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Items: 1 to 50 of 84

1.

Expression and functional analyses of ephrin type-A receptor 2 in mouse spermatogonial stem cells†.

Morimoto H, Kanatsu-Shinohara M, Orwig KE, Shinohara T.

Biol Reprod. 2020 Feb 12;102(1):220-232. doi: 10.1093/biolre/ioz156.

PMID:
31403678
2.

Fertility Preservation Outcomes in Adolescent and Young Adult Feminizing Transgender Patients.

Barnard EP, Dhar CP, Rothenberg SS, Menke MN, Witchel SF, Montano GT, Orwig KE, Valli-Pulaski H.

Pediatrics. 2019 Sep;144(3). pii: e20183943. doi: 10.1542/peds.2018-3943. Epub 2019 Aug 5.

PMID:
31383814
3.

Testicular tissue cryopreservation: 8 years of experience from a coordinated network of academic centers.

Valli-Pulaski H, Peters KA, Gassei K, Steimer SR, Sukhwani M, Hermann BP, Dwomor L, David S, Fayomi AP, Munyoki SK, Chu T, Chaudhry R, Cannon GM, Fox PJ, Jaffe TM, Sanfilippo JS, Menke MN, Lunenfeld E, Abofoul-Azab M, Sender LS, Messina J, Klimpel LM, Gosiengfiao Y, Rowell EE, Hsieh MH, Granberg CF, Reddy PP, Sandlow JI, Huleihel M, Orwig KE.

Hum Reprod. 2019 Jun 4;34(6):966-977. doi: 10.1093/humrep/dez043.

4.

Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring.

Fayomi AP, Peters K, Sukhwani M, Valli-Pulaski H, Shetty G, Meistrich ML, Houser L, Robertson N, Roberts V, Ramsey C, Hanna C, Hennebold JD, Dobrinski I, Orwig KE.

Science. 2019 Mar 22;363(6433):1314-1319. doi: 10.1126/science.aav2914. Erratum in: Science. 2019 Apr 5;364(6435):.

5.

Testicular wedge biopsy for fertility preservation in children at significant risk for azoospermia after gonadotoxic therapy.

Corkum KS, Lautz TB, Johnson EK, Reimann MB, Walz AL, Lockart BA, Brannigan RE, ValliPulaski H, Orwig KE, Rowell EE.

J Pediatr Surg. 2019 Sep;54(9):1901-1905. doi: 10.1016/j.jpedsurg.2019.01.055. Epub 2019 Feb 21.

PMID:
30853246
6.

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche.

Sosa E, Chen D, Rojas EJ, Hennebold JD, Peters KA, Wu Z, Lam TN, Mitchell JM, Sukhwani M, Tailor RC, Meistrich ML, Orwig KE, Shetty G, Clark AT.

Nat Commun. 2018 Dec 17;9(1):5339. doi: 10.1038/s41467-018-07740-7.

7.

Effect of hormone modulations on donor-derived spermatogenesis or colonization after syngeneic and xenotransplantation in mice.

Shetty G, Wu Z, Lam TNA, Phan TT, Orwig KE, Meistrich ML.

Andrology. 2019 Mar;7(2):257-265. doi: 10.1111/andr.12571. Epub 2018 Nov 23.

PMID:
30471208
8.

Donor spermatogenesis in de novo formed seminiferous tubules from transplanted testicular cells in rhesus monkey testis.

Shetty G, Mitchell JM, Lam TNA, Wu Z, Zhang J, Hill L, Tailor RC, Peters KA, Penedo MC, Orwig KE, Meistrich ML.

Hum Reprod. 2018 Dec 1;33(12):2249-2255. doi: 10.1093/humrep/dey316.

9.

Human Testis Extracellular Matrix Enhances Human Spermatogonial Stem Cell Survival In Vitro.

Murdock MH, David S, Swinehart IT, Reing JE, Tran K, Gassei K, Orwig KE, Badylak SF.

Tissue Eng Part A. 2019 Apr;25(7-8):663-676. doi: 10.1089/ten.TEA.2018.0147.

PMID:
30311859
10.

Spermatogonial stem cells and spermatogenesis in mice, monkeys and men.

Fayomi AP, Orwig KE.

Stem Cell Res. 2018 May;29:207-214. doi: 10.1016/j.scr.2018.04.009. Epub 2018 Apr 21. Review.

11.

Editorial.

Clark AT, Orwig KE.

Stem Cell Res. 2018 May;29:179. doi: 10.1016/j.scr.2018.04.006. Epub 2018 Apr 13. No abstract available.

12.

A PAX5-OCT4-PRDM1 developmental switch specifies human primordial germ cells.

Fang F, Angulo B, Xia N, Sukhwani M, Wang Z, Carey CC, Mazurie A, Cui J, Wilkinson R, Wiedenheft B, Irie N, Surani MA, Orwig KE, Reijo Pera RA.

