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Cytoplasmic dsRNA induces the expression of OCT3/4 and NANOG mRNAs in differentiated human cells.

Wang G, Kouwaki T, Mugikura K, Okamoto M, Takaki H, Funami K, Seya T, Oshiumi H.

J Biol Chem. 2019 Dec 13;294(50):18969-18979. doi: 10.1074/jbc.RA119.009783. Epub 2019 Oct 15.


Attenuation of the Innate Immune Response against Viral Infection Due to ZNF598-Promoted Binding of FAT10 to RIG-I.

Wang G, Kouwaki T, Okamoto M, Oshiumi H.

Cell Rep. 2019 Aug 20;28(8):1961-1970.e4. doi: 10.1016/j.celrep.2019.07.081.


Immune-regulatory microRNA expression levels within circulating extracellular vesicles correspond with the appearance of local symptoms after seasonal flu vaccination.

Miyashita Y, Ishikawa K, Fukushima Y, Kouwaki T, Nakamura K, Oshiumi H.

PLoS One. 2019 Jul 9;14(7):e0219510. doi: 10.1371/journal.pone.0219510. eCollection 2019.


Editorial: Emerging Viruses: Host Immunity and Novel Therapeutic Interventions.

Smed-Sörensen A, Oh DY, Oshiumi H, Hsu AC.

Front Immunol. 2018 Nov 30;9:2828. doi: 10.3389/fimmu.2018.02828. eCollection 2018. No abstract available.


Discovery of 3-Ethyl-4-(3-isopropyl-4-(4-(1-methyl-1 H-pyrazol-4-yl)-1 H-imidazol-1-yl)-1 H-pyrazolo[3,4- b]pyridin-1-yl)benzamide (TAS-116) as a Potent, Selective, and Orally Available HSP90 Inhibitor.

Uno T, Kawai Y, Yamashita S, Oshiumi H, Yoshimura C, Mizutani T, Suzuki T, Chong KT, Shigeno K, Ohkubo M, Kodama Y, Muraoka H, Funabashi K, Takahashi K, Ohkubo S, Kitade M.

J Med Chem. 2019 Jan 24;62(2):531-551. doi: 10.1021/acs.jmedchem.8b01085. Epub 2018 Dec 21.


MicroRNA-451a in extracellular, blood-resident vesicles attenuates macrophage and dendritic cell responses to influenza whole-virus vaccine.

Okamoto M, Fukushima Y, Kouwaki T, Daito T, Kohara M, Kida H, Oshiumi H.

J Biol Chem. 2018 Nov 30;293(48):18585-18600. doi: 10.1074/jbc.RA118.003862. Epub 2018 Oct 3.


Combined Blockade of IL6 and PD-1/PD-L1 Signaling Abrogates Mutual Regulation of Their Immunosuppressive Effects in the Tumor Microenvironment.

Tsukamoto H, Fujieda K, Miyashita A, Fukushima S, Ikeda T, Kubo Y, Senju S, Ihn H, Nishimura Y, Oshiumi H.

Cancer Res. 2018 Sep 1;78(17):5011-5022. doi: 10.1158/0008-5472.CAN-18-0118. Epub 2018 Jul 2.


Activation of TLR3 and its adaptor TICAM-1 increases miR-21 levels in extracellular vesicles released from human cells.

Fukushima Y, Okamoto M, Ishikawa K, Kouwaki T, Tsukamoto H, Oshiumi H.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):744-750. doi: 10.1016/j.bbrc.2018.04.146. Epub 2018 Apr 23.


TICAM-1 is dispensable in STING-mediated innate immune responses in myeloid immune cells.

Takashima K, Oshiumi H, Matsumoto M, Seya T.

Biochem Biophys Res Commun. 2018 May 23;499(4):985-991. doi: 10.1016/j.bbrc.2018.04.035. Epub 2018 Apr 9.


Regulation of RIG-I Activation by K63-Linked Polyubiquitination.

Okamoto M, Kouwaki T, Fukushima Y, Oshiumi H.

Front Immunol. 2018 Jan 5;8:1942. doi: 10.3389/fimmu.2017.01942. eCollection 2017. Review.


cGAMP Promotes Germinal Center Formation and Production of IgA in Nasal-Associated Lymphoid Tissue.

