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Items: 47


RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction.

Ptasinska A, Pickin A, Assi SA, Chin PS, Ames L, Avellino R, Gröschel S, Delwel R, Cockerill PN, Osborne CS, Bonifer C.

Cell Rep. 2019 Sep 17;28(12):3022-3031.e7. doi: 10.1016/j.celrep.2019.08.040.


Cohesin-dependent regulation of gene expression during differentiation is lost in Cohesin-mutated myeloid malignancies.

Sasca D, Yun H, Giotopoulos G, Szybinski J, Evan T, Wilson NK, Gerstung M, Gallipoli P, Green AR, Hills RK, Russell NH, Osborne CS, Papaemmanuil E, Gottgens B, Campbell PJ, Huntly BJP.

Blood. 2019 Sep 12. pii: blood.2019001553. doi: 10.1182/blood.2019001553. [Epub ahead of print]


An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain.

Debrand E, Chakalova L, Miles J, Dai YF, Goyenechea B, Dye S, Osborne CS, Horton A, Harju-Baker S, Pink RC, Caley D, Carter DRF, Peterson KR, Fraser P.

PLoS One. 2019 Aug 14;14(8):e0217532. doi: 10.1371/journal.pone.0217532. eCollection 2019.


Drug-Induced Liver Injury Caused by Kratom Use as an Alternative Pain Treatment Amid an Ongoing Opioid Epidemic.

Osborne CS, Overstreet AN, Rockey DC, Schreiner AD.

J Investig Med High Impact Case Rep. 2019 Jan-Dec;7:2324709619826167. doi: 10.1177/2324709619826167.


Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection.

Growcott EJ, Cariaga TA, Morris L, Zang X, Lopez S, Ansaldi DA, Gold J, Gamboa L, Roth T, Simmons RL, Osborne CS.

J Antimicrob Chemother. 2019 Jan 1;74(1):280. doi: 10.1093/jac/dky478. No abstract available.


Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection.

Growcott EJ, Cariaga TA, Morris L, Zang X, Lopez S, Ansaldi DA, Gold J, Gamboa L, Roth T, Simmons RL, Osborne CS.

J Antimicrob Chemother. 2019 Jan 1;74(1):108-116. doi: 10.1093/jac/dky404. Erratum in: J Antimicrob Chemother. 2019 Jan 1;74(1):280.


Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer.

Orlando G, Law PJ, Cornish AJ, Dobbins SE, Chubb D, Broderick P, Litchfield K, Hariri F, Pastinen T, Osborne CS, Taipale J, Houlston RS.

Nat Genet. 2018 Oct;50(10):1375-1380. doi: 10.1038/s41588-018-0211-z. Epub 2018 Sep 17.


The effect of P38 MAP kinase inhibition in a mouse model of influenza.

Growcott EJ, Bamba D, Galarneau JR, Leonard VHJ, Schul W, Stein D, Osborne CS.

J Med Microbiol. 2018 Mar;67(3):452-462. doi: 10.1099/jmm.0.000684. Epub 2018 Jan 24.


Global reorganisation of cis-regulatory units upon lineage commitment of human embryonic stem cells.

Freire-Pritchett P, Schoenfelder S, Várnai C, Wingett SW, Cairns J, Collier AJ, García-Vílchez R, Furlan-Magaril M, Osborne CS, Fraser P, Rugg-Gunn PJ, Spivakov M.

Elife. 2017 Mar 23;6. pii: e21926. doi: 10.7554/eLife.21926.


Capturing genomic relationships that matter.

Osborne CS, Mifsud B.

Chromosome Res. 2017 Mar;25(1):15-24. doi: 10.1007/s10577-016-9546-4. Epub 2017 Jan 11. Review.


MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs.

Wood CD, Veenstra H, Khasnis S, Gunnell A, Webb HM, Shannon-Lowe C, Andrews S, Osborne CS, West MJ.

Elife. 2016 Aug 4;5. pii: e18270. doi: 10.7554/eLife.18270.


Male Prison Inmates With Gender Dysphoria: When Is Sex Reassignment Surgery Appropriate?

Osborne CS, Lawrence AA.

Arch Sex Behav. 2016 Oct;45(7):1649-63. doi: 10.1007/s10508-016-0700-z. Epub 2016 Mar 15.


Polycomb repressive complex PRC1 spatially constrains the mouse embryonic stem cell genome.