Nat Cell Biol. 2018 Jun;20(6):655-665. doi: 10.1038/s41556-018-0094-3. Epub 2018 Apr 30.

13.

Purification of GFRα1+ and GFRα1- Spermatogonial Stem Cells Reveals a Niche-Dependent Mechanism for Fate Determination.

Garbuzov A, Pech MF, Hasegawa K, Sukhwani M, Zhang RJ, Orwig KE, Artandi SE.

Stem Cell Reports. 2018 Feb 13;10(2):553-567. doi: 10.1016/j.stemcr.2017.12.009. Epub 2018 Jan 11.

14.

"Tissue Papers" from Organ-Specific Decellularized Extracellular Matrices.

Jakus AE, Laronda MM, Rashedi AS, Robinson CM, Lee C, Jordan SW, Orwig KE, Woodruff TK, Shah RN.

Adv Funct Mater. 2017 Sep 13;27(3). pii: 1700992. doi: 10.1002/adfm.201700992. Epub 2017 Aug 7.

15.

An integration-free, virus-free rhesus macaque induced pluripotent stem cell line (riPSC90) from embryonic fibroblasts.

Sosa E, Kim R, Rojas EJ, Hosohama L, Hennebold JD, Orwig KE, Clark AT.

Stem Cell Res. 2017 May;21:5-8. doi: 10.1016/j.scr.2017.03.011. Epub 2017 Mar 15.

16.

Primate Primordial Germ Cells Acquire Transplantation Potential by Carnegie Stage 23.

Clark AT, Gkountela S, Chen D, Liu W, Sosa E, Sukhwani M, Hennebold JD, Orwig KE.

Stem Cell Reports. 2017 Jul 11;9(1):329-341. doi: 10.1016/j.stemcr.2017.05.002. Epub 2017 Jun 1.

17.

The production of glial cell line-derived neurotrophic factor by human sertoli cells is substantially reduced in sertoli cell-only testes.

Singh D, Paduch DA, Schlegel PN, Orwig KE, Mielnik A, Bolyakov A, Wright WW.

Hum Reprod. 2017 May 1;32(5):1108-1117. doi: 10.1093/humrep/dex061.

18.

DDX4-EGFP transgenic rat model for the study of germline development and spermatogenesis.

Gassei K, Sheng Y, Fayomi A, Mital P, Sukhwani M, Lin CC, Peters KA, Althouse A, Valli H, Orwig KE.

Biol Reprod. 2017 Mar 1;96(3):707-719. doi: 10.1095/biolreprod.116.142828.

19.

Fertility Preservation for Pediatric Patients: Current State and Future Possibilities.

Johnson EK, Finlayson C, Rowell EE, Gosiengfiao Y, Pavone ME, Lockart B, Orwig KE, Brannigan RE, Woodruff TK.

J Urol. 2017 Jul;198(1):186-194. doi: 10.1016/j.juro.2016.09.159. Epub 2017 Feb 9. Review.

PMID:
28189577
20.

An integration-free, virus-free rhesus macaque induced pluripotent stem cell line (riPSC89) from embryonic fibroblasts.

Sosa E, Kim R, Rojas EJ, Hosohama L, Hennebold JD, Orwig KE, Clark AT.

Stem Cell Res. 2016 Sep;17(2):444-447. doi: 10.1016/j.scr.2016.09.015. Epub 2016 Sep 17.

21.

Over Expression of NANOS3 and DAZL in Human Embryonic Stem Cells.

Panula S, Reda A, Stukenborg JB, Ramathal C, Sukhwani M, Albalushi H, Edsgärd D, Nakamura M, Söder O, Orwig KE, Yamanaka S, Reijo Pera RA, Hovatta O.

PLoS One. 2016 Oct 21;11(10):e0165268. doi: 10.1371/journal.pone.0165268. eCollection 2016.

22.

The Homeobox Transcription Factor RHOX10 Drives Mouse Spermatogonial Stem Cell Establishment.

Song HW, Bettegowda A, Lake BB, Zhao AH, Skarbrevik D, Babajanian E, Sukhwani M, Shum EY, Phan MH, Plank TM, Richardson ME, Ramaiah M, Sridhar V, de Rooij DG, Orwig KE, Zhang K, Wilkinson MF.

Cell Rep. 2016 Sep 27;17(1):149-164. doi: 10.1016/j.celrep.2016.08.090.

23.

Experimental methods to preserve male fertility and treat male factor infertility.

Gassei K, Orwig KE.

Fertil Steril. 2016 Feb;105(2):256-66. doi: 10.1016/j.fertnstert.2015.12.020. Epub 2015 Dec 30. Review.

24.

Mouse Spermatogenesis Requires Classical and Nonclassical Testosterone Signaling.

