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The Lysine Deacetylase RpdA Is Essential for Virulence in Aspergillus fumigatus.

Bauer I, Misslinger M, Shadkchan Y, Dietl AM, Petzer V, Orasch T, Abt B, Graessle S, Osherov N, Haas H.

Front Microbiol. 2019 Dec 4;10:2773. doi: 10.3389/fmicb.2019.02773. eCollection 2019.


The leucine biosynthetic pathway is crucial for adaptation to iron starvation and virulence in Aspergillus fumigatus.

Orasch T, Dietl AM, Shadkchan Y, Binder U, Bauer I, Lass-Flörl C, Osherov N, Haas H.

Virulence. 2019 Dec;10(1):925-934. doi: 10.1080/21505594.2019.1682760.


Copper Utilization, Regulation, and Acquisition by Aspergillus fumigatus.

Raffa N, Osherov N, Keller NP.

Int J Mol Sci. 2019 Apr 23;20(8). pii: E1980. doi: 10.3390/ijms20081980. Review.


Siroheme Is Essential for Assimilation of Nitrate and Sulfate as Well as Detoxification of Nitric Oxide but Dispensable for Murine Virulence of Aspergillus fumigatus.

Dietl AM, Binder U, Shadkchan Y, Osherov N, Haas H.

Front Microbiol. 2018 Nov 12;9:2615. doi: 10.3389/fmicb.2018.02615. eCollection 2018.


Riboflavin and pantothenic acid biosynthesis are crucial for iron homeostasis and virulence in the pathogenic mold Aspergillus fumigatus.

Dietl AM, Meir Z, Shadkchan Y, Osherov N, Haas H.

Virulence. 2018;9(1):1036-1049. doi: 10.1080/21505594.2018.1482181.


Contribution of ATPase copper transporters in animal but not plant virulence of the crossover pathogen Aspergillus flavus.

Yang K, Shadkchan Y, Tannous J, Landero Figueroa JA, Wiemann P, Osherov N, Wang S, Keller NP.

Virulence. 2018;9(1):1273-1286. doi: 10.1080/21505594.2018.1496774.


Vitamin Biosynthesis as an Antifungal Target.

Meir Z, Osherov N.

J Fungi (Basel). 2018 Jun 17;4(2). pii: E72. doi: 10.3390/jof4020072. Review.


Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease.

Bertuzzi M, Hayes GE, Icheoku UJ, van Rhijn N, Denning DW, Osherov N, Bignell EM.

J Fungi (Basel). 2018 Jan 8;4(1). pii: E8. doi: 10.3390/jof4010008. Review.


Phenotypic and Proteomic Analysis of the Aspergillus fumigatus ΔPrtT, ΔXprG and ΔXprGPrtT Protease-Deficient Mutants.

Shemesh E, Hanf B, Hagag S, Attias S, Shadkchan Y, Fichtman B, Harel A, Krüger T, Brakhage AA, Kniemeyer O, Osherov N.

Front Microbiol. 2017 Dec 12;8:2490. doi: 10.3389/fmicb.2017.02490. eCollection 2017.


Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 Jun 6;19(10):2174-2176. doi: 10.1016/j.celrep.2017.05.075. No abstract available.


The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatus.

Ben Yaakov D, Shadkchan Y, Albert N, Kontoyiannis DP, Osherov N.

J Antimicrob Chemother. 2017 Aug 1;72(8):2263-2272. doi: 10.1093/jac/dkx117.


Aspergillus fumigatus Copper Export Machinery and Reactive Oxygen Intermediate Defense Counter Host Copper-Mediated Oxidative Antimicrobial Offense.

Wiemann P, Perevitsky A, Lim FY, Shadkchan Y, Knox BP, Landero Figueora JA, Choera T, Niu M, Steinberger AJ, Wüthrich M, Idol RA, Klein BS, Dinauer MC, Huttenlocher A, Osherov N, Keller NP.

Cell Rep. 2017 May 2;19(5):1008-1021. doi: 10.1016/j.celrep.2017.04.019. Erratum in: Cell Rep. 2017 Jun 6;19(10 ):2174-2176.


NK Cell Recognition of Candida glabrata through Binding of NKp46 and NCR1 to Fungal Ligands Epa1, Epa6, and Epa7.

