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Principal component analysis fosr fast and model-free denoising of multi b-value diffusion-weighted MR images.

Gurney-Champion OJ, Collins DJ, Wetscherek A, Rata M, Klaassen R, van Laarhoven HWM, Harrington KJ, Oelfke U, Orton MR.

Phys Med Biol. 2019 May 17;64(10):105015. doi: 10.1088/1361-6560/ab1786.


Nursing management matters for registered nurses with a PhD working in clinical practice.

Orton ML, Andersson Å, Wallin L, Forsman H, Eldh AC.

J Nurs Manag. 2019 Jul;27(5):955-962. doi: 10.1111/jonm.12750. Epub 2019 May 15.


Probing structure of normal and malignant prostate tissue before and after radiation therapy with luminal water fraction and diffusion-weighted MRI.

Carlin D, Orton MR, Collins D, deSouza NM.

J Magn Reson Imaging. 2019 Aug;50(2):619-627. doi: 10.1002/jmri.26597. Epub 2018 Dec 27.


DNA barcode data reveal biogeographic trends in Arctic non-biting midges.

Ekrem T, Stur E, Orton MG, Adamowicz SJ.

Genome. 2018 Nov;61(11):787-796. doi: 10.1139/gen-2018-0100. Epub 2018 Oct 26.


Strengthening Delivery of Health Services Using Digital Devices.

Orton M, Agarwal S, Muhoza P, Vasudevan L, Vu A.

Glob Health Sci Pract. 2018 Oct 10;6(Suppl 1):S61-S71. doi: 10.9745/GHSP-D-18-00229. Print 2018 Oct 10. Review.


Is molecular evolution faster in the tropics?

Orton MG, May JA, Ly W, Lee DJ, Adamowicz SJ.

Heredity (Edinb). 2019 May;122(5):513-524. doi: 10.1038/s41437-018-0141-7. Epub 2018 Sep 10.


Microstructure Characterization of Bone Metastases from Prostate Cancer with Diffusion MRI: Preliminary Findings.

Bailey C, Collins DJ, Tunariu N, Orton MR, Morgan VA, Feiweier T, Hawkes DJ, Leach MO, Alexander DC, Panagiotaki E.

Front Oncol. 2018 Feb 16;8:26. doi: 10.3389/fonc.2018.00026. eCollection 2018.


Characterisation of fibrosis in chemically-induced rat mammary carcinomas using multi-modal endogenous contrast MRI on a 1.5T clinical platform.

Jerome NP, Boult JKR, Orton MR, d'Arcy JA, Nerurkar A, Leach MO, Koh DM, Collins DJ, Robinson SP.

Eur Radiol. 2018 Apr;28(4):1642-1653. doi: 10.1007/s00330-017-5083-6. Epub 2017 Oct 16.


Extracranial Soft-Tissue Tumors: Repeatability of Apparent Diffusion Coefficient Estimates from Diffusion-weighted MR Imaging.

Winfield JM, Tunariu N, Rata M, Miyazaki K, Jerome NP, Germuska M, Blackledge MD, Collins DJ, de Bono JS, Yap TA, deSouza NM, Doran SJ, Koh DM, Leach MO, Messiou C, Orton MR.

Radiology. 2017 Jul;284(1):88-99. doi: 10.1148/radiol.2017161965. Epub 2017 Mar 16.


Lung volume reproducibility under ABC control and self-sustained breath-holding.

Kaza E, Dunlop A, Panek R, Collins DJ, Orton M, Symonds-Tayler R, McQuaid D, Scurr E, Hansen V, Leach MO.

J Appl Clin Med Phys. 2017 Mar;18(2):154-162. doi: 10.1002/acm2.12034. Epub 2017 Feb 25.


Volumetry of the dominant intraprostatic tumour lesion: intersequence and interobserver differences on multiparametric MRI.

Harvey H, Orton MR, Morgan VA, Parker C, Dearnaley D, Fisher C, deSouza NM.