Toocheck C, Clister T, Shupe J, Crum C, Ravindranathan P, Lee TK, Ahn JM, Raj GV, Sukhwani M, Orwig KE, Walker WH.

Biol Reprod. 2016 Jan;94(1):11. doi: 10.1095/biolreprod.115.132068. Epub 2015 Nov 25.

25.

High telomerase is a hallmark of undifferentiated spermatogonia and is required for maintenance of male germline stem cells.

Pech MF, Garbuzov A, Hasegawa K, Sukhwani M, Zhang RJ, Benayoun BA, Brockman SA, Lin S, Brunet A, Orwig KE, Artandi SE.

Genes Dev. 2015 Dec 1;29(23):2420-34. doi: 10.1101/gad.271783.115. Epub 2015 Nov 19.

26.

DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs.

Ramathal C, Angulo B, Sukhwani M, Cui J, Durruthy-Durruthy J, Fang F, Schanes P, Turek PJ, Orwig KE, Reijo Pera R.

Sci Rep. 2015 Oct 12;5:15041. doi: 10.1038/srep15041.

27.

Human germ cell formation in xenotransplants of induced pluripotent stem cells carrying X chromosome aneuploidies.

Dominguez AA, Chiang HR, Sukhwani M, Orwig KE, Reijo Pera RA.

Sci Rep. 2014 Sep 22;4:6432. doi: 10.1038/srep06432.

28.

Whole-mount immunohistochemistry to study spermatogonial stem cells and spermatogenic lineage development in mice, monkeys, and humans.

Gassei K, Valli H, Orwig KE.

Methods Mol Biol. 2014;1210:193-202. doi: 10.1007/978-1-4939-1435-7_15.

PMID:
25173170
29.

Germ cell transplantation into mouse testes procedure.

Medrano JV, Martínez-Arroyo AM, Sukhwani M, Noguera I, Quiñonero A, Martínez-Jabaloyas JM, Pellicer A, Remohí J, Orwig KE, Simón C.

Fertil Steril. 2014 Oct;102(4):e11-2. doi: 10.1016/j.fertnstert.2014.07.669. Epub 2014 Aug 20.

PMID:
25150391
30.

Fluorescence- and magnetic-activated cell sorting strategies to isolate and enrich human spermatogonial stem cells.

Valli H, Sukhwani M, Dovey SL, Peters KA, Donohue J, Castro CA, Chu T, Marshall GR, Orwig KE.

Fertil Steril. 2014 Aug;102(2):566-580.e7. doi: 10.1016/j.fertnstert.2014.04.036. Epub 2014 Jun 2.

31.

Fate of iPSCs derived from azoospermic and fertile men following xenotransplantation to murine seminiferous tubules.

Ramathal C, Durruthy-Durruthy J, Sukhwani M, Arakaki JE, Turek PJ, Orwig KE, Reijo Pera RA.

Cell Rep. 2014 May 22;7(4):1284-97. doi: 10.1016/j.celrep.2014.03.067. Epub 2014 May 1.

32.

Fate of induced pluripotent stem cells following transplantation to murine seminiferous tubules.

Durruthy Durruthy J, Ramathal C, Sukhwani M, Fang F, Cui J, Orwig KE, Reijo Pera RA.

Hum Mol Genet. 2014 Jun 15;23(12):3071-84. doi: 10.1093/hmg/ddu012. Epub 2014 Jan 20.

33.

Germline stem cells: toward the regeneration of spermatogenesis.

Valli H, Phillips BT, Shetty G, Byrne JA, Clark AT, Meistrich ML, Orwig KE.

Fertil Steril. 2014 Jan;101(1):3-13. doi: 10.1016/j.fertnstert.2013.10.052. Epub 2013 Dec 5. Review.

34.

Rapid assembly of customized TALENs into multiple delivery systems.

Zhang Z, Zhang S, Huang X, Orwig KE, Sheng Y.

PLoS One. 2013 Nov 7;8(11):e80281. doi: 10.1371/journal.pone.0080281. eCollection 2013.

35.

Hormone suppression with GnRH antagonist promotes spermatogenic recovery from transplanted spermatogonial stem cells in irradiated cynomolgus monkeys.

Shetty G, Uthamanthil RK, Zhou W, Shao SH, Weng CC, Tailor RC, Hermann BP, Orwig KE, Meistrich ML.

Andrology. 2013 Nov;1(6):886-98. doi: 10.1111/j.2047-2927.2013.00126.x. Epub 2013 Sep 30.

36.

The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase.

Puri P, Phillips BT, Suzuki H, Orwig KE, Rajkovic A, Lapinski PE, King PD, Feng GS, Walker WH.

Stem Cells. 2014 Mar;32(3):741-53. doi: 10.1002/stem.1572.

37.

