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Items: 1 to 50 of 353

1.

Increased therapy demand and impending loss of previous residence status after proximal femur fractures can be determined by continuous gait analysis - A clinical feasibility study.

Braun BJ, Osche D, Rollmann M, Orth M, Mörsdorf P, Histing T, Pohlemann T, Herath SC.

Injury. 2019 Jul;50(7):1329-1332. doi: 10.1016/j.injury.2019.05.007. Epub 2019 May 18.

PMID:
31178148
2.

Erythropoietin does not improve fracture healing in aged mice.

Orth M, Baudach J, Scheuer C, Osche D, Veith NT, Braun BJ, Rollmann MF, Herath SC, Pohlemann T, Menger MD, Histing T.

Exp Gerontol. 2019 Jul 15;122:1-9. doi: 10.1016/j.exger.2019.04.005. Epub 2019 Apr 16.

PMID:
30998964
3.

VEGF-loaded mineral-coated microparticles improve bone repair and are associated with increased expression of epo and RUNX-2 in murine non-unions.

Orth M, Shenar AK, Scheuer C, Braun BJ, Herath SC, Holstein JH, Histing T, Yu X, Murphy WL, Pohlemann T, Laschke MW, Menger MD.

J Orthop Res. 2019 Apr;37(4):821-831. doi: 10.1002/jor.24267. Epub 2019 Mar 28.

PMID:
30835895
4.

Huntingtin Aggregates and Mitochondrial Pathology in Skeletal Muscle but not Heart of Late-Stage R6/2 Mice.

Kojer K, Hering T, Bazenet C, Weiss A, Herrmann F, Taanman JW, Orth M.

J Huntingtons Dis. 2019;8(2):145-159. doi: 10.3233/JHD-180324.

PMID:
30814364
5.

Combination of 5-Fluorouracil With Epigenetic Modifiers Induces Radiosensitization, Somatostatin Receptor 2 Expression and Radioligand Binding in Neuroendocrine Tumor Cells in Vitro.

Jin XF, Auernhammer CJ, Ilhan H, Lindner S, Nölting S, Maurer J, Spoettl G, Orth M.

J Nucl Med. 2019 Feb 22. pii: jnumed.118.224048. doi: 10.2967/jnumed.118.224048. [Epub ahead of print]

PMID:
30796167
6.

Identification of symbol digit modality test score extremes in Huntington's disease.

Braisch U, Muche R, Rothenbacher D, Landwehrmeyer GB, Long JD, Orth M; REGISTRY Investigators of the European Huntington's Disease Network and COHORT Investigators of the Huntington Study Group.

Am J Med Genet B Neuropsychiatr Genet. 2019 Apr;180(3):232-245. doi: 10.1002/ajmg.b.32719. Epub 2019 Feb 20.

PMID:
30788902
7.

Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma.

Dallmayer M, Li J, Ohmura S, Alba Rubio R, Baldauf MC, Hölting TLB, Musa J, Knott MML, Stein S, Cidre-Aranaz F, Wehweck FS, Romero-Pérez L, Gerke JS, Orth MF, Marchetto A, Kirchner T, Bach H, Sannino G, Grünewald TGP.

Cell Death Dis. 2019 Feb 11;10(2):116. doi: 10.1038/s41419-019-1372-0.

8.

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity.

Vriens K, Christen S, Parik S, Broekaert D, Yoshinaga K, Talebi A, Dehairs J, Escalona-Noguero C, Schmieder R, Cornfield T, Charlton C, Romero-Pérez L, Rossi M, Rinaldi G, Orth MF, Boon R, Kerstens A, Kwan SY, Faubert B, Méndez-Lucas A, Kopitz CC, Chen T, Fernandez-Garcia J, Duarte JAG, Schmitz AA, Steigemann P, Najimi M, Hägebarth A, Van Ginderachter JA, Sokal E, Gotoh N, Wong KK, Verfaillie C, Derua R, Munck S, Yuneva M, Beretta L, DeBerardinis RJ, Swinnen JV, Hodson L, Cassiman D, Verslype C, Christian S, Grünewald S, Grünewald TGP, Fendt SM.