Vitenshtein A, Charpak-Amikam Y, Yamin R, Bauman Y, Isaacson B, Stein N, Berhani O, Dassa L, Gamliel M, Gur C, Glasner A, Gomez C, Ben-Ami R, Osherov N, Cormack BP, Mandelboim O.

Cell Host Microbe. 2016 Oct 12;20(4):527-534. doi: 10.1016/j.chom.2016.09.008.


The anti-Aspergillus drug pipeline: Is the glass half full or empty?

Osherov N, Kontoyiannis DP.

Med Mycol. 2017 Jan 1;55(1):118-124. Epub 2016 Aug 25. Review.


Correction: Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic Target.

Osherov N, Ben-Ami R.

PLoS Pathog. 2016 Aug 17;12(8):e1005838. doi: 10.1371/journal.ppat.1005838. eCollection 2016 Aug.


Systematic Identification of Anti-Fungal Drug Targets by a Metabolic Network Approach.

Kaltdorf M, Srivastava M, Gupta SK, Liang C, Binder J, Dietl AM, Meir Z, Haas H, Osherov N, Krappmann S, Dandekar T.

Front Mol Biosci. 2016 Jun 17;3:22. doi: 10.3389/fmolb.2016.00022. eCollection 2016.


Modulation of Host Angiogenesis as a Microbial Survival Strategy and Therapeutic Target.

Osherov N, Ben-Ami R.

PLoS Pathog. 2016 Apr 14;12(4):e1005479. doi: 10.1371/journal.ppat.1005479. eCollection 2016 Apr. Review. No abstract available. Erratum in: PLoS Pathog. 2016 Aug;12(8):e1005838.


Identification and Characterization of a Novel Aspergillus fumigatus Rhomboid Family Putative Protease, RbdA, Involved in Hypoxia Sensing and Virulence.

Vaknin Y, Hillmann F, Iannitti R, Ben Baruch N, Sandovsky-Losica H, Shadkchan Y, Romani L, Brakhage A, Kniemeyer O, Osherov N.

Infect Immun. 2016 May 24;84(6):1866-1878. doi: 10.1128/IAI.00011-16. Print 2016 Jun.


Mechanisms of Bacterial (Serratia marcescens) Attachment to, Migration along, and Killing of Fungal Hyphae.

Hover T, Maya T, Ron S, Sandovsky H, Shadkchan Y, Kijner N, Mitiagin Y, Fichtman B, Harel A, Shanks RM, Bruna RE, García-Véscovi E, Osherov N.

Appl Environ Microbiol. 2016 Apr 18;82(9):2585-94. doi: 10.1128/AEM.04070-15. Print 2016 May.


Novel Water-Soluble Amphotericin B-PEG Conjugates with Low Toxicity and Potent in Vivo Efficacy.

Halperin A, Shadkchan Y, Pisarevsky E, Szpilman AM, Sandovsky H, Osherov N, Benhar I.

J Med Chem. 2016 Feb 11;59(3):1197-206. doi: 10.1021/acs.jmedchem.5b01862. Epub 2016 Jan 27.


Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis.

Ben Yaakov D, Rivkin A, Mircus G, Albert N, Dietl AM, Kovalerchick D, Carmeli S, Haas H, Kontoyiannis DP, Osherov N.

J Antimicrob Chemother. 2016 Apr;71(4):946-52. doi: 10.1093/jac/dkv446. Epub 2016 Jan 7.


Identification and characterization of a novel family of selective antifungal compounds (CANBEFs) that interfere with fungal protein synthesis.

Mircus G, Albert N, Ben-Yaakov D, Chikvashvili D, Shadkchan Y, Kontoyiannis DP, Osherov N.

Antimicrob Agents Chemother. 2015 Sep;59(9):5631-40. doi: 10.1128/AAC.00850-15. Epub 2015 Jul 6.


Identification of hypoxia-inducible target genes of Aspergillus fumigatus by transcriptome analysis reveals cellular respiration as an important contributor to hypoxic survival.

Kroll K, Pähtz V, Hillmann F, Vaknin Y, Schmidt-Heck W, Roth M, Jacobsen ID, Osherov N, Brakhage AA, Kniemeyer O.

Eukaryot Cell. 2014 Sep;13(9):1241-53. doi: 10.1128/EC.00084-14. Epub 2014 Aug 1.


