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Items: 40


Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.

Osborn MF, Coles AH, Biscans A, Haraszti RA, Roux L, Davis S, Ly S, Echeverria D, Hassler MR, Godinho BMDC, Nikan M, Khvorova A.

Nucleic Acids Res. 2019 Feb 20;47(3):1070-1081. doi: 10.1093/nar/gky1232.


Novel Cluster and Monomer-Based GalNAc Structures Induce Effective Uptake of siRNAs in Vitro and in Vivo.

Sharma VK, Osborn MF, Hassler MR, Echeverria D, Ly S, Ulashchik EA, Martynenko-Makaev YV, Shmanai VV, Zatsepin TS, Khvorova A, Watts JK.

Bioconjug Chem. 2018 Jul 18;29(7):2478-2488. doi: 10.1021/acs.bioconjchem.8b00365. Epub 2018 Jul 2.


Improving siRNA Delivery In Vivo Through Lipid Conjugation.

Osborn MF, Khvorova A.

Nucleic Acid Ther. 2018 Jun;28(3):128-136. doi: 10.1089/nat.2018.0725. Epub 2018 May 10. Review.


Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.

Osborn MF, Coles AH, Golebiowski D, Echeverria D, Moazami MP, Watts JK, Sena-Esteves M, Khvorova A.

Mol Cancer Ther. 2018 Jun;17(6):1251-1258. doi: 10.1158/1535-7163.MCT-17-1144. Epub 2018 Apr 13.


Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.

Hassler MR, Turanov AA, Alterman JF, Haraszti RA, Coles AH, Osborn MF, Echeverria D, Nikan M, Salomon WE, Roux L, Godinho BMDC, Davis SM, Morrissey DV, Zamore PD, Karumanchi SA, Moore MJ, Aronin N, Khvorova A.

Nucleic Acids Res. 2018 Mar 16;46(5):2185-2196. doi: 10.1093/nar/gky037.


Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.

Nikan M, Osborn MF, Coles AH, Biscans A, Godinho BMDC, Haraszti RA, Sapp E, Echeverria D, DiFiglia M, Aronin N, Khvorova A.

Bioconjug Chem. 2017 Jun 21;28(6):1758-1766. doi: 10.1021/acs.bioconjchem.7b00226. Epub 2017 May 10.


Adolescent Male With Knee Pain and Swelling.

Osborn MF, Cutright A.

Ann Emerg Med. 2016 Dec;68(6):779-792. doi: 10.1016/j.annemergmed.2016.04.004. No abstract available.


Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain.

Nikan M, Osborn MF, Coles AH, Godinho BM, Hall LM, Haraszti RA, Hassler MR, Echeverria D, Aronin N, Khvorova A.

Mol Ther Nucleic Acids. 2016 Aug 9;5(8):e344. doi: 10.1038/mtna.2016.50.


Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain.

Alterman JF, Hall LM, Coles AH, Hassler MR, Didiot MC, Chase K, Abraham J, Sottosanti E, Johnson E, Sapp E, Osborn MF, Difiglia M, Aronin N, Khvorova A.

Mol Ther Nucleic Acids. 2015 Dec 1;4:e266. doi: 10.1038/mtna.2015.38.


A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo.

Coles AH, Osborn MF, Alterman JF, Turanov AA, Godinho BM, Kennington L, Chase K, Aronin N, Khvorova A.

Nucleic Acid Ther. 2016 Apr;26(2):86-92. doi: 10.1089/nat.2015.0578. Epub 2015 Nov 23.


Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.

Osborn MF, Alterman JF, Nikan M, Cao H, Didiot MC, Hassler MR, Coles AH, Khvorova A.

Nucleic Acids Res. 2015 Oct 15;43(18):8664-72. doi: 10.1093/nar/gkv942. Epub 2015 Sep 22.


Corrigendum: Taking charge of siRNA delivery.

Khvorova A, Osborn MF, Hassler MR.

Nat Biotechnol. 2015 May;33(5):563. doi: 10.1038/nbt0515-563c. No abstract available.


Taking charge of siRNA delivery.

Khvorova A, Osborn MF, Hassler MR.

Nat Biotechnol. 2014 Dec;32(12):1197-8. doi: 10.1038/nbt.3091. Erratum in: Nat Biotechnol. 2015 May;33(5):563.


Platinum-RNA modifications following drug treatment in S. cerevisiae identified by click chemistry and enzymatic mapping.

Osborn MF, White JD, Haley MM, DeRose VJ.

ACS Chem Biol. 2014 Oct 17;9(10):2404-11. doi: 10.1021/cb500395z. Epub 2014 Aug 15.


Metabolic syndrome associated with ischemic stroke among the Mexican Hispanic population in the El Paso/US-Mexico border region.

Osborn MF, Miller CC, Badr A, Zhang J.

J Stroke Cerebrovasc Dis. 2014 Jul;23(6):1477-84. doi: 10.1016/j.jstrokecerebrovasdis.2013.12.017. Epub 2014 Feb 16.


