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Chitinolytic proteins secreted by Cellulosimicrobium sp. NTK2.

Niki D, Higashitani A, Osada H, Bito T, Shimizu K, Arima J.

FEMS Microbiol Lett. 2020 Apr 2. pii: fnaa055. doi: 10.1093/femsle/fnaa055. [Epub ahead of print]


Induction of secondary metabolite production by hygromycin B and identification of the 1233A biosynthetic gene cluster with a self-resistance gene.

Kato S, Motoyama T, Uramoto M, Nogawa T, Kamakura T, Osada H.

J Antibiot (Tokyo). 2020 Mar 5. doi: 10.1038/s41429-020-0295-4. [Epub ahead of print]


Epidemic of influenza A(H1N1)pdm09 analyzed by full genome sequences and the first case of oseltamivir-resistant strain in Myanmar 2017.

Kyaw Win SM, Saito R, Win NC, Lasham DJ, Kyaw Y, Lin N, Thein KN, Chon I, Odagiri T, Thein W, Kyaw LL, Tin OS, Saitoh A, Tamura T, Hirokawa C, Uchida Y, Saito T, Watanabe S, Odagiri T, Kamata K, Osada H, Dapat C, Watanabe H, Tin HH.

PLoS One. 2020 Mar 4;15(3):e0229601. doi: 10.1371/journal.pone.0229601. eCollection 2020.


Neuroprotective and vision-protective effect of preserving ATP levels by AMPK activator.

Kawashima H, Ozawa Y, Toda E, Homma K, Osada H, Narimatsu T, Nagai N, Tsubota K.

FASEB J. 2020 Feb 24. doi: 10.1096/fj.201902387RR. [Epub ahead of print]


Qualitative investigation of the factors that generate ambivalent feelings in women who give birth after receiving negative results from non-invasive prenatal testing.

Yotsumoto J, Sekizawa A, Inoue S, Suzumori N, Samura O, Yamada T, Miura K, Masuzaki H, Sawai H, Murotsuki J, Hamanoue H, Kamei Y, Endo T, Fukushima A, Katagiri Y, Takeshita N, Ogawa M, Nishizawa H, Okamoto Y, Tairaku S, Kaji T, Maeda K, Matsubara K, Ogawa M, Osada H, Ohba T, Kawano Y, Sasaki A, Sago H; Japan NIPT Consortium.

BMC Pregnancy Childbirth. 2020 Feb 17;20(1):112. doi: 10.1186/s12884-020-2763-z.


Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94.

Kato S, Motoyama T, Futamura Y, Uramoto M, Nogawa T, Hayashi T, Hirota H, Tanaka A, Takahashi-Ando N, Kamakura T, Osada H.

Biosci Biotechnol Biochem. 2020 Feb 11:1-5. doi: 10.1080/09168451.2020.1725419. [Epub ahead of print]


Pre-operative Evaluation of Lateral Pelvic Lymph Node Metastasis in Lower Rectal Cancer: Comparison of Three Different Imaging Modalities.

Amano K, Fukuchi M, Kumamoto K, Hatano S, Ohno H, Osada H, Ishibashi K, Ishida H.

J Anus Rectum Colon. 2020 Jan 30;4(1):34-40. doi: 10.23922/jarc.2019-022. eCollection 2020.


Productivity and bioactivity of enokipodins A-D of Flammulina rossica and Flammulina velutipes.

Tabuchi A, Fukushima-Sakuno E, Osaki-Oka K, Futamura Y, Motoyama T, Osada H, Ishikawa NK, Nagasawa E, Tokimoto K.

Biosci Biotechnol Biochem. 2020 Jan 16:1-11. doi: 10.1080/09168451.2020.1714421. [Epub ahead of print]


Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.

Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.

Cell Chem Biol. 2020 Feb 20;27(2):186-196.e4. doi: 10.1016/j.chembiol.2019.11.010. Epub 2019 Dec 5.


An integrated screening system for the selection of exemplary substrates for natural and engineered cytochrome P450s.

