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Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling.

Hasan S, Rahman WU, Sebo P, Osicka R.

Toxins (Basel). 2019 Jun 20;11(6). pii: E362. doi: 10.3390/toxins11060362.


Rapid Purification of Endotoxin-Free RTX Toxins.

Stanek O, Masin J, Osicka R, Jurnecka D, Osickova A, Sebo P.

Toxins (Basel). 2019 Jun 12;11(6). pii: E336. doi: 10.3390/toxins11060336.


Residues 529 to 549 participate in membrane penetration and pore-forming activity of the Bordetella adenylate cyclase toxin.

Roderova J, Osickova A, Sukova A, Mikusova G, Fiser R, Sebo P, Osicka R, Masin J.

Sci Rep. 2019 Apr 8;9(1):5758. doi: 10.1038/s41598-019-42200-2.


Cytotoxic activity of Kingella kingae RtxA toxin depends on post-translational acylation of lysine residues and cholesterol binding.

Osickova A, Balashova N, Masin J, Sulc M, Roderova J, Wald T, Brown AC, Koufos E, Chang EH, Giannakakis A, Lally ET, Osicka R.

Emerg Microbes Infect. 2018 Nov 7;7(1):178. doi: 10.1038/s41426-018-0179-x.


ABD-Derived Protein Blockers of Human IL-17 Receptor A as Non-IgG Alternatives for Modulation of IL-17-Dependent Pro-Inflammatory Axis.

Hlavničková M, Kuchař M, Osička R, Vaňková L, Petroková H, Malý M, Černý J, Arenberger P, Malý P.

Int J Mol Sci. 2018 Oct 9;19(10). pii: E3089. doi: 10.3390/ijms19103089.


A guide to polarized airway epithelial models for studies of host-pathogen interactions.

Hasan S, Sebo P, Osicka R.

FEBS J. 2018 Dec;285(23):4343-4358. doi: 10.1111/febs.14582. Epub 2018 Jul 2. Review.


Phospholipase A activity of adenylate cyclase toxin?

Masin J, Osicka R, Bumba L, Sebo P.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2489-E2490. doi: 10.1073/pnas.1722588115. Epub 2018 Feb 21. No abstract available.


Bordetella pertussis Adenylate Cyclase Toxin Disrupts Functional Integrity of Bronchial Epithelial Layers.

Hasan S, Kulkarni NN, Asbjarnarson A, Linhartova I, Osicka R, Sebo P, Gudmundsson GH.

Infect Immun. 2018 Feb 20;86(3). pii: e00445-17. doi: 10.1128/IAI.00445-17. Print 2018 Mar.


Structure-Function Relationships Underlying the Capacity of Bordetella Adenylate Cyclase Toxin to Disarm Host Phagocytes.

Novak J, Cerny O, Osickova A, Linhartova I, Masin J, Bumba L, Sebo P, Osicka R.

Toxins (Basel). 2017 Sep 24;9(10). pii: E300. doi: 10.3390/toxins9100300. Review.


The conserved tyrosine residue 940 plays a key structural role in membrane interaction of Bordetella adenylate cyclase toxin.

Masin J, Roderova J, Osickova A, Novak P, Bumba L, Fiser R, Sebo P, Osicka R.

Sci Rep. 2017 Aug 24;7(1):9330. doi: 10.1038/s41598-017-09575-6.


Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.

Skopova K, Tomalova B, Kanchev I, Rossmann P, Svedova M, Adkins I, Bibova I, Tomala J, Masin J, Guiso N, Osicka R, Sedlacek R, Kovar M, Sebo P.

Infect Immun. 2017 May 23;85(6). pii: e00937-16. doi: 10.1128/IAI.00937-16. Print 2017 Jun.


Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif.

Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R.

Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1641-E1650. doi: 10.1073/pnas.1615334114. Epub 2017 Feb 14.


p19-targeted ABD-derived protein variants inhibit IL-23 binding and exert suppressive control over IL-23-stimulated expansion of primary human IL-17+ T-cells.

Křížová L, Kuchař M, Petroková H, Osička R, Hlavničková M, Pelák O, Černý J, Kalina T, Malý P.

