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Individual and combined presenilin 1 and 2 knockouts reveal that both have highly overlapping functions in HEK293T cells.

Lessard CB, Rodriguez E, Ladd TB, Minter LM, Osborne BA, Miele L, Golde TE, Ran Y.

J Biol Chem. 2019 Jul 19;294(29):11276-11285. doi: 10.1074/jbc.RA119.008041. Epub 2019 Jun 5.


Alpha-1 Antitrypsin-Expressing Mesenchymal Stromal Cells Confer a Long-Term Survival Benefit in a Mouse Model of Lethal GvHD.

Geiger S, Ozay EI, Geumann U, Hereth MK, Magnusson T, Shanthalingam S, Hirsch D, Kälin S, Günther C, Osborne BA, Tew GN, Hermann FG, Minter LM.

Mol Ther. 2019 Aug 7;27(8):1436-1451. doi: 10.1016/j.ymthe.2019.05.007. Epub 2019 May 16.


Corrigendum: Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells.

Sorrentino C, Hossain F, Rodriguez PC, Sierra RA, Pannuti A, Hatfield S, Osborne BA, Minter LM, Miele L, Morello S.

Front Immunol. 2019 May 3;10:935. doi: 10.3389/fimmu.2019.00935. eCollection 2019.


Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells.

Sorrentino C, Hossain F, Rodriguez PC, Sierra RA, Pannuti A, Osborne BA, Minter LM, Miele L, Morello S.

Front Immunol. 2019 Feb 7;10:162. doi: 10.3389/fimmu.2019.00162. eCollection 2019. Erratum in: Front Immunol. 2019 May 03;10:935.


Cymerus™ iPSC-MSCs significantly prolong survival in a pre-clinical, humanized mouse model of Graft-vs-host disease.

Ozay EI, Vijayaraghavan J, Gonzalez-Perez G, Shanthalingam S, Sherman HL, Garrigan DT Jr, Chandiran K, Torres JA, Osborne BA, Tew GN, Slukvin II, Macdonald RA, Kelly K, Minter LM.

Stem Cell Res. 2019 Mar;35:101401. doi: 10.1016/j.scr.2019.101401. Epub 2019 Feb 1.


Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways.

Hossain F, Sorrentino C, Ucar DA, Peng Y, Matossian M, Wyczechowska D, Crabtree J, Zabaleta J, Morello S, Del Valle L, Burow M, Collins-Burow B, Pannuti A, Minter LM, Golde TE, Osborne BA, Miele L.

Front Oncol. 2018 Dec 4;8:575. doi: 10.3389/fonc.2018.00575. eCollection 2018.


Notch and T Cell Function - A Complex Tale.

Vijayaraghavan J, Osborne BA.

Adv Exp Med Biol. 2018;1066:339-354. doi: 10.1007/978-3-319-89512-3_17. Review.


Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses.

Hossain F, Majumder S, Ucar DA, Rodriguez PC, Golde TE, Minter LM, Osborne BA, Miele L.

Front Immunol. 2018 Jun 4;9:1288. doi: 10.3389/fimmu.2018.01288. eCollection 2018. Review.


Notch signaling regulates the responses of lipopolysaccharide-stimulated macrophages in the presence of immune complexes.

Wongchana W, Kongkavitoon P, Tangtanatakul P, Sittplangkoon C, Butta P, Chawalitpong S, Pattarakankul T, Osborne BA, Palaga T.

PLoS One. 2018 Jun 11;13(6):e0198609. doi: 10.1371/journal.pone.0198609. eCollection 2018.


Notch1 primes CD4 T cells for T helper type I differentiation through its early effects on miR-29.

Chandiran K, Lawlor R, Pannuti A, Perez GG, Srinivasan J, Golde TE, Miele L, Osborne BA, Minter LM.

Mol Immunol. 2018 Jul;99:191-198. doi: 10.1016/j.molimm.2018.05.002. Epub 2018 May 26.


Predicting Intention to Use Nicotine Replacement Therapy in People Attending Residential Treatment for Substance Dependence.

Kelly PJ, Townsend CJ, Osborne BA, Baker AL, Deane FP, Keane C, Ingram I, Lunn J.

