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Items: 1 to 50 of 478

1.

An efficient protein production system via gene amplification on a human artificial chromosome and the chromosome transfer to CHO cells.

Ohira T, Miyauchi K, Uno N, Shimizu N, Kazuki Y, Oshimura M, Kugoh H.

Sci Rep. 2019 Nov 18;9(1):16954. doi: 10.1038/s41598-019-53116-2.

2.

CYP3A4 Induction in the Liver and Intestine of Pregnane X Receptor/CYP3A-Humanized Mice: Approaches by Mass Spectrometry Imaging and Portal Blood Analysis.

Kobayashi K, Kuze J, Abe S, Takehara S, Minegishi G, Igarashi K, Kitajima S, Kanno J, Yamamoto T, Oshimura M, Kazuki Y.

Mol Pharmacol. 2019 Nov;96(5):600-608. doi: 10.1124/mol.119.117333. Epub 2019 Aug 27.

PMID:
31455676
3.

PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription.

Ohira T, Kojima H, Kuroda Y, Aoki S, Inaoka D, Osaki M, Wanibuchi H, Okada F, Oshimura M, Kugoh H.

PLoS One. 2019 Aug 12;14(8):e0217605. doi: 10.1371/journal.pone.0217605. eCollection 2019.

4.

NMR Analysis of Poly(Lactic Acid) via Statistical Models.

Suganuma K, Asakura T, Oshimura M, Hirano T, Ute K, Cheng HN.

Polymers (Basel). 2019 Apr 19;11(4). pii: E725. doi: 10.3390/polym11040725.

5.

Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism.

Kazuki Y, Kobayashi K, Hirabayashi M, Abe S, Kajitani N, Kazuki K, Takehara S, Takiguchi M, Satoh D, Kuze J, Sakuma T, Kaneko T, Mashimo T, Osamura M, Hashimoto M, Wakatsuki R, Hirashima R, Fujiwara R, Deguchi T, Kurihara A, Tsukazaki Y, Senda N, Yamamoto T, Scheer N, Oshimura M.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3072-3081. doi: 10.1073/pnas.1808255116. Epub 2019 Feb 4.

6.

Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo.

Minegishi G, Kazuki Y, Yamasaki Y, Okuya F, Akita H, Oshimura M, Kobayashi K.

Xenobiotica. 2019 Nov;49(11):1303-1310. doi: 10.1080/00498254.2018.1560516. Epub 2019 Jun 14.

PMID:
30561249
7.

Generation of a novel isogenic trisomy panel in human embryonic stem cells via microcell-mediated chromosome transfer.

Hiramatsu K, Abe S, Kazuki K, Osaki M, Kajitani N, Yakura Y, Oshimura M, Kazuki Y.

Biochem Biophys Res Commun. 2019 Jan 8;508(2):603-607. doi: 10.1016/j.bbrc.2018.11.138. Epub 2018 Dec 1.

PMID:
30509488
8.

Systematic Analysis of Compounds Specifically Targeting Telomeres and Telomerase for Clinical Implications in Cancer Therapy.

Lee HS, Carmena M, Liskovykh M, Peat E, Kim JH, Oshimura M, Masumoto H, Teulade-Fichou MP, Pommier Y, Earnshaw WC, Larionov V, Kouprina N.

Cancer Res. 2018 Nov 1;78(21):6282-6296. doi: 10.1158/0008-5472.CAN-18-0894. Epub 2018 Aug 30.

9.

A luciferase complementation assay system using transferable mouse artificial chromosomes to monitor protein-protein interactions mediated by G protein-coupled receptors.

Uno N, Fujimoto T, Komoto S, Kurosawa G, Sawa M, Suzuki T, Kazuki Y, Oshimura M.

Cytotechnology. 2018 Dec;70(6):1499-1508. doi: 10.1007/s10616-018-0231-7. Epub 2018 Jul 31.

10.

Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.