Autoimmunity. 2017 Mar;50(2):102-113. doi: 10.1080/08916934.2016.1272598. Epub 2017 Jan 19.


Negatively charged residues of the segment linking the enzyme and cytolysin moieties restrict the membrane-permeabilizing capacity of adenylate cyclase toxin.

Masin J, Osickova A, Sukova A, Fiser R, Halada P, Bumba L, Linhartova I, Osicka R, Sebo P.

Sci Rep. 2016 Sep 1;6:29137. doi: 10.1038/srep29137.


Expanding the tools for identifying mononuclear phagocyte subsets in swine: Reagents to porcine CD11c and XCR1.

Deloizy C, Bouguyon E, Fossum E, Sebo P, Osicka R, Bole A, Pierres M, Biacchesi S, Dalod M, Bogen B, Bertho N, Schwartz-Cornil I.

Dev Comp Immunol. 2016 Dec;65:31-40. doi: 10.1016/j.dci.2016.06.015. Epub 2016 Jun 21.


Transmembrane segments of complement receptor 3 do not participate in cytotoxic activities but determine receptor structure required for action of Bordetella adenylate cyclase toxin.

Wald T, Osickova A, Masin J, Liskova PM, Petry-Podgorska I, Matousek T, Sebo P, Osicka R.

Pathog Dis. 2016 Apr;74(3). pii: ftw008. doi: 10.1093/femspd/ftw008. Epub 2016 Jan 21.


Bordetella pertussis filamentous hemagglutinin itself does not trigger anti-inflammatory interleukin-10 production by human dendritic cells.

Villarino Romero R, Hasan S, Faé K, Holubova J, Geurtsen J, Schwarzer M, Wiertsema S, Osicka R, Poolman J, Sebo P.

Int J Med Microbiol. 2016 Jan;306(1):38-47. doi: 10.1016/j.ijmm.2015.11.003. Epub 2015 Nov 30.


Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3.

Osicka R, Osickova A, Hasan S, Bumba L, Cerny J, Sebo P.

Elife. 2015 Dec 9;4:e10766. doi: 10.7554/eLife.10766.


Bordetella adenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme.

Masin J, Osicka R, Bumba L, Sebo P.

Pathog Dis. 2015 Nov;73(8):ftv075. doi: 10.1093/femspd/ftv075. Epub 2015 Sep 20. Review.


cAMP signalling of Bordetella adenylate cyclase toxin through the SHP-1 phosphatase activates the BimEL-Bax pro-apoptotic cascade in phagocytes.

Ahmad JN, Cerny O, Linhartova I, Masin J, Osicka R, Sebo P.

Cell Microbiol. 2016 Mar;18(3):384-98. doi: 10.1111/cmi.12519. Epub 2015 Oct 7.


Novel binders derived from an albumin-binding domain scaffold targeting human prostate secretory protein 94 (PSP94).

Marečková L, Petroková H, Osička R, Kuchař M, Malý P.

Protein Cell. 2015 Oct;6(10):774-9. doi: 10.1007/s13238-015-0194-9. No abstract available.


Interaction of Bordetella adenylate cyclase toxin with complement receptor 3 involves multivalent glycan binding.

Hasan S, Osickova A, Bumba L, Novák P, Sebo P, Osicka R.

FEBS Lett. 2015 Jan 30;589(3):374-9. doi: 10.1016/j.febslet.2014.12.023. Epub 2014 Dec 29.


Filamentous hemagglutinin of Bordetella pertussis: a key adhesin with immunomodulatory properties?

Villarino Romero R, Osicka R, Sebo P.

Future Microbiol. 2014;9(12):1339-60. doi: 10.2217/fmb.14.77. Review.


Adenylate cyclase toxin-hemolysin relevance for pertussis vaccines.

Sebo P, Osicka R, Masin J.

Expert Rev Vaccines. 2014 Oct;13(10):1215-27. doi: 10.1586/14760584.2014.944900. Epub 2014 Aug 4. Review.


Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses.

Dadaglio G, Fayolle C, Zhang X, Ryffel B, Oberkampf M, Felix T, Hervas-Stubbs S, Osicka R, Sebo P, Ladant D, Leclerc C.

J Immunol. 2014 Aug 15;193(4):1787-98. doi: 10.4049/jimmunol.1302974. Epub 2014 Jul 14.


