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The Role of Local Treatment in Oligometastatic and Oligoprogressive Cancer.

Haussmann J, Matuschek C, Bölke E, Orth K, Ghadjar P, Budach W.

Dtsch Arztebl Int. 2019 Dec 13;116(50):849-856. doi: 10.3238/arztebl.2019.0849.


Long-term quality of life after preoperative radiochemotherapy in patients with localized and locally advanced breast cancer.

Haussmann J, Nestle-Kraemling C, Bölke E, Wollandt S, Speer V, Djiepmo Njanang FJ, Tamaskovics B, Gerber PA, Orth K, Ruckhaeberle E, Fehm T, Corradini S, Lammering G, Mohrmann S, Audretsch W, Maas K, Roth S, Kammers K, Budach W, Matuschek C.

Strahlenther Onkol. 2020 Jan 9. doi: 10.1007/s00066-019-01557-z. [Epub ahead of print]


A Novel Mouse Model of Enteric Vibrio parahaemolyticus Infection Reveals that the Type III Secretion System 2 Effector VopC Plays a Key Role in Tissue Invasion and Gastroenteritis.

Yang H, de Souza Santos M, Lee J, Law HT, Chimalapati S, Verdu EF, Orth K, Vallance BA.

mBio. 2019 Dec 17;10(6). pii: e02608-19. doi: 10.1128/mBio.02608-19.


GCNA Preserves Genome Integrity and Fertility Across Species.

Bhargava V, Goldstein CD, Russell L, Xu L, Ahmed M, Li W, Casey A, Servage K, Kollipara R, Picciarelli Z, Kittler R, Yatsenko A, Carmell M, Orth K, Amatruda JF, Yanowitz JL, Buszczak M.

Dev Cell. 2020 Jan 6;52(1):38-52.e10. doi: 10.1016/j.devcel.2019.11.007. Epub 2019 Dec 12.


The Role of the Type III Secretion System in the Intracellular Lifestyle of Enteric Pathogens.

De Souza Santos M, Orth K.

Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0008-2019.


Human pancreatic cancer cell exosomes, but not human normal cell exosomes, act as an initiator in cell transformation.

Stefanius K, Servage K, de Souza Santos M, Gray HF, Toombs JE, Chimalapati S, Kim MS, Malladi VS, Brekken R, Orth K.

Elife. 2019 May 28;8. pii: e40226. doi: 10.7554/eLife.40226.


Long-term cosmetic outcome after preoperative radio-/chemotherapy in locally advanced breast cancer patients.

Matuschek C, Nestle-Kraemling C, Haussmann J, Bölke E, Wollandt S, Speer V, Djiepmo Njanang FJ, Tamaskovics B, Gerber PA, Orth K, Ruckhaeberle E, Fehm T, Corradini S, Lammering G, Mohrmann S, Audretsch W, Roth S, Kammers K, Budach W.

Strahlenther Onkol. 2019 Jul;195(7):615-628. doi: 10.1007/s00066-019-01473-2. Epub 2019 May 17.


High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers.

Peng W, de Souza Santos M, Li Y, Tomchick DR, Orth K.

PLoS One. 2019 May 2;14(5):e0213423. doi: 10.1371/journal.pone.0213423. eCollection 2019.


Direct Detection of Tissue-Resident Bacteria and Chronic Inflammation in the Bladder Wall of Postmenopausal Women with Recurrent Urinary Tract Infection.

De Nisco NJ, Neugent M, Mull J, Chen L, Kuprasertkul A, de Souza Santos M, Palmer KL, Zimmern P, Orth K.

J Mol Biol. 2019 Oct 4;431(21):4368-4379. doi: 10.1016/j.jmb.2019.04.008. Epub 2019 Apr 17.


Adjuvant radiochemotherapy vs. chemotherapy alone in gastric cancer: a meta-analysis.

Matuschek C, Haussmann J, Bölke E, Tamaskovics B, Djiepmo Njanang FJ, Orth K, Peiper M, Gerber PA, Anooshar B, Kammers K, Budach W.

Strahlenther Onkol. 2019 Aug;195(8):695-706. doi: 10.1007/s00066-019-01431-y. Epub 2019 Feb 22.


Accelerated vs. conventionally fractionated adjuvant radiotherapy in high-risk head and neck cancer: a meta-analysis.

