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Cohesin-dependent regulation of gene expression during differentiation is lost in Cohesin-mutated myeloid malignancies.

Sasca D, Yun H, Giotopoulos G, Szybinski J, Evan T, Wilson NK, Gerstung M, Gallipoli P, Green AR, Hills RK, Russell NH, Osborne CS, Papaemmanuil E, Gottgens B, Campbell PJ, Huntly BJP.

Blood. 2019 Sep 12. pii: blood.2019001553. doi: 10.1182/blood.2019001553. [Epub ahead of print]


Patient-derived xenografts of central nervous system metastasis reveal expansion of aggressive minor clones.

Tew BY, Legendre C, Schroeder MA, Triche T, Gooden GC, Huang Y, Butry L, Ma DJ, Johnson K, Martinez RA, Pierobon M, Petricoin EF, O'Shaughnessy J, Osborne C, Tapia C, Buckley DN, Glen J, Bernstein M, Sarkaria JN, Toms SA, Salhia B.

Neuro Oncol. 2019 Aug 21. pii: noz137. doi: 10.1093/neuonc/noz137. [Epub ahead of print]


Frequent fires prime plant developmental responses to burning.

Simpson KJ, Olofsson JK, Ripley BS, Osborne CP.

Proc Biol Sci. 2019 Aug 28;286(1909):20191315. doi: 10.1098/rspb.2019.1315. Epub 2019 Aug 21.


Targeting the mevalonate pathway to overcome acquired anti-HER2 treatment resistance in breast cancer.

Sethunath V, Hu H, De Angelis C, Veeraraghavan J, Qin L, Wang N, Simon LM, Wang T, Fu X, Nardone A, Pereira R, Nanda S, Griffith OL, Tsimelzon A, Shaw C, Chamness GC, Reis-Filho JS, Weigelt B, Heiser LM, Hilsenbeck SG, Huang S, Rimawi MF, Gray JW, Osborne CK, Schiff R.

Mol Cancer Res. 2019 Aug 16. pii: molcanres.0756.2019. doi: 10.1158/1541-7786.MCR-19-0756. [Epub ahead of print]


An intergenic non-coding RNA promoter required for histone modifications in the human β-globin chromatin domain.

Debrand E, Chakalova L, Miles J, Dai YF, Goyenechea B, Dye S, Osborne CS, Horton A, Harju-Baker S, Pink RC, Caley D, Carter DRF, Peterson KR, Fraser P.

PLoS One. 2019 Aug 14;14(8):e0217532. doi: 10.1371/journal.pone.0217532. eCollection 2019.


One EHR should not rule them all.

Wong SC, Osborne C.

CMAJ. 2019 Jul 29;191(30):E844. doi: 10.1503/cmaj.72273. No abstract available.


Phylogeny and ecological processes influence grass coexistence at different spatial scales within the steppe biome.

Liu H, Osborne CP, Yin D, Freckleton RP, Jiang G, Liu M.

Oecologia. 2019 Sep;191(1):25-38. doi: 10.1007/s00442-019-04475-0. Epub 2019 Jul 25.


Understanding the Experience of Early Supported Discharge from the Perspective of Patients with Stroke and Their Carers and Health Care Providers: A Qualitative Review.

Osborne CL, Neville M.

Nurs Clin North Am. 2019 Sep;54(3):367-384. doi: 10.1016/j.cnur.2019.04.006. Epub 2019 Jun 15. Review.


Mesophyll porosity is modulated by the presence of functional stomata.

Lundgren MR, Mathers A, Baillie AL, Dunn J, Wilson MJ, Hunt L, Pajor R, Fradera-Soler M, Rolfe S, Osborne CP, Sturrock CJ, Gray JE, Mooney SJ, Fleming AJ.

Nat Commun. 2019 Jun 27;10(1):2825. doi: 10.1038/s41467-019-10826-5.


Nutrient sink limitation constrains growth in two barley species with contrasting growth strategies.

Burnett AC, Rogers A, Rees M, Osborne CP.

Plant Direct. 2018 Nov 12;2(11):e00094. doi: 10.1002/pld3.94. eCollection 2018 Nov.


Re-analysis of archaeobotanical remains from pre- and early agricultural sites provides no evidence for a narrowing of the wild plant food spectrum during the origins of agriculture in southwest Asia.

Wallace M, Jones G, Charles M, Forster E, Stillman E, Bonhomme V, Livarda A, Osborne CP, Rees M, Frenck G, Preece C.

