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A CK1α Activator Penetrates the Brain and Shows Efficacy Against Drug-resistant Metastatic Medulloblastoma.

Rodriguez-Blanco J, Li B, Long J, Shen C, Yang F, Orton D, Collins S, Kasahara N, Ayad NG, McCrea HJ, Roussel MF, Weiss WA, Capobianco AJ, Robbins DJ.

Clin Cancer Res. 2018 Nov 28. doi: 10.1158/1078-0432.CCR-18-1319. [Epub ahead of print]


Patch testing with alkyl glucosides: Concomitant reactions are common but not ubiquitous.

Bhoyrul B, Solman L, Kirk S, Orton D, Wilkinson M.

Contact Dermatitis. 2018 Nov 20. doi: 10.1111/cod.13186. [Epub ahead of print]


The European baseline series and recommended additions: 2019.

Wilkinson M, Gonçalo M, Aerts O, Badulici S, Bennike NH, Bruynzeel D, Dickel H, Garcia-Abujeta JL, Giménez-Arnau AM, Hamman C, Isaksson M, Johansen JD, Mahler V, Niklasson B, Orton D, Pigatto P, Ponyai G, Rustemeyer T, Schuttelaar MLA, Spiewak R, Thyssen JP, Uter W.

Contact Dermatitis. 2019 Jan;80(1):1-4. doi: 10.1111/cod.13155. Epub 2018 Nov 12. Review. No abstract available.


Micropuncture of Bowman's Space in Mice Facilitated by 2 Photon Microscopy.

Matsushita K, Golgotiu K, Orton DJ, Smith RD, Rodland KD, Piehowski PD, Hutchens MP.

J Vis Exp. 2018 Oct 11;(140). doi: 10.3791/58206.


Ancient proteins from ceramic vessels at Çatalhöyük West reveal the hidden cuisine of early farmers.

Hendy J, Colonese AC, Franz I, Fernandes R, Fischer R, Orton D, Lucquin A, Spindler L, Anvari J, Stroud E, Biehl PF, Speller C, Boivin N, Mackie M, Jersie-Christensen RR, Olsen JV, Collins MJ, Craig OE, Rosenstock E.

Nat Commun. 2018 Oct 3;9(1):4064. doi: 10.1038/s41467-018-06335-6.


Ancient goat genomes reveal mosaic domestication in the Fertile Crescent.

Daly KG, Maisano Delser P, Mullin VE, Scheu A, Mattiangeli V, Teasdale MD, Hare AJ, Burger J, Verdugo MP, Collins MJ, Kehati R, Erek CM, Bar-Oz G, Pompanon F, Cumer T, Çakırlar C, Mohaseb AF, Decruyenaere D, Davoudi H, Çevik Ö, Rollefson G, Vigne JD, Khazaeli R, Fathi H, Doost SB, Rahimi Sorkhani R, Vahdati AA, Sauer EW, Azizi Kharanaghi H, Maziar S, Gasparian B, Pinhasi R, Martin L, Orton D, Arbuckle BS, Benecke N, Manica A, Horwitz LK, Mashkour M, Bradley DG.

Science. 2018 Jul 6;361(6397):85-88. doi: 10.1126/science.aas9411.


Quality Control Analysis in Real-time (QC-ART): A Tool for Real-time Quality Control Assessment of Mass Spectrometry-based Proteomics Data.

Stanfill BA, Nakayasu ES, Bramer LM, Thompson AM, Ansong CK, Clauss TR, Gritsenko MA, Monroe ME, Moore RJ, Orton DJ, Piehowski PD, Schepmoes AA, Smith RD, Webb-Robertson BM, Metz TO; TEDDY Study Group.

Mol Cell Proteomics. 2018 Sep;17(9):1824-1836. doi: 10.1074/mcp.RA118.000648. Epub 2018 Apr 17.


A structural examination and collision cross section database for over 500 metabolites and xenobiotics using drift tube ion mobility spectrometry.

Zheng X, Aly NA, Zhou Y, Dupuis KT, Bilbao A, Paurus VL, Orton DJ, Wilson R, Payne SH, Smith RD, Baker ES.

Chem Sci. 2017 Nov 1;8(11):7724-7736. doi: 10.1039/c7sc03464d. Epub 2017 Sep 28.


(Meth)acrylate allergy: frequently missed?

Rolls S, Rajan S, Shah A, Bourke JF, Chowdhury MM, Ghaffar SA, Green C, Johnston GA, Orton DI, Reckling C, Stone NM, Wilkinson SM, Buckley DA.

