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Items: 1 to 50 of 96

1.

Snake recombination landscapes are concentrated in functional regions despite PRDM9.

Schield DR, Pasquesi GIM, Perry BW, Adams RH, Nikolakis ZL, Westfall AK, Orton RW, Meik JM, Mackessy SP, Castoe TA.

Mol Biol Evol. 2020 Jan 11. pii: msaa003. doi: 10.1093/molbev/msaa003. [Epub ahead of print]

PMID:
31926008
2.

Estimating viral bottleneck sizes for FMDV transmission within and between hosts and implications for the rate of viral evolution.

Orton RJ, Wright CF, King DP, Haydon DT.

Interface Focus. 2020 Feb 6;10(1):20190066. doi: 10.1098/rsfs.2019.0066. Epub 2019 Dec 13.

PMID:
31897294
3.

Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus.

Fahnøe U, Pedersen AG, Johnston CM, Orton RJ, Höper D, Beer M, Bukh J, Belsham GJ, Rasmussen TB.

Viruses. 2019 Oct 10;11(10). pii: E932. doi: 10.3390/v11100932.

4.

Demographic and environmental drivers of metagenomic viral diversity in vampire bats.

Bergner LM, Orton RJ, Benavides JA, Becker DJ, Tello C, Biek R, Streicker DG.

Mol Ecol. 2020 Jan;29(1):26-39. doi: 10.1111/mec.15250. Epub 2019 Oct 23.

5.

Attenuation of Infectious Bronchitis Virus in Eggs Results in Different Patterns of Genomic Variation across Multiple Replicates.

Oade MS, Keep S, Freimanis GL, Orton RJ, Britton P, Hammond JA, Bickerton E.

J Virol. 2019 Jun 28;93(14). pii: e00492-19. doi: 10.1128/JVI.00492-19. Print 2019 Jul 15.

6.

A Fatal Case of Louping-ill in a Dog: Immunolocalization and Full Genome Sequencing of the Virus.

Dagleish MP, Clark JJ, Robson C, Tucker M, Orton RJ, Rocchi MS.

J Comp Pathol. 2018 Nov;165:23-32. doi: 10.1016/j.jcpa.2018.09.004. Epub 2018 Oct 19.

7.

Resolving tradeoffs among crypsis, escape behavior, and microhabitat use in sexually dichromatic species.

Orton RW, McBrayer LD.

Oecologia. 2019 Jan;189(1):91-104. doi: 10.1007/s00442-018-4301-5. Epub 2018 Nov 14.

PMID:
30430233
8.

Predicting reservoir hosts and arthropod vectors from evolutionary signatures in RNA virus genomes.

Babayan SA, Orton RJ, Streicker DG.

Science. 2018 Nov 2;362(6414):577-580. doi: 10.1126/science.aap9072.

9.

Genetic diversity, infection prevalence, and possible transmission routes of Bartonella spp. in vampire bats.

Becker DJ, Bergner LM, Bentz AB, Orton RJ, Altizer S, Streicker DG.

PLoS Negl Trop Dis. 2018 Sep 27;12(9):e0006786. doi: 10.1371/journal.pntd.0006786. eCollection 2018 Sep.

10.

Using noninvasive metagenomics to characterize viral communities from wildlife.

Bergner LM, Orton RJ, da Silva Filipe A, Shaw AE, Becker DJ, Tello C, Biek R, Streicker DG.

Mol Ecol Resour. 2019 Jan;19(1):128-143. doi: 10.1111/1755-0998.12946. Epub 2018 Oct 19.

11.

Identifying genotype specific elevated-risk areas and associated herd risk factors for bovine tuberculosis spread in British cattle.

Orton RJ, Deason M, Bessell PR, Green DM, Kao RR, Salvador LCM.

Epidemics. 2018 Sep;24:34-42. doi: 10.1016/j.epidem.2018.02.004. Epub 2018 Mar 1.

12.

Genetic analysis of a rabies virus host shift event reveals within-host viral dynamics in a new host.

Marston DA, Horton DL, Nunez J, Ellis RJ, Orton RJ, Johnson N, Banyard AC, McElhinney LM, Freuling CM, Fırat M, Ünal N, Müller T, de Lamballerie X, Fooks AR.

Virus Evol. 2017 Dec 13;3(2):vex038. doi: 10.1093/ve/vex038. eCollection 2017 Jul.

13.

Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses.

