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Items: 1 to 50 of 104

1.

Oxidized analogs of Di(1H-indol-3-yl)methyl-4-substituted benzenes are NR4A1-dependent UPR inducers with potent and safe anti-cancer activity.

Sanchez M, Xia Z, Rico-Bautista E, Cao X, Cuddy M, Castro DJ, Correa RG, Chen L, Yu J, Bobkov A, Ruvolo V, Andreeff M, Oshima RG, Matsuzawa SI, Reed JC, Zhang XK, Hansel D, Wolf DA, Dawson MI.

Oncotarget. 2018 May 18;9(38):25057-25074. doi: 10.18632/oncotarget.25285. eCollection 2018 May 18.

2.

ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer.

Strietz J, Stepputtis SS, Preca BT, Vannier C, Kim MM, Castro DJ, Au Q, Boerries M, Busch H, Aza-Blanc P, Heynen-Genel S, Bronsert P, Kuster B, Stickeler E, Brabletz T, Oshima RG, Maurer J.

Oncotarget. 2016 Dec 13;7(50):83278-83293. doi: 10.18632/oncotarget.13086.

3.

Design and Characterization of Novel EphA2 Agonists for Targeted Delivery of Chemotherapy to Cancer Cells.

Wu B, Wang S, De SK, Barile E, Quinn BA, Zharkikh I, Purves A, Stebbins JL, Oshima RG, Fisher PB, Pellecchia M.

Chem Biol. 2015 Jul 23;22(7):876-887. doi: 10.1016/j.chembiol.2015.06.011. Epub 2015 Jul 9.

4.

ROCK1 inhibition promotes the self-renewal of a novel mouse mammary cancer stem cell.

Castro DJ, Maurer J, Hebbard L, Oshima RG.

Stem Cells. 2013 Jan;31(1):12-22. doi: 10.1002/stem.1224.

5.

Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors.

Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13016-21. doi: 10.1073/pnas.1120299109. Epub 2012 Jul 23.

6.
7.

Heteroatom-substituted analogues of orphan nuclear receptor small heterodimer partner ligand and apoptosis inducer (E)-4-[3-(1-Adamantyl)-4-hydroxyphenyl]-3-chlorocinnamic acid.

Xia Z, Farhana L, Correa RG, Das JK, Castro DJ, Yu J, Oshima RG, Reed JC, Fontana JA, Dawson MI.

J Med Chem. 2011 Jun 9;54(11):3793-816. doi: 10.1021/jm200051z. Epub 2011 May 6.

PMID:
21548569
8.

Ets2 regulates colonic stem cells and sensitivity to tumorigenesis.

Múnera J, Ceceña G, Jedlicka P, Wankell M, Oshima RG.

Stem Cells. 2011 Mar;29(3):430-9. doi: 10.1002/stem.599.

9.

Maternal embryonic leucine zipper kinase is upregulated and required in mammary tumor-initiating cells in vivo.

Hebbard LW, Maurer J, Miller A, Lesperance J, Hassell J, Oshima RG, Terskikh AV.

Cancer Res. 2010 Nov 1;70(21):8863-73. doi: 10.1158/0008-5472.CAN-10-1295. Epub 2010 Sep 22.

10.

Control of mammary tumor differentiation by SKI-606 (bosutinib).

Hebbard L, Cecena G, Golas J, Sawada J, Ellies LG, Charbono A, Williams R, Jimenez RE, Wankell M, Arndt KT, DeJoy SQ, Rollins RA, Diesl V, Follettie M, Chen L, Rosfjord E, Cardiff RD, Komatsu M, Boschelli F, Oshima RG.

Oncogene. 2011 Jan 20;30(3):301-12. doi: 10.1038/onc.2010.412. Epub 2010 Sep 6.

11.

Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy.

Cheng L, Guo J, Sun L, Fu J, Barnes PF, Metzger D, Chambon P, Oshima RG, Amagai T, Su DM.

J Biol Chem. 2010 Feb 19;285(8):5836-47. doi: 10.1074/jbc.M109.072124. Epub 2009 Dec 2.

12.

Placenta-specific gene activation and inactivation using integrase-defective lentiviral vectors with the Cre/LoxP system.

Morioka Y, Isotani A, Oshima RG, Okabe M, Ikawa M.

Genesis. 2009 Dec;47(12):793-8. doi: 10.1002/dvg.20563.

PMID:
19830817
13.

Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis.

Wei G, Srinivasan R, Cantemir-Stone CZ, Sharma SM, Santhanam R, Weinstein M, Muthusamy N, Man AK, Oshima RG, Leone G, Ostrowski MC.