Br J Dermatol. 2018 Apr;178(4):980-981. doi: 10.1111/bjd.16402. Epub 2018 Mar 10. No abstract available.


SPE-IMS-MS: An automated platform for sub-sixty second surveillance of endogenous metabolites and xenobiotics in biofluids.

Zhang X, Romm M, Zheng X, Zink EM, Kim YM, Burnum-Johnson KE, Orton DJ, Apffel A, Ibrahim YM, Monroe ME, Moore RJ, Smith JN, Ma J, Renslow RS, Thomas DG, Blackwell AE, Swinford G, Sausen J, Kurulugama RT, Eno N, Darland E, Stafford G, Fjeldsted J, Metz TO, Teeguarden JG, Smith RD, Baker ES.

Clin Mass Spectrom. 2016 Dec;2:1-10. doi: 10.1016/j.clinms.2016.11.002. Epub 2016 Dec 29.


Acrylate allergy: time to intervene.

Wilkinson M, Orton D.

Contact Dermatitis. 2017 Dec;77(6):353-355. doi: 10.1111/cod.12923. No abstract available.


A Customizable Flow Injection System for Automated, High Throughput, and Time Sensitive Ion Mobility Spectrometry and Mass Spectrometry Measurements.

Orton DJ, Tfaily MM, Moore RJ, LaMarche BL, Zheng X, Fillmore TL, Chu RK, Weitz KK, Monroe ME, Kelly RT, Smith RD, Baker ES.

Anal Chem. 2018 Jan 2;90(1):737-744. doi: 10.1021/acs.analchem.7b02986. Epub 2017 Dec 13.


Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.

Li B, Orton D, Neitzel LR, Astudillo L, Shen C, Long J, Chen X, Kirkbride KC, Doundoulakis T, Guerra ML, Zaias J, Fei DL, Rodriguez-Blanco J, Thorne C, Wang Z, Jin K, Nguyen DM, Sands LR, Marchetti F, Abreu MT, Cobb MH, Capobianco AJ, Lee E, Robbins DJ.

Sci Signal. 2017 Jun 27;10(485). pii: eaak9916. doi: 10.1126/scisignal.aak9916.


Re "International survey on skin patch test procedures, attitudes and interpretation" L.K. Tanno et al., WAOJ (2016) 9:8.

Uter W, Bruze M, Rustemeyer T, Orton D, Mahler V; European Society of Contact Dermatitis.

World Allergy Organ J. 2017 Apr 26;10(1):18. doi: 10.1186/s40413-017-0149-0. eCollection 2017.


Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses.

Zheng X, Wojcik R, Zhang X, Ibrahim YM, Burnum-Johnson KE, Orton DJ, Monroe ME, Moore RJ, Smith RD, Baker ES.

Annu Rev Anal Chem (Palo Alto Calif). 2017 Jun 12;10(1):71-92. doi: 10.1146/annurev-anchem-061516-045212. Epub 2017 Feb 23. Review.


Novel Approach to Establishing an Aldosterone: Renin Ratio Cutoff for Primary Aldosteronism.

Leung AA, Orton DJ, Chin A, Sadrzadeh H, Kline GA.

Hypertension. 2017 Mar;69(3):450-456. doi: 10.1161/HYPERTENSIONAHA.116.08407. Epub 2017 Jan 9.


Spatially-Resolved Proteomics: Rapid Quantitative Analysis of Laser Capture Microdissected Alveolar Tissue Samples.

Clair G, Piehowski PD, Nicola T, Kitzmiller JA, Huang EL, Zink EM, Sontag RL, Orton DJ, Moore RJ, Carson JP, Smith RD, Whitsett JA, Corley RA, Ambalavanan N, Ansong C.

Sci Rep. 2016 Dec 22;6:39223. doi: 10.1038/srep39223.


Comparing identified and statistically significant lipids and polar metabolites in 15-year old serum and dried blood spot samples for longitudinal studies.

Kyle JE, Casey CP, Stratton KG, Zink EM, Kim YM, Zheng X, Monroe ME, Weitz KK, Bloodsworth KJ, Orton DJ, Ibrahim YM, Moore RJ, Lee CG, Pedersen C, Orwoll E, Smith RD, Burnum-Johnson KE, Baker ES.

Rapid Commun Mass Spectrom. 2017 Mar 15;31(5):447-456. doi: 10.1002/rcm.7808.


Critically High Plasma Ammonia in an Adolescent Girl.

Orton DJ, Gifford JL, Seiden-Long I, Khan A, de Koning L.

