Pathog. 2017 Jan 31;13(1):e1006165. doi: 10.1371/journal.ppat.1006165. eCollection 2017 Jan.


Splenic CD4+ T Cells in Progressive Visceral Leishmaniasis Show a Mixed Effector-Regulatory Phenotype and Impair Macrophage Effector Function through Inhibitory Receptor Expression.

Medina-Colorado AA, Osorio EY, Saldarriaga OA, Travi BL, Kong F, Spratt H, Soong L, Melby PC.

PLoS One. 2017 Jan 19;12(1):e0169496. doi: 10.1371/journal.pone.0169496. eCollection 2017.


Transcriptional profiling of the spleen in progressive visceral leishmaniasis reveals mixed expression of type 1 and type 2 cytokine-responsive genes.

Espitia CM, Saldarriaga OA, Travi BL, Osorio EY, Hernandez A, Band M, Patel MJ, Medina AA, Cappello M, Pekosz A, Melby PC.

BMC Immunol. 2014 Nov 26;15:38. doi: 10.1186/s12865-014-0038-z.


Comparative evaluation of lesion development, tissue damage, and cytokine expression in golden hamsters (Mesocricetus auratus) infected by inocula with different Leishmania (Viannia) braziliensis concentrations.

Ribeiro-Romão RP, Moreira OC, Osorio EY, Cysne-Finkelstein L, Gomes-Silva A, Valverde JG, Pirmez C, Da-Cruz AM, Pinto EF.

Infect Immun. 2014 Dec;82(12):5203-13. doi: 10.1128/IAI.02083-14. Epub 2014 Oct 6.


Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis.

Osorio EY, Travi BL, da Cruz AM, Saldarriaga OA, Medina AA, Melby PC.

PLoS Pathog. 2014 Jun 26;10(6):e1004165. doi: 10.1371/journal.ppat.1004165. eCollection 2014 Jun.


Deficiency of lymph node-resident dendritic cells (DCs) and dysregulation of DC chemoattractants in a malnourished mouse model of Leishmania donovani infection.

Ibrahim MK, Barnes JL, Osorio EY, Anstead GM, Jimenez F, Osterholzer JJ, Travi BL, Ahuja SS, White AC Jr, Melby PC.

Infect Immun. 2014 Aug;82(8):3098-112. doi: 10.1128/IAI.01778-14. Epub 2014 May 12.


The malnutrition-related increase in early visceralization of Leishmania donovani is associated with a reduced number of lymph node phagocytes and altered conduit system flow.

Ibrahim MK, Barnes JL, Anstead GM, Jimenez F, Travi BL, Peniche AG, Osorio EY, Ahuja SS, Melby PC.

PLoS Negl Trop Dis. 2013 Aug 15;7(8):e2329. doi: 10.1371/journal.pntd.0002329. eCollection 2013.


Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression.

Osorio EY, Zhao W, Espitia C, Saldarriaga O, Hawel L, Byus CV, Travi BL, Melby PC.

PLoS Pathog. 2012 Jan;8(1):e1002417. doi: 10.1371/journal.ppat.1002417. Epub 2012 Jan 19.


Clinical, parasitologic, and immunologic evolution in dogs experimentally infected with sand fly-derived Leishmania chagasi promastigotes.

Travi BL, Osorio EY, Saldarriaga OA, Cadena H, Tabares CJ, Peniche A, Lee S, Melby PC.

Am J Trop Med Hyg. 2009 Dec;81(6):994-1003. doi: 10.4269/ajtmh.2009.09-0229.


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