Veg Hist Archaeobot. 2019;28(4):449-463. doi: 10.1007/s00334-018-0702-y. Epub 2018 Nov 17.


Disseminated Histoplasmosis as an AIDS-Defining Illness Presenting as Fever of Unknown Origin in an 11-Year-Old Female.

Kalata KE, Osborne C, Willis A, Navarro K, Fenton LZ, Smith C.

Case Rep Pediatr. 2019 May 13;2019:9417102. doi: 10.1155/2019/9417102. eCollection 2019.


Beneath the surface: Evolution of methane activity in the bacterial multicomponent monooxygenases.

Osborne CD, Haritos VS.

Mol Phylogenet Evol. 2019 Oct;139:106527. doi: 10.1016/j.ympev.2019.106527. Epub 2019 Jun 4.


The Culture Of Health In Early Care And Education: Workers' Wages, Health, And Job Characteristics.

Otten JJ, Bradford VA, Stover B, Hill HD, Osborne C, Getts K, Seixas N.

Health Aff (Millwood). 2019 May;38(5):709-720. doi: 10.1377/hlthaff.2018.05493.


HER2-enriched subtype and ERBB2 expression in HER2-positive breast cancer treated with dual HER2 blockade.

Prat A, Pascual T, De Angelis C, Gutierrez C, Llombart-Cussac A, Wang T, Cortés J, Rexer B, Paré L, Forero A, Wolff AC, Morales S, Adamo B, Brasó-Maristany F, Vidal M, Veeraraghavan J, Krop I, Galván P, Pavlick AC, Bermejo B, Izquierdo M, Rodrik-Outmezguine V, Reis-Filho JS, Hilsenbeck SG, Oliveira M, Dieci MV, Griguolo G, Fasani R, Nuciforo P, Parker JS, Conte P, Schiff R, Guarneri V, Osborne CK, Rimawi MF.

J Natl Cancer Inst. 2019 Apr 30. pii: djz042. doi: 10.1093/jnci/djz042. [Epub ahead of print]


Analytical validation of a standardised scoring protocol for Ki67 immunohistochemistry on breast cancer excision whole sections: an international multicentre collaboration.

Leung SCY, Nielsen TO, Zabaglo LA, Arun I, Badve SS, Bane AL, Bartlett JMS, Borgquist S, Chang MC, Dodson A, Ehinger A, Fineberg S, Focke CM, Gao D, Gown AM, Gutierrez C, Hugh JC, Kos Z, Laenkholm AV, Mastropasqua MG, Moriya T, Nofech-Mozes S, Osborne CK, Penault-Llorca FM, Piper T, Sakatani T, Salgado R, Starczynski J, Sugie T, van der Vegt B, Viale G, Hayes DF, McShane LM, Dowsett M; International Ki67 in Breast Cancer Working Group of the Breast International Group and North American Breast Cancer Group (BIG-NABCG).

Histopathology. 2019 Aug;75(2):225-235. doi: 10.1111/his.13880. Epub 2019 Jul 8.


The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Osborne C, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O.

Cancer Cell. 2019 Apr 15;35(4):705. doi: 10.1016/j.ccell.2019.03.012. No abstract available.


Giant malignant phyllodes tumor with metastasis to the brain.

Gregston AP, Metter DM, Osborne CRC, Pippen J Jr.

Proc (Bayl Univ Med Cent). 2019 Jan 15;32(1):116-118. doi: 10.1080/08998280.2018.1521207. eCollection 2019 Jan.


Apps and Mobile Health Technology in Rehabilitation: The Good, the Bad, and the Unknown.

Ramey L, Osborne C, Kasitinon D, Juengst S.

Phys Med Rehabil Clin N Am. 2019 May;30(2):485-497. doi: 10.1016/j.pmr.2018.12.001. Epub 2019 Mar 5. Review.


Key changes in gene expression identified for different stages of C4 evolution in Alloteropsis semialata.

Dunning LT, Moreno-Villena JJ, Lundgren MR, Dionora J, Salazar P, Adams C, Nyirenda F, Olofsson JK, Mapaura A, Grundy IM, Kayombo CJ, Dunning LA, Kentatchime F, Ariyarathne M, Yakandawala D, Besnard G, Quick WP, Bräutigam A, Osborne CP, Christin PA.

J Exp Bot. 2019 Jun 28;70(12):3255-3268. doi: 10.1093/jxb/erz149.


Germline Genetic Variants in GATA3 and Breast Cancer Treatment Outcomes in SWOG S8897 Trial and the Pathways Study.