Clin Chem. 2016 Dec;62(12):1565-1568. No abstract available.


Simultaneous Proteomic Discovery and Targeted Monitoring using Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry.

Burnum-Johnson KE, Nie S, Casey CP, Monroe ME, Orton DJ, Ibrahim YM, Gritsenko MA, Clauss TR, Shukla AK, Moore RJ, Purvine SO, Shi T, Qian W, Liu T, Baker ES, Smith RD.

Mol Cell Proteomics. 2016 Dec;15(12):3694-3705. Epub 2016 Sep 25.


Enhancing glycan isomer separations with metal ions and positive and negative polarity ion mobility spectrometry-mass spectrometry analyses.

Zheng X, Zhang X, Schocker NS, Renslow RS, Orton DJ, Khamsi J, Ashmus RA, Almeida IC, Tang K, Costello CE, Smith RD, Michael K, Baker ES.

Anal Bioanal Chem. 2017 Jan;409(2):467-476. doi: 10.1007/s00216-016-9866-4. Epub 2016 Sep 7.


Has the epidemic of allergic contact dermatitis due to methylisothiazolinone reached its peak?

Venables ZC, Bourke JF, Buckley DA, Campbell F, Chowdhury MMU, Abdul-Ghaffar S, Green C, Holden CR, McFadden J, Orton D, Sabroe RA, Sansom J, Stone NM, Wakelin SH, Wilkinson SM, Johnston GA.

Br J Dermatol. 2017 Jul;177(1):276-278. doi: 10.1111/bjd.15016. Epub 2017 May 29. No abstract available.


The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis.

Astudillo L, Da Silva TG, Wang Z, Han X, Jin K, VanWye J, Zhu X, Weaver K, Oashi T, Lopes PE, Orton D, Neitzel LR, Lee E, Landgraf R, Robbins DJ, MacKerell AD Jr, Capobianco AJ.

Cancer Res. 2016 Jun 15;76(12):3593-603. doi: 10.1158/0008-5472.CAN-16-0061. Epub 2016 Apr 13.


Fasting time and vitamin B12 levels in a community-based population.

Orton DJ, Naugler C, Sadrzadeh SM.

Clin Chim Acta. 2016 Jul 1;458:129-32. doi: 10.1016/j.cca.2016.05.005. Epub 2016 May 10.


Mass spectrometry-based monitoring of millisecond protein-ligand binding dynamics using an automated microfluidic platform.

Cong Y, Katipamula S, Trader CD, Orton DJ, Geng T, Baker ES, Kelly RT.

Lab Chip. 2016 Apr 26;16(9):1544-8. doi: 10.1039/c6lc00183a.


SNaPP: Simplified Nanoproteomics Platform for Reproducible Global Proteomic Analysis of Nanogram Protein Quantities.

Huang EL, Piehowski PD, Orton DJ, Moore RJ, Qian WJ, Casey CP, Sun X, Dey SK, Burnum-Johnson KE, Smith RD.

Endocrinology. 2016 Mar;157(3):1307-14. doi: 10.1210/en.2015-1821. Epub 2016 Jan 8.


The globalization of naval provisioning: ancient DNA and stable isotope analyses of stored cod from the wreck of the Mary Rose, AD 1545.

Hutchinson WF, Culling M, Orton DC, Hänfling B, Lawson Handley L, Hamilton-Dyer S, O'Connell TC, Richards MP, Barrett JH.

R Soc Open Sci. 2015 Sep 9;2(9):150199. doi: 10.1098/rsos.150199. eCollection 2015 Sep.


Correction: Enrichment and Broad Representation of Plant Biomass-Degrading Enzymes in the Specialized Hyphal Swellings of Leucoagaricus gongylophorus, the Fungal Symbiont of Leaf-Cutter Ants.

Aylward FO, Khadempour L, Tremmel DM, McDonald BR, Nicora CD, Wu S, Moore RJ, Orton DJ, Monroe ME, Piehowski PD, Purvine SO, Smith RD, Lipton MS, Burnum-Johnson KE, Currie CR.

PLoS One. 2015 Sep 23;10(9):e0139151. doi: 10.1371/journal.pone.0139151. eCollection 2015. No abstract available.


One-step extraction and quantitation of toxic alcohols and ethylene glycol in plasma by capillary gas chromatography (GC) with flame ionization detection (FID).

Orton DJ, Boyd JM, Affleck D, Duce D, Walsh W, Seiden-Long I.

Clin Biochem. 2016 Jan;49(1-2):132-8. doi: 10.1016/j.clinbiochem.2015.09.007. Epub 2015 Sep 15.


