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3D sub-diffraction imaging in a conventional confocal configuration by exploiting super-linear emitters.

Denkova D, Ploschner M, Das M, Parker LM, Zheng X, Lu Y, Orth A, Packer NH, Piper JA.

Nat Commun. 2019 Aug 16;10(1):3695. doi: 10.1038/s41467-019-11603-0.


Measuring the impact of a mandatory province-wide vaccinate-or-mask policy on healthcare worker absenteeism in British Columbia, Canada.

Murti M, Otterstatter M, Orth A, Balshaw R, Halani K, Brown PD, Hejazi S, Thompson D, Allison S, Bharmal A, Dawar M, Hoyano D, Lee V, Naus M, Pollock S, Bevanda J, Coughlin S, Fitzgerald J, Keen D, Maracle M, Sprague S, Henry B.

Vaccine. 2019 Jul 9;37(30):4008-4014. doi: 10.1016/j.vaccine.2019.06.007. Epub 2019 Jun 14.


Measuring the impact of influenza vaccination on healthcare worker absenteeism in the context of a province-wide mandatory vaccinate-or-mask policy.

Murti M, Otterstatter M, Orth A, Balshaw R, Halani K, Brown PD, Hejazi S, Thompson D, Allison S, Bharmal A, Dawar M, Hoyano D, Lee V, Naus M, Pollock S, Bevanda J, Coughlin S, Fitzgerald J, Keen D, Maracle M, Sprague S, Henry B.

Vaccine. 2019 Jul 9;37(30):4001-4007. doi: 10.1016/j.vaccine.2019.06.014. Epub 2019 Jun 14.


The effect of particle size on nanodiamond fluorescence and colloidal properties in biological media.

Wilson ER, Parker LM, Orth A, Nunn N, Torelli M, Shenderova O, Gibson BC, Reineck P.

Nanotechnology. 2019 Sep 20;30(38):385704. doi: 10.1088/1361-6528/ab283d. Epub 2019 Jun 10.


Optical fiber bundles: Ultra-slim light field imaging probes.

Orth A, Ploschner M, Wilson ER, Maksymov IS, Gibson BC.

Sci Adv. 2019 Apr 26;5(4):eaav1555. doi: 10.1126/sciadv.aav1555. eCollection 2019 Apr.


Survey of Awareness and Perceptions of Canadians on the Benefits and Risks of Clinical Trials.

Willison DJ, Richards DP, Orth A, Harris H, Marlin S.

Ther Innov Regul Sci. 2019 Sep;53(5):669-677. doi: 10.1177/2168479018805433. Epub 2018 Oct 29.


Structure-guided combination therapy to potently improve the function of mutant CFTRs.

Veit G, Xu H, Dreano E, Avramescu RG, Bagdany M, Beitel LK, Roldan A, Hancock MA, Lay C, Li W, Morin K, Gao S, Mak PA, Ainscow E, Orth AP, McNamara P, Edelman A, Frenkiel S, Matouk E, Sermet-Gaudelus I, Barnes WG, Lukacs GL.

Nat Med. 2018 Nov;24(11):1732-1742. doi: 10.1038/s41591-018-0200-x. Epub 2018 Oct 8.


Two-photon polymerisation 3D printed freeform micro-optics for optical coherence tomography fibre probes.

Li J, Fejes P, Lorenser D, Quirk BC, Noble PB, Kirk RW, Orth A, Wood FM, Gibson BC, Sampson DD, McLaughlin RA.

Sci Rep. 2018 Oct 4;8(1):14789. doi: 10.1038/s41598-018-32407-0.


Joint Modeling of Immune Reconstitution Post Haploidentical Stem Cell Transplantation in Pediatric Patients With Acute Leukemia Comparing CD34+-Selected to CD3/CD19-Depleted Grafts in a Retrospective Multicenter Study.

Salzmann-Manrique E, Bremm M, Huenecke S, Stech M, Orth A, Eyrich M, Schulz A, Esser R, Klingebiel T, Bader P, Herrmann E, Koehl U.

Front Immunol. 2018 Aug 14;9:1841. doi: 10.3389/fimmu.2018.01841. eCollection 2018.


Changes in hypopharyngeal glands of nurse bees (Apis mellifera) induced by pollen-containing sublethal doses of the herbicide Roundup®.

Faita MR, Oliveira EM, Alves VV Júnior, Orth AI, Nodari RO.

Chemosphere. 2018 Nov;211:566-572. doi: 10.1016/j.chemosphere.2018.07.189. Epub 2018 Aug 1.


Co-regulatory networks of human serum proteins link genetics to disease.