Human interleukin-23 receptor antagonists derived from an albumin-binding domain scaffold inhibit IL-23-dependent ex vivo expansion of IL-17-producing T-cells.

Kuchař M, Vaňková L, Petroková H, Cerný J, Osička R, Pelák O, Sípová H, Schneider B, Homola J, Sebo P, Kalina T, Malý P.

Proteins. 2014 Jun;82(6):975-89. doi: 10.1002/prot.24472. Epub 2013 Nov 23.


Quantification of potassium levels in cells treated with Bordetella adenylate cyclase toxin.

Wald T, Petry-Podgorska I, Fiser R, Matousek T, Dedina J, Osicka R, Sebo P, Masin J.

Anal Biochem. 2014 Apr 1;450:57-62. doi: 10.1016/j.ab.2013.10.039. Epub 2014 Jan 9.


Differences in purinergic amplification of osmotic cell lysis by the pore-forming RTX toxins Bordetella pertussis CyaA and Actinobacillus pleuropneumoniae ApxIA: the role of pore size.

Masin J, Fiser R, Linhartova I, Osicka R, Bumba L, Hewlett EL, Benz R, Sebo P.

Infect Immun. 2013 Dec;81(12):4571-82. doi: 10.1128/IAI.00711-13. Epub 2013 Sep 30.


Intrinsically disordered enamel matrix protein ameloblastin forms ribbon-like supramolecular structures via an N-terminal segment encoded by exon 5.

Wald T, Osickova A, Sulc M, Benada O, Semeradtova A, Rezabkova L, Veverka V, Bednarova L, Maly J, Macek P, Sebo P, Slaby I, Vondrasek J, Osicka R.

J Biol Chem. 2013 Aug 2;288(31):22333-45. doi: 10.1074/jbc.M113.456012. Epub 2013 Jun 19.


The Bordetella pertussis type III secretion system tip complex protein Bsp22 is not a protective antigen and fails to elicit serum antibody responses during infection of humans and mice.

Villarino Romero R, Bibova I, Cerny O, Vecerek B, Wald T, Benada O, Zavadilova J, Osicka R, Sebo P.

Infect Immun. 2013 Aug;81(8):2761-7. doi: 10.1128/IAI.00353-13. Epub 2013 May 20. Erratum in: Infect Immun. 2014 Jul;82(7):3088.


Environmental risk assessment of arsenic and fluoride in the Chaco Province, Argentina: research advances.

Buchhamer EE, Blanes PS, Osicka RM, Giménez MC.

J Toxicol Environ Health A. 2012;75(22-23):1437-50. doi: 10.1080/15287394.2012.721178.


Calcium influx rescues adenylate cyclase-hemolysin from rapid cell membrane removal and enables phagocyte permeabilization by toxin pores.

Fiser R, Masin J, Bumba L, Pospisilova E, Fayolle C, Basler M, Sadilkova L, Adkins I, Kamanova J, Cerny J, Konopasek I, Osicka R, Leclerc C, Sebo P.

PLoS Pathog. 2012;8(4):e1002580. doi: 10.1371/journal.ppat.1002580. Epub 2012 Apr 5.


Biophysical characterization of recombinant human ameloblastin.

Wald T, Bednárová L, Osička R, Pachl P, Sulc M, Lyngstadaas SP, Slaby I, Vondrášek J.

Eur J Oral Sci. 2011 Dec;119 Suppl 1:261-9. doi: 10.1111/j.1600-0722.2011.00913.x.


Type IV fimbrial subunit protein ApfA contributes to protection against porcine pleuropneumonia.

Sadilkova L, Nepereny J, Vrzal V, Sebo P, Osicka R.

Vet Res. 2012 Jan 12;43:2. doi: 10.1186/1297-9716-43-2.


Novel high-affinity binders of human interferon gamma derived from albumin-binding domain of protein G.

Ahmad JN, Li J, Biedermannová L, Kuchař M, Sípová H, Semerádtová A, Cerný J, Petroková H, Mikulecký P, Polínek J, Staněk O, Vondrášek J, Homola J, Malý J, Osička R, Sebo P, Malý P.

