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Items: 37

1.

Spatially and functionally distinct subclasses of breast cancer-associated fibroblasts revealed by single cell RNA sequencing.

Bartoschek M, Oskolkov N, Bocci M, Lövrot J, Larsson C, Sommarin M, Madsen CD, Lindgren D, Pekar G, Karlsson G, Ringnér M, Bergh J, Björklund Å, Pietras K.

Nat Commun. 2018 Dec 4;9(1):5150. doi: 10.1038/s41467-018-07582-3.

2.

N1-methylnicotinamide is a signalling molecule produced in skeletal muscle coordinating energy metabolism.

Ström K, Morales-Alamo D, Ottosson F, Edlund A, Hjort L, Jörgensen SW, Almgren P, Zhou Y, Martin-Rincon M, Ekman C, Pérez-López A, Ekström O, Perez-Suarez I, Mattiasson M, de Pablos-Velasco P, Oskolkov N, Ahlqvist E, Wierup N, Eliasson L, Vaag A, Groop L, Stenkula KG, Fernandez C, Calbet JAL, Holmberg HC, Hansson O.

Sci Rep. 2018 Feb 14;8(1):3016. doi: 10.1038/s41598-018-21099-1.

3.

Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.

Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC, Grarup N, Oskolkov N, Thalamuthu A, Mangino M, Liu J, Demirkan A, Lek M, Xu L, Wang G, Oldmeadow C, Gaulton KJ, Lotta LA, Miyamoto-Mikami E, Rivas MA, White T, Loh PR, Aadahl M, Amin N, Attia JR, Austin K, Benyamin B, Brage S, Cheng YC, Cięszczyk P, Derave W, Eriksson KF, Eynon N, Linneberg A, Lucia A, Massidda M, Mitchell BD, Miyachi M, Murakami H, Padmanabhan S, Pandey A, Papadimitriou I, Rajpal DK, Sale C, Schnurr TM, Sessa F, Shrine N, Tobin MD, Varley I, Wain LV, Wray NR, Lindgren CM, MacArthur DG, Waterworth DM, McCarthy MI, Pedersen O, Khaw KT, Kiel DP; GEFOS Any-Type of Fracture Consortium, Pitsiladis Y, Fuku N, Franks PW, North KN, van Duijn CM, Mather KA, Hansen T, Hansson O, Spector T, Murabito JM, Richards JB, Rivadeneira F, Langenberg C, Perry JRB, Wareham NJ, Scott RA.

Nat Commun. 2017 Jul 12;8:16015. doi: 10.1038/ncomms16015.

4.

Glucose-Induced Changes in Gene Expression in Human Pancreatic Islets: Causes or Consequences of Chronic Hyperglycemia.

Ottosson-Laakso E, Krus U, Storm P, Prasad RB, Oskolkov N, Ahlqvist E, Fadista J, Hansson O, Groop L, Vikman P.

Diabetes. 2017 Dec;66(12):3013-3028. doi: 10.2337/db17-0311. Epub 2017 Sep 7.

5.

The Genetic Landscape of Renal Complications in Type 1 Diabetes.

Sandholm N, Van Zuydam N, Ahlqvist E, Juliusdottir T, Deshmukh HA, Rayner NW, Di Camillo B, Forsblom C, Fadista J, Ziemek D, Salem RM, Hiraki LT, Pezzolesi M, Trégouët D, Dahlström E, Valo E, Oskolkov N, Ladenvall C, Marcovecchio ML, Cooper J, Sambo F, Malovini A, Manfrini M, McKnight AJ, Lajer M, Harjutsalo V, Gordin D, Parkkonen M; The FinnDiane Study Group, Tuomilehto J, Lyssenko V, McKeigue PM, Rich SS, Brosnan MJ, Fauman E, Bellazzi R, Rossing P, Hadjadj S, Krolewski A, Paterson AD; The DCCT/EDIC Study Group, Florez JC, Hirschhorn JN, Maxwell AP; GENIE Consortium, Dunger D, Cobelli C, Colhoun HM, Groop L, McCarthy MI, Groop PH; SUMMIT Consortium.