Nature. 2019 Feb;566(7744):403-406. doi: 10.1038/s41586-019-0904-1. Epub 2019 Feb 6.

PMID:
30728499
9.

Priming anti-tumor immunity by radiotherapy: Dying tumor cell-derived DAMPs trigger endothelial cell activation and recruitment of myeloid cells.

Krombach J, Hennel R, Brix N, Orth M, Schoetz U, Ernst A, Schuster J, Zuchtriegel G, Reichel CA, Bierschenk S, Sperandio M, Vogl T, Unkel S, Belka C, Lauber K.

Oncoimmunology. 2018 Nov 2;8(1):e1523097. doi: 10.1080/2162402X.2018.1523097. eCollection 2019.

10.

Marble-derived microcalcite improves bone healing in mice osteotomy.

Orth M, Shadmanov T, Scheuer C, Braun BJ, Fritz T, Holstein JH, Histing T, Laschke MW, Pohlemann T, Menger MD.

Biomed Mater. 2018 Dec 7;14(2):025001. doi: 10.1088/1748-605X/aaee54.

PMID:
30524063
11.

Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma.

Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, Stein S, Hölting TLB, Cidre-Aranaz F, Romero-Pérez L, Dallmayer M, Baldauf MC, Marchetto A, Sannino G, Knott MML, Wehweck F, Ohmura S, Li J, Hakozaki M, Kirchner T, Dandekar T, Butt E, Grünewald TGP.

Int J Cancer. 2019 Feb 15;144(4):859-867. doi: 10.1002/ijc.31903. Epub 2018 Dec 4.

PMID:
30267407
12.

Systematic identification of cancer-specific MHC-binding peptides with RAVEN.

Baldauf MC, Gerke JS, Kirschner A, Blaeschke F, Effenberger M, Schober K, Rubio RA, Kanaseki T, Kiran MM, Dallmayer M, Musa J, Akpolat N, Akatli AN, Rosman FC, Özen Ö, Sugita S, Hasegawa T, Sugimura H, Baumhoer D, Knott MML, Sannino G, Marchetto A, Li J, Busch DH, Feuchtinger T, Ohmura S, Orth MF, Thiel U, Kirchner T, Grünewald TGP.

Oncoimmunology. 2018 Jul 23;7(9):e1481558. doi: 10.1080/2162402X.2018.1481558. eCollection 2018.

13.

Response to the letter to the editor by Reilmann et al referring to our article titled "Motor cortex synchronization influences the rhythm of motor performance in premanifest Huntington's disease".

Casula EP, Mayer IMS, Desikan M, Tabrizi SJ, Rothwell JC, Orth M.

Mov Disord. 2018 Aug;33(8):1371. doi: 10.1002/mds.27471. Epub 2018 Jul 30. No abstract available.

PMID:
30058234
14.

Effects of locally applied adipose tissue-derived microvascular fragments by thermoresponsive hydrogel on bone healing.

Orth M, Altmeyer MAB, Scheuer C, Braun BJ, Holstein JH, Eglin D, D'Este M, Histing T, Laschke MW, Pohlemann T, Menger MD.

Acta Biomater. 2018 Sep 1;77:201-211. doi: 10.1016/j.actbio.2018.07.029. Epub 2018 Jul 17.

PMID:
30030175
15.

Commutability Assessment of Candidate Reference Materials for Pancreatic α-Amylase.

Deprez L, Toussaint B, Zegers I, Schimmel H, Grote-Koska D, Klauke R, Gella FJ, Orth M, Lessinger JM, Trenti T, Nilsson G, Ceriotti F.

Clin Chem. 2018 Aug;64(8):1193-1202. doi: 10.1373/clinchem.2018.289744. Epub 2018 Jun 14.