Enrichment and Broad Representation of Plant Biomass-Degrading Enzymes in the Specialized Hyphal Swellings of Leucoagaricus gongylophorus, the Fungal Symbiont of Leaf-Cutter Ants.

Aylward FO, Khadempour L, Tremmel DM, McDonald BR, Nicora CD, Wu S, Moore RJ, Orton DJ, Monroe ME, Piehowski PD, Purvine SO, Smith RD, Lipton MS, Burnum-Johnson KE, Currie CR.

PLoS One. 2015 Aug 28;10(8):e0134752. doi: 10.1371/journal.pone.0134752. eCollection 2015. Erratum in: PLoS One. 2015;10(9):e0139151.


EAACI position paper for practical patch testing in allergic contact dermatitis in children.

de Waard-van der Spek FB, Darsow U, Mortz CG, Orton D, Worm M, Muraro A, Schmid-Grendelmeier P, Grimalt R, Spiewak R, Rudzeviciene O, Flohr C, Halken S, Fiocchi A, Borrego LM, Oranje AP.

Pediatr Allergy Immunol. 2015 Nov;26(7):598-606. doi: 10.1111/pai.12463.


Enhancing bottom-up and top-down proteomic measurements with ion mobility separations.

Baker ES, Burnum-Johnson KE, Ibrahim YM, Orton DJ, Monroe ME, Kelly RT, Moore RJ, Zhang X, Théberge R, Costello CE, Smith RD.

Proteomics. 2015 Aug;15(16):2766-76. doi: 10.1002/pmic.201500048. Epub 2015 Jul 3.


Resolubilization of precipitated intact membrane proteins with cold formic acid for analysis by mass spectrometry.

Doucette AA, Vieira DB, Orton DJ, Wall MJ.

J Proteome Res. 2014 Dec 5;13(12):6001-12. doi: 10.1021/pr500864a. Epub 2014 Nov 19.


Microscale depletion of high abundance proteins in human biofluids using IgY14 immunoaffinity resin: analysis of human plasma and cerebrospinal fluid.

Hyung SW, Piehowski PD, Moore RJ, Orton DJ, Schepmoes AA, Clauss TR, Chu RK, Fillmore TL, Brewer H, Liu T, Zhao R, Smith RD.

Anal Bioanal Chem. 2014 Nov;406(28):7117-25. doi: 10.1007/s00216-014-8058-3. Epub 2014 Sep 6.


Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis.

Li B, Flaveny CA, Giambelli C, Fei DL, Han L, Hang BI, Bai F, Pei XH, Nose V, Burlingame O, Capobianco AJ, Orton D, Lee E, Robbins DJ.

PLoS One. 2014 Jul 8;9(7):e101969. doi: 10.1371/journal.pone.0101969. eCollection 2014.


Pyrvinium attenuates Hedgehog signaling downstream of smoothened.

Li B, Fei DL, Flaveny CA, Dahmane N, Baubet V, Wang Z, Bai F, Pei XH, Rodriguez-Blanco J, Hang B, Orton D, Han L, Wang B, Capobianco AJ, Lee E, Robbins DJ.

Cancer Res. 2014 Sep 1;74(17):4811-21. doi: 10.1158/0008-5472.CAN-14-0317. Epub 2014 Jul 3.


Cases of occupational dermatitis and asthma in beauticians that were reported to The Health and Occupation Research (THOR) network from 1996 to 2011.

Kwok C, Money A, Carder M, Turner S, Agius R, Orton D, Wilkinson M.

Clin Exp Dermatol. 2014 Jul;39(5):590-5. doi: 10.1111/ced.12367.


Data sharing reveals complexity in the westward spread of domestic animals across Neolithic Turkey.

Arbuckle BS, Kansa SW, Kansa E, Orton D, Çakırlar C, Gourichon L, Atici L, Galik A, Marciniak A, Mulville J, Buitenhuis H, Carruthers D, De Cupere B, Demirergi A, Frame S, Helmer D, Martin L, Peters J, Pöllath N, Pawłowska K, Russell N, Twiss K, Würtenberger D.

PLoS One. 2014 Jun 13;9(6):e99845. doi: 10.1371/journal.pone.0099845. eCollection 2014. Erratum in: PLoS One. 2014;9(9):e107824.


Characterization of individual mouse cerebrospinal fluid proteomes.

Smith JS, Angel TE, Chavkin C, Orton DJ, Moore RJ, Smith RD.

Proteomics. 2014 May;14(9):1102-6. doi: 10.1002/pmic.201300241. Epub 2014 Mar 20.