Shaw AE, Hughes J, Gu Q, Behdenna A, Singer JB, Dennis T, Orton RJ, Varela M, Gifford RJ, Wilson SJ, Palmarini M.

PLoS Biol. 2017 Dec 18;15(12):e2004086. doi: 10.1371/journal.pbio.2004086. eCollection 2017 Dec.

14.

Novel hemotropic mycoplasmas are widespread and genetically diverse in vampire bats.

Volokhov DV, Becker DJ, Bergner LM, Camus MS, Orton RJ, Chizhikov VE, Altizer SM, Streicker DG.

Epidemiol Infect. 2017 Nov;145(15):3154-3167. doi: 10.1017/S095026881700231X. Epub 2017 Oct 24.

15.

Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV).

Lefkowitz EJ, Dempsey DM, Hendrickson RC, Orton RJ, Siddell SG, Smith DB.

Nucleic Acids Res. 2018 Jan 4;46(D1):D708-D717. doi: 10.1093/nar/gkx932.

16.

Quantifying the roles of host movement and vector dispersal in the transmission of vector-borne diseases of livestock.

Sumner T, Orton RJ, Green DM, Kao RR, Gubbins S.

PLoS Comput Biol. 2017 Apr 3;13(4):e1005470. doi: 10.1371/journal.pcbi.1005470. eCollection 2017 Apr.

17.

Consensus statement: Virus taxonomy in the age of metagenomics.

Simmonds P, Adams MJ, Benkő M, Breitbart M, Brister JR, Carstens EB, Davison AJ, Delwart E, Gorbalenya AE, Harrach B, Hull R, King AM, Koonin EV, Krupovic M, Kuhn JH, Lefkowitz EJ, Nibert ML, Orton R, Roossinck MJ, Sabanadzovic S, Sullivan MB, Suttle CA, Tesh RB, van der Vlugt RA, Varsani A, Zerbini FM.

Nat Rev Microbiol. 2017 Mar;15(3):161-168. doi: 10.1038/nrmicro.2016.177. Epub 2017 Jan 3.

PMID:
28134265
18.

50 years of the International Committee on Taxonomy of Viruses: progress and prospects.

Adams MJ, Lefkowitz EJ, King AM, Harrach B, Harrison RL, Knowles NJ, Kropinski AM, Krupovic M, Kuhn JH, Mushegian AR, Nibert ML, Sabanadzovic S, Sanfaçon H, Siddell SG, Simmonds P, Varsani A, Zerbini FM, Orton RJ, Smith DB, Gorbalenya AE, Davison AJ.

Arch Virol. 2017 May;162(5):1441-1446. doi: 10.1007/s00705-016-3215-y. Epub 2017 Jan 11.

PMID:
28078475
19.

Vesivirus 2117 capsids more closely resemble sapovirus and lagovirus particles than other known vesivirus structures.

Conley M, Emmott E, Orton R, Taylor D, Carneiro DG, Murata K, Goodfellow IG, Hansman GS, Bhella D.

J Gen Virol. 2017 Jan;98(1):68-76. doi: 10.1099/jgv.0.000658. Epub 2017 Feb 6.

20.

Investigating intra-host and intra-herd sequence diversity of foot-and-mouth disease virus.

King DJ, Freimanis GL, Orton RJ, Waters RA, Haydon DT, King DP.

Infect Genet Evol. 2016 Oct;44:286-292. doi: 10.1016/j.meegid.2016.07.010. Epub 2016 Jul 12.

21.

Bioinformatics tools for analysing viral genomic data.

Orton RJ, Gu Q, Hughes J, Maabar M, Modha S, Vattipally SB, Wilkie GS, Davison AJ.

Rev Sci Tech. 2016 Apr;35(1):271-85. doi: 10.20506/rst.35.1.2432. Review.

22.

Late Ebola virus relapse causing meningoencephalitis: a case report.

Jacobs M, Rodger A, Bell DJ, Bhagani S, Cropley I, Filipe A, Gifford RJ, Hopkins S, Hughes J, Jabeen F, Johannessen I, Karageorgopoulos D, Lackenby A, Lester R, Liu RS, MacConnachie A, Mahungu T, Martin D, Marshall N, Mepham S, Orton R, Palmarini M, Patel M, Perry C, Peters SE, Porter D, Ritchie D, Ritchie ND, Seaton RA, Sreenu VB, Templeton K, Warren S, Wilkie GS, Zambon M, Gopal R, Thomson EC.