PMID:
29903873
16.

Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas?

Baldauf MC, Gerke JS, Orth MF, Dallmayer M, Baumhoer D, de Alava E, Hartmann W, Kirchner T, Grünewald TGP.

Mod Pathol. 2018 Jun;31(6):997-999. doi: 10.1038/s41379-018-0009-7. Epub 2018 Jun 12. No abstract available.

17.

Population-specific genetic modification of Huntington's disease in Venezuela.

Chao MJ, Kim KH, Shin JW, Lucente D, Wheeler VC, Li H, Roach JC, Hood L, Wexler NS, Jardim LB, Holmans P, Jones L, Orth M, Kwak S, MacDonald ME, Gusella JF, Lee JM.

PLoS Genet. 2018 May 11;14(5):e1007274. doi: 10.1371/journal.pgen.1007274. eCollection 2018 May.

18.

Natural biological variation of white matter microstructure is accentuated in Huntington's disease.

Gregory S, Crawford H, Seunarine K, Leavitt B, Durr A, Roos RAC, Scahill RI, Tabrizi SJ, Rees G, Langbehn D, Orth M.

Hum Brain Mapp. 2018 Apr 22. doi: 10.1002/hbm.24191. [Epub ahead of print]

19.

Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets.

Baldauf MC, Orth MF, Dallmayer M, Marchetto A, Gerke JS, Rubio RA, Kiran MM, Musa J, Knott MML, Ohmura S, Li J, Akpolat N, Akatli AN, Özen Ö, Dirksen U, Hartmann W, de Alava E, Baumhoer D, Sannino G, Kirchner T, Grünewald TGP.

Oncotarget. 2017 Aug 4;9(2):1587-1601. doi: 10.18632/oncotarget.20098. eCollection 2018 Jan 5.

20.

Motor cortex synchronization influences the rhythm of motor performance in premanifest huntington's disease.

Casula EP, Mayer IMS, Desikan M, Tabrizi SJ, Rothwell JC, Orth M.

Mov Disord. 2018 Mar;33(3):440-448. doi: 10.1002/mds.27285. Epub 2018 Jan 22.

PMID:
29356133
21.

CHCHD10 mutations p.R15L and p.G66V cause motoneuron disease by haploinsufficiency.

Brockmann SJ, Freischmidt A, Oeckl P, Müller K, Ponna SK, Helferich AM, Paone C, Reinders J, Kojer K, Orth M, Jokela M, Auranen M, Udd B, Hermann A, Danzer KM, Lichtner P, Walther P, Ludolph AC, Andersen PM, Otto M, Kursula P, Just S, Weishaupt JH.

Hum Mol Genet. 2018 Feb 15;27(4):706-715. doi: 10.1093/hmg/ddx436.

PMID:
29315381
22.

Opinion: redefining the role of the physician in laboratory medicine in the context of emerging technologies, personalised medicine and patient autonomy ('4P medicine').

Orth M, Averina M, Chatzipanagiotou S, Faure G, Haushofer A, Kusec V, Machado A, Misbah SA, Oosterhuis W, Pulkki K, Twomey PJ, Wieland E.

J Clin Pathol. 2019 Mar;72(3):191-197. doi: 10.1136/jclinpath-2017-204734. Epub 2017 Dec 22.

23.

Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layer.

Sernadela P, González-Castro L, Carta C, van der Horst E, Lopes P, Kaliyaperumal R, Thompson M, Thompson R, Queralt-Rosinach N, Lopez E, Wood L, Robertson A, Lamanna C, Gilling M, Orth M, Merino-Martinez R, Posada M, Taruscio D, Lochmüller H, Robinson P, Roos M, Oliveira JL.

Biomed Res Int. 2017;2017:8327980. doi: 10.1155/2017/8327980. Epub 2017 Oct 29.

24.