Br J Radiol. 2017 Mar;90(1071):20160416. doi: 10.1259/bjr.20160416. Epub 2017 Jan 5.


Extended T2-IVIM model for correction of TE dependence of pseudo-diffusion volume fraction in clinical diffusion-weighted magnetic resonance imaging.

Jerome NP, d'Arcy JA, Feiweier T, Koh DM, Leach MO, Collins DJ, Orton MR.

Phys Med Biol. 2016 Dec 21;61(24):N667-N680. Epub 2016 Nov 28.


T2-adjusted computed diffusion-weighted imaging: A novel method to enhance tumour visualisation.

Cheng L, Blackledge MD, Collins DJ, Orton MR, Jerome NP, Feiweier T, Rata M, Morgan V, Tunariu N, Leach MO, Koh DM.

Comput Biol Med. 2016 Dec 1;79:92-98. doi: 10.1016/j.compbiomed.2016.09.022. Epub 2016 Oct 1.


Feasibility and applicability of diffusion-weighted and dynamic contrast-enhanced magnetic resonance imaging in routine assessments of children with high-grade gliomas.

Carceller F, Jerome NP, Miyazaki K, Collins DJ, Orton MR, d'Arcy JA, Wallace T, Moreno L, Pearson AD, Zacharoulis S, Leach MO, Marshall LV, Koh DM.

Pediatr Blood Cancer. 2017 Feb;64(2):279-283. doi: 10.1002/pbc.26216. Epub 2016 Sep 12.


Development of a temperature-controlled phantom for magnetic resonance quality assurance of diffusion, dynamic, and relaxometry measurements.

Jerome NP, Papoutsaki MV, Orton MR, Parkes HG, Winfield JM, Boss MA, Leach MO, deSouza NM, Collins DJ.

Med Phys. 2016 Jun;43(6):2998-3007. doi: 10.1118/1.4948997.


Separation of type and grade in cervical tumours using non-mono-exponential models of diffusion-weighted MRI.

Winfield JM, Orton MR, Collins DJ, Ind TE, Attygalle A, Hazell S, Morgan VA, deSouza NM.

Eur Radiol. 2017 Feb;27(2):627-636. doi: 10.1007/s00330-016-4417-0. Epub 2016 May 24.


Chronic Opioid Usage in Surgical Patients in a Large Academic Center.

Jiang X, Orton M, Feng R, Hossain E, Malhotra NR, Zager EL, Liu R.

Ann Surg. 2017 Apr;265(4):722-727. doi: 10.1097/SLA.0000000000001780.


Inter- and Intra-Observer Repeatability of Quantitative Whole-Body, Diffusion-Weighted Imaging (WBDWI) in Metastatic Bone Disease.

Blackledge MD, Tunariu N, Orton MR, Padhani AR, Collins DJ, Leach MO, Koh DM.

PLoS One. 2016 Apr 28;11(4):e0153840. doi: 10.1371/journal.pone.0153840. eCollection 2016.


Repeatability of derived parameters from histograms following non-Gaussian diffusion modelling of diffusion-weighted imaging in a paediatric oncological cohort.

Jerome NP, Miyazaki K, Collins DJ, Orton MR, d'Arcy JA, Wallace T, Moreno L, Pearson AD, Marshall LV, Carceller F, Leach MO, Zacharoulis S, Koh DM.

Eur Radiol. 2017 Jan;27(1):345-353. Epub 2016 Mar 22.


Diffusion-weighted imaging outside the brain: Consensus statement from an ISMRM-sponsored workshop.

Taouli B, Beer AJ, Chenevert T, Collins D, Lehman C, Matos C, Padhani AR, Rosenkrantz AB, Shukla-Dave A, Sigmund E, Tanenbaum L, Thoeny H, Thomassin-Naggara I, Barbieri S, Corcuera-Solano I, Orton M, Partridge SC, Koh DM.

J Magn Reson Imaging. 2016 Sep;44(3):521-40. doi: 10.1002/jmri.25196. Epub 2016 Feb 19. Review.