J Am Soc Nephrol. 2017 Feb;28(2):557-574. doi: 10.1681/ASN.2016020231. Epub 2016 Sep 19.

6.

LoFtool: a gene intolerance score based on loss-of-function variants in 60 706 individuals.

Fadista J, Oskolkov N, Hansson O, Groop L.

Bioinformatics. 2017 Feb 15;33(4):471-474. doi: 10.1093/bioinformatics/btv602.

PMID:
27563026
7.

Identification of proliferative and mature β-cells in the islets of Langerhans.

Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H.

Nature. 2016 Jul 21;535(7612):430-4. Epub 2016 Jul 11.

PMID:
27398620
8.

A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.

Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ.

PLoS Genet. 2016 May 19;12(5):e1006033. doi: 10.1371/journal.pgen.1006033. eCollection 2016 May.

9.

Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes.

Prasad RB, Lessmark A, Almgren P, Kovacs G, Hansson O, Oskolkov N, Vitai M, Ladenvall C, Kovacs P, Fadista J, Lachmann M, Zhou Y, Sonestedt E, Poon W, Wollheim CB, Orho-Melander M, Stumvoll M, Tuomi T, Pääbo S, Koranyi L, Groop L.

Diabetologia. 2016 Aug;59(8):1702-13. doi: 10.1007/s00125-016-3973-9. Epub 2016 May 7.

PMID:
27155871
10.

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes.

Dooley J, Tian L, Schonefeldt S, Delghingaro-Augusto V, Garcia-Perez JE, Pasciuto E, Di Marino D, Carr EJ, Oskolkov N, Lyssenko V, Franckaert D, Lagou V, Overbergh L, Vandenbussche J, Allemeersch J, Chabot-Roy G, Dahlstrom JE, Laybutt DR, Petrovsky N, Socha L, Gevaert K, Jetten AM, Lambrechts D, Linterman MA, Goodnow CC, Nolan CJ, Lesage S, Schlenner SM, Liston A.

Nat Genet. 2016 May;48(5):519-27. doi: 10.1038/ng.3531. Epub 2016 Mar 21.

11.

Salicylic Acid Conjugated Dendrimers Are a Tunable, High Performance CEST MRI NanoPlatform.

Lesniak WG, Oskolkov N, Song X, Lal B, Yang X, Pomper M, Laterra J, Nimmagadda S, McMahon MT.

Nano Lett. 2016 Apr 13;16(4):2248-53. doi: 10.1021/acs.nanolett.5b04517. Epub 2016 Mar 1.

12.

HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.

Zhou Y, Oskolkov N, Shcherbina L, Ratti J, Kock KH, Su J, Martin B, Oskolkova MZ, Göransson O, Bacon J, Li W, Bucciarelli S, Cilio C, Brazma A, Thatcher B, Rung J, Wierup N, Renström E, Groop L, Hansson O.

Mol Cell Endocrinol. 2016 Jul 15;430:138-45. doi: 10.1016/j.mce.2016.01.027. Epub 2016 Feb 1.

PMID:
26845344
13.

Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI.

Li J, Feng X, Zhu W, Oskolkov N, Zhou T, Kim BK, Baig N, McMahon MT, Oldfield E.

Chemistry. 2016 Jan 4;22(1):264-71. doi: 10.1002/chem.201503942. Epub 2015 Nov 30.

14.

