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Simultaneous angiotensin receptor blockade and glucagon-like peptide-1 receptor activation ameliorate albuminuria in obese insulin-resistant rats.

Rodriguez R, Escobedo B, Lee AY, Thorwald M, Godoy-Lugo JA, Nakano D, Nishiyama A, Parkes DG, Ortiz RM.

Clin Exp Pharmacol Physiol. 2020 Mar;47(3):422-431. doi: 10.1111/1440-1681.13206. Epub 2019 Dec 5.


Deep brain stimulation for dystonia in Finland during 2007-2016.

Ortiz RM, Scheperjans F, Pekkonen E.

BMC Neurol. 2019 Jun 24;19(1):137. doi: 10.1186/s12883-019-1370-y.


Comorbidity and retirement in cervical dystonia.

Ortiz RM, Scheperjans F, Mertsalmi T, Pekkonen E.

J Neurol. 2019 Sep;266(9):2216-2223. doi: 10.1007/s00415-019-09402-0. Epub 2019 May 31.


We Don't Have a Lot of Healthy Options: Food Environment Perceptions of First-Year, Minority College Students Attending a Food Desert Campus.

Dhillon J, Diaz Rios LK, Aldaz KJ, De La Cruz N, Vu E, Asad Asghar S, Kuse Q, Ortiz RM.

Nutrients. 2019 Apr 11;11(4). pii: E816. doi: 10.3390/nu11040816.


Nrf2-related gene expression is impaired during a glucose challenge in type II diabetic rat hearts.

Thorwald MA, Godoy-Lugo JA, Rodriguez GJ, Rodriguez MA, Jamal M, Kinoshita H, Nakano D, Nishiyama A, Forman HJ, Ortiz RM.

Free Radic Biol Med. 2019 Jan;130:306-317. doi: 10.1016/j.freeradbiomed.2018.10.405. Epub 2018 Oct 11.


Glucoregulatory and Cardiometabolic Profiles of Almond vs. Cracker Snacking for 8 Weeks in Young Adults: A Randomized Controlled Trial.

Dhillon J, Thorwald M, De La Cruz N, Vu E, Asghar SA, Kuse Q, Diaz Rios LK, Ortiz RM.

Nutrients. 2018 Jul 25;10(8). pii: E960. doi: 10.3390/nu10080960.


Silencing of HIF-1 in WSSV-infected white shrimp: Effect on viral load and antioxidant enzymes.

Miranda-Cruz MM, Poom-Llamas JJ, Godoy-Lugo JA, Ortiz RM, Gómez-Jiménez S, Rosas-Rodríguez JA, Morán-Palacio EF, Soñanez-Organis JG.

Comp Biochem Physiol C Toxicol Pharmacol. 2018 Nov;213:19-26. doi: 10.1016/j.cbpc.2018.07.004. Epub 2018 Jul 21.


Angiotensin receptor and tumor necrosis factor-α activation contributes to glucose intolerance independent of systolic blood pressure in obese rats.

Rodriguez R, Lee A, Mathis KW, Broome HJ, Thorwald M, Martinez B, Nakano D, Nishiyama A, Ryan MJ, Ortiz RM.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1081-F1090. doi: 10.1152/ajprenal.00156.2018. Epub 2018 Jul 11.


Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats.

Rodriguez R, Moreno M, Lee AY, Godoy-Lugo JA, Nakano D, Nishiyama A, Parkes D, Awayda MS, Ortiz RM.

Hypertens Res. 2018 Oct;41(10):798-808. doi: 10.1038/s41440-018-0070-0. Epub 2018 Jul 9.


Chronic AT1 blockade improves glucose homeostasis in obese OLETF rats.

Rodriguez R, Minas JN, Vazquez-Medina JP, Nakano D, Parkes DG, Nishiyama A, Ortiz RM.

J Endocrinol. 2018 Jun;237(3):271-284. doi: 10.1530/JOE-17-0678. Epub 2018 Apr 11.