Assessment of renal function using intravoxel incoherent motion diffusion-weighted imaging and dynamic contrast-enhanced MRI.

Bane O, Wagner M, Zhang JL, Dyvorne HA, Orton M, Rusinek H, Taouli B.

J Magn Reson Imaging. 2016 Aug;44(2):317-26. doi: 10.1002/jmri.25171. Epub 2016 Feb 8.


Modeling non-linear kinetics of hyperpolarized [1-(13)C] pyruvate in the crystalloid-perfused rat heart.

Mariotti E, Orton MR, Eerbeek O, Ashruf JF, Zuurbier CJ, Southworth R, Eykyn TR.

NMR Biomed. 2016 Apr;29(4):377-86. doi: 10.1002/nbm.3464. Epub 2016 Jan 18.


Addressing Risk and Reluctance at the Nexus of HIV and Anal Cancer Screening.

Ka'opua LS, Cassel K, Shiramizu B, Stotzer RL, Robles A, Kapua C, Orton M, Milne C, Sesepasara M.

Health Promot Pract. 2016 Jan;17(1):21-30. doi: 10.1177/1524839915615611. Epub 2015 Dec 2.


Patient autonomy and shared decision making in the management of urethral cancer.

Serrano N, Chang M, Leland Rogers C, Orton M, Mannino R, Grob M, Agarwal R, Moghanaki D.

Pract Radiat Oncol. 2016 Jan-Feb;6(1):66-70. doi: 10.1016/j.prro.2015.09.002. Epub 2015 Sep 12. No abstract available.


Distortion correction of echo-planar diffusion-weighted images of uterine cervix.

deSouza NM, Orton M, Downey K, Morgan VA, Collins DJ, Giles SL, Payne GS.

J Magn Reson Imaging. 2016 May;43(5):1218-23. doi: 10.1002/jmri.25080. Epub 2015 Oct 20.


Assessment of repeatability and treatment response in early phase clinical trials using DCE-MRI: comparison of parametric analysis using MR- and CT-derived arterial input functions.

Rata M, Collins DJ, Darcy J, Messiou C, Tunariu N, Desouza N, Young H, Leach MO, Orton MR.

Eur Radiol. 2016 Jul;26(7):1991-8. doi: 10.1007/s00330-015-4012-9. Epub 2015 Sep 18.


Diffusion-weighted MR imaging of metastatic abdominal and pelvic tumours is sensitive to early changes induced by a VEGF inhibitor using alternative diffusion attenuation models.

Orton MR, Messiou C, Collins D, Morgan VA, Tessier J, Young H, deSouza N, Leach MO.

Eur Radiol. 2016 May;26(5):1412-9. doi: 10.1007/s00330-015-3933-7. Epub 2015 Aug 8.


Evaluation of diffusion models in breast cancer.

Panek R, Borri M, Orton M, O'Flynn E, Morgan V, Giles SL, deSouza N, Leach MO, Schmidt MA.

Med Phys. 2015 Aug;42(8):4833-9. doi: 10.1118/1.4927255.


Development of a diffusion-weighted MRI protocol for multicentre abdominal imaging and evaluation of the effects of fasting on measurement of apparent diffusion coefficients (ADCs) in healthy liver.

Winfield JM, Papoutsaki MV, Ragheb H, Morris DM, Heerschap A, ter Voert EG, Kuijer JP, Pieters IC, Douglas NH, Orton M, de Souza NM; QuIC-ConCePT Consortium.

Br J Radiol. 2015 May;88(1049):20140717. doi: 10.1259/bjr.20140717. Epub 2015 Mar 19.


Demonstration of the reproducibility of free-breathing diffusion-weighted MRI and dynamic contrast enhanced MRI in children with solid tumours: a pilot study.

Miyazaki K, Jerome NP, Collins DJ, Orton MR, d'Arcy JA, Wallace T, Moreno L, Pearson AD, Marshall LV, Carceller F, Leach MO, Zacharoulis S, Koh DM.