German S3 Guideline Nonrestorative Sleep/Sleep Disorders, chapter "Sleep-Related Breathing Disorders in Adults," short version: German Sleep Society (Deutsche Gesellschaft für Schlafforschung und Schlafmedizin, DGSM).

Mayer G, Arzt M, Braumann B, Ficker JH, Fietze I, Frohnhofen H, Galetke W, Maurer JT, Orth M, Penzel T, Pistner H, Randerath W, Rösslein M, Sitter H, Stuck BA.

Somnologie (Berl). 2017;21(4):290-301. doi: 10.1007/s11818-017-0136-2. Epub 2017 Nov 7. Review. No abstract available.

25.

GSK3α/β: A Novel Therapeutic Target for Neuroendocrine Tumors.

Aristizabal Prada ET, Weis C, Orth M, Lauseker M, Spöttl G, Maurer J, Grabowski P, Grossman A, Auernhammer CJ, Nölting S.

Neuroendocrinology. 2018;106(4):335-351. doi: 10.1159/000481887. Epub 2017 Oct 2.

PMID:
28968593
26.

Influence of age and housing systems on properties of tibia and humerus of Lohmann White hens1: Bone properties of laying hens in commercial housing systems.

Regmi P, Nelson N, Haut RC, Orth MW, Karcher DM.

Poult Sci. 2017 Oct 1;96(10):3755-3762. doi: 10.3382/ps/pex194.

PMID:
28938787
27.

A modifier of Huntington's disease onset at the MLH1 locus.

Lee JM, Chao MJ, Harold D, Abu Elneel K, Gillis T, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF.

Hum Mol Genet. 2017 Oct 1;26(19):3859-3867. doi: 10.1093/hmg/ddx286.

28.

Notes from the Field: Vibrio cholerae Serogroup O1, Serotype Inaba - Minnesota, August 2016.

Hall V, Medus C, Wahl G, Sorenson A, Orth M, Santovenia M, Burdette E, Smith K.

MMWR Morb Mortal Wkly Rep. 2017 Sep 15;66(36):961-962. doi: 10.15585/mmwr.mm6636a6. No abstract available.

29.

Taxane-mediated radiosensitization derives from chromosomal missegregation on tripolar mitotic spindles orchestrated by AURKA and TPX2.

Orth M, Unger K, Schoetz U, Belka C, Lauber K.

Oncogene. 2018 Jan 4;37(1):52-62. doi: 10.1038/onc.2017.304. Epub 2017 Sep 4.

PMID:
28869599
30.

[Obstructive Sleep Apnea Syndrome and Pregnancy].

Orth M, Schäfer T, Schiermeier S, Rasche K.

Pneumologie. 2018 Mar;72(3):187-196. doi: 10.1055/s-0043-113429. Epub 2017 Aug 25. German.

PMID:
28841741
31.

Haplotype-based stratification of Huntington's disease.

Chao MJ, Gillis T, Atwal RS, Mysore JS, Arjomand J, Harold D, Holmans P, Jones L, Orth M, Myers RH, Kwak S, Wheeler VC, MacDonald ME, Gusella JF, Lee JM.

Eur J Hum Genet. 2017 Nov;25(11):1202-1209. doi: 10.1038/ejhg.2017.125. Epub 2017 Aug 23.

32.

The reliability of commonly used electrophysiology measures.

Brown KE, Lohse KR, Mayer IMS, Strigaro G, Desikan M, Casula EP, Meunier S, Popa T, Lamy JC, Odish O, Leavitt BR, Durr A, Roos RAC, Tabrizi SJ, Rothwell JC, Boyd LA, Orth M.

Brain Stimul. 2017 Nov - Dec;10(6):1102-1111. doi: 10.1016/j.brs.2017.07.011. Epub 2017 Jul 31.

PMID:
28807846
33.

The use of error and uncertainty methods in the medical laboratory.