Adipose transcriptome analysis provides novel insights into molecular regulation of prolonged fasting in northern elephant seal pups.

Martinez B, Khudyakov J, Rutherford K, Crocker DE, Gemmell N, Ortiz RM.

Physiol Genomics. 2018 Jul 1;50(7):495-503. doi: 10.1152/physiolgenomics.00002.2018. Epub 2018 Apr 6.


Regulation of lactate dehydrogenase in response to WSSV infection in the shrimp Litopenaeus vannamei.

Hernández-Palomares MLE, Godoy-Lugo JA, Gómez-Jiménez S, Gámez-Alejo LA, Ortiz RM, Muñoz-Valle JF, Peregrino-Uriarte AB, Yepiz-Plascencia G, Rosas-Rodríguez JA, Soñanez-Organis JG.

Fish Shellfish Immunol. 2018 Mar;74:401-409. doi: 10.1016/j.fsi.2018.01.011. Epub 2018 Jan 12.


Objective Endoscopic Measurements of Central Airway Stenosis: A Pilot Study.

Gil D, Ortiz RM, Sánchez C, Rosell A; SENSA team.

Respiration. 2018;95(1):63-69. doi: 10.1159/000479888. Epub 2017 Oct 28.


Angiotensin receptor blockade improves cardiac mitochondrial activity in response to an acute glucose load in obese insulin resistant rats.

Thorwald M, Rodriguez R, Lee A, Martinez B, Peti-Peterdi J, Nakano D, Nishiyama A, Ortiz RM.

Redox Biol. 2018 Apr;14:371-378. doi: 10.1016/j.redox.2017.10.005. Epub 2017 Oct 7.


Insulin induces a shift in lipid and primary carbon metabolites in a model of fasting-induced insulin resistance.

Olmstead KI, La Frano MR, Fahrmann J, Grapov D, Viscarra JA, Newman JW, Fiehn O, Crocker DE, Filipp FV, Ortiz RM.

Metabolomics. 2017 May;13(5). pii: 60. doi: 10.1007/s11306-017-1186-y. Epub 2017 Mar 27.


Increased sensitivity of thyroid hormone-mediated signaling despite prolonged fasting.

Martinez B, Scheibner M, Soñanez-Organis JG, Jaques JT, Crocker DE, Ortiz RM.

Gen Comp Endocrinol. 2017 Oct 1;252:36-47. doi: 10.1016/j.ygcen.2017.07.023. Epub 2017 Jul 22.


Fasting increases the phosphorylation of AMPK and expression of sirtuin1 in muscle of adult male northern elephant seals (Mirounga angustirostris).

Lee D, Martinez B, Crocker DE, Ortiz RM.

Physiol Rep. 2017 Feb;5(4). pii: e13114. doi: 10.14814/phy2.13114. Epub 2017 Feb 27.


Thyroid Hormone Regulation and Insulin Resistance: Insights From Animals Naturally Adapted to Fasting.

Martinez B, Ortiz RM.

Physiology (Bethesda). 2017 Mar;32(2):141-151. doi: 10.1152/physiol.00018.2016. Review.


Exogenous thyroxine improves glucose intolerance in insulin-resistant rats.

Vazquez-Anaya G, Martinez B, Soñanez-Organis JG, Nakano D, Nishiyama A, Ortiz RM.

J Endocrinol. 2017 Mar;232(3):501-511. doi: 10.1530/JOE-16-0428. Epub 2016 Dec 15.


Thyroid hormone-stimulated increases in PGC-1α and UCP2 promote life history-specific endocrine changes and maintain a lipid-based metabolism.

Martinez B, Soñanez-Organis JG, Godoy-Lugo JA, Horin LJ, Crocker DE, Ortiz RM.

Am J Physiol Regul Integr Comp Physiol. 2017 Feb 1;312(2):R189-R196. doi: 10.1152/ajpregu.00395.2016. Epub 2016 Nov 30.