Emilsson V, Ilkov M, Lamb JR, Finkel N, Gudmundsson EF, Pitts R, Hoover H, Gudmundsdottir V, Horman SR, Aspelund T, Shu L, Trifonov V, Sigurdsson S, Manolescu A, Zhu J, Olafsson Ö, Jakobsdottir J, Lesley SA, To J, Zhang J, Harris TB, Launer LJ, Zhang B, Eiriksdottir G, Yang X, Orth AP, Jennings LL, Gudnason V.

Science. 2018 Aug 24;361(6404):769-773. doi: 10.1126/science.aaq1327. Epub 2018 Aug 2.


Super-multiplexed fluorescence microscopy via photostability contrast.

Orth A, Ghosh RN, Wilson ER, Doughney T, Brown H, Reineck P, Thompson JG, Gibson BC.

Biomed Opt Express. 2018 Jun 6;9(7):2943-2954. doi: 10.1364/BOE.9.002943. eCollection 2018 Jul 1.


GPR68 Senses Flow and Is Essential for Vascular Physiology.

Xu J, Mathur J, Vessières E, Hammack S, Nonomura K, Favre J, Grimaud L, Petrus M, Francisco A, Li J, Lee V, Xiang FL, Mainquist JK, Cahalan SM, Orth AP, Walker JR, Ma S, Lukacs V, Bordone L, Bandell M, Laffitte B, Xu Y, Chien S, Henrion D, Patapoutian A.

Cell. 2018 Apr 19;173(3):762-775.e16. doi: 10.1016/j.cell.2018.03.076.


Extended depth of field imaging through multicore optical fibers.

Orth A, Ploschner M, Maksymov IS, Gibson BC.

Opt Express. 2018 Mar 5;26(5):6407-6419. doi: 10.1364/OE.26.006407.


A dual-mode mobile phone microscope using the onboard camera flash and ambient light.

Orth A, Wilson ER, Thompson JG, Gibson BC.

Sci Rep. 2018 Feb 19;8(1):3298. doi: 10.1038/s41598-018-21543-2.


Reproductive Biology of Varronia curassavica Jacq. (Boraginaceae).

Hoeltgebaum MP, Montagna T, Lando AP, Puttkammer C, Orth AI, Guerra MP, Reis MSD.

An Acad Bras Cienc. 2018 Jan-Mar;90(1):59-71. doi: 10.1590/0001-3765201820160273. Epub 2018 Feb 1.


Functional profiling of microtumors to identify cancer associated fibroblast-derived drug targets.

Horman SR, To J, Lamb J, Zoll JH, Leonetti N, Tu B, Moran R, Newlin R, Walker JR, Orth AP.

Oncotarget. 2017 Oct 20;8(59):99913-99930. doi: 10.18632/oncotarget.21915. eCollection 2017 Nov 21.


Fluorescence brightness and photostability of individual copper (I) oxide nanocubes.

Zohora N, Kandjani AE, Orth A, Brown HM, Hutchinson MR, Gibson BC.

Sci Rep. 2017 Dec 4;7(1):16905. doi: 10.1038/s41598-017-17295-0.


Whole exome sequencing of wild-derived inbred strains of mice improves power to link phenotype and genotype.

Chang PL, Kopania E, Keeble S, Sarver BAJ, Larson E, Orth A, Belkhir K, Boursot P, Bonhomme F, Good JM, Dean MD.

Mamm Genome. 2017 Oct;28(9-10):416-425. doi: 10.1007/s00335-017-9704-9. Epub 2017 Aug 17.


Magnetic field-induced enhancement of the nitrogen-vacancy fluorescence quantum yield.

Capelli M, Reineck P, Lau DWM, Orth A, Jeske J, Doherty MW, Ohshima T, Greentree AD, Gibson BC.

Nanoscale. 2017 Jul 13;9(27):9299-9304. doi: 10.1039/c7nr02093g.


Automatic identification of variables in epidemiological datasets using logic regression.

Lorenz MW, Abdi NA, Scheckenbach F, Pflug A, Bülbül A, Catapano AL, Agewall S, Ezhov M, Bots ML, Kiechl S, Orth A; PROG-IMT study group.

BMC Med Inform Decis Mak. 2017 Apr 13;17(1):40. doi: 10.1186/s12911-017-0429-1.


Microscopy, Meet Big Data.

Orth A, Schaak D, Schonbrun E.

Cell Syst. 2017 Mar 22;4(3):260-261. doi: 10.1016/j.cels.2017.03.009.


Evaluation of different time schedules in training with the Da Vinci simulator.