Nitta SI, Hashimoto M, Kazuki Y, Takehara S, Suzuki H, Oshimura M, Akita H, Chiba K, Kobayashi K.

AAPS J. 2018 Apr 9;20(3):61. doi: 10.1208/s12248-018-0186-9.

PMID:
29858698
11.

Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.

Yamasaki Y, Kobayashi K, Okuya F, Kajitani N, Kazuki K, Abe S, Takehara S, Ito S, Ogata S, Uemura T, Ohtsuki S, Minegishi G, Akita H, Chiba K, Oshimura M, Kazuki Y.

Drug Metab Dispos. 2018 Nov;46(11):1756-1766. doi: 10.1124/dmd.118.081216. Epub 2018 May 18.

PMID:
29777024
12.

Production of a Human Cell Line with a Plant Chromosome.

Wada N, Kazuki Y, Kazuki K, Inoue T, Fukui K, Oshimura M.

Methods Mol Biol. 2018;1772:289-296. doi: 10.1007/978-1-4939-7795-6_16.

PMID:
29754235
13.

Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9.

Honma K, Abe S, Endo T, Uno N, Oshimura M, Ohbayashi T, Kazuki Y.

PLoS One. 2018 Mar 5;13(3):e0193642. doi: 10.1371/journal.pone.0193642. eCollection 2018.

14.

Bioluminescence-based cytotoxicity assay for simultaneous evaluation of cell viability and membrane damage in human hepatoma HepG2 cells.

Uno K, Murotomi K, Kazuki Y, Oshimura M, Nakajima Y.

Luminescence. 2018 May;33(3):616-624. doi: 10.1002/bio.3454. Epub 2018 Feb 8.

PMID:
29424036
15.

Human and mouse artificial chromosome technologies for studies of pharmacokinetics and toxicokinetics.

Satoh D, Abe S, Kobayashi K, Nakajima Y, Oshimura M, Kazuki Y.

Drug Metab Pharmacokinet. 2018 Feb;33(1):17-30. doi: 10.1016/j.dmpk.2018.01.002. Epub 2018 Jan 11. Review.

16.

Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy.

Benedetti S, Uno N, Hoshiya H, Ragazzi M, Ferrari G, Kazuki Y, Moyle LA, Tonlorenzi R, Lombardo A, Chaouch S, Mouly V, Moore M, Popplewell L, Kazuki K, Katoh M, Naldini L, Dickson G, Messina G, Oshimura M, Cossu G, Tedesco FS.

EMBO Mol Med. 2018 Feb;10(2):254-275. doi: 10.15252/emmm.201607284.

17.

Combinations of chromosome transfer and genome editing for the development of cell/animal models of human disease and humanized animal models.

Uno N, Abe S, Oshimura M, Kazuki Y.

J Hum Genet. 2018 Feb;63(2):145-156. doi: 10.1038/s10038-017-0378-7. Epub 2017 Nov 27. Review.

PMID:
29180645
18.

Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology.

Abe S, Kobayashi K, Oji A, Sakuma T, Kazuki K, Takehara S, Nakamura K, Okada A, Tsukazaki Y, Senda N, Honma K, Yamamoto T, Ikawa M, Chiba K, Oshimura M, Kazuki Y.

Sci Rep. 2017 Nov 9;7(1):15189. doi: 10.1038/s41598-017-15033-0.

19.

Establishment of a novel hepatocyte model that expresses four cytochrome P450 genes stably via mammalian-derived artificial chromosome for pharmacokinetics and toxicity studies.

Satoh D, Iwado S, Abe S, Kazuki K, Wakuri S, Oshimura M, Kazuki Y.

PLoS One. 2017 Oct 24;12(10):e0187072. doi: 10.1371/journal.pone.0187072. eCollection 2017.

20.

CRISPR/Cas9-induced transgene insertion and telomere-associated truncation of a single human chromosome for chromosome engineering in CHO and A9 cells.

Uno N, Hiramatsu K, Uno K, Komoto S, Kazuki Y, Oshimura M.

