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Items: 37


Two alternative mechanisms regulate the onset of chaperone-mediated assembly of the proteasomal ATPases.

Nahar A, Fu X, Polovin G, Orth JD, Park S.

J Biol Chem. 2019 Apr 19;294(16):6562-6577. doi: 10.1074/jbc.RA118.006298. Epub 2019 Feb 27.


Loss of p53 expression in cancer cells alters cell cycle response after inhibition of exportin-1 but does not prevent cell death.

Marcus JM, Burke RT, Doak AE, Park S, Orth JD.

Cell Cycle. 2018;17(11):1329-1344. doi: 10.1080/15384101.2018.1480224. Epub 2018 Jul 23.


Inhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells.

Burke RT, Marcus JM, Orth JD.

Oncotarget. 2017 Jun 13;8(24):39460-39475. doi: 10.18632/oncotarget.17063.


Longitudinal tracking of single live cancer cells to understand cell cycle effects of the nuclear export inhibitor, selinexor.

Marcus JM, Burke RT, DeSisto JA, Landesman Y, Orth JD.

Sci Rep. 2015 Sep 24;5:14391. doi: 10.1038/srep14391.


In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy.

Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ.

Nat Methods. 2015 Jun;12(6):577-85. doi: 10.1038/nmeth.3363. Epub 2015 Apr 13.


Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin.

Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R.

Sci Transl Med. 2014 Nov 5;6(261):261ra152. doi: 10.1126/scitranslmed.3009318.


Genome-scale metabolic reconstructions of multiple Escherichia coli strains highlight strain-specific adaptations to nutritional environments.

Monk JM, Charusanti P, Aziz RK, Lerman JA, Premyodhin N, Orth JD, Feist AM, Palsson BØ.

Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20338-43. doi: 10.1073/pnas.1307797110. Epub 2013 Nov 25.


In silico method for modelling metabolism and gene product expression at genome scale.

Lerman JA, Hyduke DR, Latif H, Portnoy VA, Lewis NE, Orth JD, Schrimpe-Rutledge AC, Smith RD, Adkins JN, Zengler K, Palsson BO.

Nat Commun. 2012 Jul 3;3:929. doi: 10.1038/ncomms1928.


Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction.

Orth JD, Loewer A, Lahav G, Mitchison TJ.

Mol Biol Cell. 2012 Feb;23(4):567-76. doi: 10.1091/mbc.E11-09-0781. Epub 2011 Dec 14.


A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011.

Orth JD, Conrad TM, Na J, Lerman JA, Nam H, Feist AM, Palsson BØ.

Mol Syst Biol. 2011 Oct 11;7:535. doi: 10.1038/msb.2011.65.


Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0.

Schellenberger J, Que R, Fleming RM, Thiele I, Orth JD, Feist AM, Zielinski DC, Bordbar A, Lewis NE, Rahmanian S, Kang J, Hyduke DR, Palsson BØ.

Nat Protoc. 2011 Aug 4;6(9):1290-307. doi: 10.1038/nprot.2011.308.


Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells.

Tang Y, Orth JD, Xie T, Mitchison TJ.

Cancer Lett. 2011 Nov 1;310(1):15-24. doi: 10.1016/j.canlet.2011.05.024. Epub 2011 Jun 24.


Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics.

Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ.

Cancer Res. 2011 Jul 1;71(13):4608-16. doi: 10.1158/0008-5472.CAN-11-0412. Epub 2011 Jun 28.


Reconstruction and Use of Microbial Metabolic Networks: the Core Escherichia coli Metabolic Model as an Educational Guide.

Orth JD, Fleming RM, Palsson BØ.

EcoSal Plus. 2010 Sep;4(1). doi: 10.1128/ecosalplus.10.2.1.


Systematizing the generation of missing metabolic knowledge.

Orth JD, Palsson BØ.

Biotechnol Bioeng. 2010 Oct 15;107(3):403-12. doi: 10.1002/bit.22844. Review.


Cell death when the SAC is out of commission.

Huang HC, Shi J, Orth JD, Mitchison TJ.

Cell Cycle. 2010 Jun 1;9(11):2049-50. Epub 2010 Jun 1. No abstract available.


What is flux balance analysis?

Orth JD, Thiele I, Palsson BØ.