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A, Rayner NW, Robertson N, Scott RA, Prokopenko I, Scott LJ, Green T, Sparso T, Thuillier D, Yengo L, Grallert H, Wahl S, Frånberg M, Strawbridge RJ, Kestler H, Chheda H, Eisele L, Gustafsson S, Steinthorsdottir V, Thorleifsson G, Qi L, Karssen LC, van Leeuwen EM, Willems SM, Li M, Chen H, Fuchsberger C, Kwan P, Ma C, Linderman M, Lu Y, Thomsen SK, Rundle JK, Beer NL, van de Bunt M, Chalisey A, Kang HM, Voight BF, Abecasis GR, Almgren P, Baldassarre D, Balkau B, Benediktsson R, Blüher M, Boeing H, Bonnycastle LL, Bottinger EP, Burtt NP, Carey J, Charpentier G, Chines PS, Cornelis MC, Couper DJ, Crenshaw AT, van Dam RM, Doney AS, Dorkhan M, Edkins S, Eriksson JG, Esko T, Eury E, Fadista J, Flannick J, Fontanillas P, Fox C, Franks PW, Gertow K, Gieger C, Gigante B, Gottesman O, Grant GB, Grarup N, Groves CJ, Hassinen M, Have CT, Herder C, Holmen OL, Hreidarsson AB, Humphries SE, Hunter DJ, Jackson AU, Jonsson A, Jørgensen ME, Jørgensen T, Kao WH, Kerrison ND, Kinnunen L, Klopp N, Kong A, Kovacs P, Kraft P, Kravic J, Langford C, Leander K, Liang L, Lichtner P, Lindgren CM, Lindholm E, Linneberg A, Liu CT, Lobbens S, Luan J, Lyssenko V, Männistö S, McLeod O, Meyer J, Mihailov E, Mirza G, Mühleisen TW, Müller-Nurasyid M, Navarro C, Nöthen MM, Oskolkov NN, Owen KR, Palli D, Pechlivanis S, Peltonen L, Perry JR, Platou CG, Roden M, Ruderfer D, Rybin D, van der Schouw YT, Sennblad B, Sigurðsson G, Stančáková A, Steinbach G, Storm P, Strauch K, Stringham HM, Sun Q, Thorand B, Tikkanen E, Tonjes A, Trakalo J, Tremoli E, Tuomi T, Wennauer R, Wiltshire S, Wood AR, Zeggini E, Dunham I, Birney E, Pasquali L, Ferrer J, Loos RJ, Dupuis J, Florez JC, Boerwinkle E, Pankow JS, van Duijn C, Sijbrands E, Meigs JB, Hu FB, Thorsteinsdottir U, Stefansson K, Lakka TA, Rauramaa R, Stumvoll M, Pedersen NL, Lind L, Keinanen-Kiukaanniemi SM, Korpi-Hyövälti E, Saaristo TE, Saltevo J, Kuusisto J, Laakso M, Metspalu A, Erbel R, Jöcke KH, Moebus S, Ripatti S, Salomaa V, Ingelsson E, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Koistinen H, Tuomilehto J, Hveem K, Njølstad I, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, de Faire U, Hamsten A, Illig T, Peters A, Cauchi S, Sladek R, Froguel P, Hansen T, Pedersen O, Morris AD, Palmer CN, Kathiresan S, Melander O, Nilsson PM, Groop LC, Barroso I, Langenberg C, Wareham NJ, O'Callaghan CA, Gloyn AL, Altshuler D, Boehnke M, Teslovich TM, McCarthy MI, Morris AP; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium.

Nat Genet. 2015 Dec;47(12):1415-25. doi: 10.1038/ng.3437. Epub 2015 Nov 9.

15.

A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging.

Su J, Ekman C, Oskolkov N, Lahti L, Ström K, Brazma A, Groop L, Rung J, Hansson O.

Skelet Muscle. 2015 Oct 9;5:35. doi: 10.1186/s13395-015-0059-1. eCollection 2015.

16.

Myocardin Family Members Drive Formation of Caveolae.

Krawczyk KK, Yao Mattisson I, Ekman M, Oskolkov N, Grantinge R, Kotowska D, Olde B, Hansson O, Albinsson S, Miano JM, Rippe C, Swärd K.

PLoS One. 2015 Aug 5;10(8):e0133931. doi: 10.1371/journal.pone.0133931. eCollection 2015.

17.

Biophysical Characterization of Human Protamine-1 as a Responsive CEST MR Contrast Agent.

Oskolkov N, Bar-Shir A, Chan KW, Song X, van Zijl PC, Bulte JW, Gilad AA, McMahon MT.

ACS Macro Lett. 2015 Jan 20;4(1):34-38. Epub 2014 Dec 16.

18.

Liposome-based mucus-penetrating particles (MPP) for mucosal theranostics: demonstration of diamagnetic chemical exchange saturation transfer (diaCEST) magnetic resonance imaging (MRI).