Sci Rep. 2017 Oct 6;7(1):12739. doi: 10.1038/s41598-017-10418-7.

21.

Transfer of a Mouse Artificial Chromosome into Spermatogonial Stem Cells Generates Transchromosomic Mice.

Shinohara T, Kazuki K, Ogonuki N, Morimoto H, Matoba S, Hiramatsu K, Honma K, Suzuki T, Hara T, Ogura A, Oshimura M, Kanatsu-Shinohara M, Kazuki Y.

Stem Cell Reports. 2017 Oct 10;9(4):1180-1191. doi: 10.1016/j.stemcr.2017.08.012. Epub 2017 Sep 21.

22.

Continuous long-term cytotoxicity monitoring in 3D spheroids of beetle luciferase-expressing hepatocytes by nondestructive bioluminescence measurement.

Yasunaga M, Fujita Y, Saito R, Oshimura M, Nakajima Y.

BMC Biotechnol. 2017 Jun 20;17(1):54. doi: 10.1186/s12896-017-0374-1.

23.

Gender Difference of Hepatic and Intestinal CYP3A4 in CYP3AHumanized Mice Generated by a Human Chromosome-engineering Technique.

Kobayashi K, Abe C, Endo M, Kazuki Y, Oshimura M, Chiba K.

Drug Metab Lett. 2017 Nov 17;11(1):60-67. doi: 10.2174/1872312811666170404153804.

PMID:
28393714
24.

Multiple expression cassette exchange via TP901-1, R4, and Bxb1 integrase systems on a mouse artificial chromosome.

Tomimatsu K, Kokura K, Nishida T, Yoshimura Y, Kazuki Y, Narita M, Oshimura M, Ohbayashi T.

FEBS Open Bio. 2017 Jan 28;7(3):306-317. doi: 10.1002/2211-5463.12169. eCollection 2017 Mar.

25.

Development of Caco-2 cells co-expressing CYP3A4 and NADPH-cytochrome P450 reductase using a human artificial chromosome for the prediction of intestinal extraction ratio of CYP3A4 substrates.

Takenaka T, Kazuki K, Harada N, Kuze J, Chiba M, Iwao T, Matsunaga T, Abe S, Oshimura M, Kazuki Y.

Drug Metab Pharmacokinet. 2017 Feb;32(1):61-68. doi: 10.1016/j.dmpk.2016.08.004. Epub 2016 Aug 26.

PMID:
28139373
26.

Correlation between luminescence intensity and cytotoxicity in cell-based cytotoxicity assay using luciferase.

Wakuri S, Yamakage K, Kazuki Y, Kazuki K, Oshimura M, Aburatani S, Yasunaga M, Nakajima Y.

Anal Biochem. 2017 Apr 1;522:18-29. doi: 10.1016/j.ab.2017.01.015. Epub 2017 Jan 20.

PMID:
28111305
27.

A kidney injury molecule-1 (Kim-1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells.

Kokura K, Kuromi Y, Endo T, Anzai N, Kazuki Y, Oshimura M, Ohbayashi T.

J Gene Med. 2016 Oct;18(10):273-281. doi: 10.1002/jgm.2925.

28.

Maintenance and Function of a Plant Chromosome in Human Cells.

Wada N, Kazuki Y, Kazuki K, Inoue T, Fukui K, Oshimura M.

ACS Synth Biol. 2017 Feb 17;6(2):301-310. doi: 10.1021/acssynbio.6b00180. Epub 2016 Oct 17.

PMID:
27696824
29.

Allogeneic transplantation of iPS cell-derived cardiomyocytes regenerates primate hearts.

Shiba Y, Gomibuchi T, Seto T, Wada Y, Ichimura H, Tanaka Y, Ogasawara T, Okada K, Shiba N, Sakamoto K, Ido D, Shiina T, Ohkura M, Nakai J, Uno N, Kazuki Y, Oshimura M, Minami I, Ikeda U.