The three Aspergillus fumigatus CFEM-domain GPI-anchored proteins (CfmA-C) affect cell-wall stability but do not play a role in fungal virulence.

Vaknin Y, Shadkchan Y, Levdansky E, Morozov M, Romano J, Osherov N.

Fungal Genet Biol. 2014 Feb;63:55-64. doi: 10.1016/j.fgb.2013.12.005. Epub 2013 Dec 20.


The top three areas of basic research on Aspergillus fumigatus in 2011.

Osherov N.

Ann N Y Acad Sci. 2012 Dec;1273:74-7. doi: 10.1111/j.1749-6632.2012.06798.x.


Interaction of the pathogenic mold Aspergillus fumigatus with lung epithelial cells.

Osherov N.

Front Microbiol. 2012 Sep 26;3:346. doi: 10.3389/fmicb.2012.00346. eCollection 2012.


Host-Fungal Interactions: Pathogenicity versus Immunity.

Tavanti A, Naglik JR, Osherov N.

Int J Microbiol. 2012;2012:562480. doi: 10.1155/2012/562480. Epub 2012 May 27. No abstract available.


Transcriptional and proteomic analysis of the Aspergillus fumigatus ΔprtT protease-deficient mutant.

Hagag S, Kubitschek-Barreira P, Neves GW, Amar D, Nierman W, Shalit I, Shamir R, Lopes-Bezerra L, Osherov N.

PLoS One. 2012;7(4):e33604. doi: 10.1371/journal.pone.0033604. Epub 2012 Apr 13.


Trivalent ultrashort lipopeptides are potent pH dependent antifungal agents.

Arnusch CJ, Albada HB, van Vaardegem M, Liskamp RM, Sahl HG, Shadkchan Y, Osherov N, Shai Y.

J Med Chem. 2012 Feb 9;55(3):1296-302. doi: 10.1021/jm2014474. Epub 2012 Feb 1.


Ultrashort peptide bioconjugates are exclusively antifungal agents and synergize with cyclodextrin and amphotericin B.

Arnusch CJ, Ulm H, Josten M, Shadkchan Y, Osherov N, Sahl HG, Shai Y.

Antimicrob Agents Chemother. 2012 Jan;56(1):1-9. doi: 10.1128/AAC.00468-11. Epub 2011 Oct 17.


PrtT-regulated proteins secreted by Aspergillus fumigatus activate MAPK signaling in exposed A549 lung cells leading to necrotic cell death.

Sharon H, Amar D, Levdansky E, Mircus G, Shadkchan Y, Shamir R, Osherov N.

PLoS One. 2011 Mar 11;6(3):e17509. doi: 10.1371/journal.pone.0017509.


The Aspergillus fumigatus cspA gene encoding a repeat-rich cell wall protein is important for normal conidial cell wall architecture and interaction with host cells.

Levdansky E, Kashi O, Sharon H, Shadkchan Y, Osherov N.

Eukaryot Cell. 2010 Sep;9(9):1403-15. doi: 10.1128/EC.00126-10. Epub 2010 Jul 23.


Therapy of murine pulmonary aspergillosis with antibody-alliinase conjugates and alliin.

Appel E, Vallon-Eberhard A, Rabinkov A, Brenner O, Shin I, Sasson K, Shadkchan Y, Osherov N, Jung S, Mirelman D.

Antimicrob Agents Chemother. 2010 Feb;54(2):898-906. doi: 10.1128/AAC.01267-09. Epub 2009 Nov 30.


Identification of novel cell wall destabilizing antifungal compounds using a conditional Aspergillus nidulans protein kinase C mutant.

Mircus G, Hagag S, Levdansky E, Sharon H, Shadkchan Y, Shalit I, Osherov N.

J Antimicrob Chemother. 2009 Oct;64(4):755-63. doi: 10.1093/jac/dkp270. Epub 2009 Jul 31.


Transcription factor PrtT controls expression of multiple secreted proteases in the human pathogenic mold Aspergillus fumigatus.

Sharon H, Hagag S, Osherov N.

Infect Immun. 2009 Sep;77(9):4051-60. doi: 10.1128/IAI.00426-09. Epub 2009 Jun 29.