Güldner C, Orth A, Dworschak P, Diogo I, Mandapathil M, Teymoortash A, Walliczek-Dworschak U.

Surg Endosc. 2017 Oct;31(10):4118-4125. doi: 10.1007/s00464-017-5460-x. Epub 2017 Mar 9.


Dictionary-enhanced imaging cytometry.

Orth A, Schaak D, Schonbrun E.

Sci Rep. 2017 Feb 22;7:43148. doi: 10.1038/srep43148.


The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERα.

Britschgi A, Duss S, Kim S, Couto JP, Brinkhaus H, Koren S, De Silva D, Mertz KD, Kaup D, Varga Z, Voshol H, Vissieres A, Leroy C, Roloff T, Stadler MB, Scheel CH, Miraglia LJ, Orth AP, Bonamy GM, Reddy VA, Bentires-Alj M.

Nature. 2017 Jan 26;541(7638):541-545. doi: 10.1038/nature20829. Epub 2017 Jan 9.


High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine Receptor.

Groot-Kormelink PJ, Ferrand S, Kelley N, Bill A, Freuler F, Imbert PE, Marelli A, Gerwin N, Sivilotti LG, Miraglia L, Orth AP, Oakeley EJ, Schopfer U, Siehler S.

PLoS One. 2016 Sep 20;11(9):e0163129. doi: 10.1371/journal.pone.0163129. eCollection 2016.


Chronic Responses of Daphnia magna Under Dietary Exposure to Leaves of a Transgenic (Event MON810) Bt-Maize Hybrid and its Conventional Near-Isoline.

Holderbaum DF, Cuhra M, Wickson F, Orth AI, Nodari RO, Bøhn T.

J Toxicol Environ Health A. 2015;78(15):993-1007. doi: 10.1080/15287394.2015.1037877.


Eurasian house mouse (Mus musculus L.) differentiation at microsatellite loci identifies the Iranian plateau as a phylogeographic hotspot.

Hardouin EA, Orth A, Teschke M, Darvish J, Tautz D, Bonhomme F.

BMC Evol Biol. 2015 Feb 25;15:26. doi: 10.1186/s12862-015-0306-4.


Identification of synthetic lethality of PRKDC in MYC-dependent human cancers by pooled shRNA screening.

Zhou Z, Patel M, Ng N, Hsieh MH, Orth AP, Walker JR, Batalov S, Harris JL, Liu J.

BMC Cancer. 2014 Dec 13;14:944. doi: 10.1186/1471-2407-14-944.


High throughput multichannel fluorescence microscopy with microlens arrays.

Orth A, Crozier KB.

Opt Express. 2014 Jul 28;22(15):18101-12. doi: 10.1364/OE.22.018101.


High throughput mutagenesis for identification of residues regulating human prostacyclin (hIP) receptor expression and function.

Bill A, Rosethorne EM, Kent TC, Fawcett L, Burchell L, van Diepen MT, Marelli A, Batalov S, Miraglia L, Orth AP, Renaud NA, Charlton SJ, Gosling M, Gaither LA, Groot-Kormelink PJ.

PLoS One. 2014 Jun 2;9(6):e97973. doi: 10.1371/journal.pone.0097973. eCollection 2014.


Genome-wide analysis reveals the ancient and recent admixture history of East African Shorthorn Zebu from Western Kenya.

Mbole-Kariuki MN, Sonstegard T, Orth A, Thumbi SM, Bronsvoort BM, Kiara H, Toye P, Conradie I, Jennings A, Coetzer K, Woolhouse ME, Hanotte O, Tapio M.

Heredity (Edinb). 2014 Oct;113(4):297-305. doi: 10.1038/hdy.2014.31. Epub 2014 Apr 16.


SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.

Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, Reinhardt J, Orth AP, Patapoutian A.

Cell. 2014 Apr 10;157(2):447-458. doi: 10.1016/j.cell.2014.03.024.


Autoantibodies to glutamate receptor antigens in multiple sclerosis and Rasmussen's encephalitis.

Trippe J, Steinke K, Orth A, Faustmann PM, Hollmann M, Haase CG.

Neuroimmunomodulation. 2014;21(4):189-94. doi: 10.1159/000356519. Epub 2014 Feb 6.


Assessment of dietary exposure to flavouring substances via consumption of flavoured teas. Part II: transfer rates of linalool and linalyl esters into Earl Grey tea infusions.

Orth AM, Poplacean I, Fastowski O, Engel KH.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2014;31(2):207-17. doi: 10.1080/19440049.2013.866717. Epub 2014 Jan 21.


An HTS-compatible 3D colony formation assay to identify tumor-specific chemotherapeutics.

