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Items: 36

1.

AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.

Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, Wang X, Taygerly JP, Vimolratana M, Zancanella M, Zhu L, Cajulis E, Osgood T, Sun J, Damon L, Egan RK, Greninger P, McClanaghan JD, Gong J, Moujalled D, Pomilio G, Beltran P, Benes CH, Roberts AW, Huang DC, Wei A, Canon J, Coxon A, Hughes PE.

Cancer Discov. 2018 Dec;8(12):1582-1597. doi: 10.1158/2159-8290.CD-18-0387. Epub 2018 Sep 25. Erratum in: Cancer Discov. 2019 Jul;9(7):980.

PMID:
30254093
2.

Provision of nutrition support therapies in the recent Iraq and Afghanistan conflicts.

Stankorb SM, Ramsey C, Clark H, Osgood T.

Nutr Clin Pract. 2014 Oct;29(5):605-11. Review.

PMID:
25606636
3.

The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents.

Canon J, Osgood T, Olson SH, Saiki AY, Robertson R, Yu D, Eksterowicz J, Ye Q, Jin L, Chen A, Zhou J, Cordover D, Kaufman S, Kendall R, Oliner JD, Coxon A, Radinsky R.

Mol Cancer Ther. 2015 Mar;14(3):649-58. doi: 10.1158/1535-7163.MCT-14-0710. Epub 2015 Jan 7.

4.

Discovery of AM-7209, a potent and selective 4-amidobenzoic acid inhibitor of the MDM2-p53 interaction.

Rew Y, Sun D, Yan X, Beck HP, Canon J, Chen A, Duquette J, Eksterowicz J, Fox BM, Fu J, Gonzalez AZ, Houze J, Huang X, Jiang M, Jin L, Li Y, Li Z, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, Oliner JD, Osgood T, Saiki AY, Shaffer P, Wang YC, Wortman S, Yakowec P, Ye Q, Yu D, Zhao X, Zhou J, Medina JC, Olson SH.

J Med Chem. 2014 Dec 26;57(24):10499-511. doi: 10.1021/jm501550p. Epub 2014 Dec 4.

PMID:
25384157
5.

Discovery of Potent and Simplified Piperidinone-Based Inhibitors of the MDM2-p53 Interaction.

Yu M, Wang Y, Zhu J, Bartberger MD, Canon J, Chen A, Chow D, Eksterowicz J, Fox B, Fu J, Gribble M, Huang X, Li Z, Liu JJ, Lo MC, McMinn D, Oliner JD, Osgood T, Rew Y, Saiki AY, Shaffer P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Olson SH, Medina JC, Sun D.

ACS Med Chem Lett. 2014 Jun 30;5(8):894-9. doi: 10.1021/ml500142b. eCollection 2014 Aug 14.

6.

MDM2 antagonists synergize broadly and robustly with compounds targeting fundamental oncogenic signaling pathways.

Saiki AY, Caenepeel S, Yu D, Lofgren JA, Osgood T, Robertson R, Canon J, Su C, Jones A, Zhao X, Deshpande C, Payton M, Ledell J, Hughes PE, Oliner JD.

Oncotarget. 2014 Apr 30;5(8):2030-43.

7.

Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres.

Gonzalez AZ, Li Z, Beck HP, Canon J, Chen A, Chow D, Duquette J, Eksterowicz J, Fox BM, Fu J, Huang X, Houze J, Jin L, Li Y, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, Oliner JD, Osgood T, Rew Y, Saiki AY, Shaffer P, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Olson SH, Sun D, Medina JC.

J Med Chem. 2014 Apr 10;57(7):2963-88. doi: 10.1021/jm401911v. Epub 2014 Mar 27.

PMID:
24601644
8.

Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction.

Gonzalez AZ, Eksterowicz J, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Duquette J, Fox BM, Fu J, Huang X, Houze JB, Jin L, Li Y, Li Z, Ling Y, Lo MC, Long AM, McGee LR, McIntosh J, McMinn DL, Oliner JD, Osgood T, Rew Y, Saiki AY, Shaffer P, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Olson SH, Medina JC, Sun D.

J Med Chem. 2014 Mar 27;57(6):2472-88. doi: 10.1021/jm401767k. Epub 2014 Mar 4.

PMID:
24548297
9.

Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development.

Sun D, Li Z, Rew Y, Gribble M, Bartberger MD, Beck HP, Canon J, Chen A, Chen X, Chow D, Deignan J, Duquette J, Eksterowicz J, Fisher B, Fox BM, Fu J, Gonzalez AZ, Gonzalez-Lopez De Turiso F, Houze JB, Huang X, Jiang M, Jin L, Kayser F, Liu JJ, Lo MC, Long AM, Lucas B, McGee LR, McIntosh J, Mihalic J, Oliner JD, Osgood T, Peterson ML, Roveto P, Saiki AY, Shaffer P, Toteva M, Wang Y, Wang YC, Wortman S, Yakowec P, Yan X, Ye Q, Yu D, Yu M, Zhao X, Zhou J, Zhu J, Olson SH, Medina JC.