Schoenfelder S, Sugar R, Dimond A, Javierre BM, Armstrong H, Mifsud B, Dimitrova E, Matheson L, Tavares-Cadete F, Furlan-Magaril M, Segonds-Pichon A, Jurkowski W, Wingett SW, Tabbada K, Andrews S, Herman B, LeProust E, Osborne CS, Koseki H, Fraser P, Luscombe NM, Elderkin S.

Nat Genet. 2015 Oct;47(10):1179-1186. doi: 10.1038/ng.3393. Epub 2015 Aug 31.


Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C.

Mifsud B, Tavares-Cadete F, Young AN, Sugar R, Schoenfelder S, Ferreira L, Wingett SW, Andrews S, Grey W, Ewels PA, Herman B, Happe S, Higgs A, LeProust E, Follows GA, Fraser P, Luscombe NM, Osborne CS.

Nat Genet. 2015 Jun;47(6):598-606. doi: 10.1038/ng.3286. Epub 2015 May 4.


The pluripotent regulatory circuitry connecting promoters to their long-range interacting elements.

Schoenfelder S, Furlan-Magaril M, Mifsud B, Tavares-Cadete F, Sugar R, Javierre BM, Nagano T, Katsman Y, Sakthidevi M, Wingett SW, Dimitrova E, Dimond A, Edelman LB, Elderkin S, Tabbada K, Darbo E, Andrews S, Herman B, Higgs A, LeProust E, Osborne CS, Mitchell JA, Luscombe NM, Fraser P.

Genome Res. 2015 Apr;25(4):582-97. doi: 10.1101/gr.185272.114. Epub 2015 Mar 9.


Molecular pathways: transcription factories and chromosomal translocations.

Osborne CS.

Clin Cancer Res. 2014 Jan 15;20(2):296-300. doi: 10.1158/1078-0432.CCR-12-3667. Epub 2013 Oct 28. Review.


Pairing of homologous regions in the mouse genome is associated with transcription but not imprinting status.

Krueger C, King MR, Krueger F, Branco MR, Osborne CS, Niakan KK, Higgins MJ, Reik W.

PLoS One. 2012;7(7):e38983. doi: 10.1371/journal.pone.0038983. Epub 2012 Jul 3.


Large scale loss of data in low-diversity illumina sequencing libraries can be recovered by deferred cluster calling.

Krueger F, Andrews SR, Osborne CS.

PLoS One. 2011 Jan 28;6(1):e16607. doi: 10.1371/journal.pone.0016607.


Meet the neighbours: tools to dissect nuclear structure and function.

Osborne CS, Ewels PA, Young AN.

Brief Funct Genomics. 2011 Jan;10(1):11-7. doi: 10.1093/bfgp/elq034. Epub 2011 Jan 21. Review.


In vivo characterization of the peptide deformylase inhibitor LBM415 in murine infection models.

Osborne CS, Neckermann G, Fischer E, Pecanka R, Yu D, Manni K, Goldovitz J, Amaral K, Dzink-Fox J, Ryder NS.

Antimicrob Agents Chemother. 2009 Sep;53(9):3777-81. doi: 10.1128/AAC.00026-09. Epub 2009 Jul 13.


Where shall we meet? A role for genome organisation and nuclear sub-compartments in mediating interchromosomal interactions.

Osborne CS, Eskiw CH.

J Cell Biochem. 2008 Aug 1;104(5):1553-61. doi: 10.1002/jcb.21750. Review.


Intergenic transcription, cell-cycle and the developmentally regulated epigenetic profile of the human beta-globin locus.

Miles J, Mitchell JA, Chakalova L, Goyenechea B, Osborne CS, O'Neill L, Tanimoto K, Engel JD, Fraser P.

PLoS One. 2007 Jul 18;2(7):e630.


Myc dynamically and preferentially relocates to a transcription factory occupied by Igh.

Osborne CS, Chakalova L, Mitchell JA, Horton A, Wood AL, Bolland DJ, Corcoran AE, Fraser P.

PLoS Biol. 2007 Aug;5(8):e192.


Raising the curtains on interchromosomal interactions.

Krueger C, Osborne CS.

Trends Genet. 2006 Dec;22(12):637-9. Epub 2006 Sep 25. Review.


Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine.

Osborne CS, Leitner I, Hofbauer B, Fielding CA, Favre B, Ryder NS.

Antimicrob Agents Chemother. 2006 Jun;50(6):2234-6.


The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.

Parker MJ, Licence S, Erlandsson L, Galler GR, Chakalova L, Osborne CS, Morgan G, Fraser P, Jumaa H, Winkler TH, Skok J, Mårtensson IL.

EMBO J. 2005 Nov 16;24(22):3895-905. Epub 2005 Nov 10.


Replication and transcription: shaping the landscape of the genome.