Larsen V, Barlow WE, Yang JJ, Zhu Q, Liu S, Kwan ML, Ergas IJ, Roh JM, Hutchins LF, Kadlubar SA, Albain KS, Rae JM, Yeh IT, Ravdin PM, Martino S, Lyss AP, Osborne CK, Hortobagyi GN, Kushi LH, Hayes DF, Ambrosone CB, Yao S.

Clin Breast Cancer. 2019 Aug;19(4):225-235.e2. doi: 10.1016/j.clbc.2019.02.010. Epub 2019 Mar 6.


A combinatorial biomarker predicts pathologic complete response to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2+ breast cancer.

Veeraraghavan J, De Angelis C, Mao R, Wang T, Herrera S, Pavlick AC, Contreras A, Nuciforo P, Mayer IA, Forero A, Nanda R, Goetz MP, Chang JC, Wolff AC, Krop IE, Fuqua SAW, Prat A, Hilsenbeck SG, Weigelt B, Reis-Filho JS, Gutierrez C, Osborne CK, Rimawi MF, Schiff R.

Ann Oncol. 2019 Mar 23. pii: mdz076. doi: 10.1093/annonc/mdz076. [Epub ahead of print]


Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis.

Ramirez AB, Bhat R, Sahay D, De Angelis C, Thangavel H, Hedayatpour S, Dobrolecki LE, Nardone A, Giuliano M, Nagi C, Rimawi M, Osborne CK, Lewis MT, Stilwell JL, Kaldjian EP, Schiff R, Trivedi MV.

BMC Cancer. 2019 Mar 12;19(1):220. doi: 10.1186/s12885-019-5382-1.


Tissue-specific BMAL1 cistromes reveal that rhythmic transcription is associated with rhythmic enhancer-enhancer interactions.

Beytebiere JR, Trott AJ, Greenwell BJ, Osborne CA, Vitet H, Spence J, Yoo SH, Chen Z, Takahashi JS, Ghaffari N, Menet JS.

Genes Dev. 2019 Mar 1;33(5-6):294-309. doi: 10.1101/gad.322198.118. Epub 2019 Feb 25.


Drug-Induced Liver Injury Caused by Kratom Use as an Alternative Pain Treatment Amid an Ongoing Opioid Epidemic.

Osborne CS, Overstreet AN, Rockey DC, Schreiner AD.

J Investig Med High Impact Case Rep. 2019 Jan-Dec;7:2324709619826167. doi: 10.1177/2324709619826167.


Lateral transfers of large DNA fragments spread functional genes among grasses.

Dunning LT, Olofsson JK, Parisod C, Choudhury RR, Moreno-Villena JJ, Yang Y, Dionora J, Quick WP, Park M, Bennetzen JL, Besnard G, Nosil P, Osborne CP, Christin PA.

Proc Natl Acad Sci U S A. 2019 Feb 20. pii: 201810031. doi: 10.1073/pnas.1810031116. [Epub ahead of print]


Imaging in prodromal dementia with Lewy bodies: Where do we stand?

Durcan R, Donaghy P, Osborne C, Taylor JP, Thomas AJ.

Int J Geriatr Psychiatry. 2019 May;34(5):635-646. doi: 10.1002/gps.5071. Epub 2019 Mar 15. Review.


Linking the behavioral assessment screening tool to the international classification of functioning, disability, and health as a novel indicator of content validity.

Osborne CL, Kauvar DS, Juengst SB.

Disabil Rehabil. 2019 Jan 18:1-8. doi: 10.1080/09638288.2018.1539128. [Epub ahead of print]


Correction for Wood et al., "Enhancer Control of MicroRNA miR-155 Expression in Epstein-Barr Virus-Infected B Cells".

Wood CD, Carvell T, Gunnell A, Ojeniyi OO, Osborne C, West MJ.

J Virol. 2019 Jan 17;93(3). pii: e01893-18. doi: 10.1128/JVI.01893-18. Print 2019 Feb 1. No abstract available.


Neurologic Manifestations of Influenza A(H3N2) Infection in Children During the 2016-2017 Season.

Rao S, Martin J, Ahearn MA, Osborne C, Moss A, Dempsey A, Dominguez SR, Weinberg A, Messacar KB.

J Pediatric Infect Dis Soc. 2018 Dec 27. doi: 10.1093/jpids/piy130. [Epub ahead of print]


C4 anatomy can evolve via a single developmental change.

Lundgren MR, Dunning LT, Olofsson JK, Moreno-Villena JJ, Bouvier JW, Sage TL, Khoshravesh R, Sultmanis S, Stata M, Ripley BS, Vorontsova MS, Besnard G, Adams C, Cuff N, Mapaura A, Bianconi ME, Long CM, Christin PA, Osborne CP.