Signatures for mass spectrometry data quality.

Amidan BG, Orton DJ, Lamarche BL, Monroe ME, Moore RJ, Venzin AM, Smith RD, Sego LH, Tardiff MF, Payne SH.

J Proteome Res. 2014 Apr 4;13(4):2215-22. doi: 10.1021/pr401143e. Epub 2014 Mar 24.


Reprint of "GELFrEE fractionation combined with mass spectrometry for proteome analysis of secreted toxins from Enteropathogenic Escherichia coli (EPEC)".

Orton DJ, Arsenault DJ, Thomas NA, Doucette AA.

Mol Cell Probes. 2014 Apr-Jun;28(2-3):83-90. doi: 10.1016/j.mcp.2014.01.004. Epub 2014 Jan 29.


Evaluating echocardiogram and indirect blood pressure results in male western lowland gorillas (Gorilla gorilla gorilla) during three phases of an anesthetic protocol.

Napier JE, Kutinsky IB, Armstrong DL, Orton D, Hicks CL, Waldoch J, Devlin WH.

J Zoo Wildl Med. 2013 Dec;44(4):875-81.


Advancing the high throughput identification of liver fibrosis protein signatures using multiplexed ion mobility spectrometry.

Baker ES, Burnum-Johnson KE, Jacobs JM, Diamond DL, Brown RN, Ibrahim YM, Orton DJ, Piehowski PD, Purdy DE, Moore RJ, Danielson WF 3rd, Monroe ME, Crowell KL, Slysz GW, Gritsenko MA, Sandoval JD, Lamarche BL, Matzke MM, Webb-Robertson BJ, Simons BC, McMahon BJ, Bhattacharya R, Perkins JD, Carithers RL Jr, Strom S, Self SG, Katze MG, Anderson GA, Smith RD.

Mol Cell Proteomics. 2014 Apr;13(4):1119-27. doi: 10.1074/mcp.M113.034595. Epub 2014 Jan 8.


The identification of novel potential injury mechanisms and candidate biomarkers in renal allograft rejection by quantitative proteomics.

Sigdel TK, Salomonis N, Nicora CD, Ryu S, He J, Dinh V, Orton DJ, Moore RJ, Hsieh SC, Dai H, Thien-Vu M, Xiao W, Smith RD, Qian WJ, Camp DG 2nd, Sarwal MM.

Mol Cell Proteomics. 2014 Feb;13(2):621-31. doi: 10.1074/mcp.M113.030577. Epub 2013 Dec 12.


Proteomic analysis of rat proximal tubule cells following stretch-induced apoptosis in an in vitro model of kidney obstruction.

Orton DJ, Doucette AA, Maksym GN, MacLellan DL.

J Proteomics. 2014 Apr 4;100:125-35. doi: 10.1016/j.jprot.2013.11.025. Epub 2013 Dec 4.


Dual LC-MS platform for high-throughput proteome analysis.

Orton DJ, Wall MJ, Doucette AA.

J Proteome Res. 2013 Dec 6;12(12):5963-70. doi: 10.1021/pr400738a. Epub 2013 Oct 30.


The antihelmintic drug pyrvinium pamoate targets aggressive breast cancer.

Xu W, Lacerda L, Debeb BG, Atkinson RL, Solley TN, Li L, Orton D, McMurray JS, Hang BI, Lee E, Klopp AH, Ueno NT, Reuben JM, Krishnamurthy S, Woodward WA.

PLoS One. 2013 Aug 27;8(8):e71508. doi: 10.1371/journal.pone.0071508. eCollection 2013.


Targeting the Wnt pathway in synovial sarcoma models.

Barham W, Frump AL, Sherrill TP, Garcia CB, Saito-Diaz K, VanSaun MN, Fingleton B, Gleaves L, Orton D, Capecchi MR, Blackwell TS, Lee E, Yull F, Eid JE.

Cancer Discov. 2013 Nov;3(11):1286-301. doi: 10.1158/2159-8290.CD-13-0138. Epub 2013 Aug 6.


GELFrEE fractionation combined with mass spectrometry for proteome analysis of secreted toxins from Enteropathogenic Escherichia coli (EPEC).

Orton DJ, Arsenault DJ, Thomas NA, Doucette AA.

Mol Cell Probes. 2013 Oct-Dec;27(5-6):200-7. doi: 10.1016/j.mcp.2013.06.004. Epub 2013 Jul 2. Corrected and republished in: Mol Cell Probes. 2014 Apr-Jun;28(2-3):83-90.


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