Horman SR, To J, Orth AP.

J Biomol Screen. 2013 Dec;18(10):1298-308. doi: 10.1177/1087057113499405. Epub 2013 Aug 5.


Light field moment imaging.

Orth A, Crozier KB.

Opt Lett. 2013 Aug 1;38(15):2666-8. doi: 10.1364/OL.38.002666.


Assessment of dietary exposure to flavouring substances via consumption of flavoured teas. Part 1: occurrence and contents of monoterpenes in Earl Grey teas marketed in the European Union.

Orth AM, Yu L, Engel KH.

Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(10):1701-14. doi: 10.1080/19440049.2013.817687. Epub 2013 Jul 26.


Akt-mediated phosphorylation of argonaute 2 downregulates cleavage and upregulates translational repression of MicroRNA targets.

Horman SR, Janas MM, Litterst C, Wang B, MacRae IJ, Sever MJ, Morrissey DV, Graves P, Luo B, Umesalma S, Qi HH, Miraglia LJ, Novina CD, Orth AP.

Mol Cell. 2013 May 9;50(3):356-67. doi: 10.1016/j.molcel.2013.03.015. Epub 2013 Apr 18.


The delta subfamily of glutamate receptors: characterization of receptor chimeras and mutants.

Orth A, Tapken D, Hollmann M.

Eur J Neurosci. 2013 May;37(10):1620-30. doi: 10.1111/ejn.12193. Epub 2013 Mar 31.


Gigapixel fluorescence microscopy with a water immersion microlens array.

Orth A, Crozier K.

Opt Express. 2013 Jan 28;21(2):2361-8. doi: 10.1364/OE.21.002361.


FGFR2 promotes breast tumorigenicity through maintenance of breast tumor-initiating cells.

Kim S, Dubrovska A, Salamone RJ, Walker JR, Grandinetti KB, Bonamy GM, Orth AP, Elliott J, Porta DG, Garcia-Echeverria C, Reddy VA.

PLoS One. 2013;8(1):e51671. doi: 10.1371/journal.pone.0051671. Epub 2013 Jan 2.


Measuring the pressures across microfluidic droplets with an optical tweezer.

Jin Y, Orth A, Schonbrun E, Crozier KB.

Opt Express. 2012 Oct 22;20(22):24450-64. doi: 10.1364/OE.20.024450.


Viral metagenomics demonstrates that domestic pigs are a potential reservoir for Ndumu virus.

Masembe C, Michuki G, Onyango M, Rumberia C, Norling M, Bishop RP, Djikeng A, Kemp SJ, Orth A, Skilton RA, Ståhl K, Fischer A.

Virol J. 2012 Sep 24;9:218. doi: 10.1186/1743-422X-9-218.


Microscopy with microlens arrays: high throughput, high resolution and light-field imaging.

Orth A, Crozier K.

Opt Express. 2012 Jun 4;20(12):13522-31. doi: 10.1364/OE.20.013522.


Cofactors required for TLR7- and TLR9-dependent innate immune responses.

Chiang CY, Engel A, Opaluch AM, Ramos I, Maestre AM, Secundino I, De Jesus PD, Nguyen QT, Welch G, Bonamy GM, Miraglia LJ, Orth AP, Nizet V, Fernandez-Sesma A, Zhou Y, Barton GM, Chanda SK.

Cell Host Microbe. 2012 Mar 15;11(3):306-18. doi: 10.1016/j.chom.2012.02.002.


Creating and modulating microdomains in pore-spanning membranes.

Orth A, Johannes L, Römer W, Steinem C.

Chemphyschem. 2012 Jan 16;13(1):108-14. doi: 10.1002/cphc.201100644. Epub 2011 Dec 1.


Multiplexed pressure sensing with elastomer membranes.

Orth A, Schonbrun E, Crozier KB.

Lab Chip. 2011 Nov 21;11(22):3810-5. doi: 10.1039/c1lc20114j. Epub 2011 Sep 30.


Tumor suppressor protein (p)53, is a regulator of NF-kappaB repression by the glucocorticoid receptor.

Murphy SH, Suzuki K, Downes M, Welch GL, De Jesus P, Miraglia LJ, Orth AP, Chanda SK, Evans RM, Verma IM.

Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17117-22. doi: 10.1073/pnas.1114420108. Epub 2011 Sep 26.


Residues at the tip of the pore loop of NR3B-containing NMDA receptors determine Ca2+ permeability and Mg2+ block.

Cavara NA, Orth A, Hicking G, Seebohm G, Hollmann M.

BMC Neurosci. 2010 Oct 19;11:133. doi: 10.1186/1471-2202-11-133.

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