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Items: 1 to 50 of 59

1.

Effect of chronic phenobarbitone administration on liver tumour formation in the C57BL/10J mouse.

Jones HB, Orton TC, Lake BG.

Food Chem Toxicol. 2009 Jun;47(6):1333-40. doi: 10.1016/j.fct.2009.03.014. Epub 2009 Mar 17.

PMID:
19298838
2.

Statin-induced myopathy in the rat: relationship between systemic exposure, muscle exposure and myopathy.

Sidaway J, Wang Y, Marsden AM, Orton TC, Westwood FR, Azuma CT, Scott RC.

Xenobiotica. 2009 Jan;39(1):90-8. doi: 10.1080/00498250802585539 .

PMID:
19219751
3.

Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase reduce receptor-mediated endocytosis in opossum kidney cells.

Sidaway JE, Davidson RG, McTaggart F, Orton TC, Scott RC, Smith GJ, Brunskill NJ.

J Am Soc Nephrol. 2004 Sep;15(9):2258-65.

4.

Tissue-specific expression and subcellular distribution of murine glutathione S-transferase class kappa.

Thomson RE, Bigley AL, Foster JR, Jowsey IR, Elcombe CR, Orton TC, Hayes JD.

J Histochem Cytochem. 2004 May;52(5):653-62.

PMID:
15100242
5.

Biochemical and genetic characterization of a murine class Kappa glutathione S-transferase.

Jowsey IR, Thomson RE, Orton TC, Elcombe CR, Hayes JD.

Biochem J. 2003 Jul 15;373(Pt 2):559-69.

6.

Tissue-specific inactivation of murine M6P/IGF2R.

Wylie AA, Pulford DJ, McVie-Wylie AJ, Waterland RA, Evans HK, Chen YT, Nolan CM, Orton TC, Jirtle RL.

Am J Pathol. 2003 Jan;162(1):321-8.

7.
8.
9.

Identification of phenobarbitone-modulated genes in mouse liver by differential display.

Garcia-Allan C, Lord PG, Loughlin JM, Orton TC, Sidaway JE.

J Biochem Mol Toxicol. 2000;14(2):65-72.

PMID:
10630419
10.

EGF-Induced receptor autophosphorylation in primary hepatocytes isolated from phenobarbitone-treated mice.

Fletcher K, Lord PG, Orton TC, Chipman JK, Strain AJ.

Biochem Biophys Res Commun. 1999 Jul 5;260(2):483-7.

PMID:
10403793
11.

Postmenopausal HRT--a role for a safe antioestrogen.

Jackson I, Steinberg M, Orton TC.

Int J Clin Pract. 1998 Jan-Feb;52(1):5-6. No abstract available.

PMID:
9536559
13.

The response of hepatocytes isolated from phenobarbitone treated mice to mitogenic growth factors.

Fletcher K, Orton TC, Chipman JK, Strain AJ.

Arch Toxicol. 1997;71(7):422-8.

PMID:
9209687
14.

Carcinogenicity of cyproterone acetate in the mouse.

Tucker MJ, Kalinowski AE, Orton TC.

Carcinogenesis. 1996 Jul;17(7):1473-6.

PMID:
8706251
15.

Expression of growth factors and growth factor receptors in the liver of C57BL/10J mice following administration of phenobarbitone.

Orton TC, Doughty SE, Kalinowski AE, Lord PG, Wadsworth PF.

Carcinogenesis. 1996 May;17(5):973-81.

PMID:
8640946
16.

M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.

De Souza AT, Hankins GR, Washington MK, Orton TC, Jirtle RL.

Nat Genet. 1995 Dec;11(4):447-9.

PMID:
7493029
17.

Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors.

De Souza AT, Hankins GR, Washington MK, Fine RL, Orton TC, Jirtle RL.

Oncogene. 1995 May 4;10(9):1725-9.

PMID:
7753549
18.

Ras mutations in methylclofenapate-induced B6C3F1 and C57BL/10J mouse liver tumours.

Stanley LA, Blackburn DR, Devereaux S, Foley J, Lord PG, Maronpot RR, Orton TC, Anderson MW.

Carcinogenesis. 1994 Jun;15(6):1125-31.

PMID:
8020144
19.
20.

Proto-oncogene activation in liver tumors of hepatocarcinogenesis-resistant strains of mice.

Stanley LA, Devereux TR, Foley J, Lord PG, Maronpot RR, Orton TC, Anderson MW.

Carcinogenesis. 1992 Dec;13(12):2427-33.

PMID:
1361883
21.

Point mutation analysis of ras genes in spontaneous and chemically induced C57Bl/10J mouse liver tumours.

Lord PG, Hardaker KJ, Loughlin JM, Marsden AM, Orton TC.

Carcinogenesis. 1992 Aug;13(8):1383-7.

PMID:
1499088
22.

Hepatocarcinogenic effect of vinyl carbamate in the C57Bl/10J strain mouse.

Wright JA, Marsden AM, Willets JM, Orton TC.

Toxicol Pathol. 1991;19(3):258-65.

PMID:
1664139
23.
25.

Teratogenicity of phenylhydantoins in an in vitro system: molecular orbital-generated quantitative structure-toxicity relationships.

