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Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.

Coutinho de Oliveira L, Volpon L, Rahardjo AK, Osborne MJ, Culjkovic-Kraljacic B, Trahan C, Oeffinger M, Kwok BH, Borden KLB.

Proc Natl Acad Sci U S A. 2019 Nov 26;116(48):24056-24065. doi: 10.1073/pnas.1904752116. Epub 2019 Nov 11.


Variance in Reproductive Success is Driven by Environmental Factors, not Mating System, in Bonytails.

Osborne MJ, Sanchez AV, Dowling TE, Turner TF.

Trans Am Fish Soc. 2018 Nov;147(6):1100-1114. doi: 10.1002/tafs.10105. Epub 2018 Jul 21.


Biochemical and Structural Insights into the Eukaryotic Translation Initiation Factor eIF4E.

Volpon L, Osborne MJ, Borden KLB.

Curr Protein Pept Sci. 2019;20(6):525-535. doi: 10.2174/1389203720666190110142438. Review.


Overcoming Drug Resistance through the Development of Selective Inhibitors of UDP-Glucuronosyltransferase Enzymes.

Osborne MJ, Coutinho de Oliveira L, Volpon L, Zahreddine HA, Borden KLB.

J Mol Biol. 2019 Jan 18;431(2):258-272. doi: 10.1016/j.jmb.2018.11.007. Epub 2018 Nov 11.


Chemical shift assignment of the viral protein genome-linked (VPg) from potato virus Y.

Coutinho de Oliveira L, Volpon L, Osborne MJ, Borden KLB.

Biomol NMR Assign. 2019 Apr;13(1):9-13. doi: 10.1007/s12104-018-9842-3. Epub 2018 Sep 21.


Backbone assignment of the apo-form of the human C-terminal domain of UDP-glucuronosyltransferase 1A (UGT1A).

Osborne MJ, Coutinho de Oliveira L, Volpon L, Borden KLB.

Biomol NMR Assign. 2018 Oct;12(2):315-318. doi: 10.1007/s12104-018-9830-7. Epub 2018 Jun 22.


A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

Volpon L, Culjkovic-Kraljacic B, Sohn HS, Blanchet-Cohen A, Osborne MJ, Borden KLB.

RNA. 2017 Jun;23(6):927-937. doi: 10.1261/rna.060137.116. Epub 2017 Mar 21.


Spatio-temporal variation in parasite communities maintains diversity at the major histocompatibility complex class IIβ in the endangered Rio Grande silvery minnow.

Osborne MJ, Pilger TJ, Lusk JD, Turner TF.

Mol Ecol. 2017 Jan;26(2):471-489. doi: 10.1111/mec.13936. Epub 2016 Dec 22.


Endoscopic stenting of acutely obstructing colorectal cancer: a 10-year review from a tertiary referral centre.

Padwick RT, Chauhan V, Newman M, Francombe J, Osborne MJ.

ANZ J Surg. 2016 Oct;86(10):778-781. doi: 10.1111/ans.13614. Epub 2016 Apr 27.


Importin 8 mediates m7G cap-sensitive nuclear import of the eukaryotic translation initiation factor eIF4E.

Volpon L, Culjkovic-Kraljacic B, Osborne MJ, Ramteke A, Sun Q, Niesman A, Chook YM, Borden KL.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):5263-8. doi: 10.1073/pnas.1524291113. Epub 2016 Apr 25.


Biogeography of "Cyprinella lutrensis": intensive genetic sampling from the Pecos River 'melting pot' reveals a dynamic history and phylogenetic complexity.

Osborne MJ, Diver TA, Hoagstrom CW, Turner TF.

Biol J Linn Soc Lond. 2016 Feb 1;117(2):264-284. Epub 2015 Sep 26.


The eukaryotic translation initiation factor eIF4E in the nucleus: taking the road less traveled.

Osborne MJ, Borden KL.

Immunol Rev. 2015 Jan;263(1):210-23. doi: 10.1111/imr.12240. Review.


Comparative riverscape genetics reveals reservoirs of genetic diversity for conservation and restoration of Great Plains fishes.

Osborne MJ, Perkin JS, Gido KB, Turner TF.

Mol Ecol. 2014 Dec;23(23):5663-79. doi: 10.1111/mec.12970. Epub 2014 Nov 15.


LIMD2 is a small LIM-only protein overexpressed in metastatic lesions that regulates cell motility and tumor progression by directly binding to and activating the integrin-linked kinase.

Peng H, Talebzadeh-Farrooji M, Osborne MJ, Prokop JW, McDonald PC, Karar J, Hou Z, He M, Kebebew E, Orntoft T, Herlyn M, Caton AJ, Fredericks W, Malkowicz B, Paterno CS, Carolin AS, Speicher DW, Skordalakes E, Huang Q, Dedhar S, Borden KLB, Rauscher FJ 3rd.