Kanoh N, Kawamata-Asano A, Suzuki K, Takahashi Y, Miyazawa T, Nakamura T, Moriya T, Hirano H, Osada H, Iwabuchi Y, Takahashi S.

Sci Rep. 2019 Dec 2;9(1):18023. doi: 10.1038/s41598-019-54473-8.


Dietary Spirulina Supplementation Protects Visual Function From Photostress by Suppressing Retinal Neurodegeneration in Mice.

Okamoto T, Kawashima H, Osada H, Toda E, Homma K, Nagai N, Imai Y, Tsubota K, Ozawa Y.

Transl Vis Sci Technol. 2019 Nov 20;8(6):20. doi: 10.1167/tvst.8.6.20. eCollection 2019 Nov.


Special issue: Nucleoside antibiotics, polyoxin and beyond.

Osada H.

J Antibiot (Tokyo). 2019 Dec;72(12):853-854. doi: 10.1038/s41429-019-0238-0. Epub 2019 Nov 27. No abstract available.


CRM646-A, a Fungal Metabolite, Induces Nucleus Condensation by Increasing Ca2+ Levels in Rat 3Y1 Fibroblast Cells.

Asami Y, Kim SO, Jang JP, Ko SK, Kim BY, Osada H, Jang JH, Ahn JS.

J Microbiol Biotechnol. 2020 Jan 28;30(1):31-37. doi: 10.4014/jmb.1908.08043.


Prematurely ruptured dominant follicles often retain competent oocytes in infertile women.

Teramoto S, Osada H, Shozu M.

Sci Rep. 2019 Oct 21;9(1):15041. doi: 10.1038/s41598-019-51551-9.


Comparison of microplate- and bottle-based methods to age yeast for chronological life span assays.

Kwong MMY, Lee JW, Samian MR, Watanabe N, Osada H, Ong EBB.

J Microbiol Methods. 2019 Dec;167:105743. doi: 10.1016/j.mimet.2019.105743. Epub 2019 Oct 16.


YO-001A, a new antifungal agent produced by Streptomyces sp. YO15-A001.

Yamamoto K, Futamura Y, Uson-Lopez RA, Aono H, Shimizu T, Osada H.

J Antibiot (Tokyo). 2019 Dec;72(12):986-990. doi: 10.1038/s41429-019-0239-z. Epub 2019 Oct 10.


Discovery and applications of nucleoside antibiotics beyond polyoxin.

Osada H.

J Antibiot (Tokyo). 2019 Dec;72(12):855-864. doi: 10.1038/s41429-019-0237-1. Epub 2019 Sep 25. Review.


Distribution of corneal spherical aberration in a Tanzanian population.

Asano H, Hiraoka T, Seki Y, Shibata T, Osada H, Saruta T, Hatsusaka N, Fujikake F, Tabata Y, Mhina C, Sanyiwa A, Oshika T, Sasaki H.

PLoS One. 2019 Sep 12;14(9):e0222297. doi: 10.1371/journal.pone.0222297. eCollection 2019.


Abscisic Acid Derivatives with Different Alkyl Chain Lengths Activate Distinct Abscisic Acid Receptor Subfamilies.

Yoshida K, Kondoh Y, Iwahashi F, Nakano T, Honda K, Nagano E, Osada H.

ACS Chem Biol. 2019 Sep 20;14(9):1964-1971. doi: 10.1021/acschembio.9b00453. Epub 2019 Sep 9.


Structure and biological activity of Metarhizin C, a stereoisomer of BR-050 from Tolypocladium album RK17-F0007.

Nogawa T, Kawatani M, Okano A, Futamura Y, Aono H, Shimizu T, Kato N, Kikuchi H, Osada H.

J Antibiot (Tokyo). 2019 Dec;72(12):996-1000. doi: 10.1038/s41429-019-0229-1. Epub 2019 Sep 3.


The factor structure and construct validity of the parent-reported Inventory of Callous-Unemotional Traits among school-aged children and adolescents.

Yoshida S, Adachi M, Takahashi M, Takanyanagi N, Yasuda S, Osada H, Nakamura K.

