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Items: 34

1.

The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes.

Meyerovich K, Ortis F, Cardozo AK.

J Mol Endocrinol. 2018 Aug;61(2):F1-F6. doi: 10.1530/JME-16-0183. Epub 2018 May 4. Review.

PMID:
29728424
2.

Prolactin protects against cytokine-induced beta-cell death by NFκB and JNK inhibition.

Nardelli TR, Vanzela EC, Benedicto KC, Brozzi F, Fujita A, Cardozo AK, Eizirik DL, Boschero AC, Ortis F.

J Mol Endocrinol. 2018 Jul;61(1):25-36. doi: 10.1530/JME-16-0257. Epub 2018 Apr 9.

PMID:
29632026
3.

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation.

Meyerovich K, Ortis F, Allagnat F, Cardozo AK.

J Mol Endocrinol. 2016 Jul;57(1):R1-R17. doi: 10.1530/JME-15-0306. Epub 2016 Apr 11. Review.

PMID:
27067637
4.

A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes.

Fukaya M, Brorsson CA, Meyerovich K, Catrysse L, Delaroche D, Vanzela EC, Ortis F, Beyaert R, Nielsen LB, Andersen ML, Mortensen HB, Pociot F, van Loo G, Størling J, Cardozo AK.

Mol Endocrinol. 2016 Jan;30(1):48-61. doi: 10.1210/me.2015-1176. Epub 2015 Dec 10.

5.

The non-canonical NF-κB pathway is induced by cytokines in pancreatic beta cells and contributes to cell death and proinflammatory responses in vitro.

Meyerovich K, Fukaya M, Terra LF, Ortis F, Eizirik DL, Cardozo AK.

Diabetologia. 2016 Mar;59(3):512-21. doi: 10.1007/s00125-015-3817-z. Epub 2015 Dec 3.

PMID:
26634571
6.

Augmented β-Cell Function and Mass in Glucocorticoid-Treated Rodents Are Associated with Increased Islet Ir-β /AKT/mTOR and Decreased AMPK/ACC and AS160 Signaling.

Protzek AO, Costa-Júnior JM, Rezende LF, Santos GJ, Araújo TG, Vettorazzi JF, Ortis F, Carneiro EM, Rafacho A, Boschero AC.

Int J Endocrinol. 2014;2014:983453. doi: 10.1155/2014/983453. Epub 2014 Sep 17.

7.

Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKII.

Santos GJ, Ferreira SM, Ortis F, Rezende LF, Li C, Naji A, Carneiro EM, Kaestner KH, Boschero AC.

Mol Metab. 2014 Apr 15;3(4):484-9. doi: 10.1016/j.molmet.2014.03.011. eCollection 2014 Jul.

8.

JunB protects β-cells from lipotoxicity via the XBP1-AKT pathway.

Cunha DA, Gurzov EN, Naamane N, Ortis F, Cardozo AK, Bugliani M, Marchetti P, Eizirik DL, Cnop M.

Cell Death Differ. 2014 Aug;21(8):1313-24. doi: 10.1038/cdd.2014.53. Epub 2014 May 2.

9.

Differential usage of NF-κB activating signals by IL-1β and TNF-α in pancreatic beta cells.

Ortis F, Miani M, Colli ML, Cunha DA, Gurzov EN, Allagnat F, Chariot A, Eizirik DL.

FEBS Lett. 2012 Apr 5;586(7):984-9. doi: 10.1016/j.febslet.2012.02.021. Epub 2012 Feb 22.

10.

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.

Eizirik DL, Sammeth M, Bouckenooghe T, Bottu G, Sisino G, Igoillo-Esteve M, Ortis F, Santin I, Colli ML, Barthson J, Bouwens L, Hughes L, Gregory L, Lunter G, Marselli L, Marchetti P, McCarthy MI, Cnop M.

PLoS Genet. 2012;8(3):e1002552. doi: 10.1371/journal.pgen.1002552. Epub 2012 Mar 8.

11.

Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation.

Gurzov EN, Barthson J, Marhfour I, Ortis F, Naamane N, Igoillo-Esteve M, Gysemans C, Mathieu C, Kitajima S, Marchetti P, Ørntoft TF, Bakiri L, Wagner EF, Eizirik DL.

Oncogene. 2012 Mar 29;31(13):1723-32. doi: 10.1038/onc.2011.353. Epub 2011 Aug 15.

PMID:
21841823
12.

Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and beta-cell apoptosis.

Berchtold LA, Størling ZM, Ortis F, Lage K, Bang-Berthelsen C, Bergholdt R, Hald J, Brorsson CA, Eizirik DL, Pociot F, Brunak S, Størling J.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):E681-8. doi: 10.1073/pnas.1104384108. Epub 2011 Jun 24.

13.

STAT1 is a master regulator of pancreatic {beta}-cell apoptosis and islet inflammation.

Moore F, Naamane N, Colli ML, Bouckenooghe T, Ortis F, Gurzov EN, Igoillo-Esteve M, Mathieu C, Bontempi G, Thykjaer T, Ørntoft TF, Eizirik DL.

J Biol Chem. 2011 Jan 14;286(2):929-41. doi: 10.1074/jbc.M110.162131. Epub 2010 Oct 27.

14.

p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic beta-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress.

Gurzov EN, Germano CM, Cunha DA, Ortis F, Vanderwinden JM, Marchetti P, Zhang L, Eizirik DL.

J Biol Chem. 2010 Jun 25;285(26):19910-20. doi: 10.1074/jbc.M110.122374. Epub 2010 Apr 26.