Takaki H, Takashima K, Oshiumi H, Ainai A, Suzuki T, Hasegawa H, Matsumoto M, Seya T.

Med Sci (Basel). 2017 Dec 18;5(4). pii: E35. doi: 10.3390/medsci5040035.


Immune-suppressive effects of interleukin-6 on T-cell-mediated anti-tumor immunity.

Tsukamoto H, Fujieda K, Senju S, Ikeda T, Oshiumi H, Nishimura Y.

Cancer Sci. 2018 Mar;109(3):523-530. doi: 10.1111/cas.13433. Epub 2017 Nov 16. Review.


DNAJB1/HSP40 Suppresses Melanoma Differentiation-Associated Gene 5-Mitochondrial Antiviral Signaling Protein Function in Conjunction with HSP70.

Takashima K, Oshiumi H, Matsumoto M, Seya T.

J Innate Immun. 2018;10(1):44-55. doi: 10.1159/000480740. Epub 2017 Oct 26.


Aureobasidium pullulans-cultured fluid induces IL-18 production, leading to Th1-polarization during influenza A virus infection.

Fujikura D, Muramatsu D, Toyomane K, Chiba S, Daito T, Iwai A, Kouwaki T, Okamoto M, Higashi H, Kida H, Oshiumi H.

J Biochem. 2018 Jan 1;163(1):31-38. doi: 10.1093/jb/mvx062.


Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response.

Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, Matsumoto M, Seya T, Oshiumi H.

Sci Rep. 2017 Sep 19;7(1):11905. doi: 10.1038/s41598-017-12224-7.


Functional interfaces between TICAM-2/TRAM and TICAM-1/TRIF in TLR4 signaling.

Funami K, Matsumoto M, Oshiumi H, Inagaki F, Seya T.

Biochem Soc Trans. 2017 Aug 15;45(4):929-935. doi: 10.1042/BST20160259. Epub 2017 Jun 19. Review.


Toll-like receptor 3 in nasal CD103+ dendritic cells is involved in immunoglobulin A production.

Takaki H, Kure S, Oshiumi H, Sakoda Y, Suzuki T, Ainai A, Hasegawa H, Matsumoto M, Seya T.

Mucosal Immunol. 2018 Jan;11(1):82-96. doi: 10.1038/mi.2017.48. Epub 2017 Jun 15.


Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections.

Okamoto M, Tsukamoto H, Kouwaki T, Seya T, Oshiumi H.

Viral Immunol. 2017 Jul/Aug;30(6):408-420. doi: 10.1089/vim.2016.0178. Epub 2017 Jun 13. Review.


Development of mouse models for analysis of human virus infections.

Takaki H, Oshiumi H, Shingai M, Matsumoto M, Seya T.

Microbiol Immunol. 2017 Apr;61(3-4):107-113. doi: 10.1111/1348-0421.12477. Review.


Extracellular Vesicles Deliver Host and Virus RNA and Regulate Innate Immune Response.

Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, Oshiumi H.

Int J Mol Sci. 2017 Mar 20;18(3). pii: E666. doi: 10.3390/ijms18030666. Review.


HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.

Shibata Y, Tokunaga F, Goto E, Komatsu G, Gohda J, Saeki Y, Tanaka K, Takahashi H, Sawasaki T, Inoue S, Oshiumi H, Seya T, Nakano H, Tanaka Y, Iwai K, Inoue JI.

PLoS Pathog. 2017 Jan 19;13(1):e1006162. doi: 10.1371/journal.ppat.1006162. eCollection 2017 Jan.


Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection.

Kouwaki T, Fukushima Y, Daito T, Sanada T, Yamamoto N, Mifsud EJ, Leong CR, Tsukiyama-Kohara K, Kohara M, Matsumoto M, Seya T, Oshiumi H.

Front Immunol. 2016 Aug 31;7:335. doi: 10.3389/fimmu.2016.00335. eCollection 2016.


Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo.

Leong CR, Funami K, Oshiumi H, Mengao D, Takaki H, Matsumoto M, Aly HH, Watashi K, Chayama K, Seya T.

Oncotarget. 2016 Oct 18;7(42):68179-68193. doi: 10.18632/oncotarget.11907.


Biphasic function of TLR3 adjuvant on tumor and spleen dendritic cells promotes tumor T cell infiltration and regression in a vaccine therapy.