Nat Biotechnol. 2010 Mar;28(3):245-8. doi: 10.1038/nbt.1614. No abstract available.


Model-driven evaluation of the production potential for growth-coupled products of Escherichia coli.

Feist AM, Zielinski DC, Orth JD, Schellenberger J, Herrgard MJ, Palsson BØ.

Metab Eng. 2010 May;12(3):173-86. doi: 10.1016/j.ymben.2009.10.003. Epub 2009 Oct 17.


An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor.

Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ.

PLoS One. 2009 Oct 5;4(10):e7339. doi: 10.1371/journal.pone.0007339.


Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly.

Huang HC, Shi J, Orth JD, Mitchison TJ.

Cancer Cell. 2009 Oct 6;16(4):347-58. doi: 10.1016/j.ccr.2009.08.020.


Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate.

Orth JD, Tang Y, Shi J, Loy CT, Amendt C, Wilm C, Zenke FT, Mitchison TJ.

Mol Cancer Ther. 2008 Nov;7(11):3480-9. doi: 10.1158/1535-7163.MCT-08-0684. Epub 2008 Oct 30.


Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.

Shi J, Orth JD, Mitchison T.

Cancer Res. 2008 May 1;68(9):3269-76. doi: 10.1158/0008-5472.CAN-07-6699.


Get off my back! Rapid receptor internalization through circular dorsal ruffles.

Orth JD, McNiven MA.

Cancer Res. 2006 Dec 1;66(23):11094-6. Review.


A novel endocytic mechanism of epidermal growth factor receptor sequestration and internalization.

Orth JD, Krueger EW, Weller SG, McNiven MA.

Cancer Res. 2006 Apr 1;66(7):3603-10.


Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport.

Cao H, Weller S, Orth JD, Chen J, Huang B, Chen JL, Stamnes M, McNiven MA.

Nat Cell Biol. 2005 May;7(5):483-92. Epub 2005 Apr 10.


Caveolin-1 interacts directly with dynamin-2.

Yao Q, Chen J, Cao H, Orth JD, McCaffery JM, Stan RV, McNiven MA.

J Mol Biol. 2005 Apr 29;348(2):491-501.


Foot and mouth: podosomes, invadopodia and circular dorsal ruffles.

Buccione R, Orth JD, McNiven MA.

Nat Rev Mol Cell Biol. 2004 Aug;5(8):647-57. Review.


Cdc42 and the actin-related protein/neural Wiskott-Aldrich syndrome protein network mediate cellular invasion by Cryptosporidium parvum.

Chen XM, Huang BQ, Splinter PL, Orth JD, Billadeau DD, McNiven MA, LaRusso NF.

Infect Immun. 2004 May;72(5):3011-21.


A dynamin-cortactin-Arp2/3 complex mediates actin reorganization in growth factor-stimulated cells.

Krueger EW, Orth JD, Cao H, McNiven MA.

Mol Biol Cell. 2003 Mar;14(3):1085-96.


Cortactin is a component of clathrin-coated pits and participates in receptor-mediated endocytosis.

Cao H, Orth JD, Chen J, Weller SG, Heuser JE, McNiven MA.

Mol Cell Biol. 2003 Mar;23(6):2162-70.


Dynamin at the actin-membrane interface.

Orth JD, McNiven MA.

Curr Opin Cell Biol. 2003 Feb;15(1):31-9. Review.


The large GTPase dynamin regulates actin comet formation and movement in living cells.

Orth JD, Krueger EW, Cao H, McNiven MA.

Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):167-72.


Characterization of the X-linked murine centrin Cetn2 gene.

Hart PE, Poynter GM, Whitehead CM, Orth JD, Glantz JN, Busby RC, Barrett SL, Salisbury JL.

Gene. 2001 Feb 21;264(2):205-13.


Regulated interactions between dynamin and the actin-binding protein cortactin modulate cell shape.

McNiven MA, Kim L, Krueger EW, Orth JD, Cao H, Wong TW.

J Cell Biol. 2000 Oct 2;151(1):187-98.


Testis-specific murine centrin, Cetn1: genomic characterization and evidence for retroposition of a gene encoding a centrosome protein.

Hart PE, Glantz JN, Orth JD, Poynter GM, Salisbury JL.

Genomics. 1999 Sep 1;60(2):111-20.


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