J Med Chem. 2014 Feb 27;57(4):1454-72. doi: 10.1021/jm401753e. Epub 2014 Feb 5.

PMID:
24456472
10.

Rational design and binding mode duality of MDM2-p53 inhibitors.

Gonzalez-Lopez de Turiso F, Sun D, Rew Y, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Correll TL, Huang X, Julian LD, Kayser F, Lo MC, Long AM, McMinn D, Oliner JD, Osgood T, Powers JP, Saiki AY, Schneider S, Shaffer P, Xiao SH, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Medina JC, Olson SH.

J Med Chem. 2013 May 23;56(10):4053-70. doi: 10.1021/jm400293z. Epub 2013 May 6.

PMID:
23597064
11.

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

Rew Y, Sun D, Gonzalez-Lopez De Turiso F, Bartberger MD, Beck HP, Canon J, Chen A, Chow D, Deignan J, Fox BM, Gustin D, Huang X, Jiang M, Jiao X, Jin L, Kayser F, Kopecky DJ, Li Y, Lo MC, Long AM, Michelsen K, Oliner JD, Osgood T, Ragains M, Saiki AY, Schneider S, Toteva M, Yakowec P, Yan X, Ye Q, Yu D, Zhao X, Zhou J, Medina JC, Olson SH.

J Med Chem. 2012 Jun 14;55(11):4936-54. doi: 10.1021/jm300354j. Epub 2012 May 9.

PMID:
22524527
12.

Anti-tumor activity of motesanib in a medullary thyroid cancer model.

Coxon A, Bready J, Kaufman S, Estrada J, Osgood T, Canon J, Wang L, Radinsky R, Kendall R, Hughes P, Polverino A.

J Endocrinol Invest. 2012 Feb;35(2):181-90. doi: 10.3275/7609. Epub 2011 Mar 21.

PMID:
21422803
13.

Inhibition of RANKL increases the anti-tumor effect of the EGFR inhibitor panitumumab in a murine model of bone metastasis.

Canon J, Bryant R, Roudier M, Osgood T, Jones J, Miller R, Coxon A, Radinsky R, Dougall WC.

Bone. 2010 Jun;46(6):1613-9. doi: 10.1016/j.bone.2010.03.001. Epub 2010 Mar 6.

PMID:
20215062
14.

U74389F, a 21-aminosteroid antioxidant, improves neoendothelial morphology, but not neointimal thickening after balloon catheter injury.

Murthy SN, Akers DL Jr, Chen IL, Osgood TA Jr, Santiago R, Fonseca VA, Kadowitz PJ, McNamara DB.

Can J Physiol Pharmacol. 2009 Dec;87(12):1102-9. doi: 10.1139/Y09-109.

PMID:
20029547
15.

Therapeutic potential of hepatocyte growth factor/scatter factor neutralizing antibodies: inhibition of tumor growth in both autocrine and paracrine hepatocyte growth factor/scatter factor:c-Met-driven models of leiomyosarcoma.

Gao CF, Xie Q, Zhang YW, Su Y, Zhao P, Cao B, Furge K, Sun J, Rex K, Osgood T, Coxon A, Burgess TL, Vande Woude GF.

Mol Cancer Ther. 2009 Oct;8(10):2803-10. doi: 10.1158/1535-7163.MCT-09-0125.

16.

Identification of a novel recepteur d'origine nantais/c-met small-molecule kinase inhibitor with antitumor activity in vivo.

Zhang Y, Kaplan-Lefko PJ, Rex K, Yang Y, Moriguchi J, Osgood T, Mattson B, Coxon A, Reese M, Kim TS, Lin J, Chen A, Burgess TL, Dussault I.

Cancer Res. 2008 Aug 15;68(16):6680-7. doi: 10.1158/0008-5472.CAN-07-6782.

17.

Patient care interventions by pharmacy students in the intensive care unit.

Thompson AN, Osgood TS, Ragucci KR.

Am J Health Syst Pharm. 2007 Sep 1;64(17):1788-9. No abstract available.

PMID:
17724354
18.

Sonographic features of drug-induced splenic congestion.

O'Brien RT, Waller KR 3rd, Osgood TL.

Vet Radiol Ultrasound. 2004 May-Jun;45(3):225-7.

PMID:
15200260
19.