Eur Radiol. 2015 Sep;25(9):2641-50. doi: 10.1007/s00330-015-3666-7. Epub 2015 Mar 15.


Perceptions of overweight in US and global cultures.

Johnson WG, Bluestein BB, Dasilva F, Moubray NI, Orton ML, Balagaye H, Paredes KF, Kim M.

Eat Behav. 2015 Apr;17:125-9. doi: 10.1016/j.eatbeh.2015.01.015. Epub 2015 Feb 11.


Modelling DW-MRI data from primary and metastatic ovarian tumours.

Winfield JM, deSouza NM, Priest AN, Wakefield JC, Hodgkin C, Freeman S, Orton MR, Collins DJ.

Eur Radiol. 2015 Jul;25(7):2033-40. doi: 10.1007/s00330-014-3573-3. Epub 2015 Jan 21.


Use of the temporal median and trimmed mean mitigates effects of respiratory motion in multiple-acquisition abdominal diffusion imaging.

Jerome NP, Orton MR, d'Arcy JA, Feiweier T, Tunariu N, Koh DM, Leach MO, Collins DJ.

Phys Med Biol. 2015 Jan 21;60(2):N9-20. doi: 10.1088/0031-9155/60/2/N9. Epub 2015 Jan 5.


Dichloroacetate induces autophagy in colorectal cancer cells and tumours.

Lin G, Hill DK, Andrejeva G, Boult JK, Troy H, Fong AC, Orton MR, Panek R, Parkes HG, Jafar M, Koh DM, Robinson SP, Judson IR, Griffiths JR, Leach MO, Eykyn TR, Chung YL.

Br J Cancer. 2014 Jul 15;111(2):375-85. doi: 10.1038/bjc.2014.281. Epub 2014 Jun 3.


Assessment of treatment response by total tumor volume and global apparent diffusion coefficient using diffusion-weighted MRI in patients with metastatic bone disease: a feasibility study.

Blackledge MD, Collins DJ, Tunariu N, Orton MR, Padhani AR, Leach MO, Koh DM.

PLoS One. 2014 Apr 7;9(4):e91779. doi: 10.1371/journal.pone.0091779. eCollection 2014.


Reduced Warburg effect in cancer cells undergoing autophagy: steady- state 1H-MRS and real-time hyperpolarized 13C-MRS studies.

Lin G, Andrejeva G, Wong Te Fong AC, Hill DK, Orton MR, Parkes HG, Koh DM, Robinson SP, Leach MO, Eykyn TR, Chung YL.

PLoS One. 2014 Mar 25;9(3):e92645. doi: 10.1371/journal.pone.0092645. eCollection 2014.


Diffusion-weighted magnetic resonance imaging for assessment of lung lesions: repeatability of the apparent diffusion coefficient measurement.

Bernardin L, Douglas NH, Collins DJ, Giles SL, O'Flynn EA, Orton M, deSouza NM.

Eur Radiol. 2014 Feb;24(2):502-11. doi: 10.1007/s00330-013-3048-y. Epub 2013 Nov 26.


Model free approach to kinetic analysis of real-time hyperpolarized 13C magnetic resonance spectroscopy data.

Hill DK, Orton MR, Mariotti E, Boult JK, Panek R, Jafar M, Parkes HG, Jamin Y, Miniotis MF, Al-Saffar NM, Beloueche-Babari M, Robinson SP, Leach MO, Chung YL, Eykyn TR.

PLoS One. 2013 Sep 4;8(9):e71996. doi: 10.1371/journal.pone.0071996. eCollection 2013.


Stacked autoencoders for unsupervised feature learning and multiple organ detection in a pilot study using 4D patient data.

Shin HC, Orton MR, Collins DJ, Doran SJ, Leach MO.

IEEE Trans Pattern Anal Mach Intell. 2013 Aug;35(8):1930-43. doi: 10.1109/TPAMI.2012.277.


¹H NMR and hyperpolarized ¹³C NMR assays of pyruvate-lactate: a comparative study.