Yu T, Chan KW, Anonuevo A, Song X, Schuster BS, Chattopadhyay S, Xu Q, Oskolkov N, Patel H, Ensign LM, van Zjil PC, McMahon MT, Hanes J.

Nanomedicine. 2015 Feb;11(2):401-5. doi: 10.1016/j.nano.2014.09.019. Epub 2014 Nov 15.

19.

RNA sequencing: current and prospective uses in metabolic research.

Vikman P, Fadista J, Oskolkov N.

J Mol Endocrinol. 2014 Oct;53(2):R93-101. doi: 10.1530/JME-14-0170. Review.

PMID:
25228274
20.

TCF7L2 is a master regulator of insulin production and processing.

Zhou Y, Park SY, Su J, Bailey K, Ottosson-Laakso E, Shcherbina L, Oskolkov N, Zhang E, Thevenin T, Fadista J, Bennet H, Vikman P, Wierup N, Fex M, Rung J, Wollheim C, Nobrega M, Renström E, Groop L, Hansson O.

Hum Mol Genet. 2014 Dec 15;23(24):6419-31. doi: 10.1093/hmg/ddu359. Epub 2014 Jul 11.

21.

Porous tantalum and tantalum oxide nanoparticles for regenerative medicine.

Mohandas G, Oskolkov N, McMahon MT, Walczak P, Janowski M.

Acta Neurobiol Exp (Wars). 2014;74(2):188-96. Review.

22.

Leveraging cross-species transcription factor binding site patterns: from diabetes risk loci to disease mechanisms.

Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N, Fadista J, Ehlers K, Wahl S, Hoffmann C, Qian K, Rönn T, Riess H, Müller-Nurasyid M, Bretschneider N, Schroeder T, Skurk T, Horsthemke B; DIAGRAM+Consortium, Spieler D, Klingenspor M, Seifert M, Kern MJ, Mejhert N, Dahlman I, Hansson O, Hauck SM, Blüher M, Arner P, Groop L, Illig T, Suhre K, Hsu YH, Mellgren G, Hauner H, Laumen H.

Cell. 2014 Jan 16;156(1-2):343-58. doi: 10.1016/j.cell.2013.10.058.

23.

Human protamine-1 as an MRI reporter gene based on chemical exchange.

Bar-Shir A, Liu G, Chan KW, Oskolkov N, Song X, Yadav NN, Walczak P, McMahon MT, van Zijl PC, Bulte JW, Gilad AA.

ACS Chem Biol. 2014 Jan 17;9(1):134-8. doi: 10.1021/cb400617q. Epub 2013 Oct 25.

24.

Transfection of infectious RNA and DNA/RNA layered vectors of semliki forest virus by the cell-penetrating peptide based reagent PepFect6.

Pärn K, Viru L, Lehto T, Oskolkov N, Langel Ü, Merits A.

PLoS One. 2013 Jul 8;8(7):e69659. doi: 10.1371/journal.pone.0069659. Print 2013.

25.

Nuclear Overhauser enhancement (NOE) imaging in the human brain at 7T.

Jones CK, Huang A, Xu J, Edden RA, Schär M, Hua J, Oskolkov N, Zacà D, Zhou J, McMahon MT, Pillai JJ, van Zijl PC.

Neuroimage. 2013 Aug 15;77:114-24. doi: 10.1016/j.neuroimage.2013.03.047. Epub 2013 Apr 6.

26.

New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids.

Arukuusk P, Pärnaste L, Oskolkov N, Copolovici DM, Margus H, Padari K, Möll K, Maslovskaja J, Tegova R, Kivi G, Tover A, Pooga M, Ustav M, Langel U.

Biochim Biophys Acta. 2013 May;1828(5):1365-73. doi: 10.1016/j.bbamem.2013.01.011. Epub 2013 Jan 26.

27.

Peptide-based glioma-targeted drug delivery vector gHoPe2.

Eriste E, Kurrikoff K, Suhorutšenko J, Oskolkov N, Copolovici DM, Jones S, Laakkonen P, Howl J, Langel Ü.

Bioconjug Chem. 2013 Mar 20;24(3):305-13. doi: 10.1021/bc300370w. Epub 2013 Feb 19.