Eliminating malignant contamination from therapeutic human spermatogonial stem cells.

Dovey SL, Valli H, Hermann BP, Sukhwani M, Donohue J, Castro CA, Chu T, Sanfilippo JS, Orwig KE.

J Clin Invest. 2013 Apr;123(4):1833-43. doi: 10.1172/JCI65822. Epub 2013 Mar 15.

38.

Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy.

Skaznik-Wikiel ME, McGuire MM, Sukhwani M, Donohue J, Chu T, Krivak TC, Rajkovic A, Orwig KE.

Fertil Steril. 2013 Jun;99(7):2045-54.e3. doi: 10.1016/j.fertnstert.2013.01.135. Epub 2013 Feb 26.

39.

SALL4 expression in gonocytes and spermatogonial clones of postnatal mouse testes.

Gassei K, Orwig KE.

PLoS One. 2013;8(1):e53976. doi: 10.1371/journal.pone.0053976. Epub 2013 Jan 11.

40.

Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm.

Hermann BP, Sukhwani M, Winkler F, Pascarella JN, Peters KA, Sheng Y, Valli H, Rodriguez M, Ezzelarab M, Dargo G, Peterson K, Masterson K, Ramsey C, Ward T, Lienesch M, Volk A, Cooper DK, Thomson AW, Kiss JE, Penedo MC, Schatten GP, Mitalipov S, Orwig KE.

Cell Stem Cell. 2012 Nov 2;11(5):715-26. doi: 10.1016/j.stem.2012.07.017.

41.

Direct differentiation of human pluripotent stem cells into haploid spermatogenic cells.

Easley CA 4th, Phillips BT, McGuire MM, Barringer JM, Valli H, Hermann BP, Simerly CR, Rajkovic A, Miki T, Orwig KE, Schatten GP.

Cell Rep. 2012 Sep 27;2(3):440-6. doi: 10.1016/j.celrep.2012.07.015. Epub 2012 Aug 23.

42.

Fruitful progress to fertility: male fertility in the test tube.

Clark AT, Phillips BT, Orwig KE.

Nat Med. 2011 Dec 6;17(12):1564-5. doi: 10.1038/nm.2594. No abstract available.

PMID:
22146462
43.

Separating spermatogonia from cancer cells in contaminated prepubertal primate testis cell suspensions.

Hermann BP, Sukhwani M, Salati J, Sheng Y, Chu T, Orwig KE.

Hum Reprod. 2011 Dec;26(12):3222-31. doi: 10.1093/humrep/der343. Epub 2011 Oct 20.

44.

The elusive spermatogonial stem cell marker?

Hermann BP, Phillips BT, Orwig KE.

Biol Reprod. 2011 Aug;85(2):221-3. doi: 10.1095/biolreprod.111.093146. Epub 2011 May 12. No abstract available.

45.

Thalidomide treatment attenuates chemotherapy-induced gonadal toxicity.

Ochalski ME, Shuttleworth JJ, Chu T, Orwig KE.

Fertil Steril. 2011 Feb;95(2):819-22. doi: 10.1016/j.fertnstert.2010.09.020. Retraction in: Fertil Steril. 2015 Feb;103(2):580. Fertil Steril. 2015 Mar;103(3):863.

PMID:
20889152
46.

Systems biology discoveries using non-human primate pluripotent stem and germ cells: novel gene and genomic imprinting interactions as well as unique expression patterns.

Ben-Yehudah A, Easley CA 4th, Hermann BP, Castro C, Simerly C, Orwig KE, Mitalipov S, Schatten G.

Stem Cell Res Ther. 2010 Aug 5;1(3):24. doi: 10.1186/scrt24. Review.

47.

Spermatogonial stem cell regulation and spermatogenesis.

Phillips BT, Gassei K, Orwig KE.

Philos Trans R Soc Lond B Biol Sci. 2010 May 27;365(1546):1663-78. doi: 10.1098/rstb.2010.0026. Review.

48.

Generation and characterization of a Tet-On (rtTA-M2) transgenic rat.

Sheng Y, Lin CC, Yue J, Sukhwani M, Shuttleworth JJ, Chu T, Orwig KE.

BMC Dev Biol. 2010 Feb 16;10:17. doi: 10.1186/1471-213X-10-17.

49.

Spermatogonial stem cells in higher primates: are there differences from those in rodents?

Hermann BP, Sukhwani M, Hansel MC, Orwig KE.

Reproduction. 2010 Mar;139(3):479-93. doi: 10.1530/REP-09-0255. Epub 2009 Oct 30. Review.

50.

Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques.

Hermann BP, Sukhwani M, Simorangkir DR, Chu T, Plant TM, Orwig KE.

Hum Reprod. 2009 Jul;24(7):1704-16. doi: 10.1093/humrep/dep073. Epub 2009 Mar 31.

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