Picazoplatin, an azide-containing platinum(II) derivative for target analysis by click chemistry.

White JD, Osborn MF, Moghaddam AD, Guzman LE, Haley MM, DeRose VJ.

J Am Chem Soc. 2013 Aug 14;135(32):11680-3. doi: 10.1021/ja402453k. Epub 2013 Aug 6.


Embryologic Association of Tornwaldt's Cyst with Cerebral Artery Abnormalities and Infarction: A Case Report.

Osborn MF, Buchanan BK, Akle N, Badr A, Zhang J.

Case Rep Pediatr. 2012;2012:129503. doi: 10.1155/2012/129503. Epub 2012 Oct 8.


Binding of kinetically inert metal ions to RNA: the case of platinum(II).

Chapman EG, Hostetter AA, Osborn MF, Miller AL, DeRose VJ.

Met Ions Life Sci. 2011;9:347-77. Review.


RNA-Pt adducts following cisplatin treatment of Saccharomyces cerevisiae.

Hostetter AA, Osborn MF, DeRose VJ.

ACS Chem Biol. 2012 Jan 20;7(1):218-25. doi: 10.1021/cb200279p. Epub 2011 Nov 15.


Excited state proton transfer in the red fluorescent protein mKeima.

Henderson JN, Osborn MF, Koon N, Gepshtein R, Huppert D, Remington SJ.

J Am Chem Soc. 2009 Sep 23;131(37):13212-3. doi: 10.1021/ja904665x.


Obstetric factitious disorder: is it more common than we think?

Guthrie EA, Lavin JM, Rosimilia A, Tasker M, Osborn MF, Donnai P.

Br J Clin Pract. 1996 Mar;50(2):113-4.


Improved sensitivity of an enzyme immunoassay IDEIA for detecting Chlamydia trachomatis.

Thomas BJ, Osborn MF, Gilchrist C, Taylor-Robinson D.

J Clin Pathol. 1989 Jul;42(7):759-62.


Evidence that Chlamydia trachomatis causes seronegative arthritis in women.

Taylor-Robinson D, Thomas BJ, Dixey J, Osborn MF, Furr PM, Keat AC.

Ann Rheum Dis. 1988 Apr;47(4):295-9.


Susceptibility of different serovars of Chlamydia trachomatis to inactivation by normal human serum.

Osborn MF, Johnson AP, Taylor-Robinson D.

Genitourin Med. 1985 Aug;61(4):244-6.


A study of the susceptibility of three species of primate to vaginal colonization with Gardnerella vaginalis.

Johnson AP, Ison CA, Hetherington CM, Osborn MF, Southerton G, London WT, Easmon CS, Taylor-Robinson D.

Br J Exp Pathol. 1984 Jun;65(3):389-96.


A colposcopic and histological study of experimental chlamydial cervicitis in marmosets.

Johnson AP, Hare MJ, Wilbanks GD, Cooper P, Hetherington CM, Al-Kurdi M, Osborn MF, Taylor-Robinson D.

Br J Exp Pathol. 1984 Feb;65(1):59-65.


Vaginal colonization of pig-tailed macaques by Gardnerella vaginalis.

Johnson AP, Ison CA, Hetherington CM, Osborn MF, Southerton G, London WT, Easmon CS, Taylor-Robinson D.

Scand J Urol Nephrol Suppl. 1984;86:207-10.


A study of inactivation of Chlamydia trachomatis by normal human serum.

Johnson AP, Osborn MF, Rowntree S, Thomas BJ, Taylor-Robinson D.

Br J Vener Dis. 1983 Dec;59(6):369-72.


Scanning electron microscopy of the interaction between Haemophilus influenzae and organ cultures of rat trachea.

Johnson AP, Clark JB, Osborn MF.

J Med Microbiol. 1983 Nov;16(4):477-82.


Sexual problems in obstetrics and gynaecology.

Osborn MF.

Br J Hosp Med. 1983 Oct;30(4):264-6, 268.


A study of the relationship between ABO blood groups, secretor status and infection with Neisseria gonorrhoeae.

Johnson AP, Osborn MF, Hanna NF, Dawson SG, McManus TJ, Taylor-Robinson D.

J Infect. 1983 Mar;6(2):171-4.


Immunity to reinfection of the genital tract of marmosets with Chlamydia trachomatis.

Johnson AP, Osborn MF, Thomas BJ, Hetherington CM, Taylor-Robinson D.

Br J Exp Pathol. 1981 Dec;62(6):606-13.


Experimental infection of the marmoset genital tract with Chlamydia trachomatis.

Johnson AP, Hetherington CM, Osborn MF, Thomas BJ, Taylor-Robinson D.

Br J Exp Pathol. 1980 Jun;61(3):291-5.


Effect of T-cell deficiency on the chronicity of arthritis induced in mice by Mycoplasma pulmonis.

Keystone EC, Taylor-Robinson D, Osborn MF, Ling L, Pope C, Fornasier V.

Infect Immun. 1980 Jan;27(1):192-6.


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