Effect of short-term treatment with a monoclonal antibody to P-selectin on balloon catheter-induced: intimal hyperplasia, re-endothelialization, and attenuation of endothelial-dependent relaxation.

Akers DL, Lefer DJ, Chen IL, Wilkens RG, Rice J, Aurora H, Osgood TA, Bedi B, Tenaglia AN, Buda AJ, Kadowitz PJ, McNamara DB.

Mol Cell Biochem. 1997 Nov;176(1-2):13-20.

PMID:
9406139
20.

A quantitative evaluation of Fourier components in transparent and opaque calf cornea.

Gisselberg M, Clark JI, Vaezy S, Osgood TB.

Am J Anat. 1991 Aug;191(4):408-18.

PMID:
1951139
21.

Inhibition of corneal epithelial cell migration by cadmium and mercury.

Ubels JL, Osgood TB.

Bull Environ Contam Toxicol. 1991 Feb;46(2):230-6. No abstract available.

PMID:
2018869
22.
23.

Electrolyte composition of lacrimal gland fluid and tears of normal and vitamin A-deficient rabbits.

Rismondo V, Osgood TB, Leering P, Hattenhauer MG, Ubels JL, Edelhauser HF.

CLAO J. 1989 Jul-Sep;15(3):222-8.

PMID:
2776293
24.

The relationship between secretion of retinol and protein by the lacrimal gland.

Ubels JL, Rismondo V, Osgood TB.

Invest Ophthalmol Vis Sci. 1989 May;30(5):952-60.

PMID:
2722449
25.

Vitamin A is stored as fatty acyl esters of retinol in the lacrimal gland.

Ubels JL, Osgood TB, Foley KM.

Curr Eye Res. 1988 Oct;7(10):1009-16.

PMID:
3229120
26.

Tear secretion and lacrimal gland function of rabbits treated with isotretinoin.

Rismondo V, Ubels JL, Osgood TB.

J Am Acad Dermatol. 1988 Aug;19(2 Pt 1):280-5.

PMID:
3170794
27.

Inhibition of phase separation by reagents that prevent X-irradiation cataract in vivo.

Clark JI, Osgood TB, Trask SJ.

Exp Eye Res. 1987 Dec;45(6):961-7.

PMID:
2828097
28.

Inhibition of lens opacification in x-irradiated rats treated with WR-77913.

Osgood TB, Menard TW, Clark JI, Krohn KA.

Invest Ophthalmol Vis Sci. 1986 Dec;27(12):1780-4.

PMID:
3025129
29.

Radioprotection against cataract formation by WR-77913 in gamma-irradiated rats.

Menard TW, Osgood TB, Clark JI, Spence AM, Steele JE, Krohn KA, Livesey JC.

Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1483-6.

PMID:
3019964
30.

The DST in psychiatric outpatients with generalized anxiety disorder, panic disorder, or primary affective disorder.

Avery DH, Osgood TB, Ishiki DM, Wilson LG, Kenny M, Dunner DL.

Am J Psychiatry. 1985 Jul;142(7):844-8.

PMID:
4014507
31.

Individual lipids and proximate analysis of various foods. 2. Frankfurters and other meat and poultry products.

Newkirk DR, Sheppard AJ, Hubbard WD, Osgood T.

J Agric Food Chem. 1978 Mar-Apr;26(2):349-50. No abstract available.

PMID:
632428
32.

Gas-liquid chromatographic determination of cholesterol and other sterols in foods.

Sheppard AJ, Newkirk DR, Hubbard WD, Osgood T.

J Assoc Off Anal Chem. 1977 Nov;60(6):1302-6.

PMID:
924932
33.

Individual lipids and proximate analysis of various foods. 1. French fried potatoes from ten chain restaurants.

Hubbard WD, Prosser AR, Sheppard AJ, Newkirk DR, Osgood T, Tombropoulos E, Jones ST.

J Agric Food Chem. 1977 Nov-Dec;25(6):1280-1. No abstract available.

PMID:
915127
34.

Comparison of various methods for the extraction of total lipids, fatty acids, cholesterol, and other sterols from food products.

Hubbard WD, Sheppard AJ, Newkirk DR, Prosser AR, Osgood T.

J Am Oil Chem Soc. 1977 Feb;54(2):81-3. No abstract available.

PMID:
833420
35.

Linkage studies in Lenz microphthalmia.

Ogunye OO, Murray RF, Osgood T.

Hum Hered. 1975;25(6):493-500.

PMID:
1225823
36.

Electrical Conductance of Short Gaps in Air.

Hutchisson E, Osgood TH, Fearon RE.

Proc Natl Acad Sci U S A. 1935 Sep;21(9):542-8. No abstract available.

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