Matuschek C, Haussmann J, Bölke E, Gripp S, Schuler PJ, Tamaskovics B, Gerber PA, Djiepmo-Njanang FJ, Kammers K, Plettenberg C, Anooshahr B, Orth K, Budach W.

Radiat Oncol. 2018 Oct 4;13(1):195. doi: 10.1186/s13014-018-1133-8.


Protein AMPylation by an Evolutionarily Conserved Pseudokinase.

Sreelatha A, Yee SS, Lopez VA, Park BC, Kinch LN, Pilch S, Servage KA, Zhang J, Jiou J, Karasiewicz-Urbańska M, Łobocka M, Grishin NV, Orth K, Kucharczyk R, Pawłowski K, Tomchick DR, Tagliabracci VS.

Cell. 2018 Oct 18;175(3):809-821.e19. doi: 10.1016/j.cell.2018.08.046. Epub 2018 Sep 27.


Preventing Surgical Site Infections Related to Abdominal Drains in the Intensive Care Unit.

Orth K.

Crit Care Nurse. 2018 Aug;38(4):20-26. doi: 10.4037/ccn2018254.


Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration.

Moehlman AT, Casey AK, Servage K, Orth K, Krämer H.

Elife. 2018 Jul 17;7. pii: e38752. doi: 10.7554/eLife.38752.


Understanding genomic diversity in Pseudomonas syringae throughout the forest and on the trees.

Baltrus DA, Orth KN.

New Phytol. 2018 Jul;219(2):482-484. doi: 10.1111/nph.15269. No abstract available.


My winding trail while fulfilling my love for science and family.

Orth K.

J Biol Chem. 2018 Jul 6;293(27):10435-10437. doi: 10.1074/jbc.AW118.003225. Epub 2018 Apr 11.


Natural Transformation in Vibrio parahaemolyticus: a Rapid Method To Create Genetic Deletions.

Chimalapati S, de Souza Santos M, Servage K, De Nisco NJ, Dalia AB, Orth K.

J Bacteriol. 2018 Jul 10;200(15). pii: e00032-18. doi: 10.1128/JB.00032-18. Print 2018 Aug 1.


Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies.

Casey AK, Moehlman AT, Zhang J, Servage KA, Krämer H, Orth K.

J Biol Chem. 2018 Feb 2;293(5):1550. doi: 10.1074/jbc.AAC118.001798. Epub 2018 Feb 2. No abstract available.


Rise of a Cereal Killer: The Biology of Magnaporthe oryzae Biotrophic Growth.

Fernandez J, Orth K.

Trends Microbiol. 2018 Jul;26(7):582-597. doi: 10.1016/j.tim.2017.12.007. Epub 2018 Jan 24. Review.


The Biochemistry of Sensing: Enteric Pathogens Regulate Type III Secretion in Response to Environmental and Host Cues.

De Nisco NJ, Rivera-Cancel G, Orth K.

mBio. 2018 Jan 16;9(1). pii: e02122-17. doi: 10.1128/mBio.02122-17. Review.


Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies.

Casey AK, Moehlman AT, Zhang J, Servage KA, Krämer H, Orth K.

J Biol Chem. 2017 Dec 22;292(51):21193-21204. doi: 10.1074/jbc.M117.799296. Epub 2017 Oct 31. Erratum in: J Biol Chem. 2018 Feb 2;293(5):1550.


Type VI secretion system MIX-effectors carry both antibacterial and anti-eukaryotic activities.

Ray A, Schwartz N, de Souza Santos M, Zhang J, Orth K, Salomon D.

EMBO Rep. 2017 Nov;18(11):1978-1990. doi: 10.15252/embr.201744226. Epub 2017 Sep 14.


Enzymes Involved in AMPylation and deAMPylation.

Casey AK, Orth K.

Chem Rev. 2018 Feb 14;118(3):1199-1215. doi: 10.1021/acs.chemrev.7b00145. Epub 2017 Aug 18. Review.


T3SS effector VopL inhibits the host ROS response, promoting the intracellular survival of Vibrio parahaemolyticus.

de Souza Santos M, Salomon D, Orth K.

PLoS Pathog. 2017 Jun 22;13(6):e1006438. doi: 10.1371/journal.ppat.1006438. eCollection 2017 Jun.