Hill DK, Jamin Y, Orton MR, Tardif N, Parkes HG, Robinson SP, Leach MO, Chung YL, Eykyn TR.

NMR Biomed. 2013 Oct;26(10):1321-1325. doi: 10.1002/nbm.2957. Epub 2013 May 27.


Perfusion CT vascular parameters do not correlate with immunohistochemically derived microvessel density count in colorectal tumors.

Dighe S, Blake H, Jeyadevan N, Castellano I, Koh DM, Orton M, Chandler I, Swift I, Brown G.

Radiology. 2013 Aug;268(2):400-10. doi: 10.1148/radiol.13112460. Epub 2013 Apr 16.


Comparison of free-breathing with navigator-controlled acquisition regimes in abdominal diffusion-weighted magnetic resonance images: Effect on ADC and IVIM statistics.

Jerome NP, Orton MR, d'Arcy JA, Collins DJ, Koh DM, Leach MO.

J Magn Reson Imaging. 2014 Jan;39(1):235-40. doi: 10.1002/jmri.24140. Epub 2013 Apr 11.


Improved intravoxel incoherent motion analysis of diffusion weighted imaging by data driven Bayesian modeling.

Orton MR, Collins DJ, Koh DM, Leach MO.

Magn Reson Med. 2014 Jan;71(1):411-20. doi: 10.1002/mrm.24649. Epub 2013 Feb 13.


Diagnosis of Klinefelter's syndrome is confounded by obesity.

Hartland AJ, Khan A, Mirza S, Orton M.

BMJ. 2013 Jan 30;346:f515. doi: 10.1136/bmj.f515. No abstract available.


Diffusion-weighted imaging of the liver with multiple b values: effect of diffusion gradient polarity and breathing acquisition on image quality and intravoxel incoherent motion parameters--a pilot study.

Dyvorne HA, Galea N, Nevers T, Fiel MI, Carpenter D, Wong E, Orton M, de Oliveira A, Feiweier T, Vachon ML, Babb JS, Taouli B.

Radiology. 2013 Mar;266(3):920-9. doi: 10.1148/radiol.12120686. Epub 2012 Dec 6.


Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases.

Andreou A, Koh DM, Collins DJ, Blackledge M, Wallace T, Leach MO, Orton MR.

Eur Radiol. 2013 Feb;23(2):428-34. doi: 10.1007/s00330-012-2604-1. Epub 2012 Oct 6.


Informatics in radiology: development of a research PACS for analysis of functional imaging data in clinical research and clinical trials.

Doran SJ, d'Arcy J, Collins DJ, Andriantsimiavona R, Orton M, Koh DM, Leach MO.

Radiographics. 2012 Nov-Dec;32(7):2135-50. doi: 10.1148/rg.327115138. Epub 2012 Aug 28.


Advanced solid tumors treated with cediranib: comparison of dynamic contrast-enhanced MR imaging and CT as markers of vascular activity.

Messiou C, Orton M, Ang JE, Collins DJ, Morgan VA, Mears D, Castellano I, Papadatos-Pastos D, Brunetto A, Tunariu N, Mann H, Tessier J, Young H, Ghiorghiu D, Marley S, Kaye SB, deBono JS, Leach MO, deSouza NM.

Radiology. 2012 Nov;265(2):426-36. doi: 10.1148/radiol.12112565. Epub 2012 Aug 13.


Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging.

Leach MO, Morgan B, Tofts PS, Buckley DL, Huang W, Horsfield MA, Chenevert TL, Collins DJ, Jackson A, Lomas D, Whitcher B, Clarke L, Plummer R, Judson I, Jones R, Alonzi R, Brunner T, Koh DM, Murphy P, Waterton JC, Parker G, Graves MJ, Scheenen TW, Redpath TW, Orton M, Karczmar G, Huisman H, Barentsz J, Padhani A; Experimental Cancer Medicine Centres Imaging Network Steering Committee.

Eur Radiol. 2012 Jul;22(7):1451-64. doi: 10.1007/s00330-012-2446-x. Epub 2012 May 7.


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