Nature. 2016 Oct 20;538(7625):388-391. doi: 10.1038/nature19815. Epub 2016 Oct 10.

PMID:
27723741
30.

Effects of duration of electric pulse on in vitro development of cloned cat embryos with human artificial chromosome vector.

Do L, Wittayarat M, Terazono T, Sato Y, Taniguchi M, Tanihara F, Takemoto T, Kazuki Y, Kazuki K, Oshimura M, Otoi T.

Reprod Domest Anim. 2016 Dec;51(6):1039-1043. doi: 10.1111/rda.12766. Epub 2016 Aug 28.

PMID:
27568550
31.

Evaluation of an Hprt-Luciferase Reporter Gene on a Mammalian Artificial Chromosome in Response to Cytotoxicity.

Endo T, Noda N, Kuromi Y, Kokura K, Kazuki Y, Oshimura M, Ohbayashi T.

Yonago Acta Med. 2016 Jun 29;59(2):174-82. eCollection 2016 Jun.

32.

Induction of genomic instability and activation of autophagy in artificial human aneuploid cells.

Ariyoshi K, Miura T, Kasai K, Fujishima Y, Oshimura M, Yoshida MA.

Mutat Res. 2016 Aug;790:19-30. doi: 10.1016/j.mrfmmm.2016.06.001. Epub 2016 Jun 14.

PMID:
27343755
33.

Highly Efficient Transfer of Chromosomes to a Broad Range of Target Cells Using Chinese Hamster Ovary Cells Expressing Murine Leukemia Virus-Derived Envelope Proteins.

Suzuki T, Kazuki Y, Oshimura M, Hara T.

PLoS One. 2016 Jun 7;11(6):e0157187. doi: 10.1371/journal.pone.0157187. eCollection 2016.

34.

Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model.

Choi IY, Lim H, Estrellas K, Mula J, Cohen TV, Zhang Y, Donnelly CJ, Richard JP, Kim YJ, Kim H, Kazuki Y, Oshimura M, Li HL, Hotta A, Rothstein J, Maragakis N, Wagner KR, Lee G.

Cell Rep. 2016 Jun 7;15(10):2301-2312. doi: 10.1016/j.celrep.2016.05.016. Epub 2016 May 26.

35.

A Cytoplasmic Form of Gaussia luciferase Provides a Highly Sensitive Test for Cytotoxicity.

Tsuji S, Ohbayashi T, Yamakage K, Oshimura M, Tada M.

PLoS One. 2016 May 26;11(5):e0156202. doi: 10.1371/journal.pone.0156202. eCollection 2016.

36.

Cyp3a deficiency enhances androgen receptor activity and cholesterol synthesis in the mouse prostate.

Hashimoto M, Kobayashi K, Yamazaki M, Kazuki Y, Takehara S, Oshimura M, Chiba K.

J Steroid Biochem Mol Biol. 2016 Oct;163:121-8. doi: 10.1016/j.jsbmb.2016.04.018. Epub 2016 Apr 29.

PMID:
27137100
37.

Dynamics of epigenetic regulation at the single-cell level.

Bintu L, Yong J, Antebi YE, McCue K, Kazuki Y, Uno N, Oshimura M, Elowitz MB.

Science. 2016 Feb 12;351(6274):720-4. doi: 10.1126/science.aab2956.

38.

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model.

Kazuki Y, Akita M, Kobayashi K, Osaki M, Satoh D, Ohta R, Abe S, Takehara S, Kazuki K, Yamazaki H, Kamataki T, Oshimura M.

Sci Rep. 2016 Feb 23;6:21419. doi: 10.1038/srep21419.

39.

Regulation of functional KCNQ1OT1 lncRNA by β-catenin.

Sunamura N, Ohira T, Kataoka M, Inaoka D, Tanabe H, Nakayama Y, Oshimura M, Kugoh H.

Sci Rep. 2016 Feb 12;6:20690. doi: 10.1038/srep20690.

40.
41.

Studies of Tumor Suppressor Genes via Chromosome Engineering.