Ecol Lett. 2019 Feb;22(2):302-312. doi: 10.1111/ele.13191. Epub 2018 Dec 17.


The oral selective oestrogen receptor degrader (SERD) AZD9496 is comparable to fulvestrant in antagonising ER and circumventing endocrine resistance.

Nardone A, Weir H, Delpuech O, Brown H, De Angelis C, Cataldo ML, Fu X, Shea MJ, Mitchell T, Veeraraghavan J, Nagi C, Pilling M, Rimawi MF, Trivedi M, Hilsenbeck SG, Chamness GC, Jeselsohn R, Osborne CK, Schiff R.

Br J Cancer. 2019 Feb;120(3):331-339. doi: 10.1038/s41416-018-0354-9. Epub 2018 Dec 17.


Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor-Positive Early Breast Cancer: PALLET Trial.

Johnston S, Puhalla S, Wheatley D, Ring A, Barry P, Holcombe C, Boileau JF, Provencher L, Robidoux A, Rimawi M, McIntosh SA, Shalaby I, Stein RC, Thirlwell M, Dolling D, Morden J, Snowdon C, Perry S, Cornman C, Batten LM, Jeffs LK, Dodson A, Martins V, Modi A, Osborne CK, Pogue-Geile KL, Cheang MCU, Wolmark N, Julian TB, Fisher K, MacKenzie M, Wilcox M, Huang Bartlett C, Koehler M, Dowsett M, Bliss JM, Jacobs SA.

J Clin Oncol. 2019 Jan 20;37(3):178-189. doi: 10.1200/JCO.18.01624. Epub 2018 Dec 6.


Borrelia parkeri in Ornithodoros parkeri (Ixodida: Argasidae) Collected Using Compact Dry Ice Traps in Madera County, California.

Osborne CJ, Crosbie PR, Van Laar TA.

J Med Entomol. 2019 Feb 25;56(2):579-583. doi: 10.1093/jme/tjy213.


Cyclin E1 and Rb modulation as common events at time of resistance to palbociclib in hormone receptor-positive breast cancer.

Guarducci C, Bonechi M, Benelli M, Biagioni C, Boccalini G, Romagnoli D, Verardo R, Schiff R, Osborne CK, De Angelis C, Di Leo A, Malorni L, Migliaccio I.

NPJ Breast Cancer. 2018 Nov 28;4:38. doi: 10.1038/s41523-018-0092-4. eCollection 2018.


Factors associated with delayed and late ART initiation among people living with HIV in BC: results from the engage study.

Kesselring S, Osborne C, Bever A, Salters K, Cui Z, Chia J, Moore DM, Parashar S, Kaida A, Samji H, Duddy J, Gabler K, Howard T, Nash D, McCandless LC, Patterson TL, Corneil T, Montaner JSG, Hogg RS.

AIDS Care. 2019 Jul;31(7):885-892. doi: 10.1080/09540121.2018.1549722. Epub 2018 Nov 22.


Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection.

Growcott EJ, Cariaga TA, Morris L, Zang X, Lopez S, Ansaldi DA, Gold J, Gamboa L, Roth T, Simmons RL, Osborne CS.

J Antimicrob Chemother. 2019 Jan 1;74(1):280. doi: 10.1093/jac/dky478. No abstract available.


Bundle sheath chloroplast volume can house sufficient Rubisco to avoid limiting C4 photosynthesis during chilling.

Pignon CP, Lundgren MR, Osborne CP, Long SP.

J Exp Bot. 2019 Jan 1;70(1):357-365. doi: 10.1093/jxb/ery345.


Phylogenetic patterns and phenotypic profiles of the species of plants and mammals farmed for food.

Milla R, Bastida JM, Turcotte MM, Jones G, Violle C, Osborne CP, Chacón-Labella J, Sosinski ÊE Jr, Kattge J, Laughlin DC, Forey E, Minden V, Cornelissen JHC, Amiaud B, Kramer K, Boenisch G, He T, Pillar VD, Byun C.

Nat Ecol Evol. 2018 Nov;2(11):1808-1817. doi: 10.1038/s41559-018-0690-4. Epub 2018 Oct 22.


Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection.

Growcott EJ, Cariaga TA, Morris L, Zang X, Lopez S, Ansaldi DA, Gold J, Gamboa L, Roth T, Simmons RL, Osborne CS.