Lancet. 2016 Jul 30;388(10043):498-503. doi: 10.1016/S0140-6736(16)30386-5. Epub 2016 May 18.

23.

Use of bacterial whole-genome sequencing to investigate local persistence and spread in bovine tuberculosis.

Trewby H, Wright D, Breadon EL, Lycett SJ, Mallon TR, McCormick C, Johnson P, Orton RJ, Allen AR, Galbraith J, Herzyk P, Skuce RA, Biek R, Kao RR.

Epidemics. 2016 Mar;14:26-35. doi: 10.1016/j.epidem.2015.08.003. Epub 2015 Oct 19.

24.

Creation of Functional Viruses from Non-Functional cDNA Clones Obtained from an RNA Virus Population by the Use of Ancestral Reconstruction.

Fahnøe U, Pedersen AG, Dräger C, Orton RJ, Blome S, Höper D, Beer M, Rasmussen TB.

PLoS One. 2015 Oct 20;10(10):e0140912. doi: 10.1371/journal.pone.0140912. eCollection 2015.

25.

Next-generation sequencing shows West Nile virus quasispecies diversification after a single passage in a carrion crow (Corvus corone) in vivo infection model.

Dridi M, Rosseel T, Orton R, Johnson P, Lecollinet S, Muylkens B, Lambrecht B, Van Borm S.

J Gen Virol. 2015 Oct;96(10):2999-3009. doi: 10.1099/jgv.0.000231. Epub 2015 Jul 9.

PMID:
26297666
26.

Distinguishing low frequency mutations from RT-PCR and sequence errors in viral deep sequencing data.

Orton RJ, Wright CF, Morelli MJ, King DJ, Paton DJ, King DP, Haydon DT.

BMC Genomics. 2015 Mar 24;16:229. doi: 10.1186/s12864-015-1456-x.

27.

Next-generation sequencing in veterinary medicine: how can the massive amount of information arising from high-throughput technologies improve diagnosis, control, and management of infectious diseases?

Van Borm S, Belák S, Freimanis G, Fusaro A, Granberg F, Höper D, King DP, Monne I, Orton R, Rosseel T.

Methods Mol Biol. 2015;1247:415-36. doi: 10.1007/978-1-4939-2004-4_30. Review.

PMID:
25399113
28.

Estimating epidemiological parameters for bovine tuberculosis in British cattle using a Bayesian partial-likelihood approach.

O'Hare A, Orton RJ, Bessell PR, Kao RR.

Proc Biol Sci. 2014 Apr 9;281(1783):20140248. doi: 10.1098/rspb.2014.0248. Print 2014 May 22.

29.

Observing micro-evolutionary processes of viral populations at multiple scales.

Orton RJ, Wright CF, Morelli MJ, Juleff N, Thébaud G, Knowles NJ, Valdazo-González B, Paton DJ, King DP, Haydon DT.

Philos Trans R Soc Lond B Biol Sci. 2013 Feb 4;368(1614):20120203. doi: 10.1098/rstb.2012.0203. Print 2013 Mar 19. Review.

30.

Whole genome sequencing reveals local transmission patterns of Mycobacterium bovis in sympatric cattle and badger populations.

Biek R, O'Hare A, Wright D, Mallon T, McCormick C, Orton RJ, McDowell S, Trewby H, Skuce RA, Kao RR.

PLoS Pathog. 2012;8(11):e1003008. doi: 10.1371/journal.ppat.1003008. Epub 2012 Nov 29.

31.

Developing a framework for risk-based surveillance of tuberculosis in cattle: a case study of its application in Scotland.

Bessell PR, Orton R, O'Hare A, Mellor DJ, Logue D, Kao RR.

Epidemiol Infect. 2013 Feb;141(2):314-23. doi: 10.1017/S0950268812000635. Epub 2012 Apr 26. Erratum in: Epidemiol Infect. 2013 Feb;141(2):324.

32.

Risk factors for bovine Tuberculosis at the national level in Great Britain.

Bessell PR, Orton R, White PC, Hutchings MR, Kao RR.

BMC Vet Res. 2012 May 7;8:51. doi: 10.1186/1746-6148-8-51.

33.

Risk of Foot-and-Mouth Disease spread due to sole occupancy authorities and linked cattle holdings.

Orton RJ, Bessell PR, Birch CP, O'Hare A, Kao RR.

PLoS One. 2012;7(4):e35089. doi: 10.1371/journal.pone.0035089. Epub 2012 Apr 19.

34.