FOXE1 Polymorphism Interacts with Dietary Iodine Intake in Differentiated Thyroid Cancer Risk in the Cuban Population.

Ren Y, Lence-Anta JJ, Pereda CM, Chappe M, Velasco M, Infante I, Bustillo M, Turcios S, Leufroy A, Guérin T, Noël L, Lesueur F, Maillard S, Cléro E, Xhaard C, Allodji RS, Rubino C, Rodriguez R, Ortiz RM, de Vathaire F.

Thyroid. 2016 Dec;26(12):1752-1760. Epub 2016 Oct 27.


Recreational Physical Activity and Differentiated Thyroid Cancer Risk: A Pooled Analysis of Two Case-Control Studies.

Xhaard C, Lence-Anta JJ, Ren Y, Borson-Chazot F, Sassolas G, Schvartz C, Colonna M, Lacour B, Danzon A, Velten M, Clero E, Maillard S, Marrer E, Bailly L, Mariné Barjoan E, Schlumberger M, Orgiazzi J, Adjadj E, Pereda CM, Turcios S, Velasco M, Chappe M, Infante I, Bustillo M, García A, Salazar S, Rodriguez R, Benadjaoud MA, Ortiz RM, Rubino C, de Vathaire F.

Eur Thyroid J. 2016 Jul;5(2):132-8. doi: 10.1159/000445887. Epub 2016 May 21.


HIF-1α and PPARγ during physiological cardiac hypertrophy induced by pregnancy: Transcriptional activities and effects on target genes.

Soñanez-Organis JG, Godoy-Lugo JA, Hernández-Palomares ML, Rodríguez-Martínez D, Rosas-Rodríguez JA, González-Ochoa G, Virgen-Ortiz A, Ortiz RM.

Gene. 2016 Oct 15;591(2):376-81. doi: 10.1016/j.gene.2016.06.025. Epub 2016 Jun 14.


Glucose delays the insulin-induced increase in thyroid hormone-mediated signaling in adipose of prolong-fasted elephant seal pups.

Martinez B, Soñanez-Organis JG, Viscarra JA, Jaques JT, MacKenzie DS, Crocker DE, Ortiz RM.

Am J Physiol Regul Integr Comp Physiol. 2016 Mar 15;310(6):R502-12. doi: 10.1152/ajpregu.00054.2015. Epub 2016 Jan 6.


Angiotensin and mineralocorticoid receptor antagonism attenuates cardiac oxidative stress in angiotensin II-infused rats.

Minas JN, Thorwald MA, Conte D, Vázquez-Medina JP, Nishiyama A, Ortiz RM.

Clin Exp Pharmacol Physiol. 2015 Nov;42(11):1178-88. doi: 10.1111/1440-1681.12473.


Muscle transcriptome response to ACTH administration in a free-ranging marine mammal.

Khudyakov JI, Champagne CD, Preeyanon L, Ortiz RM, Crocker DE.

Physiol Genomics. 2015 Aug;47(8):318-30. doi: 10.1152/physiolgenomics.00030.2015. Epub 2015 Jun 2.


Oxidative stress is a potential cost of breeding in male and female northern elephant seals.

Sharick JT, Vazquez-Medina JP, Ortiz RM, Crocker DE.

Funct Ecol. 2015 Mar 1;29(3):367-376.


Thyroid volume and its relation to anthropometric measures in a healthy cuban population.

Turcios S, Lence-Anta JJ, Santana JL, Pereda CM, Velasco M, Chappe M, Infante I, Bustillo M, García A, Clero E, Maillard S, Rodriguez R, Xhaard C, Ren Y, Rubino C, Ortiz RM, de Vathaire F.

Eur Thyroid J. 2015 Mar;4(1):55-61. doi: 10.1159/000371346. Epub 2015 Feb 26.


Common variants at the 9q22.33, 14q13.3 and ATM loci, and risk of differentiated thyroid cancer in the Cuban population.