J Dual Diagn. 2018 Apr-Jun;14(2):120-129. doi: 10.1080/15504263.2018.1442951. Epub 2019 Feb 17.


Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance.

Sierra RA, Trillo-Tinoco J, Mohamed E, Yu L, Achyut BR, Arbab A, Bradford JW, Osborne BA, Miele L, Rodriguez PC.

Cancer Res. 2017 Oct 15;77(20):5628-5638. doi: 10.1158/0008-5472.CAN-17-0357. Epub 2017 Sep 13.


γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct.

Ran Y, Hossain F, Pannuti A, Lessard CB, Ladd GZ, Jung JI, Minter LM, Osborne BA, Miele L, Golde TE.

EMBO Mol Med. 2017 Jul;9(7):950-966. doi: 10.15252/emmm.201607265.


The Client Satisfaction Questionnaire-8: Psychometric properties in a cross-sectional survey of people attending residential substance abuse treatment.

Kelly PJ, Kyngdon F, Ingram I, Deane FP, Baker AL, Osborne BA.

Drug Alcohol Rev. 2018 Jan;37(1):79-86. doi: 10.1111/dar.12522. Epub 2017 May 7.


Passive therapy with humanized anti-staphylococcal enterotoxin B antibodies attenuates systemic inflammatory response and protects from lethal pneumonia caused by staphylococcal enterotoxin B-producing Staphylococcus aureus.

Karau MJ, Tilahun ME, Krogman A, Osborne BA, Goldsby RA, David CS, Mandrekar JN, Patel R, Rajagopalan G.

Virulence. 2017 Oct 3;8(7):1148-1159. doi: 10.1080/21505594.2016.1267894. Epub 2016 Dec 7.


Intracellular Delivery of Anti-pPKCθ (Thr538) via Protein Transduction Domain Mimics for Immunomodulation.

Ozay EI, Gonzalez-Perez G, Torres JA, Vijayaraghavan J, Lawlor R, Sherman HL, Garrigan DT Jr, Burnside AS, Osborne BA, Tew GN, Minter LM.

Mol Ther. 2016 Dec;24(12):2118-2130. doi: 10.1038/mt.2016.177. Epub 2016 Sep 16.


Immunomodulatory effects of coated gold nanoparticles in LPS-stimulated in vitro and in vivo murine model systems.

Moyano DF, Liu Y, Ayaz F, Hou S, Puangploy P, Duncan B, Osborne BA, Rotello VM.

Chem. 2016;1(2):320-327. doi: 10.1016/j.chempr.2016.07.007. Epub 2016 Aug 11.


Impact of Notch1 Deletion in Macrophages on Proinflammatory Cytokine Production and the Outcome of Experimental Autoimmune Encephalomyelitis.

Wongchana W, Lawlor RG, Osborne BA, Palaga T.

J Immunol. 2015 Dec 1;195(11):5337-46. doi: 10.4049/jimmunol.1401770. Epub 2015 Oct 26.


Non-canonical notch signaling in cancer and immunity.

Ayaz F, Osborne BA.

Front Oncol. 2014 Dec 4;4:345. doi: 10.3389/fonc.2014.00345. eCollection 2014. Review.


Resource competition in plant invasions: emerging patterns and research needs.

Gioria M, Osborne BA.

Front Plant Sci. 2014 Sep 29;5:501. doi: 10.3389/fpls.2014.00501. eCollection 2014. Review.


Regulation of oxidative stress by methylation-controlled J protein controls macrophage responses to inflammatory insults.

Navasa N, Martín I, Iglesias-Pedraz JM, Beraza N, Atondo E, Izadi H, Ayaz F, Fernández-Álvarez S, Hatle K, Som A, Dienz O, Osborne BA, Martínez-Chantar ML, Rincón M, Anguita J.

J Infect Dis. 2015 Jan 1;211(1):135-45. doi: 10.1093/infdis/jiu389. Epub 2014 Jul 14.


NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome.

Shin HM, Tilahun ME, Cho OH, Chandiran K, Kuksin CA, Keerthivasan S, Fauq AH, Golde TE, Miele L, Thome M, Osborne BA, Minter LM.

Front Immunol. 2014 May 26;5:249. doi: 10.3389/fimmu.2014.00249. eCollection 2014.