Blood. 2009 Jul 30;114(5):1123-30. doi: 10.1182/blood-2009-03-211391. Epub 2009 May 1.

14.

Contrasting expression of keratins in mouse and human embryonic stem cells.

Maurer J, Nelson B, Ceceña G, Bajpai R, Mercola M, Terskikh A, Oshima RG.

PLoS One. 2008;3(10):e3451. doi: 10.1371/journal.pone.0003451. Epub 2008 Oct 20.

15.

Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines.

Jaksch M, Múnera J, Bajpai R, Terskikh A, Oshima RG.

Cancer Res. 2008 Oct 1;68(19):7882-6. doi: 10.1158/0008-5472.CAN-08-0723.

16.

Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury.

Toivola DM, Nakamichi I, Strnad P, Michie SA, Ghori N, Harada M, Zeh K, Oshima RG, Baribault H, Omary MB.

Am J Pathol. 2008 Apr;172(4):882-92. doi: 10.2353/ajpath.2008.070830. Epub 2008 Mar 18.

17.

T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model.

Hebbard LW, Garlatti M, Young LJ, Cardiff RD, Oshima RG, Ranscht B.

Cancer Res. 2008 Mar 1;68(5):1407-16. doi: 10.1158/0008-5472.CAN-07-2953. Erratum in: Cancer Res. 2008 Apr 15;68(8):3076.

18.

Ets2 is required for trophoblast stem cell self-renewal.

Wen F, Tynan JA, Cecena G, Williams R, Múnera J, Mavrothalassitis G, Oshima RG.

Dev Biol. 2007 Dec 1;312(1):284-99. Epub 2007 Sep 22.

19.

Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo.

Allen SD, Garrett JT, Rawale SV, Jones AL, Phillips G, Forni G, Morris JC, Oshima RG, Kaumaya PT.

J Immunol. 2007 Jul 1;179(1):472-82.

20.

Transcriptional repressor erf determines extraembryonic ectoderm differentiation.

Papadaki C, Alexiou M, Cecena G, Verykokakis M, Bilitou A, Cross JC, Oshima RG, Mavrothalassitis G.

Mol Cell Biol. 2007 Jul;27(14):5201-13. Epub 2007 May 14.

21.

Intermediate filaments: a historical perspective.

Oshima RG.

Exp Cell Res. 2007 Jun 10;313(10):1981-94. Epub 2007 Apr 11. Review.

22.

Role of Gab2 in mammary tumorigenesis and metastasis.

Ke Y, Wu D, Princen F, Nguyen T, Pang Y, Lesperance J, Muller WJ, Oshima RG, Feng GS.

Oncogene. 2007 Jul 26;26(34):4951-60. Epub 2007 Feb 19.

PMID:
17310989
23.
24.

Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer.

Okada Y, Ueshin Y, Isotani A, Saito-Fujita T, Nakashima H, Kimura K, Mizoguchi A, Oh-Hora M, Mori Y, Ogata M, Oshima RG, Okabe M, Ikawa M.

Nat Biotechnol. 2007 Feb;25(2):233-7. Epub 2007 Jan 14.

PMID:
17220877
25.

Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation.

Ke Y, Lesperance J, Zhang EE, Bard-Chapeau EA, Oshima RG, Muller WJ, Feng GS.

J Biol Chem. 2006 Nov 10;281(45):34374-80. Epub 2006 Sep 7.

26.

Differential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogene.

Cecena G, Wen F, Cardiff RD, Oshima RG.

Am J Pathol. 2006 Jan;168(1):310-20.

27.

Keratin 8 overexpression promotes mouse Mallory body formation.

Nakamichi I, Toivola DM, Strnad P, Michie SA, Oshima RG, Baribault H, Omary MB.

J Cell Biol. 2005 Dec 19;171(6):931-7.

28.

Ets2-dependent microenvironmental support of mouse mammary tumors.

Tynan JA, Wen F, Muller WJ, Oshima RG.

Oncogene. 2005 Oct 20;24(46):6870-6.

PMID:
16007139
29.

Antitumor activity of rapamycin in a transgenic mouse model of ErbB2-dependent human breast cancer.

Liu M, Howes A, Lesperance J, Stallcup WB, Hauser CA, Kadoya K, Oshima RG, Abraham RT.

Cancer Res. 2005 Jun 15;65(12):5325-36.

30.

Activated Ets2 is required for persistent inflammatory responses in the motheaten viable model.

Wei G, Guo J, Doseff AI, Kusewitt DF, Man AK, Oshima RG, Ostrowski MC.