Brown LP, Lewis DF, Flint OP, Orton TC, Gibson GG.

Xenobiotica. 1989 Dec;19(12):1471-81.

PMID:
2618094
26.
27.
28.

In vitro metabolism of teratogens by differentiating rat embryo cells.

Brown LP, Flint OP, Orton TC, Gibson GG.

Food Chem Toxicol. 1986 Jun-Jul;24(6-7):737-42.

PMID:
3781427
29.

Practolol: aspects of its metabolism and ocular binding in the hamster.

Rosenbaum SE, Lindup WE, Orton TC.

Xenobiotica. 1986 Jun;16(6):567-73.

PMID:
3751112
30.

Comparative pharmacokinetics and subacute toxicity of di(2-ethylhexyl) phthalate (DEHP) in rats and marmosets: extrapolation of effects in rodents to man.

Rhodes C, Orton TC, Pratt IS, Batten PL, Bratt H, Jackson SJ, Elcombe CR.

Environ Health Perspect. 1986 Mar;65:299-307.

31.

Chemical teratogenesis: testing methods and the role of metabolism.

Brown LP, Flint OP, Orton TC, Gibson GG.

Drug Metab Rev. 1986;17(3-4):221-60. Review. No abstract available.

PMID:
3552539
32.

Practolol and its metabolites: tissue localization and retention in the hamster.

Rosenbaum SE, Lindup WE, Orton TC.

J Pharmacol Exp Ther. 1985 Aug;234(2):485-90.

PMID:
4020682
33.

An in vitro assay for teratogens with cultures of rat embryo midbrain and limb bud cells.

Flint OP, Orton TC.

Toxicol Appl Pharmacol. 1984 Nov;76(2):383-95.

PMID:
6495342
34.
35.

Clobuzarit: species differences in the morphological and biochemical response of the liver following chronic administration.

Orton TC, Adam HK, Bentley M, Holloway B, Tucker MJ.

Toxicol Appl Pharmacol. 1984 Mar 30;73(1):138-51.

PMID:
6424266
36.

Dynamics of xenobiotic metabolism by isolated rat hepatocytes using a multichannel perifusion system.

Orton TC, Sorman AE, Crisp DN, Sturdee AP.

Xenobiotica. 1983 Dec;13(12):743-53.

PMID:
6675327
37.

Metabolic activation and bacterial mutagenicity of aflatoxin B1 in two different test systems.

Lowery C, Orton TC, Garner RC.

Toxicology. 1983 Dec;29(1-2):131-41.

PMID:
6419391
38.

Hepatic microsomal glucuronidation of clofibric acid in the adult and neonate albino rat.

Odum J, Orton TC.

Biochem Pharmacol. 1983 Dec 1;32(23):3565-9.

PMID:
6418177
39.

Metabolic capability of rat hepatocytes isolated by perfusion and tissue slice techniques.

Sturdee AP, Beirne JM, Sörman AE, Orton TC, Crisp DM.

Life Sci. 1983 Mar 28;32(13):1463-9.

PMID:
6835000
40.

A TLC fluorescence derivatization assay for chlorpromazine and its non-conjugated hepatic microsomal metabolites.

Blanchard DS, Burke MD, Orton TC.

J Pharm Biomed Anal. 1983;1(2):195-203.

PMID:
16867818
41.

The disposition of 14C-di-2-ethylhexylphthalate (DEHP) in the marmoset.

Rhodes C, Elcombe CR, Batten PL, Bratt H, Jackson SJ, Pratt IS, Orton TC.

Dev Toxicol Environ Sci. 1983;11:579-81. No abstract available.

PMID:
6428856
43.

A multichannel perifusion system for the continuous monitoring of glycogenolysis and gluconeogenesis in isolated rat hepatocytes.

Crisp DM, Sörman AE, Beirne JM, Orton TC, Sturdee AP.

Eur J Biochem. 1982 Apr 1;123(2):377-81.

45.
46.

The effect of 3-methylcholanthrene on urinary 6 beta-hydroxycortisol excretion and hepatic enzyme activity in the marmoset monkey (Callithrix jacchus).

Challiner M, Park BK, Odum J, Orton TC.

Biochem Pharmacol. 1981 Aug 1;30(15):2131-4. No abstract available.

PMID:
6794571
47.

The effects of phenobarbitone on urinary 6 beta-hydroxycortisol excretion and hepatic enzyme activity in the marmoset monkey (Callithrix jacchus).

Challiner MR, Park BK, Odum J, Orton TC, Parker GL.

Biochem Pharmacol. 1980 Dec;29(24):3319-24. No abstract available.

PMID:
6971098
49.

The distribution and irreversible tissue binding of practolol and its metabolites in the hamster [proceedings].

Lindup WE, Longshaw S, Orton TC, Whittaker SE.

Br J Pharmacol. 1979 Jul;66(3):504P. No abstract available.

50.

Metabolism studies with practolol [proceedings].

Case DE, Lindup WE, Lowery C, Orton TC, Reeves PR, Whittaker SE.

Br J Pharmacol. 1978 Jun;63(2):352P. No abstract available.

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