Chakalova L, Debrand E, Mitchell JA, Osborne CS, Fraser P.

Nat Rev Genet. 2005 Sep;6(9):669-77. Review.


Amino acid substitution in Trichophyton rubrum squalene epoxidase associated with resistance to terbinafine.

Osborne CS, Leitner I, Favre B, Ryder NS.

Antimicrob Agents Chemother. 2005 Jul;49(7):2840-4.


Molecular determinants of NOTCH4 transcription in vascular endothelium.

Wu J, Iwata F, Grass JA, Osborne CS, Elnitski L, Fraser P, Ohneda O, Yamamoto M, Bresnick EH.

Mol Cell Biol. 2005 Feb;25(4):1458-74.


The Corfu deltabeta thalassemia deletion disrupts gamma-globin gene silencing and reveals post-transcriptional regulation of HbF expression.

Chakalova L, Osborne CS, Dai YF, Goyenechea B, Metaxotou-Mavromati A, Kattamis A, Kattamis C, Fraser P.

Blood. 2005 Mar 1;105(5):2154-60. Epub 2004 Nov 9.


Active genes dynamically colocalize to shared sites of ongoing transcription.

Osborne CS, Chakalova L, Brown KE, Carter D, Horton A, Debrand E, Goyenechea B, Mitchell JA, Lopes S, Reik W, Fraser P.

Nat Genet. 2004 Oct;36(10):1065-71. Epub 2004 Sep 7.


Antifungal drug response in an in vitro model of dermatophyte nail infection.

Osborne CS, Leitner I, Favre B, Ryder NS.

Med Mycol. 2004 Apr;42(2):159-63.


In vitro analysis of the ability of Trichophyton rubrum to become resistant to terbinafine.

Osborne CS, Hofbauer B, Favre B, Ryder NS.

Antimicrob Agents Chemother. 2003 Nov;47(11):3634-6.


LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1.

Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M.

Science. 2003 Oct 17;302(5644):415-9. Erratum in: Science. 2003 Oct 24;302(5645):568.


Retrovirus silencer blocking by the cHS4 insulator is CTCF independent.

Yao S, Osborne CS, Bharadwaj RR, Pasceri P, Sukonnik T, Pannell D, Recillas-Targa F, West AG, Ellis J.

Nucleic Acids Res. 2003 Sep 15;31(18):5317-23.


Novel 112 kb (epsilonGgammaAgamma) deltabeta-thalassaemia deletion in a Dutch family.

Harteveld CL, Osborne CS, Peters M, van der Werf S, Plug R, Fraser P, Giordano PC.

Br J Haematol. 2003 Sep;122(5):855-8.


Long-range chromatin regulatory interactions in vivo.

Carter D, Chakalova L, Osborne CS, Dai YF, Fraser P.

Nat Genet. 2002 Dec;32(4):623-6. Epub 2002 Nov 11.


Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code.

Pannell D, Osborne CS, Yao S, Sukonnik T, Pasceri P, Karaiskakis A, Okano M, Li E, Lipshitz HD, Ellis J.

EMBO J. 2000 Nov 1;19(21):5884-94.


Generation of an improved luciferase reporter gene plasmid that employs a novel mechanism for high-copy replication.

Bert AG, Burrows J, Osborne CS, Cockerill PN.

Plasmid. 2000 Sep;44(2):173-82.


Amelioration of retroviral vector silencing in locus control region beta-globin-transgenic mice and transduced F9 embryonic cells.

Osborne CS, Pasceri P, Singal R, Sukonnik T, Ginder GD, Ellis J.

J Virol. 1999 Jul;73(7):5490-6.


Investigation into the tensile properties of collagen/chondroitin-6-sulphate gels: the effect of crosslinking agents and diamines.

Osborne CS, Barbenel JC, Smith D, Savakis M, Grant MH.

Med Biol Eng Comput. 1998 Jan;36(1):129-34.


Investigation into cell growth on collagen/chondroitin-6-sulphate gels: the effect of crosslinking agents and diamines.

Osborne CS, Reid WH, Grant MH.

J Mater Sci Mater Med. 1997 Apr;8(4):179-84.


Regulation of GM-CSF gene transcription by core-binding factor.

Cockerill PN, Osborne CS, Bert AG, Grotto RJ.

Cell Growth Differ. 1996 Jul;7(7):917-22.


Transcriptional regulation of mouse granulocyte-macrophage colony-stimulating factor/IL-3 locus.

Osborne CS, Vadas MA, Cockerill PN.

J Immunol. 1995 Jul 1;155(1):226-35.


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