PLoS One. 2019 Aug 16;14(8):e0221046. doi: 10.1371/journal.pone.0221046. eCollection 2019.


Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647.

Lopez JAV, Nogawa T, Futamura Y, Shimizu T, Osada H.

J Antibiot (Tokyo). 2019 Dec;72(12):991-995. doi: 10.1038/s41429-019-0217-5. Epub 2019 Aug 8.


Mechanism of Action of Prethioviridamide, an Anticancer Ribosomally Synthesized and Post-Translationally Modified Peptide with a Polythioamide Structure.

Takase S, Kurokawa R, Kondoh Y, Honda K, Suzuki T, Kawahara T, Ikeda H, Dohmae N, Osada H, Shin-Ya K, Kushiro T, Yoshida M, Matsumoto K.

ACS Chem Biol. 2019 Aug 16;14(8):1819-1828. doi: 10.1021/acschembio.9b00410. Epub 2019 Jul 31.


Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice.

Li J, Sun K, Muroi M, Gao L, Chang YT, Osada H, Xiang L, Qi J.

J Cell Mol Med. 2019 Sep;23(9):6283-6294. doi: 10.1111/jcmm.14514. Epub 2019 Jun 30.


Structure Characterization and Action Mechanism of an Antiaging New Compound from Gastrodia elata Blume.

Farooq U, Pan Y, Lin Y, Wang Y, Osada H, Xiang L, Qi J.

Oxid Med Cell Longev. 2019 May 6;2019:5459862. doi: 10.1155/2019/5459862. eCollection 2019.


Aquaporin 4 Suppresses Neural Hyperactivity and Synaptic Fatigue and Fine-Tunes Neurotransmission to Regulate Visual Function in the Mouse Retina.

Ozawa Y, Toda E, Kawashima H, Homma K, Osada H, Nagai N, Abe Y, Yasui M, Tsubota K.

Mol Neurobiol. 2019 Dec;56(12):8124-8135. doi: 10.1007/s12035-019-01661-2. Epub 2019 Jun 12.


Dementia Cafés as a Community Resource for Persons With Early-Stage Cognitive Disorders: A Nationwide Survey in Japan.

Takechi H, Yabuki T, Takahashi M, Osada H, Kato S.

J Am Med Dir Assoc. 2019 Dec;20(12):1515-1520. doi: 10.1016/j.jamda.2019.04.017. Epub 2019 May 31.


Age-specific values of Access anti-Müllerian hormone immunoassay carried out on Japanese patients with infertility: a retrospective large-scale study.

Segawa T, Omi K, Watanabe Y, Sone Y, Handa M, Kuroda M, Miyauchi O, Osada H, Teramoto S.

BMC Womens Health. 2019 Apr 25;19(1):57. doi: 10.1186/s12905-019-0752-z.


β-carboline biomediators induce reveromycin production in Streptomyces sp. SN-593.

Panthee S, Takahashi S, Hayashi T, Shimizu T, Osada H.

Sci Rep. 2019 Apr 9;9(1):5802. doi: 10.1038/s41598-019-42268-w.


Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors.

Shu K, Iwamoto N, Honda K, Kondoh Y, Hirano H, Osada H, Ohno H, Fujii N, Oishi S.

Bioconjug Chem. 2019 May 15;30(5):1395-1404. doi: 10.1021/acs.bioconjchem.9b00154. Epub 2019 Apr 17.


A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.

Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H.

FEBS Lett. 2019 Apr;593(8):763-776. doi: 10.1002/1873-3468.13361. Epub 2019 Mar 23.


Pregnancy and neonatal outcomes of small follicle-derived blastocyst transfer in modified natural cycle in vitro fertilization.

Teramoto S, Osada H, Sato Y, Shozu M.

Fertil Steril. 2019 Apr;111(4):747-752. doi: 10.1016/j.fertnstert.2018.11.038. Epub 2019 Feb 28.


3β,23,28-Trihydroxy-12-oleanene 3β-Caffeate from Desmodium sambuense-Induced Neurogenesis in PC12 Cells Mediated by ER Stress and BDNF-TrkB Signaling Pathways.