Notch signaling regulates the phosphorylation of Akt and survival of lipopolysaccharide-activated macrophages via regulator of G protein signaling 19 (RGS19).

Sangphech N, Osborne BA, Palaga T.

Immunobiology. 2014 Sep;219(9):653-60. doi: 10.1016/j.imbio.2014.03.020. Epub 2014 Apr 6.


Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells.

Dongre A, Surampudi L, Lawlor RG, Fauq AH, Miele L, Golde TE, Minter LM, Osborne BA.

Front Immunol. 2014 Feb 12;5:54. doi: 10.3389/fimmu.2014.00054. eCollection 2014.


Importance of sequence specific hydrophobicity in synthetic protein transduction domain mimics.

Sgolastra F, Minter LM, Osborne BA, Tew GN.

Biomacromolecules. 2014 Mar 10;15(3):812-20. doi: 10.1021/bm401634r. Epub 2014 Feb 26.


γ-Secretase inhibitors and modulators.

Golde TE, Koo EH, Felsenstein KM, Osborne BA, Miele L.

Biochim Biophys Acta. 2013 Dec;1828(12):2898-907. doi: 10.1016/j.bbamem.2013.06.005. Epub 2013 Jun 17. Review.


Novel protein transduction domain mimics as nonviral delivery vectors for siRNA targeting NOTCH1 in primary human T cells.

Tezgel AÖ, Gonzalez-Perez G, Telfer JC, Osborne BA, Minter LM, Tew GN.

Mol Ther. 2013 Jan;21(1):201-9. doi: 10.1038/mt.2012.209. Epub 2012 Oct 16.


Transient pharmacologic lowering of Aβ production prior to deposition results in sustained reduction of amyloid plaque pathology.

Das P, Verbeeck C, Minter L, Chakrabarty P, Felsenstein K, Kukar T, Maharvi G, Fauq A, Osborne BA, Golde TE.

Mol Neurodegener. 2012 Aug 14;7:39. doi: 10.1186/1750-1326-7-39.


Notch and the survival of regulatory T cells: location is everything!

Minter LM, Osborne BA.

Sci Signal. 2012 Jul 24;5(234):pe31. doi: 10.1126/scisignal.2003358.


Canonical and non-canonical Notch signaling in CD4⁺ T cells.

Minter LM, Osborne BA.

Curr Top Microbiol Immunol. 2012;360:99-114. doi: 10.1007/82_2012_233. Review.


Chimeric anti-staphylococcal enterotoxin B antibodies and lovastatin act synergistically to provide in vivo protection against lethal doses of SEB.

Tilahun ME, Kwan A, Natarajan K, Quinn M, Tilahun AY, Xie C, Margulies DH, Osborne BA, Goldsby RA, Rajagopalan G.

PLoS One. 2011;6(11):e27203. doi: 10.1371/journal.pone.0027203. Epub 2011 Nov 15.


Notch signaling regulates mouse and human Th17 differentiation.

Keerthivasan S, Suleiman R, Lawlor R, Roderick J, Bates T, Minter L, Anguita J, Juncadella I, Nickoloff BJ, Le Poole IC, Miele L, Osborne BA.

J Immunol. 2011 Jul 15;187(2):692-701. doi: 10.4049/jimmunol.1003658. Epub 2011 Jun 17.


Notch, a T-ALL order.

Osborne BA.

Blood. 2011 Mar 10;117(10):2749-50. doi: 10.1182/blood-2011-01-330225. No abstract available.


The tick saliva immunosuppressor, Salp15, contributes to Th17-induced pathology during Experimental Autoimmune Encephalomyelitis.

Juncadella IJ, Bates TC, Suleiman R, Monteagudo-Mera A, Olson CM Jr, Navasa N, Olivera ER, Osborne BA, Anguita J.

Biochem Biophys Res Commun. 2010 Nov 5;402(1):105-9. doi: 10.1016/j.bbrc.2010.09.125.


Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies.

Tilahun ME, Rajagopalan G, Shah-Mahoney N, Lawlor RG, Tilahun AY, Xie C, Natarajan K, Margulies DH, Ratner DI, Osborne BA, Goldsby RA.

Infect Immun. 2010 Jun;78(6):2801-11. doi: 10.1128/IAI.01121-09. Epub 2010 Mar 22.


Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice.

Yan H, Blackburn AC, McLary SC, Tao L, Roberts AL, Xavier EA, Dickinson ES, Seo JH, Arenas RB, Otis CN, Cao QJ, Lawlor RG, Osborne BA, Kittrell FS, Medina D, Jerry DJ.

Am J Pathol. 2010 Mar;176(3):1421-32. doi: 10.2353/ajpath.2010.090438. Epub 2010 Jan 28.


Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.

Hao L, Rizzo P, Osipo C, Pannuti A, Wyatt D, Cheung LW, Sonenshein G, Osborne BA, Miele L.

Oncogene. 2010 Jan 14;29(2):201-13. doi: 10.1038/onc.2009.323. Epub 2009 Oct 19.


Phosphorylation of Nur77 by the MEK-ERK-RSK cascade induces mitochondrial translocation and apoptosis in T cells.

Wang A, Rud J, Olson CM Jr, Anguita J, Osborne BA.

J Immunol. 2009 Sep 1;183(5):3268-77. doi: 10.4049/jimmunol.0900894. Epub 2009 Aug 12.


Notch regulates cytolytic effector function in CD8+ T cells.

Cho OH, Shin HM, Miele L, Golde TE, Fauq A, Minter LM, Osborne BA.

J Immunol. 2009 Mar 15;182(6):3380-9. doi: 10.4049/jimmunol.0802598.


B-CLL kicks it up a Notch.

Osborne BA.

Blood. 2009 Jan 22;113(4):765-6. doi: 10.1182/blood-2008-10-182998. No abstract available.


Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases.

Joshi I, Minter LM, Telfer J, Demarest RM, Capobianco AJ, Aster JC, Sicinski P, Fauq A, Golde TE, Osborne BA.

Blood. 2009 Feb 19;113(8):1689-98. doi: 10.1182/blood-2008-03-147967. Epub 2008 Nov 10.


Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells.

Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, Das P, Golde TE, Osborne BA.

Blood. 2008 Sep 1;112(5):1813-21. doi: 10.1182/blood-2008-03-144980. Epub 2008 Jun 11.


Notch signaling is activated by TLR stimulation and regulates macrophage functions.

Palaga T, Buranaruk C, Rengpipat S, Fauq AH, Golde TE, Kaufmann SH, Osborne BA.

Eur J Immunol. 2008 Jan;38(1):174-83.


Off the beaten pathway: the complex cross talk between Notch and NF-kappaB.

Osipo C, Golde TE, Osborne BA, Miele LA.

Lab Invest. 2008 Jan;88(1):11-7. Epub 2007 Dec 3.


c-Jun N-terminal kinase 1 is required for Toll-like receptor 1 gene expression in macrophages.

Izadi H, Motameni AT, Bates TC, Olivera ER, Villar-Suarez V, Joshi I, Garg R, Osborne BA, Davis RJ, Rincón M, Anguita J.

Infect Immun. 2007 Oct;75(10):5027-34. Epub 2007 Jul 30.


Notch signalling during peripheral T-cell activation and differentiation.

Osborne BA, Minter LM.

Nat Rev Immunol. 2007 Jan;7(1):64-75. Epub 2006 Dec 15. Review.


Defects of immune regulation in the presenilin-1 mutant knockin mouse.

Morgan GA, Guo Q, Chan SL, Gary DS, Osborne BA, Mattson MP.

Neuromolecular Med. 2007;9(1):35-45.


Dying for a living: plants do it too.

Rubinstein B, Osborne BA.

Cell Death Differ. 1997 Dec;4(8):647-8. No abstract available.


Notch1 augments NF-kappaB activity by facilitating its nuclear retention.

Shin HM, Minter LM, Cho OH, Gottipati S, Fauq AH, Golde TE, Sonenshein GE, Osborne BA.

EMBO J. 2006 Jan 11;25(1):129-38. Epub 2005 Dec 1.


Hyperbaric oxygen inhibits benign and malignant human mammary epithelial cell proliferation.

Granowitz EV, Tonomura N, Benson RM, Katz DM, Band V, Makari-Judson GP, Osborne BA.

Anticancer Res. 2005 Nov-Dec;25(6B):3833-42.

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