The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier.

Sturm OE, Orton R, Grindlay J, Birtwistle M, Vyshemirsky V, Gilbert D, Calder M, Pitt A, Kholodenko B, Kolch W.

Sci Signal. 2010 Dec 21;3(153):ra90. doi: 10.1126/scisignal.2001212.

35.

Computational modelling of kinase signalling cascades.

Gilbert D, Heiner M, Breitling R, Orton R.

Methods Mol Biol. 2010;661:369-84. doi: 10.1007/978-1-60761-795-2_22.

PMID:
20811995
36.

Cell fate decisions are specified by the dynamic ERK interactome.

von Kriegsheim A, Baiocchi D, Birtwistle M, Sumpton D, Bienvenut W, Morrice N, Yamada K, Lamond A, Kalna G, Orton R, Gilbert D, Kolch W.

Nat Cell Biol. 2009 Dec;11(12):1458-64. doi: 10.1038/ncb1994. Epub 2009 Nov 22.

37.

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway.

Orton RJ, Adriaens ME, Gormand A, Sturm OE, Kolch W, Gilbert DR.

BMC Syst Biol. 2009 Oct 5;3:100. doi: 10.1186/1752-0509-3-100.

38.

Version control of pathway models using XML patches.

Saffrey P, Orton R.

BMC Syst Biol. 2009 Mar 17;3:34. doi: 10.1186/1752-0509-3-34.

39.

Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.

Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR.

IET Syst Biol. 2008 Jul;2(4):173-83. doi: 10.1049/iet-syb:20070066.

PMID:
18681747
40.

A structured approach for the engineering of biochemical network models, illustrated for signalling pathways.

Breitling R, Gilbert D, Heiner M, Orton R.

Brief Bioinform. 2008 Sep;9(5):404-21. doi: 10.1093/bib/bbn026. Epub 2008 Jun 23. Review.

PMID:
18573813
41.

A novel starch for the treatment of glycogen storage diseases.

Bhattacharya K, Orton RC, Qi X, Mundy H, Morley DW, Champion MP, Eaton S, Tester RF, Lee PJ.

J Inherit Metab Dis. 2007 Jun;30(3):350-7. Epub 2007 May 19.

PMID:
17514432
42.

Computational methodologies for modelling, analysis and simulation of signalling networks.

Gilbert D, Fuss H, Gu X, Orton R, Robinson S, Vyshemirsky V, Kurth MJ, Downes CS, Dubitzky W.

Brief Bioinform. 2006 Dec;7(4):339-53. Epub 2006 Nov 20. Review.

PMID:
17116646
43.

Bilateral complete isolated cryptophthalmos: a case report.

Egier D, Orton R, Allen L, Siu VM.

Ophthalmic Genet. 2005 Dec;26(4):185-9.

PMID:
16352480
44.

Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway.

Orton RJ, Sturm OE, Vyshemirsky V, Calder M, Gilbert DR, Kolch W.

Biochem J. 2005 Dec 1;392(Pt 2):249-61. Review.

45.

YETI: Yeast Exploration Tool Integrator.

Orton RJ, Sellers WI, Gerloff DL.

Bioinformatics. 2004 Jan 22;20(2):284-5.

PMID:
14734325
46.

Iris lymphoma in a pediatric cardiac transplant recipient: clinicopathologic findings.

Chan SM, Hutnik CM, Heathcote JG, Orton RB, Banerjee D.

Ophthalmology. 2000 Aug;107(8):1479-82.

PMID:
10919894
47.

Ocular alkali burn associated with automobile air-bag activation.

White JE, McClafferty K, Orton RB, Tokarewicz AC, Nowak ES.

CMAJ. 1995 Oct 1;153(7):933-4.

48.

The 20-prism-dioptre base-out test: an indicator of peripheral binocularity.

Kaban T, Smith K, Beldavs R, Cadera W, Orton RB.

Can J Ophthalmol. 1995 Aug;30(5):247-50.

PMID:
8529158
49.

Synergistic divergence associated with aberrant trigeminal innervation.

Kaban TJ, Smith K, Orton RB.

Can J Ophthalmol. 1994 Jun;29(3):146-50. Review. No abstract available.

PMID:
7922857
50.

Natural history of presumed congenital Brown syndrome.

Kaban TJ, Smith K, Orton RB, Noel LP, Clarke W, Cadera W.

Arch Ophthalmol. 1993 Jul;111(7):943-6.

PMID:
8328936

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