Cheng L, Muroi M, Cao S, Bian L, Osada H, Xiang L, Qi J.

Mol Pharm. 2019 Apr 1;16(4):1423-1432. doi: 10.1021/acs.molpharmaceut.8b00939. Epub 2019 Feb 26.


Mechanism of the natural product moracin-O derived MO-460 and its targeting protein hnRNPA2B1 on HIF-1α inhibition.

Soung NK, Kim HM, Asami Y, Kim DH, Cho Y, Naik R, Jang Y, Jang K, Han HJ, Ganipisetti SR, Cha-Molstad H, Hwang J, Lee KH, Ko SK, Jang JH, Ryoo IJ, Kwon YT, Lee KS, Osada H, Lee K, Kim BY, Ahn JS.

Exp Mol Med. 2019 Feb 12;51(2):1-14. doi: 10.1038/s12276-018-0200-4.


Ultraviolet B-induced Otx2 expression in lens epithelial cells promotes epithelial-mesenchymal transition.

Yoshitomi Y, Osada H, Satake H, Kojima M, Saito-Takatsuji H, Ikeda T, Yoshitake Y, Ishigaki Y, Kubo E, Sasaki H, Yonekura H.

Biol Open. 2019 Feb 18;8(2). pii: bio035691. doi: 10.1242/bio.035691.


Identification of a chemical modulator of EZH2-mediated silencing by cell-based high-throughput screening assay.

Murashima A, Shinjo K, Katsushima K, Onuki T, Kondoh Y, Osada H, Kagaya N, Shin-Ya K, Kimura H, Yoshida M, Murakami S, Kondo Y.

J Biochem. 2019 Jul 1;166(1):41-50. doi: 10.1093/jb/mvz007.


Using BEAN-counter to quantify genetic interactions from multiplexed barcode sequencing experiments.

Simpkins SW, Deshpande R, Nelson J, Li SC, Piotrowski JS, Ward HN, Yashiroda Y, Osada H, Yoshida M, Boone C, Myers CL.

Nat Protoc. 2019 Feb;14(2):415-440. doi: 10.1038/s41596-018-0099-1.


A small-molecule ligand of valosin-containing protein/p97 inhibits cancer cell-accelerated fibroblast migration.

Suvarna K, Honda K, Muroi M, Kondoh Y, Osada H, Watanabe N.

J Biol Chem. 2019 Mar 1;294(9):2988-2996. doi: 10.1074/jbc.RA118.004741. Epub 2019 Jan 4.


Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists.

Mikame Y, Yoshida K, Hashizume D, Hirai G, Nagasawa K, Osada H, Sodeoka M.

Chemistry. 2019 Mar 7;25(14):3496-3500. doi: 10.1002/chem.201806056. Epub 2019 Feb 12.


Classification of factors involved in nonreportable results of noninvasive prenatal testing (NIPT) and prediction of success rate of second NIPT.

Suzumori N, Sekizawa A, Takeda E, Samura O, Sasaki A, Akaishi R, Wada S, Hamanoue H, Hirahara F, Kuriki H, Sawai H, Nakamura H, Yamada T, Miura K, Masuzaki H, Yamashita T, Kamei Y, Namba A, Murotsuki J, Tanemoto T, Fukushima A, Haino K, Tairaku S, Matsubara K, Maeda K, Kaji T, Ogawa M, Osada H, Nishizawa H, Okamoto Y, Kanagawa T, Kakigano A, Endo M, Kitagawa M, Ogawa M, Izumi S, Katagiri Y, Takeshita N, Kasai Y, Naruse K, Neki R, Masuyama H, Hyodo M, Kawano Y, Ohba T, Ichizuka K, Nagamatsu T, Watanabe A, Nishikawa N, Hamajima N, Shirato N, Yotsumoto J, Nishiyama M, Koide K, Hirose T, Sago H.

Prenat Diagn. 2019 Jan;39(2):100-106. doi: 10.1002/pd.5408. Epub 2019 Jan 10.