Oosterhuis WP, Bayat H, Armbruster D, Coskun A, Freeman KP, Kallner A, Koch D, Mackenzie F, Migliarino G, Orth M, Sandberg S, Sylte MS, Westgard S, Theodorsson E.

Clin Chem Lab Med. 2018 Jan 26;56(2):209-219. doi: 10.1515/cclm-2017-0341.

34.

Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries.

Boeva V, Louis-Brennetot C, Peltier A, Durand S, Pierre-Eugène C, Raynal V, Etchevers HC, Thomas S, Lermine A, Daudigeos-Dubus E, Geoerger B, Orth MF, Grünewald TGP, Diaz E, Ducos B, Surdez D, Carcaboso AM, Medvedeva I, Deller T, Combaret V, Lapouble E, Pierron G, Grossetête-Lalami S, Baulande S, Schleiermacher G, Barillot E, Rohrer H, Delattre O, Janoueix-Lerosey I.

Nat Genet. 2017 Sep;49(9):1408-1413. doi: 10.1038/ng.3921. Epub 2017 Jul 24.

PMID:
28740262
35.

Next steps in Ewing sarcoma (epi-)genomics.

Sannino G, Orth MF, Grünewald TG.

Future Oncol. 2017 Jun;13(14):1207-1211. doi: 10.2217/fon-2017-0159. Epub 2017 Jun 7. No abstract available.

PMID:
28589731
36.

Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer's disease patients.

Bridel C, Hoffmann T, Meyer A, Durieux S, Koel-Simmelink MA, Orth M, Scheltens P, Lues I, Teunissen CE.

Alzheimers Res Ther. 2017 Jun 6;9(1):38. doi: 10.1186/s13195-017-0266-6.

37.

The MTH1 inhibitor TH588 demonstrates anti-tumoral effects alone and in combination with everolimus, 5-FU and gamma-irradiation in neuroendocrine tumor cells.

Aristizabal Prada ET, Orth M, Nölting S, Spöttl G, Maurer J, Auernhammer C.

PLoS One. 2017 May 25;12(5):e0178375. doi: 10.1371/journal.pone.0178375. eCollection 2017.

38.

Capnocytophaga canimorsus - An underestimated cause of periprosthetic joint infection?

Orth M, Orth P, Anagnostakos K.

Knee. 2017 Aug;24(4):876-881. doi: 10.1016/j.knee.2017.04.011. Epub 2017 May 16.

PMID:
28526202
39.

Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells.

Elia I, Broekaert D, Christen S, Boon R, Radaelli E, Orth MF, Verfaillie C, Grünewald TGP, Fendt SM.

Nat Commun. 2017 May 11;8:15267. doi: 10.1038/ncomms15267.

40.

Weight-bearing recommendations after operative fracture treatment-fact or fiction? Gait results with and feasibility of a dynamic, continuous pedobarography insole.

Braun BJ, Veith NT, Rollmann M, Orth M, Fritz T, Herath SC, Holstein JH, Pohlemann T.

Int Orthop. 2017 Aug;41(8):1507-1512. doi: 10.1007/s00264-017-3481-7. Epub 2017 Apr 19.

PMID:
28421239
41.

Intact sensory-motor network structure and function in far from onset premanifest Huntington's disease.

Gorges M, Müller HP, Mayer IM, Grupe GS, Kammer T, Grön G, Kassubek J, Landwehrmeyer GB, Wolf RC, Orth M.

Sci Rep. 2017 Mar 7;7:43841. doi: 10.1038/srep43841.

42.

[A new continuous gait analysis system for ankle fracture aftercare].

Braun BJ, Veith NT, Herath SC, Hell R, Rollmann M, Orth M, Holstein JH, Pohlemann T.

Unfallchirurg. 2018 Apr;121(4):293-299. doi: 10.1007/s00113-017-0332-3. German.

PMID:
28235983
43.

A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises.