J Antimicrob Chemother. 2019 Jan 1;74(1):108-116. doi: 10.1093/jac/dky404.


The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation.

Martinez-Soria N, McKenzie L, Draper J, Ptasinska A, Issa H, Potluri S, Blair HJ, Pickin A, Isa A, Chin PS, Tirtakusuma R, Coleman D, Nakjang S, Assi S, Forster V, Reza M, Law E, Berry P, Mueller D, Osborne C, Elder A, Bomken SN, Pal D, Allan JM, Veal GJ, Cockerill PN, Wichmann C, Vormoor J, Lacaud G, Bonifer C, Heidenreich O.

Cancer Cell. 2018 Oct 8;34(4):626-642.e8. doi: 10.1016/j.ccell.2018.08.015. Erratum in: Cancer Cell. 2019 Apr 15;35(4):705.


In-hospital outcomes of STEMI patients on warfarin undergoing primary PCI.

Marbach JA, Almufleh A, Bernick J, Blondeau M, Osborne C, Russo J, Hibbert B, Froeschl M, Labinaz M, Glover C, Dick A, So D, Chong AY, Le May M.

Catheter Cardiovasc Interv. 2019 Jan 1;93(1):41-47. doi: 10.1002/ccd.27720. Epub 2018 Sep 30.


Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.

Lee PS, Lapointe G, Madera AM, Simmons RL, Xu W, Yifru A, Tjandra M, Karur S, Rico A, Thompson K, Bojkovic J, Xie L, Uehara K, Liu A, Shu W, Bellamacina C, McKenney D, Morris L, Tonn GR, Osborne C, Benton BM, McDowell L, Fu J, Sweeney ZK.

J Med Chem. 2018 Oct 25;61(20):9360-9370. doi: 10.1021/acs.jmedchem.8b01287. Epub 2018 Oct 3.


Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer.

Orlando G, Law PJ, Cornish AJ, Dobbins SE, Chubb D, Broderick P, Litchfield K, Hariri F, Pastinen T, Osborne CS, Taipale J, Houlston RS.

Nat Genet. 2018 Oct;50(10):1375-1380. doi: 10.1038/s41588-018-0211-z. Epub 2018 Sep 17.


Can synthetic urine replace authentic urine to "beat" workplace drug testing?

Kim VJ, Okano CK, Osborne CR, Frank DM, Meana CT, Castaneto MS.

Drug Test Anal. 2019 Feb;11(2):331-335. doi: 10.1002/dta.2497. Epub 2018 Oct 14.


Horizontal gene transfer of three co-inherited methane monooxygenase systems gave rise to methanotrophy in the Proteobacteria.

Osborne CD, Haritos VS.

Mol Phylogenet Evol. 2018 Dec;129:171-181. doi: 10.1016/j.ympev.2018.08.010. Epub 2018 Aug 24.


Ectomesoderm and epithelial-mesenchymal transition-related genes in spiralian development.

Osborne CC, Perry KJ, Shankland M, Henry JQ.

Dev Dyn. 2018 Oct;247(10):1097-1120. doi: 10.1002/dvdy.24667. Epub 2018 Oct 4.


First-Line Trastuzumab Plus an Aromatase Inhibitor, With or Without Pertuzumab, in Human Epidermal Growth Factor Receptor 2-Positive and Hormone Receptor-Positive Metastatic or Locally Advanced Breast Cancer (PERTAIN): A Randomized, Open-Label Phase II Trial.

Rimawi M, Ferrero JM, de la Haba-Rodriguez J, Poole C, De Placido S, Osborne CK, Hegg R, Easton V, Wohlfarth C, Arpino G; PERTAIN Study Group.

J Clin Oncol. 2018 Oct 1;36(28):2826-2835. doi: 10.1200/JCO.2017.76.7863. Epub 2018 Aug 14.


Enhancer Control of MicroRNA miR-155 Expression in Epstein-Barr Virus-Infected B Cells.

Wood CD, Carvell T, Gunnell A, Ojeniyi OO, Osborne C, West MJ.

J Virol. 2018 Sep 12;92(19). pii: e00716-18. doi: 10.1128/JVI.00716-18. Print 2018 Oct 1. Erratum in: J Virol. 2019 Jan 17;93(3):.


The Use of Ommaya Reservoirs to Deliver Central Nervous System-Directed Chemotherapy in Childhood Acute Lymphoblastic Leukaemia.

Wilson R, Osborne C, Halsey C.

Paediatr Drugs. 2018 Aug;20(4):293-301. doi: 10.1007/s40272-018-0298-9. Review.


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