Proteins. 2012 Mar;80(3):774-89. doi: 10.1002/prot.23234. Epub 2011 Nov 24.


RTX proteins: a highly diverse family secreted by a common mechanism.

Linhartová I, Bumba L, Mašín J, Basler M, Osička R, Kamanová J, Procházková K, Adkins I, Hejnová-Holubová J, Sadílková L, Morová J, Sebo P.

FEMS Microbiol Rev. 2010 Nov;34(6):1076-112. doi: 10.1111/j.1574-6976.2010.00231.x. Review.


Adenylate cyclase toxin translocates across target cell membrane without forming a pore.

Osickova A, Masin J, Fayolle C, Krusek J, Basler M, Pospisilova E, Leclerc C, Osicka R, Sebo P.

Mol Microbiol. 2010 Mar;75(6):1550-62. doi: 10.1111/j.1365-2958.2010.07077.x. Epub 2010 Feb 23.


Oligomerization is involved in pore formation by Bordetella adenylate cyclase toxin.

Vojtova-Vodolanova J, Basler M, Osicka R, Knapp O, Maier E, Cerny J, Benada O, Benz R, Sebo P.

FASEB J. 2009 Sep;23(9):2831-43. doi: 10.1096/fj.09-131250. Epub 2009 May 5.


Single-step affinity purification of recombinant proteins using a self-excising module from Neisseria meningitidis FrpC.

Sadilkova L, Osicka R, Sulc M, Linhartova I, Novak P, Sebo P.

Protein Sci. 2008 Oct;17(10):1834-43. doi: 10.1110/ps.035733.108. Epub 2008 Jul 28.


RTX cytotoxins recognize beta2 integrin receptors through N-linked oligosaccharides.

Morova J, Osicka R, Masin J, Sebo P.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5355-60. doi: 10.1073/pnas.0711400105. Epub 2008 Mar 28.


Integrin subunit CD18 Is the T-lymphocyte receptor for the Helicobacter pylori vacuolating cytotoxin.

Sewald X, Gebert-Vogl B, Prassl S, Barwig I, Weiss E, Fabbri M, Osicka R, Schiemann M, Busch DH, Semmrich M, Holzmann B, Sebo P, Haas R.

Cell Host Microbe. 2008 Jan 17;3(1):20-9. doi: 10.1016/j.chom.2007.11.003.


Segments crucial for membrane translocation and pore-forming activity of Bordetella adenylate cyclase toxin.

Basler M, Knapp O, Masin J, Fiser R, Maier E, Benz R, Sebo P, Osicka R.

J Biol Chem. 2007 Apr 27;282(17):12419-29. Epub 2007 Mar 8.


The iron-regulated transcriptome and proteome of Neisseria meningitidis serogroup C.

Basler M, Linhartová I, Halada P, Novotná J, Bezousková S, Osicka R, Weiser J, Vohradský J, Sebo P.

Proteomics. 2006 Dec;6(23):6194-206.


Meningococcal adhesion suppresses proapoptotic gene expression and promotes expression of genes supporting early embryonic and cytoprotective signaling of human endothelial cells.

Linhartova I, Basler M, Ichikawa J, Pelicic V, Osicka R, Lory S, Nassif X, Sebo P.

FEMS Microbiol Lett. 2006 Oct;263(1):109-18.


The Neisseria meningitidis outer membrane lipoprotein FrpD binds the RTX protein FrpC.

Prochazkova K, Osicka R, Linhartova I, Halada P, Sulc M, Sebo P.

J Biol Chem. 2005 Feb 4;280(5):3251-8. Epub 2004 Nov 2.


Interaction of Bordetella pertussis adenylate cyclase with CD11b/CD18: Role of toxin acylation and identification of the main integrin interaction domain.

El-Azami-El-Idrissi M, Bauche C, Loucka J, Osicka R, Sebo P, Ladant D, Leclerc C.

J Biol Chem. 2003 Oct 3;278(40):38514-21. Epub 2003 Jul 28.


Neisseria meningitidis RTX proteins are not required for virulence in infant rats.

Forman S, Linhartova I, Osicka R, Nassif X, Sebo P, Pelicic V.

Infect Immun. 2003 Apr;71(4):2253-7.

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