Schönsteiner SS, Bauder Mißbach H, Benner A, Mack S, Hamel T, Orth M, Landwehrmeyer B, Süßmuth SD, Geitner C, Mayer-Steinacker R, Riester A, Prokein A, Erhardt E, Kunecki J, Eisenschink AM, Rawer R, Döhner H, Kirchner E, Schlenk RF.

Exp Hematol Oncol. 2017 Feb 7;6:5. doi: 10.1186/s40164-017-0065-6. eCollection 2017.

44.

White matter predicts functional connectivity in premanifest Huntington's disease.

McColgan P, Gregory S, Razi A, Seunarine KK, Gargouri F, Durr A, Roos RA, Leavitt BR, Scahill RI, Clark CA, Tabrizi SJ, Rees G; Track On‐HD Investigators, Coleman A, Decolongon J, Fan M, Petkau T, Jauffret C, Justo D, Lehericy S, Nigaud K, Valabrègue R, Choonderbeek A, Hart EP, Hensman Moss DJ, Crawford H, Johnson E, Papoutsi M, Berna C, Reilmann R, Weber N, Stout J, Labuschagne I, Landwehrmeyer B, Orth M, Johnson H.

Ann Clin Transl Neurol. 2017 Jan 16;4(2):106-118. doi: 10.1002/acn3.384. eCollection 2017 Feb.

45.

BMP-2-coated mineral coated microparticles improve bone repair in atrophic non-unions.

Orth M, Kruse NJ, Braun BJ, Scheuer C, Holstein JH, Khalil A, Yu X, Murphy WL, Pohlemann T, Laschke MW, Menger MD.

Eur Cell Mater. 2017 Jan 2;33:1-12. doi: 10.22203/eCM.v033a01.

46.

Important but not Enough - Information about HD Related Topics and Peer and Professional Support for Young Adults from HD Families.

Braisch U, Martinez-Horta S, MacDonald M, Orth M.

J Huntingtons Dis. 2016 Dec 15;5(4):379-387.

PMID:
27983563
47.

Mitochondrial cristae remodelling is associated with disrupted OPA1 oligomerisation in the Huntington's disease R6/2 fragment model.

Hering T, Kojer K, Birth N, Hallitsch J, Taanman JW, Orth M.

Exp Neurol. 2017 Feb;288:167-175. doi: 10.1016/j.expneurol.2016.10.017. Epub 2016 Nov 23.

PMID:
27889468
48.

Predictive value of clinical scoring and simplified gait analysis for acetabulum fractures.

Braun BJ, Wrona J, Veith NT, Rollman M, Orth M, Herath SC, Holstein JH, Pohlemann T.

J Surg Res. 2016 Dec;206(2):405-410. doi: 10.1016/j.jss.2016.08.061. Epub 2016 Aug 23.

PMID:
27884336
49.

Identification of extreme motor phenotypes in Huntington's disease.

Braisch U, Hay B, Muche R, Rothenbacher D, Landwehrmeyer GB, Long JD, Orth M; REGISTRY Investigators of the European Huntington's Disease Network and COHORT Investigators of the Huntington Study Group.

Am J Med Genet B Neuropsychiatr Genet. 2017 Apr;174(3):283-294. doi: 10.1002/ajmg.b.32514. Epub 2016 Nov 21.

PMID:
27868347
50.

Genomic amplification of Fanconi anemia complementation group A (FancA) in head and neck squamous cell carcinoma (HNSCC): Cellular mechanisms of radioresistance and clinical relevance.

Hess J, Unger K, Orth M, Schötz U, Schüttrumpf L, Zangen V, Gimenez-Aznar I, Michna A, Schneider L, Stamp R, Selmansberger M, Braselmann H, Hieber L, Drexler GA, Kuger S, Klein D, Jendrossek V, Friedl AA, Belka C, Zitzelsberger H, Lauber K.

Cancer Lett. 2017 Feb 1;386:87-99. doi: 10.1016/j.canlet.2016.11.014. Epub 2016 Nov 17.

PMID:
27867017

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