Pereda CM, Lesueur F, Pertesi M, Robinot N, Lence-Anta JJ, Turcios S, Velasco M, Chappe M, Infante I, Bustillo M, García A, Clero E, Xhaard C, Ren Y, Maillard S, Damiola F, Rubino C, Salazar S, Rodriguez R, Ortiz RM, de Vathaire F.

BMC Genet. 2015 Mar 1;16:22. doi: 10.1186/s12863-015-0180-5.


Plasma FGF21 concentrations, adipose fibroblast growth factor receptor-1 and β-klotho expression decrease with fasting in northern elephant seals.

Suzuki M, Lee AY, Vázquez-Medina JP, Viscarra JA, Crocker DE, Ortiz RM.

Gen Comp Endocrinol. 2015 May 15;216:86-9. doi: 10.1016/j.ygcen.2015.03.009. Epub 2015 Apr 7.


Transcriptome analysis of northern elephant seal (Mirounga angustirostris) muscle tissue provides a novel molecular resource and physiological insights.

Khudyakov JI, Preeyanon L, Champagne CD, Ortiz RM, Crocker DE.

BMC Genomics. 2015 Feb 8;16:64. doi: 10.1186/s12864-015-1253-6.


Environmental, lifestyle, and anthropometric risk factors for differentiated thyroid cancer in cuba: a case-control study.

Lence-Anta JJ, Xhaard C, Ortiz RM, Kassim H, Pereda CM, Turcios S, Velasco M, Chappe M, Infante I, Bustillo M, García A, Clero E, Maillard S, Salazar S, Rodriguez R, de Vathaire F.

Eur Thyroid J. 2014 Sep;3(3):189-96. doi: 10.1159/000362928. Epub 2014 Aug 28.


Prolonged food deprivation increases mRNA expression of deiodinase 1 and 2, and thyroid hormone receptor β-1 in a fasting-adapted mammal.

Martinez B, Soñanez-Organis JG, Vázquez-Medina JP, Viscarra JA, MacKenzie DS, Crocker DE, Ortiz RM.

J Exp Biol. 2013 Dec 15;216(Pt 24):4647-54. doi: 10.1242/jeb.085290.


Development enhances hypometabolism in northern elephant seal pups (Mirounga angustirostris).

Tift MS, Ranalli EC, Houser DS, Ortiz RM, Crocker DE.

Funct Ecol. 2013 Oct 1;27(5). doi: 10.1111/1365-2435.12111.


Insulin and GLP-1 infusions demonstrate the onset of adipose-specific insulin resistance in a large fasting mammal: potential glucogenic role for GLP-1.

Viscarra JA, Rodriguez R, Vazquez-Medina JP, Lee A, Tift MS, Tavoni SK, Crocker DE, Ortiz RM.

Physiol Rep. 2013 Aug;1(2):e00023.


Angiotensin receptor-mediated oxidative stress is associated with impaired cardiac redox signaling and mitochondrial function in insulin-resistant rats.

Vázquez-Medina JP, Popovich I, Thorwald MA, Viscarra JA, Rodriguez R, Sonanez-Organis JG, Lam L, Peti-Peterdi J, Nakano D, Nishiyama A, Ortiz RM.

Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H599-607. doi: 10.1152/ajpheart.00101.2013. Epub 2013 Jun 14.


Prolonged fasting activates hypoxia inducible factors-1α, -2α and -3α in a tissue-specific manner in northern elephant seal pups.

Soñanez-Organis JG, Vázquez-Medina JP, Crocker DE, Ortiz RM.

Gene. 2013 Sep 10;526(2):155-63. doi: 10.1016/j.gene.2013.05.004. Epub 2013 May 22.


Activation of systemic, but not local, renin-angiotensin system is associated with upregulation of TNF-α during prolonged fasting in northern elephant seal pups.

Suzuki M, Vázquez-Medina JP, Viscarra JA, Soñanez-Organis JG, Crocker DE, Ortiz RM.

