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Items: 18


The architecture of EGFR's basal complexes reveals autoinhibition mechanisms in dimers and oligomers.

Zanetti-Domingues LC, Korovesis D, Needham SR, Tynan CJ, Sagawa S, Roberts SK, Kuzmanic A, Ortiz-Zapater E, Jain P, Roovers RC, Lajevardipour A, van Bergen En Henegouwen PMP, Santis G, Clayton AHA, Clarke DT, Gervasio FL, Shan Y, Shaw DE, Rolfe DJ, Parker PJ, Martin-Fernandez ML.

Nat Commun. 2018 Oct 18;9(1):4325. doi: 10.1038/s41467-018-06632-0.


Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface.

Claus J, Patel G, Autore F, Colomba A, Weitsman G, Soliman TN, Roberts S, Zanetti-Domingues LC, Hirsch M, Collu F, George R, Ortiz-Zapater E, Barber PR, Vojnovic B, Yarden Y, Martin-Fernandez ML, Cameron A, Fraternali F, Ng T, Parker PJ.

Elife. 2018 May 1;7. pii: e32271. doi: 10.7554/eLife.32271.


KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation.

Pike R, Ortiz-Zapater E, Lumicisi B, Santis G, Parsons M.

Sci Signal. 2018 Jan 30;11(515). pii: eaaq1060. doi: 10.1126/scisignal.aaq1060.


CAR: A key regulator of adhesion and inflammation.

Ortiz-Zapater E, Santis G, Parsons M.

Int J Biochem Cell Biol. 2017 Aug;89:1-5. doi: 10.1016/j.biocel.2017.05.025. Epub 2017 May 22. Review.


MET-EGFR dimerization in lung adenocarcinoma is dependent on EGFR mtations and altered by MET kinase inhibition.

Ortiz-Zapater E, Lee RW, Owen W, Weitsman G, Fruhwirth G, Dunn RG, Neat MJ, McCaughan F, Parker P, Ng T, Santis G.

PLoS One. 2017 Jan 31;12(1):e0170798. doi: 10.1371/journal.pone.0170798. eCollection 2017.


Fascin Regulates Nuclear Movement and Deformation in Migrating Cells.

Jayo A, Malboubi M, Antoku S, Chang W, Ortiz-Zapater E, Groen C, Pfisterer K, Tootle T, Charras G, Gundersen GG, Parsons M.

Dev Cell. 2016 Aug 22;38(4):371-83. doi: 10.1016/j.devcel.2016.07.021.


TNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers.

Morton PE, Hicks A, Ortiz-Zapater E, Raghavan S, Pike R, Noble A, Woodfin A, Jenkins G, Rayner E, Santis G, Parsons M.

Sci Rep. 2016 May 19;6:26321. doi: 10.1038/srep26321.


Time-domain microfluidic fluorescence lifetime flow cytometry for high-throughput Förster resonance energy transfer screening.

Nedbal J, Visitkul V, Ortiz-Zapater E, Weitsman G, Chana P, Matthews DR, Ng T, Ameer-Beg SM.

Cytometry A. 2015 Feb;87(2):104-18. doi: 10.1002/cyto.a.22616. Epub 2014 Dec 18.


The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility.

Kiuchi T, Ortiz-Zapater E, Monypenny J, Matthews DR, Nguyen LK, Barbeau J, Coban O, Lawler K, Burford B, Rolfe DJ, de Rinaldis E, Dafou D, Simpson MA, Woodman N, Pinder S, Gillett CE, Devauges V, Poland SP, Fruhwirth G, Marra P, Boersma YL, Plückthun A, Gullick WJ, Yarden Y, Santis G, Winn M, Kholodenko BN, Martin-Fernandez ML, Parker P, Tutt A, Ameer-Beg SM, Ng T.

Sci Signal. 2014 Aug 19;7(339):ra78. doi: 10.1126/scisignal.2005157.


Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation.

Martínez-Bosch N, Fernández-Barrena MG, Moreno M, Ortiz-Zapater E, Munné-Collado J, Iglesias M, André S, Gabius HJ, Hwang RF, Poirier F, Navas C, Guerra C, Fernández-Zapico ME, Navarro P.

Cancer Res. 2014 Jul 1;74(13):3512-24. doi: 10.1158/0008-5472.CAN-13-3013. Epub 2014 May 8.


Gene expression profiling of endobronchial ultrasound (EBUS)-derived cytological fine needle aspirates from hilar and mediastinal lymph nodes in non-small cell lung cancer.

Lee R, Cousins DJ, Ortiz-Zapater E, Breen R, McLean E, Santis G.

Cytopathology. 2013 Dec;24(6):351-5. doi: 10.1111/cyt.12034. Epub 2012 Dec 10.


Key contribution of CPEB4-mediated translational control to cancer progression.

Ortiz-Zapater E, Pineda D, Martínez-Bosch N, Fernández-Miranda G, Iglesias M, Alameda F, Moreno M, Eliscovich C, Eyras E, Real FX, Méndez R, Navarro P.

Nat Med. 2011 Dec 4;18(1):83-90. doi: 10.1038/nm.2540.


Galectin-1 is a novel functional receptor for tissue plasminogen activator in pancreatic cancer.

Roda O, Ortiz-Zapater E, Martínez-Bosch N, Gutiérrez-Gallego R, Vila-Perelló M, Ampurdanés C, Gabius HJ, André S, Andreu D, Real FX, Navarro P.

Gastroenterology. 2009 Apr;136(4):1379-90, e1-5. doi: 10.1053/j.gastro.2008.12.039. Epub 2008 Dec 13.


Trafficking of the human transferrin receptor in plant cells: effects of tyrphostin A23 and brefeldin A.

Ortiz-Zapater E, Soriano-Ortega E, Marcote MJ, Ortiz-Masiá D, Aniento F.

Plant J. 2006 Dec;48(5):757-70. Epub 2006 Oct 19.


Uptake of endocytic markers by rice cells: variations related to the growth phase.

Bahaji A, Cornejo MJ, Ortiz-Zapater E, Contreras I, Aniento F.

Eur J Cell Biol. 2001 Feb;80(2):178-86.


Characterization of Cop I coat proteins in plant cells.

Contreras I, Ortiz-Zapater E, Castilho LM, Aniento F.

Biochem Biophys Res Commun. 2000 Jun 24;273(1):176-82.


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