In vitro synergy of caspofungin with licensed and novel antifungal drugs against clinical isolates of Fusarium spp.

Shalit I, Shadkchan Y, Mircus G, Osherov N.

Med Mycol. 2009;47(5):457-62. doi: 10.1080/13693780802232910.


Aspergillus strain typing in the genomics era.

Klaassen CH, Osherov N.

Stud Mycol. 2007;59:47-51. doi: 10.3114/sim.2007.59.06.


The Aspergillus nidulans cetA and calA genes are involved in conidial germination and cell wall morphogenesis.

Belaish R, Sharon H, Levdansky E, Greenstein S, Shadkchan Y, Osherov N.

Fungal Genet Biol. 2008 Mar;45(3):232-42. Epub 2007 Jul 20.


Alcohol-conferred hemolysis in yeast is a consequence of increased respiratory burden.

Shuster A, Osherov N, Leikin-Frenkel A, Rosenberg M.

FEMS Yeast Res. 2007 Sep;7(6):879-86. Epub 2007 Jun 7.


Coding tandem repeats generate diversity in Aspergillus fumigatus genes.

Levdansky E, Romano J, Shadkchan Y, Sharon H, Verstrepen KJ, Fink GR, Osherov N.

Eukaryot Cell. 2007 Aug;6(8):1380-91. Epub 2007 Jun 8.


The Aspergillus nidulans pkcA gene is involved in polarized growth, morphogenesis and maintenance of cell wall integrity.

Ronen R, Sharon H, Levdansky E, Romano J, Shadkchan Y, Osherov N.

Curr Genet. 2007 May;51(5):321-9. Epub 2007 Apr 4.


Use of the Porcine Intestinal Epithelium (PIE)-Assay to analyze early stages of colonization by the human fungal pathogen Candida albicans.

Wendland J, Hellwig D, Walther A, Sickinger S, Shadkchan Y, Martin R, Bauer J, Osherov N, Tretiakov A, Saluz HP.

J Basic Microbiol. 2006;46(6):513-23.


Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence.

Romano J, Nimrod G, Ben-Tal N, Shadkchan Y, Baruch K, Sharon H, Osherov N.

Microbiology. 2006 Jul;152(Pt 7):1919-28.


Analysis of the Aspergillus nidulans thaumatin-like cetA gene and evidence for transcriptional repression of pyr4 expression in the cetA-disrupted strain.

Greenstein S, Shadkchan Y, Jadoun J, Sharon C, Markovich S, Osherov N.

Fungal Genet Biol. 2006 Jan;43(1):42-53. Epub 2005 Dec 22.


Anti-inflammatory effects of moxifloxacin on IL-8, IL-1beta and TNF-alpha secretion and NFkappaB and MAP-kinase activation in human monocytes stimulated with Aspergillus fumigatus.

Shalit I, Halperin D, Haite D, Levitov A, Romano J, Osherov N, Fabian I.

J Antimicrob Chemother. 2006 Feb;57(2):230-5. Epub 2005 Dec 13.


Alcohol-mediated haemolysis in yeast.

Shuster A, Osherov N, Rosenberg M.

Yeast. 2004 Dec;21(16):1335-42.


Genomic approach to identification of mutations affecting caspofungin susceptibility in Saccharomyces cerevisiae.

Markovich S, Yekutiel A, Shalit I, Shadkchan Y, Osherov N.

Antimicrob Agents Chemother. 2004 Oct;48(10):3871-6.


In vitro activity of caspofungin combined with sulfamethoxazole against clinical isolates of Aspergillus spp.

Yekutiel A, Shalit I, Shadkchan Y, Osherov N.

Antimicrob Agents Chemother. 2004 Sep;48(9):3279-83.


Involvement of secreted Aspergillus fumigatus proteases in disruption of the actin fiber cytoskeleton and loss of focal adhesion sites in infected A549 lung pneumocytes.

Kogan TV, Jadoun J, Mittelman L, Hirschberg K, Osherov N.

J Infect Dis. 2004 Jun 1;189(11):1965-73. Epub 2004 May 11.


Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis.

Shadkchan Y, Shemesh E, Mirelman D, Miron T, Rabinkov A, Wilchek M, Osherov N.

J Antimicrob Chemother. 2004 May;53(5):832-6. Epub 2004 Mar 24.


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