Proteomic Profiling for Target Identification of Biologically Active Small Molecules Using 2D DIGE.

Muroi M, Osada H.

Methods Mol Biol. 2019;1888:127-139. doi: 10.1007/978-1-4939-8891-4_7.


Induction of Nectriapyrone Biosynthesis in the Rice Blast Fungus Pyricularia oryzae by Disturbance of the Two-Component Signal Transduction System.

Motoyama T, Nogawa T, Hayashi T, Hirota H, Osada H.

Chembiochem. 2019 Mar 1;20(5):693-700. doi: 10.1002/cbic.201800620. Epub 2019 Jan 23.


Efficacy and safety of growth hormone treatment in Japanese children with small-for-gestational-age short stature in accordance with Japanese guidelines.

Yokoya S, Tanaka T, Itabashi K, Osada H, Hirai H, Seino Y.

Clin Pediatr Endocrinol. 2018;27(4):225-234. doi: 10.1297/cpe.27.225. Epub 2018 Oct 30.


Catenulisporolides, Glycosylated Triene Macrolides from the Chemically Underexploited Actinomycete Catenulispora Species.

Son S, Hong YS, Futamura Y, Jang M, Lee JK, Heo KT, Ko SK, Lee JS, Takahashi S, Osada H, Jang JH, Ahn JS.

Org Lett. 2018 Nov 16;20(22):7234-7238. doi: 10.1021/acs.orglett.8b03160. Epub 2018 Oct 31.


Predicting bioprocess targets of chemical compounds through integration of chemical-genetic and genetic interactions.

Simpkins SW, Nelson J, Deshpande R, Li SC, Piotrowski JS, Wilson EH, Gebre AA, Safizadeh H, Okamoto R, Yoshimura M, Costanzo M, Yashiroda Y, Ohya Y, Osada H, Yoshida M, Boone C, Myers CL.

PLoS Comput Biol. 2018 Oct 30;14(10):e1006532. doi: 10.1371/journal.pcbi.1006532. eCollection 2018 Oct.


Correction to "Structures and Synthesis of Hitoyopodins: Bioactive Aromatic Sesquiterpenoids Produced by the Mushroom Coprinopsis cinerea".

Otaka J, Shimizu T, Futamura Y, Hashizume D, Osada H.

Org Lett. 2018 Nov 16;20(22):7352. doi: 10.1021/acs.orglett.8b03400. Epub 2018 Oct 29. No abstract available.


Anti-Angiogenesis Effects Induced by Octaminomycins A and B against HUVECs.

Jang JP, Han JM, Jung HJ, Osada H, Jang JH, Ahn JS.

J Microbiol Biotechnol. 2018 Aug 28;28(8):1332-1338. doi: 10.4014/jmb.1806.06046.


Construction of a potato fraction library for the investigation of functional secondary metabolites.

Nogawa T, Futamura Y, Okano A, Suto M, Nakamura J, Ishihara K, Osada H.

Biosci Biotechnol Biochem. 2019 Jan;83(1):65-75. doi: 10.1080/09168451.2018.1525273. Epub 2018 Oct 5.


Structures and Synthesis of Hitoyopodins: Bioactive Aromatic Sesquiterpenoids Produced by the Mushroom Coprinopsis cinerea.

Otaka J, Shimizu T, Futamura Y, Hashizume D, Osada H.

Org Lett. 2018 Oct 5;20(19):6294-6297. doi: 10.1021/acs.orglett.8b02788. Epub 2018 Sep 20. Erratum in: Org Lett. 2018 Nov 16;20(22):7352.


Aturanosides A and B, Glycosylated Anthraquinones with Antiangiogenic Activity from a Soil-Derived Streptomyces Species.

Jang JP, Hwang GJ, Jang M, Takahashi S, Ko SK, Osada H, Jang JH, Ahn JS.

J Nat Prod. 2018 Sep 28;81(9):2004-2009. doi: 10.1021/acs.jnatprod.8b00307. Epub 2018 Sep 12.


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