Azuma M, Takeda Y, Nakajima H, Sugiyama H, Ebihara T, Oshiumi H, Matsumoto M, Seya T.

Oncoimmunology. 2016 May 19;5(8):e1188244. doi: 10.1080/2162402X.2016.1188244. eCollection 2016 Aug.


STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation.

Takashima K, Takeda Y, Oshiumi H, Shime H, Okabe M, Ikawa M, Matsumoto M, Seya T.

Biochem Biophys Res Commun. 2016 Sep 30;478(4):1764-71. doi: 10.1016/j.bbrc.2016.09.021. Epub 2016 Sep 5.


The dataset of proteins specifically interacted with activated TICAM-1.

Funami K, Matsumoto M, Oshiumi H, Obuse C, Seya T.

Data Brief. 2016 Jun 28;8:697-9. doi: 10.1016/j.dib.2016.06.030. eCollection 2016 Sep.


Accessory Factors of Cytoplasmic Viral RNA Sensors Required for Antiviral Innate Immune Response.

Oshiumi H, Kouwaki T, Seya T.

Front Immunol. 2016 May 25;7:200. doi: 10.3389/fimmu.2016.00200. eCollection 2016. Review.


Double-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells.

Kasamatsu J, Deng M, Azuma M, Funami K, Shime H, Oshiumi H, Matsumoto M, Kasahara M, Seya T.

BMC Immunol. 2016 May 3;17(1):9. doi: 10.1186/s12865-016-0147-y.


[Nucleic acid pattern recognition for innate sensing of hepatitis B virus (HBV)].

Seya T, Funami K, Matsumoto M, Oshiumi H.

Nihon Rinsho. 2015 Dec;73 Suppl 9:392-6. Japanese. No abstract available.


Links between recognition and degradation of cytoplasmic viral RNA in innate immune response.

Oshiumi H, Mifsud EJ, Daito T.

Rev Med Virol. 2016 Mar;26(2):90-101. doi: 10.1002/rmv.1865. Epub 2015 Dec 8. Review.


Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV).

Nakai M, Oshiumi H, Funami K, Okamoto M, Matsumoto M, Seya T, Sakamoto N.

Sensors (Basel). 2015 Oct 23;15(10):27160-73. doi: 10.3390/s151027160. Review.


RIOK3 keeps MDA5 inactive.

Takashima K, Oshiumi H, Seya T.

Oncotarget. 2015 Oct 13;6(31):30423-4. doi: 10.18632/oncotarget.5265. No abstract available.


Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.

Funami K, Matsumoto M, Enokizono Y, Ishii N, Tatematsu M, Oshiumi H, Inagaki F, Seya T.

J Immunol. 2015 Nov 1;195(9):4456-65. doi: 10.4049/jimmunol.1402628. Epub 2015 Sep 25.


Evolution of the DEAD box helicase family in chicken: chickens have no DHX9 ortholog.

Sato H, Oshiumi H, Takaki H, Hikono H, Seya T.

Microbiol Immunol. 2015 Oct;59(10):633-40. doi: 10.1111/1348-0421.12322.


Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation.

Ebihara T, Azuma M, Oshiumi H, Kasamatsu J, Iwabuchi K, Matsumoto K, Saito H, Taniguchi T, Matsumoto M, Seya T.

J Exp Med. 2015 Jul 27;212(8):1337. doi: 10.1084/jem.2009157307012015c. Epub 2015 Jul 13. No abstract available.


DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation.

Oshiumi H, Miyashita M, Okamoto M, Morioka Y, Okabe M, Matsumoto M, Seya T.

Cell Rep. 2015 May 26;11(8):1193-207. doi: 10.1016/j.celrep.2015.04.047. Epub 2015 May 14.


PolyI:C-Induced, TLR3/RIP3-Dependent Necroptosis Backs Up Immune Effector-Mediated Tumor Elimination In Vivo.

Takemura R, Takaki H, Okada S, Shime H, Akazawa T, Oshiumi H, Matsumoto M, Teshima T, Seya T.

Cancer Immunol Res. 2015 Aug;3(8):902-14. doi: 10.1158/2326-6066.CIR-14-0219. Epub 2015 Apr 21.


Nucleic Acid Sensors Involved in the Recognition of HBV in the Liver-Specific in vivo Transfection Mouse Models-Pattern Recognition Receptors and Sensors for HBV.