Cancer Res. 2014 Mar 1;74(5):1390-1403. doi: 10.1158/0008-5472.CAN-13-1275.


eIF4E3, a new actor in mRNA metabolism and tumor suppression.

Volpon L, Osborne MJ, Culjkovic-Kraljacic B, Borden KL.

Cell Cycle. 2013 Apr 15;12(8):1159-60. doi: 10.4161/cc.24566. Epub 2013 Apr 9. No abstract available.


Conformational changes induced in the eukaryotic translation initiation factor eIF4E by a clinically relevant inhibitor, ribavirin triphosphate.

Volpon L, Osborne MJ, Zahreddine H, Romeo AA, Borden KL.

Biochem Biophys Res Commun. 2013 May 10;434(3):614-9. doi: 10.1016/j.bbrc.2013.03.125. Epub 2013 Apr 10.


Genetic analysis of captive spawning strategies for the endangered Rio Grande Silvery Minnow.

Osborne MJ, Perez TL, Altenbach CS, Turner TF.

J Hered. 2013 May-Jun;104(3):437-46. doi: 10.1093/jhered/est013. Epub 2013 Mar 21.


eIF4E3 acts as a tumor suppressor by utilizing an atypical mode of methyl-7-guanosine cap recognition.

Osborne MJ, Volpon L, Kornblatt JA, Culjkovic-Kraljacic B, Baguet A, Borden KL.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3877-82. doi: 10.1073/pnas.1216862110. Epub 2013 Feb 19.


MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.

Fontan L, Yang C, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H, Melnick A.

Cancer Cell. 2012 Dec 11;22(6):812-24. doi: 10.1016/j.ccr.2012.11.003.


Genetic monitoring and complex population dynamics: insights from a 12-year study of the Rio Grande silvery minnow.

Osborne MJ, Carson EW, Turner TF.

Evol Appl. 2012 Sep;5(6):553-74. doi: 10.1111/j.1752-4571.2011.00235.x. Epub 2012 Jan 12.


Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E.

Siddiqui N, Tempel W, Nedyalkova L, Volpon L, Wernimont AK, Osborne MJ, Park HW, Borden KL.

J Mol Biol. 2012 Feb 3;415(5):781-92. doi: 10.1016/j.jmb.2011.12.002. Epub 2011 Dec 9.


Straight to colonoscopy: the ideal patient pathway for the 2-week suspected cancer referrals?

Fallis SA, Busby K, Francombe J, Osborne MJ.

Ann R Coll Surg Engl. 2011 Sep;93(6):495; author reply 495. doi: 10.1308/rcsann.2011.93.6.495b. No abstract available.


Isolation and characterization of major histocompatibility class IIβ genes in an endangered North American cyprinid fish, the Rio Grande silvery minnow (Hybognathus amarus).

Osborne MJ, Turner TF.

Fish Shellfish Immunol. 2011 Jun;30(6):1275-82. doi: 10.1016/j.fsi.2011.03.019. Epub 2011 Apr 2.


Production of functionalized polyhydroxyalkanoates by genetically modified Methylobacterium extorquens strains.

Höfer P, Choi YJ, Osborne MJ, Miguez CB, Vermette P, Groleau D.

Microb Cell Fact. 2010 Sep 16;9:70. doi: 10.1186/1475-2859-9-70.


Genetic effective size, N(e), tracks density in a small freshwater cyprinid, Pecos bluntnose shiner (Notropis simus pecosensis).

Osborne MJ, Davenport SR, Hoagstrom CW, Turner TF.

Mol Ecol. 2010 Jul;19(14):2832-44. doi: 10.1111/j.1365-294X.2010.04695.x. Epub 2010 Jun 23.


Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.

Volpon L, Osborne MJ, Capul AA, de la Torre JC, Borden KL.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5441-6. doi: 10.1073/pnas.0909877107. Epub 2010 Mar 8.


Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function.

Rolef Ben-Shahar T, Castillo AG, Osborne MJ, Borden KL, Kornblatt J, Verreault A.

Mol Cell Biol. 2009 Dec;29(24):6353-65. doi: 10.1128/MCB.01051-09. Epub 2009 Oct 12.


Using sterile co-polymer overgloves as undergloves prevents hands from 'smelling' after contaminated abdominal surgery.

Padwick RT, Osborne MJ.

Ann R Coll Surg Engl. 2009 Jul;91(5):439. No abstract available.


NMR assignment of the arenaviral protein Z from Lassa fever virus.

Volpon L, Osborne MJ, Borden KL.

Biomol NMR Assign. 2008 Jun;2(1):81-4. doi: 10.1007/s12104-008-9090-z.


Solution structure of YaeO, a Rho-specific inhibitor of transcription termination.