J Immunol. 2004 Jul 15;173(2):1374-9.

31.

Angiogenic acceleration of Neu induced mammary tumor progression and metastasis.

Oshima RG, Lesperance J, Munoz V, Hebbard L, Ranscht B, Sharan N, Muller WJ, Hauser CA, Cardiff RD.

Cancer Res. 2004 Jan 1;64(1):169-79.

32.

Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors.

Galang CK, Muller WJ, Foos G, Oshima RG, Hauser CA.

J Biol Chem. 2004 Mar 19;279(12):11281-92. Epub 2003 Dec 8.

33.

Ets2-dependent stromal regulation of mouse mammary tumors.

Man AK, Young LJ, Tynan JA, Lesperance J, Egeblad M, Werb Z, Hauser CA, Muller WJ, Cardiff RD, Oshima RG.

Mol Cell Biol. 2003 Dec;23(23):8614-25.

34.

Ets2 is not required for Ras or Neu/ErbB-2 mediated cellular transformation in vitro.

Hevér A, Oshima RG, Hauser CA.

Exp Cell Res. 2003 Oct 15;290(1):132-43.

PMID:
14516794
35.

Keratin 8 protection of placental barrier function.

Jaquemar D, Kupriyanov S, Wankell M, Avis J, Benirschke K, Baribault H, Oshima RG.

J Cell Biol. 2003 May 26;161(4):749-56.

36.

Expression of conditional cre recombinase in epithelial tissues of transgenic mice.

Wen F, Cecena G, Munoz-Ritchie V, Fuchs E, Chambon P, Oshima RG.

Genesis. 2003 Feb;35(2):100-6.

37.

DEDD regulates degradation of intermediate filaments during apoptosis.

Lee JC, Schickling O, Stegh AH, Oshima RG, Dinsdale D, Cohen GM, Peter ME.

J Cell Biol. 2002 Sep 16;158(6):1051-66. Epub 2002 Sep 16.

38.

Apoptosis and keratin intermediate filaments.

Oshima RG.

Cell Death Differ. 2002 May;9(5):486-92. Review.

39.

Contributions of mouse biology to breast cancer research.

Cardiff RD, Bern HA, Faulkin LJ, Daniel CW, Smith GH, Young LJ, Medina D, Gardner MB, Wellings SR, Shyamala G, Guzman RC, Rajkumar L, Yang J, Thordarson G, Nandi S, MacLeod CL, Oshima RG, Man AK, Sawai ET, Gregg JP, Cheung AT, Lau DH.

Comp Med. 2002 Feb;52(1):12-31. Review. No abstract available.

PMID:
11900409
40.

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer.

Dankort D, Maslikowski B, Warner N, Kanno N, Kim H, Wang Z, Moran MF, Oshima RG, Cardiff RD, Muller WJ.

Mol Cell Biol. 2001 Mar;21(5):1540-51.

41.

Cytokeratins 8 and 19 in the mouse placental development.

Tamai Y, Ishikawa T, Bösl MR, Mori M, Nozaki M, Baribault H, Oshima RG, Taketo MM.

J Cell Biol. 2000 Oct 30;151(3):563-72.

42.

Keratin-dependent, epithelial resistance to tumor necrosis factor-induced apoptosis.

Caulin C, Ware CF, Magin TM, Oshima RG.

J Cell Biol. 2000 Apr 3;149(1):17-22.

43.

An Alu element from the K18 gene confers position-independent expression in transgenic mice.

Willoughby DA, Vilalta A, Oshima RG.

J Biol Chem. 2000 Jan 14;275(2):759-68.

44.

A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice.

Neznanov N, Man AK, Yamamoto H, Hauser CA, Cardiff RD, Oshima RG.

Cancer Res. 1999 Sep 1;59(17):4242-6.

45.
46.

Defective trophoblast function in mice with a targeted mutation of Ets2.

Yamamoto H, Flannery ML, Kupriyanov S, Pearce J, McKercher SR, Henkel GW, Maki RA, Werb Z, Oshima RG.

Genes Dev. 1998 May 1;12(9):1315-26.

47.
48.

A regulatory element within a coding exon modulates keratin 18 gene expression in transgenic mice.

Neznanov N, Umezawa A, Oshima RG.

J Biol Chem. 1997 Oct 31;272(44):27549-57.

49.
50.

Methylation of an ETS site in the intron enhancer of the keratin 18 gene participates in tissue-specific repression.

Umezawa A, Yamamoto H, Rhodes K, Klemsz MJ, Maki RA, Oshima RG.

Mol Cell Biol. 1997 Sep;17(9):4885-94.

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