J Exp Biol. 2013 Sep 1;216(Pt 17):3215-21. doi: 10.1242/jeb.085225. Epub 2013 May 16.


Prolonged fasting activates Nrf2 in post-weaned elephant seals.

Vázquez-Medina JP, Soñanez-Organis JG, Rodriguez R, Viscarra JA, Nishiyama A, Crocker DE, Ortiz RM.

J Exp Biol. 2013 Aug 1;216(Pt 15):2870-8. doi: 10.1242/jeb.081927. Epub 2013 Apr 25.


Cellular mechanisms regulating fuel metabolism in mammals: role of adipose tissue and lipids during prolonged food deprivation.

Viscarra JA, Ortiz RM.

Metabolism. 2013 Jul;62(7):889-97. doi: 10.1016/j.metabol.2012.12.014. Epub 2013 Jan 26. Review.


Angiotensin receptor blockade recovers hepatic UCP2 expression and aconitase and SDH activities and ameliorates hepatic oxidative damage in insulin resistant rats.

Montez P, Vázquez-Medina JP, Rodríguez R, Thorwald MA, Viscarra JA, Lam L, Peti-Peterdi J, Nakano D, Nishiyama A, Ortiz RM.

Endocrinology. 2012 Dec;153(12):5746-59. doi: 10.1210/en.2012-1390. Epub 2012 Oct 18.


Decreased expression of adipose CD36 and FATP1 are associated with increased plasma non-esterified fatty acids during prolonged fasting in northern elephant seal pups (Mirounga angustirostris).

Viscarra JA, Vázquez-Medina JP, Rodriguez R, Champagne CD, Adams SH, Crocker DE, Ortiz RM.

J Exp Biol. 2012 Jul 15;215(Pt 14):2455-64. doi: 10.1242/jeb.069070.


Prolonged fasting increases purine recycling in post-weaned northern elephant seals.

Soñanez-Organis JG, Vázquez-Medina JP, Zenteno-Savín T, Aguilar A, Crocker DE, Ortiz RM.

J Exp Biol. 2012 May 1;215(Pt 9):1448-55. doi: 10.1242/jeb.067173.


Elucidating nature's solutions to heart, lung, and blood diseases and sleep disorders.

Carey HV, Martin SL, Horwitz BA, Yan L, Bailey SM, Podrabsky J, Storz JF, Ortiz RM, Wong RP, Lathrop DA.

Circ Res. 2012 Mar 30;110(7):915-21. doi: 10.1161/CIRCRESAHA.111.255398.


The insulation bag: learning thermoregulation through a "hands-in" activity.

Limson M, Krontiris-Litowitz J, Ortiz RM, Pressley TA, Matyas ML.

Adv Physiol Educ. 2012 Mar;36(1):65-7. doi: 10.1152/advan.00102.2011. No abstract available.


Angiotensin receptor blockade increases pancreatic insulin secretion and decreases glucose intolerance during glucose supplementation in a model of metabolic syndrome.

Rodriguez R, Viscarra JA, Minas JN, Nakano D, Nishiyama A, Ortiz RM.

Endocrinology. 2012 Apr;153(4):1684-95. doi: 10.1210/en.2011-1885. Epub 2012 Feb 21.


Coping with physiological oxidative stress: a review of antioxidant strategies in seals.

Vázquez-Medina JP, Zenteno-Savín T, Elsner R, Ortiz RM.

J Comp Physiol B. 2012 Aug;182(6):741-50. doi: 10.1007/s00360-012-0652-0. Epub 2012 Feb 11. Review.


Hormone and metabolite changes associated with extended breeding fasts in male northern elephant seals (Mirounga angustirostris).

Crocker DE, Ortiz RM, Houser DS, Webb PM, Costa DP.

Comp Biochem Physiol A Mol Integr Physiol. 2012 Apr;161(4):388-94. doi: 10.1016/j.cbpa.2011.12.013. Epub 2011 Dec 29.


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