Kugoh H, Ohira T, Oshimura M.

Cancers (Basel). 2015 Dec 30;8(1). pii: E4. doi: 10.3390/cancers8010004. Review.

42.

Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy.

Uno N, Uno K, Komoto S, Suzuki T, Hiratsuka M, Osaki M, Kazuki Y, Oshimura M.

Mol Ther Nucleic Acids. 2015 Dec 15;4:e272. doi: 10.1038/mtna.2015.45.

43.

Variation in the Effect of Particulate Matter on Pulmonary Function in Schoolchildren in Western Japan and Its Relation with Interleukin-8.

Watanabe M, Noma H, Kurai J, Sano H, Kitano H, Saito R, Kimura Y, Aiba S, Oshimura M, Shimizu E.

Int J Environ Res Public Health. 2015 Nov 9;12(11):14229-43. doi: 10.3390/ijerph121114229.

44.

Use of a Human Artificial Chromosome for Delivering Trophic Factors in a Rodent Model of Amyotrophic Lateral Sclerosis.

Watanabe Y, Kazuki Y, Kazuki K, Ebiki M, Nakanishi M, Nakamura K, Yoshida Yamakawa M, Hosokawa H, Ohbayashi T, Oshimura M, Nakashima K.

Mol Ther Nucleic Acids. 2015 Oct 6;4:e253. doi: 10.1038/mtna.2015.28.

45.

Repression of hTERT transcription by the introduction of chromosome 3 into human oral squamous cell carcinoma.

Nishio S, Ohira T, Sunamura N, Oshimura M, Ryoke K, Kugoh H.

Biochem Biophys Res Commun. 2015 Oct 30;466(4):755-9. doi: 10.1016/j.bbrc.2015.09.119. Epub 2015 Sep 26.

PMID:
26410534
46.

Difference in interleukin-8 transcriptional activity induced in THP-G8 cells by particulate matter collected in winter and summer in western Japan.

Watanabe M, Kurai J, Minato S, Noma H, Sano H, Saito R, Aiba S, Oshimura M, Hatakeyama K, Yamasaki A, Shimizu E.

J Med Invest. 2015;62(3-4):145-8. doi: 10.2152/jmi.62.145.

47.

Murine Cyp3a knockout chimeric mice with humanized liver: prediction of the metabolic profile of nefazodone in humans.

Nakada N, Kawamura A, Kamimura H, Sato K, Kazuki Y, Kakuni M, Ohbuchi M, Kato K, Tateno C, Oshimura M, Usui T.

Biopharm Drug Dispos. 2016 Jan;37(1):3-14. doi: 10.1002/bdd.1990.

PMID:
26352195
48.

Construction of a Luciferase Reporter System to Monitor Osteogenic Differentiation of Mesenchymal Stem Cells by Using a Mammalian Artificial Chromosome Vector.

Narai T, Katoh M, Inoue T, Taniguchi M, Kazuki K, Kazuki Y, Sato K, Kodani I, Ryoke K, Oshimura M.

Yonago Acta Med. 2015 Mar;58(1):23-9. Epub 2015 Mar 27.

49.

Retargeting of microcell fusion towards recipient cell-oriented transfer of human artificial chromosome.

Hiratsuka M, Ueda K, Uno N, Uno K, Fukuhara S, Kurosaki H, Takehara S, Osaki M, Kazuki Y, Kurosawa Y, Nakamura T, Katoh M, Oshimura M.

BMC Biotechnol. 2015 Jun 19;15:58. doi: 10.1186/s12896-015-0142-z.

50.

Decreased pulmonary function in school children in Western Japan after exposures to Asian desert dusts and its association with interleukin-8.

Watanabe M, Noma H, Kurai J, Sano H, Saito R, Abe S, Kimura Y, Aiba S, Oshimura M, Yamasaki A, Shimizu E.

Biomed Res Int. 2015;2015:583293. doi: 10.1155/2015/583293. Epub 2015 Apr 28.

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