Leong CR, Oshiumi H, Suzuki T, Matsumoto M, Seya T.

Med Sci (Basel). 2015 Apr 15;3(2):16-24. doi: 10.3390/medsci3020016.


RIOK3-mediated phosphorylation of MDA5 interferes with its assembly and attenuates the innate immune response.

Takashima K, Oshiumi H, Takaki H, Matsumoto M, Seya T.

Cell Rep. 2015 Apr 14;11(2):192-200.


[Chronic hepatitis C virus infection attenuates host antiviral innate immune response].

Oshiumi H, Matsumoto M, Seya T.

Nihon Rinsho. 2015 Feb;73(2):234-8. Review. Japanese.


INAM plays a critical role in IFN-γ production by NK cells interacting with polyinosinic-polycytidylic acid-stimulated accessory cells.

Kasamatsu J, Azuma M, Oshiumi H, Morioka Y, Okabe M, Ebihara T, Matsumoto M, Seya T.

J Immunol. 2014 Nov 15;193(10):5199-207. doi: 10.4049/jimmunol.1400924. Epub 2014 Oct 15.


A MAVS/TICAM-1-independent interferon-inducing pathway contributes to regulation of hepatitis B virus replication in the mouse hydrodynamic injection model.

Leong CR, Oshiumi H, Okamoto M, Azuma M, Takaki H, Matsumoto M, Chayama K, Seya T.

J Innate Immun. 2015;7(1):47-58. doi: 10.1159/000365113. Epub 2014 Aug 8.


Dendritic cell subsets involved in type I IFN induction in mouse measles virus infection models.

Takaki H, Oshiumi H, Matsumoto M, Seya T.

Int J Biochem Cell Biol. 2014 Aug;53:329-33. doi: 10.1016/j.biocel.2014.05.001. Epub 2014 Jun 4.


IPS-1 is essential for type III IFN production by hepatocytes and dendritic cells in response to hepatitis C virus infection.

Okamoto M, Oshiumi H, Azuma M, Kato N, Matsumoto M, Seya T.

J Immunol. 2014 Mar 15;192(6):2770-7. doi: 10.4049/jimmunol.1301459. Epub 2014 Feb 14.


Cell type-specific subcellular localization of phospho-TBK1 in response to cytoplasmic viral DNA.

Suzuki T, Oshiumi H, Miyashita M, Aly HH, Matsumoto M, Seya T.

PLoS One. 2013 Dec 9;8(12):e83639. doi: 10.1371/journal.pone.0083639. eCollection 2013.


Myeloid-derived suppressor cells confer tumor-suppressive functions on natural killer cells via polyinosinic:polycytidylic acid treatment in mouse tumor models.

Shime H, Kojima A, Maruyama A, Saito Y, Oshiumi H, Matsumoto M, Seya T.

J Innate Immun. 2014;6(3):293-305. doi: 10.1159/000355126. Epub 2013 Oct 29.


MAVS-dependent IRF3/7 bypass of interferon β-induction restricts the response to measles infection in CD150Tg mouse bone marrow-derived dendritic cells.

Takaki H, Honda K, Atarashi K, Kobayashi F, Ebihara T, Oshiumi H, Matsumoto M, Shingai M, Seya T.

Mol Immunol. 2014 Feb;57(2):100-10. doi: 10.1016/j.molimm.2013.08.007. Epub 2013 Oct 4.


The MyD88 pathway in plasmacytoid and CD4+ dendritic cells primarily triggers type I IFN production against measles virus in a mouse infection model.

Takaki H, Takeda M, Tahara M, Shingai M, Oshiumi H, Matsumoto M, Seya T.

J Immunol. 2013 Nov 1;191(9):4740-7. doi: 10.4049/jimmunol.1301744. Epub 2013 Sep 27.


A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses.

Oshiumi H, Miyashita M, Matsumoto M, Seya T.

PLoS Pathog. 2013;9(8):e1003533. doi: 10.1371/journal.ppat.1003533. Epub 2013 Aug 8.


Toll-IL-1-receptor-containing adaptor molecule-1: a signaling adaptor linking innate immunity to adaptive immunity.

Matsumoto M, Funami K, Oshiumi H, Seya T.

Prog Mol Biol Transl Sci. 2013;117:487-510. doi: 10.1016/B978-0-12-386931-9.00018-0. Review.


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