Science Signaling Podcast for 16 May 2017: Vibrio rewires host cells.

De Nisco NJ, Orth K, VanHook AM.

Sci Signal. 2017 May 16;10(479). pii: eaan5621. doi: 10.1126/scisignal.aan5621.


The cytotoxic type 3 secretion system 1 of Vibrio rewires host gene expression to subvert cell death and activate cell survival pathways.

De Nisco NJ, Kanchwala M, Li P, Fernandez J, Xing C, Orth K.

Sci Signal. 2017 May 16;10(479). pii: eaal4501. doi: 10.1126/scisignal.aal4501.


Acute Hepatopancreatic Necrosis Disease-Causing Vibrio parahaemolyticus Strains Maintain an Antibacterial Type VI Secretion System with Versatile Effector Repertoires.

Li P, Kinch LN, Ray A, Dalia AB, Cong Q, Nunan LM, Camilli A, Grishin NV, Salomon D, Orth K.

Appl Environ Microbiol. 2017 Jun 16;83(13). pii: e00737-17. doi: 10.1128/AEM.00737-17. Print 2017 Jul 1.


The benefit of adjuvant radiotherapy after breast conserving surgery in older patients with low risk breast cancer- a meta-analysis of randomized trials.

Matuschek C, Bölke E, Haussmann J, Mohrmann S, Nestle-Krämling C, Gerber PA, Corradini S, Orth K, Kammers K, Budach W.

Radiat Oncol. 2017 Mar 23;12(1):60. doi: 10.1186/s13014-017-0796-x.


Biochemical basis for activation of virulence genes by bile salts in Vibrio parahaemolyticus.

Rivera-Cancel G, Orth K.

Gut Microbes. 2017 Jul 4;8(4):366-373. doi: 10.1080/19490976.2017.1287655. Epub 2017 Jan 27. Review.


Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury.

Huebinger RM, Stones DH, de Souza Santos M, Carlson DL, Song J, Vaz DP, Keen E, Wolf SE, Orth K, Krachler AM.

Sci Rep. 2016 Dec 20;6:39341. doi: 10.1038/srep39341.


Proteomics Analysis Reveals Previously Uncharacterized Virulence Factors in Vibrio proteolyticus.

Ray A, Kinch LN, de Souza Santos M, Grishin NV, Orth K, Salomon D.

mBio. 2016 Jul 26;7(4). pii: e01077-16. doi: 10.1128/mBio.01077-16.


Bile salt receptor complex activates a pathogenic type III secretion system.

Li P, Rivera-Cancel G, Kinch LN, Salomon D, Tomchick DR, Grishin NV, Orth K.

Elife. 2016 Jul 5;5. pii: e15718. doi: 10.7554/eLife.15718.


Influence of dosimetric and clinical criteria on the requirement of artificial nutrition during radiotherapy of head and neck cancer patients.

Matuschek C, Bölke E, Geigis C, Kammers K, Ganswindt U, Scheckenbach K, Gripp S, Simiantonakis J, Hoffmann TK, Greve J, Gerber PA, Orth K, Roeder H, Hautmann MG, Budach W.

Radiother Oncol. 2016 Jul;120(1):28-35. doi: 10.1016/j.radonc.2016.05.017. Epub 2016 Jun 10.


Induction chemotherapy followed by concurrent radio-chemotherapy versus concurrent radio-chemotherapy alone as treatment of locally advanced squamous cell carcinoma of the head and neck (HNSCC): A meta-analysis of randomized trials.

Budach W, Bölke E, Kammers K, Gerber PA, Orth K, Gripp S, Matuschek C.

Radiother Oncol. 2016 Feb;118(2):238-43. doi: 10.1016/j.radonc.2015.10.014. Epub 2015 Nov 14.


Type VI Secretion System Toxins Horizontally Shared between Marine Bacteria.

Salomon D, Klimko JA, Trudgian DC, Kinch LN, Grishin NV, Mirzaei H, Orth K.

PLoS Pathog. 2015 Aug 25;11(8):e1005128. doi: 10.1371/journal.ppat.1005128. eCollection 2015 Aug.


Effects of Radiotherapy in the treatment of multiple myeloma: a retrospective analysis of a Single Institution.