Gutiérrez P, Kozlov G, Gabrielli L, Elias D, Osborne MJ, Gallouzi IE, Gehring K.

J Biol Chem. 2007 Aug 10;282(32):23348-53. Epub 2007 Jun 11.


The structurally disordered KRAB repression domain is incorporated into a protease resistant core upon binding to KAP-1-RBCC domain.

Peng H, Gibson LC, Capili AD, Borden KL, Osborne MJ, Harper SL, Speicher DW, Zhao K, Marmorstein R, Rock TA, Rauscher FJ 3rd.

J Mol Biol. 2007 Jul 6;370(2):269-89. Epub 2007 Mar 24.


Conformational analyses of a partially-folded bioactive prodomain of human furin.

Bhattacharjya S, Xu P, Wang P, Osborne MJ, Ni F.

Biopolymers. 2007 Jul;86(4):329-44.


Solution structure of the PABC domain from wheat poly (A)-binding protein: an insight into RNA metabolic and translational control in plants.

Siddiqui N, Osborne MJ, Gallie DR, Gehring K.

Biochemistry. 2007 Apr 10;46(14):4221-31. Epub 2007 Mar 15.


Cap-free structure of eIF4E suggests a basis for conformational regulation by its ligands.

Volpon L, Osborne MJ, Topisirovic I, Siddiqui N, Borden KL.

EMBO J. 2006 Nov 1;25(21):5138-49. Epub 2006 Oct 12.


Life history and environmental variation interact to determine effective population to census size ratio.

Turner TF, Osborne MJ, Moyer GR, Benavides MA, Alò D.

Proc Biol Sci. 2006 Dec 22;273(1605):3065-73.


NMR assignment of human eukaryotic translation initiation factor 4E (eIF4E) in its cap-free form.

Volpon L, Osborne MJ, Borden KL.

J Biomol NMR. 2006;36 Suppl 1:65. Epub 2006 Jul 27. No abstract available.


Pregnancy outcomes after maternal exposure to simvastatin and lovastatin.

Pollack PS, Shields KE, Burnett DM, Osborne MJ, Cunningham ML, Stepanavage ME.

Birth Defects Res A Clin Mol Teratol. 2005 Nov;73(11):888-96.


The solution structure of the oxidative stress-related protein YggX from Escherichia coli.

Osborne MJ, Siddiqui N, Landgraf D, Pomposiello PJ, Gehring K.

Protein Sci. 2005 Jun;14(6):1673-8. Epub 2005 May 9.


Solution structure of the carbon storage regulator protein CsrA from Escherichia coli.

Gutiérrez P, Li Y, Osborne MJ, Pomerantseva E, Liu Q, Gehring K.

J Bacteriol. 2005 May;187(10):3496-501.


Energy landscape picture of overaging and rejuvenation in a sheared glass.

Lacks DJ, Osborne MJ.

Phys Rev Lett. 2004 Dec 17;93(25):255501. Epub 2004 Dec 13.


Surface segregation in liquid mixtures with strong interspecies attraction.

Osborne MJ, Lacks DJ.

Phys Rev E Stat Nonlin Soft Matter Phys. 2004 Jul;70(1 Pt 1):010501. Epub 2004 Jul 30.


The solution structure of ChaB, a putative membrane ion antiporter regulator from Escherichia coli.

Osborne MJ, Siddiqui N, Iannuzzi P, Gehring K.

BMC Struct Biol. 2004 Aug 11;4:9.


Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation.

Gutiérrez P, Osborne MJ, Siddiqui N, Trempe JF, Arrowsmith C, Gehring K.

Protein Sci. 2004 Mar;13(3):659-67.


The solution structure of YbcJ from Escherichia coli reveals a recently discovered alphaL motif involved in RNA binding.

Volpon L, Lievre C, Osborne MJ, Gandhi S, Iannuzzi P, Larocque R, Cygler M, Gehring K, Ekiel I.

J Bacteriol. 2003 Jul;185(14):4204-10.


Molecular phylogenetics of the Diprotodontia (kangaroos, wombats, koala, possums, and allies).

Osborne MJ, Christidis L, Norman JA.

Mol Phylogenet Evol. 2002 Nov;25(2):219-28.


Structural dynamics of the membrane translocation domain of colicin E9 and its interaction with TolB.

Collins ES, Whittaker SB, Tozawa K, MacDonald C, Boetzel R, Penfold CN, Reilly A, Clayden NJ, Osborne MJ, Hemmings AM, Kleanthous C, James R, Moore GR.

J Mol Biol. 2002 May 3;318(3):787-804.


Backbone dynamics in dihydrofolate reductase complexes: role of loop flexibility in the catalytic mechanism.

Osborne MJ, Schnell J, Benkovic SJ, Dyson HJ, Wright PE.

Biochemistry. 2001 Aug 21;40(33):9846-59.


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