15.

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.

Igoillo-Esteve M, Marselli L, Cunha DA, Ladrière L, Ortis F, Grieco FA, Dotta F, Weir GC, Marchetti P, Eizirik DL, Cnop M.

Diabetologia. 2010 Jul;53(7):1395-405. doi: 10.1007/s00125-010-1707-y. Epub 2010 Apr 6. Erratum in: Diabetologia. 2012 Mar;55(3):863.

PMID:
20369226
16.

Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis.

Allagnat F, Christulia F, Ortis F, Pirot P, Lortz S, Lenzen S, Eizirik DL, Cardozo AK.

Diabetologia. 2010 Jun;53(6):1120-30. doi: 10.1007/s00125-010-1699-7. Epub 2010 Mar 29.

PMID:
20349222
17.

Identification of new pancreatic beta cell targets for in vivo imaging by a systems biology approach.

Bouckenooghe T, Flamez D, Ortis F, Goldman S, Eizirik DL.

Curr Pharm Des. 2010 May;16(14):1609-18. Review.

PMID:
20146665
18.

Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary beta-cells.

Ortis F, Naamane N, Flamez D, Ladrière L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, Eizirik DL.

Diabetes. 2010 Feb;59(2):358-74. doi: 10.2337/db09-1159. Epub 2009 Nov 23.

19.

MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic beta-cell responses to the viral by-product double-stranded RNA.

Colli ML, Moore F, Gurzov EN, Ortis F, Eizirik DL.

Hum Mol Genet. 2010 Jan 1;19(1):135-46. doi: 10.1093/hmg/ddp474.

20.

Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB.

Cunha DA, Ladrière L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL, Cnop M.

Diabetes. 2009 Dec;58(12):2851-62. doi: 10.2337/db09-0685. Epub 2009 Aug 31.

21.

Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis.

Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK, Eizirik DL.

Cell Death Differ. 2009 Nov;16(11):1539-50. doi: 10.1038/cdd.2009.99. Epub 2009 Jul 24.

22.

The role of inflammation in insulitis and beta-cell loss in type 1 diabetes.

Eizirik DL, Colli ML, Ortis F.

Nat Rev Endocrinol. 2009 Apr;5(4):219-26. doi: 10.1038/nrendo.2009.21. Review.

PMID:
19352320
23.

JunB Inhibits ER Stress and Apoptosis in Pancreatic Beta Cells.

Gurzov EN, Ortis F, Bakiri L, Wagner EF, Eizirik DL.

PLoS One. 2008 Aug 21;3(8):e3030. doi: 10.1371/journal.pone.0003030.

24.

Initiation and execution of lipotoxic ER stress in pancreatic beta-cells.

Cunha DA, Hekerman P, Ladrière L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, Overbergh L, Mathieu C, Lupi R, Hai T, Herchuelz A, Marchetti P, Rutter GA, Eizirik DL, Cnop M.

J Cell Sci. 2008 Jul 15;121(Pt 14):2308-18. doi: 10.1242/jcs.026062. Epub 2008 Jun 17.

25.

Use of a systems biology approach to understand pancreatic beta-cell death in Type 1 diabetes.

Eizirik DL, Moore F, Flamez D, Ortis F.

Biochem Soc Trans. 2008 Jun;36(Pt 3):321-7. doi: 10.1042/BST0360321. Review.

PMID:
18481950
26.

Induction of nuclear factor-kappaB and its downstream genes by TNF-alpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells.

Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, Théâtre E, Verhaeghe C, Magnusson NE, Chariot A, Orntoft TF, Eizirik DL.

Diabetologia. 2008 Jul;51(7):1213-25. doi: 10.1007/s00125-008-0999-7. Epub 2008 May 8.

27.

Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.

Cardozo AK, Buchillier V, Mathieu M, Chen J, Ortis F, Ladrière L, Allaman-Pillet N, Poirot O, Kellenberger S, Beckmann JS, Eizirik DL, Bonny C, Maurer F.

Biochim Biophys Acta. 2007 Sep;1768(9):2222-34. Epub 2007 Jun 14.

28.

Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue.

Guri AJ, Hontecillas R, Ferrer G, Casagran O, Wankhade U, Noble AM, Eizirik DL, Ortis F, Cnop M, Liu D, Si H, Bassaganya-Riera J.

J Nutr Biochem. 2008 Apr;19(4):216-28. Epub 2007 Jul 6.

PMID:
17618105
29.

Transcriptional regulation of the endoplasmic reticulum stress gene chop in pancreatic insulin-producing cells.

Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL, Cardozo AK.

Diabetes. 2007 Apr;56(4):1069-77.

30.

Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.

Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J, Eizirik DL.

J Biol Chem. 2007 Feb 9;282(6):3989-97. Epub 2006 Dec 8.

31.

Cytokine-induced proapoptotic gene expression in insulin-producing cells is related to rapid, sustained, and nonoscillatory nuclear factor-kappaB activation.

Ortis F, Cardozo AK, Crispim D, Störling J, Mandrup-Poulsen T, Eizirik DL.

Mol Endocrinol. 2006 Aug;20(8):1867-79. Epub 2006 Mar 23.

PMID:
16556731
32.

Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells.

Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A, Eizirik DL.

Diabetes. 2005 Feb;54(2):452-61.

33.
34.

Immunopurification of polyclonal antibodies to recombinant proteins of the same gene family.

Pompéia C, Ortis F, Armelin MC.

Biotechniques. 1996 Dec;21(6):986-8, 990. No abstract available.

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