Matuschek C, Ochtrop TA, Bölke E, Ganswindt U, Fenk R, Gripp S, Kröpil P, Gerber PA, Kammers K, Hamilton J, Orth K, Budach W.

Radiat Oncol. 2015 Mar 28;10:71. doi: 10.1186/s13014-015-0374-z.


Type VI secretion system.

Salomon D, Orth K.

Curr Biol. 2015 Mar 30;25(7):R265-6. doi: 10.1016/j.cub.2015.02.031.


Vibrio effector protein VopQ inhibits fusion of V-ATPase-containing membranes.

Sreelatha A, Bennett TL, Carpinone EM, O'Brien KM, Jordan KD, Burdette DL, Orth K, Starai VJ.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):100-5. doi: 10.1073/pnas.1413764111. Epub 2014 Dec 1.


Subversion of the cytoskeleton by intracellular bacteria: lessons from Listeria, Salmonella and Vibrio.

de Souza Santos M, Orth K.

Cell Microbiol. 2015 Feb;17(2):164-73. doi: 10.1111/cmi.12399. Epub 2015 Jan 8. Review.


Unfolded protein response-regulated Drosophila Fic (dFic) protein reversibly AMPylates BiP chaperone during endoplasmic reticulum homeostasis.

Ham H, Woolery AR, Tracy C, Stenesen D, Krämer H, Orth K.

J Biol Chem. 2014 Dec 26;289(52):36059-69. doi: 10.1074/jbc.M114.612515. Epub 2014 Nov 13.


AMPylation of Rho GTPases subverts multiple host signaling processes.

Woolery AR, Yu X, LaBaer J, Orth K.

J Biol Chem. 2014 Nov 21;289(47):32977-88. doi: 10.1074/jbc.M114.601310. Epub 2014 Oct 9.


Structural and regulatory mutations in Vibrio parahaemolyticus type III secretion systems display variable effects on virulence.

Calder T, de Souza Santos M, Attah V, Klimko J, Fernandez J, Salomon D, Krachler AM, Orth K.

FEMS Microbiol Lett. 2014 Dec;361(2):107-14. doi: 10.1111/1574-6968.12619. Epub 2014 Oct 31.


Vibrio type III effector VPA1380 is related to the cysteine protease domain of large bacterial toxins.

Calder T, Kinch LN, Fernandez J, Salomon D, Grishin NV, Orth K.

PLoS One. 2014 Aug 6;9(8):e104387. doi: 10.1371/journal.pone.0104387. eCollection 2014.


Copper-catalyzed azide-alkyne cycloaddition (click chemistry)-based detection of global pathogen-host AMPylation on self-assembled human protein microarrays.

Yu X, Woolery AR, Luong P, Hao YH, Grammel M, Westcott N, Park J, Wang J, Bian X, Demirkan G, Hang HC, Orth K, LaBaer J.

Mol Cell Proteomics. 2014 Nov;13(11):3164-76. doi: 10.1074/mcp.M114.041103. Epub 2014 Jul 29.


H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1.

Salomon D, Klimko JA, Orth K.

Microbiology. 2014 Sep;160(Pt 9):1867-1873. doi: 10.1099/mic.0.080028-0. Epub 2014 Jul 1.


Marker for type VI secretion system effectors.

Salomon D, Kinch LN, Trudgian DC, Guo X, Klimko JA, Grishin NV, Mirzaei H, Orth K.

Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9271-6. doi: 10.1073/pnas.1406110111. Epub 2014 Jun 9.


Increased CD44s and decreased CD44v6 RNA expression are associated with better survival in myxofibrosarcoma patients: a pilot study.

Matuschek C, Lehnhardt M, Gerber PA, Poremba C, Hamilton J, Lammering G, Orth K, Budach W, Bojar H, Bölke E, Peiper M.

Eur J Med Res. 2014 Feb 3;19:6. doi: 10.1186/2047-783X-19-6.


Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides.

Salomon D, Guo Y, Kinch LN, Grishin NV, Gardner KH, Orth K.

Nat Commun. 2013;4:2973. doi: 10.1038/ncomms3973.


Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation.

Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR.

ACS Chem Biol. 2014 Feb 21;9(2):433-42. doi: 10.1021/cb4006886. Epub 2013 Nov 25.

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