PMID:
23350661
28.

Cell-penetrating peptides split into two groups based on modulation of intracellular calcium concentration.

Lorents A, Kodavali PK, Oskolkov N, Langel Ü, Hällbrink M, Pooga M.

J Biol Chem. 2012 May 11;287(20):16880-9. doi: 10.1074/jbc.M111.318063. Epub 2012 Mar 21.

29.

Cell-penetrating peptides, PepFects, show no evidence of toxicity and immunogenicity in vitro and in vivo.

Suhorutsenko J, Oskolkov N, Arukuusk P, Kurrikoff K, Eriste E, Copolovici DM, Langel U.

Bioconjug Chem. 2011 Nov 16;22(11):2255-62. doi: 10.1021/bc200293d. Epub 2011 Oct 10.

PMID:
21978260
30.

A peptide-based vector for efficient gene transfer in vitro and in vivo.

Lehto T, Simonson OE, Mäger I, Ezzat K, Sork H, Copolovici DM, Viola JR, Zaghloul EM, Lundin P, Moreno PM, Mäe M, Oskolkov N, Suhorutšenko J, Smith CI, Andaloussi SE.

Mol Ther. 2011 Aug;19(8):1457-67. doi: 10.1038/mt.2011.10. Epub 2011 Feb 22.

31.

Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo.

Andaloussi SE, Lehto T, Mäger I, Rosenthal-Aizman K, Oprea II, Simonson OE, Sork H, Ezzat K, Copolovici DM, Kurrikoff K, Viola JR, Zaghloul EM, Sillard R, Johansson HJ, Said Hassane F, Guterstam P, Suhorutšenko J, Moreno PM, Oskolkov N, Hälldin J, Tedebark U, Metspalu A, Lebleu B, Lehtiö J, Smith CI, Langel U.

Nucleic Acids Res. 2011 May;39(9):3972-87. doi: 10.1093/nar/gkq1299. Epub 2011 Jan 17.

32.

Nematic ordering of polymers in confined geometry applied to DNA packaging in viral capsids.

Oskolkov NN, Linse P, Potemkin II, Khokhlov AR.

J Phys Chem B. 2011 Jan 27;115(3):422-32. doi: 10.1021/jp108461z. Epub 2010 Dec 27.

PMID:
21186830
33.

Delivery of nucleic acids with a stearylated (RxR)4 peptide using a non-covalent co-incubation strategy.

Lehto T, Abes R, Oskolkov N, Suhorutsenko J, Copolovici DM, Mäger I, Viola JR, Simonson OE, Ezzat K, Guterstam P, Eriste E, Smith CI, Lebleu B, Samir El Andaloussi, Langel U.

J Control Release. 2010 Jan 4;141(1):42-51. doi: 10.1016/j.jconrel.2009.08.028. Epub 2009 Sep 8.

PMID:
19744531
34.

A stearylated CPP for delivery of splice correcting oligonucleotides using a non-covalent co-incubation strategy.

Mäe M, El Andaloussi S, Lundin P, Oskolkov N, Johansson HJ, Guterstam P, Langel U.

J Control Release. 2009 Mar 19;134(3):221-7. doi: 10.1016/j.jconrel.2008.11.025. Epub 2008 Dec 6.

PMID:
19105971
35.

Effect of low-molecular-weight salt on the nematic ordering in solutions of rodlike polyelectrolytes.

Potemkin II, Oskolkov NN, Khokhlov AR, Reineker P.

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Aug;72(2 Pt 1):021804. Epub 2005 Aug 12.

PMID:
16196594
36.

Screening for the optimal specificity profile of protein kinase C using electrospray mass-spectrometry.

Loog M, Ek B, Oskolkov N, Närvänen A, Järv J, Ek P.

J Biomol Screen. 2005 Jun;10(4):320-8.

PMID:
15964933
37.

Comparison of cAMP-dependent protein kinase substrate specificity in reaction with proteins and synthetic peptides.

Loog M, Oskolkov N, O'Farrell F, Ek P, Järv J.

Biochim Biophys Acta. 2005 Mar 14;1747(2):261-6. Epub 2004 Dec 28.

PMID:
15698961

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