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A Phase 2a Study of DP2-antagonist GB001 for Asthma.

Asano K, Sagara H, Ichinose M, Hirata M, Nakajima A, Ortega H, Tohda Y.

J Allergy Clin Immunol Pract. 2019 Nov 25. pii: S2213-2198(19)30955-9. doi: 10.1016/j.jaip.2019.11.016. [Epub ahead of print]


A phase 2 study to evaluate the safety, efficacy and pharmacokinetics of DP2 antagonist GB001 and to explore biomarkers of airway inflammation in mild-to-moderate asthma.

Ortega H, Fitzgerald M, Raghupathi K, Tompkins CA, Shen J, Dittrich K, Pattwell C, Singh D.

Clin Exp Allergy. 2019 Oct 28. doi: 10.1111/cea.13524. [Epub ahead of print]


Unexpected fish diversity gradients in the Amazon basin.

Oberdorff T, Dias MS, Jézéquel C, Albert JS, Arantes CC, Bigorne R, Carvajal-Valleros FM, De Wever A, Frederico RG, Hidalgo M, Hugueny B, Leprieur F, Maldonado M, Maldonado-Ocampo J, Martens K, Ortega H, Sarmiento J, Tedesco PA, Torrente-Vilara G, Winemiller KO, Zuanon J.

Sci Adv. 2019 Sep 11;5(9):eaav8681. doi: 10.1126/sciadv.aav8681. eCollection 2019 Sep.


Hemodynamic changes detected by Doppler ultrasonography in the ovaries of cattle during early development of cystic ovarian disease.

Díaz PU, Belotti EM, Notaro US, Salvetti NR, Leiva CJM, Durante LI, Marelli BE, Stangaferro ML, Ortega HH.

Anim Reprod Sci. 2019 Oct;209:106164. doi: 10.1016/j.anireprosci.2019.106164. Epub 2019 Aug 9.


Efficacy of add-on mepolizumab in adolescents with severe eosinophilic asthma.

Yancey SW, Ortega HG, Keene ON, Bradford ES.

Allergy Asthma Clin Immunol. 2019 Sep 3;15:53. doi: 10.1186/s13223-019-0366-x. eCollection 2019.


Follicular structures of cows with cystic ovarian disease present altered expression of cytokines.

Stassi AF, Gareis NC, Marelli BE, Matiller V, Leiva CJM, Rey F, Ortega HH, Salvetti NR, Baravalle ME.

Zygote. 2019 Oct;27(5):285-298. doi: 10.1017/S0967199419000285. Epub 2019 Aug 15.


Liver fatty acid metabolism associations with reproductive performance of dairy cattle.

Angeli E, Rodríguez FM, Rey F, Santiago G, Matiller V, Ortega HH, Hein GJ.

Anim Reprod Sci. 2019 Sep;208:106104. doi: 10.1016/j.anireprosci.2019.06.016. Epub 2019 Jun 21.


Antifungal compounds from Streptomyces associated with attine ants also inhibit Leishmania donovani.

Ortega HE, Ferreira LLG, Melo WGP, Oliveira ALL, Ramos Alvarenga RF, Lopes NP, Bugni TS, Andricopulo AD, Pupo MT.

PLoS Negl Trop Dis. 2019 Aug 5;13(8):e0007643. doi: 10.1371/journal.pntd.0007643. eCollection 2019 Aug.


Contribution of the VEGF system to the follicular persistence associated with bovine cystic ovaries.

Stassi AF, Gasser F, Velázquez MML, Belotti EM, Gareis NC, Rey F, Ortega HH, Salvetti NR, Baravalle ME.

Theriogenology. 2019 Oct 15;138:52-65. doi: 10.1016/j.theriogenology.2019.07.002. Epub 2019 Jul 3.


Association of depressive symptoms with health status and markers of uncontrolled severe asthma.

Khurana S, Lyness JM, Mallett S, Nelsen LM, Prazma CM, Albers FC, Forshag M, Llanos JP, Yancey SW, Ortega HG.

Allergy Asthma Proc. 2019 Jul 1;40(4):230-239. doi: 10.2500/aap.2019.40.4229.


Outcomes following mepolizumab treatment discontinuation: real-world experience from an open-label trial.

Ortega H, Lemiere C, Llanos JP, Forshag M, Price R, Albers F, Yancey S, Castro M.

Allergy Asthma Clin Immunol. 2019 Jun 10;15:37. doi: 10.1186/s13223-019-0348-z. eCollection 2019.


Immune status during postpartum, peri-implantation and early pregnancy in cattle: An updated view.

Velázquez MML, Peralta MB, Angeli E, Stassi AF, Gareis NC, Durante L, Cainelli S, Salvetti NR, Rey F, Ortega HH.

Anim Reprod Sci. 2019 Jul;206:1-10. doi: 10.1016/j.anireprosci.2019.05.010. Epub 2019 May 22. Review.


Who Hurts More? A Multicenter Prospective Study of In-Hospital Opioid Use in Pediatric Trauma Patients in the Midwest.

Pelaez CA, Davis JW, Spilman SK, Guzzo HM, Wetjen KM, Randell KA, Ortega HW, Pitcher GJ, Kenardy J, Ramirez MR.

J Am Coll Surg. 2019 Oct;229(4):404-414. doi: 10.1016/j.jamcollsurg.2019.05.021. Epub 2019 May 21.


A Comparison of Pediatric Traumatic Injuries on Farms and Residences from 2009 to 2014.

Cooper G, Zagel A, Nickel A, Ortega H.

J Rural Health. 2019 Sep;35(4):453-459. doi: 10.1111/jrh.12372. Epub 2019 May 14.


Update on immunogenicity in severe asthma: Experience with mepolizumab.

Ortega HG, Meyer E, Brusselle G, Asano K, Prazma CM, Albers FC, Mallett SA, Yancey SW, Gleich GJ.

J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2469-2475.e1. doi: 10.1016/j.jaip.2019.03.042. Epub 2019 Apr 5. No abstract available.


Disease burden in patients with asthma before initiating biologics: A retrospective cohort database study.

Ortega H, Hahn B, Tran JN, Bell C, Shams SA, Llanos JP.

Allergy Asthma Proc. 2019 May 1;40(3):146-153. doi: 10.2500/aap.2019.40.4220. Epub 2019 Mar 29.


Real-world characteristics and disease burden of patients with asthma prior to treatment initiation with mepolizumab or omalizumab: a retrospective cohort database study.

Llanos JP, Bell CF, Packnett E, Thiel E, Irwin DE, Hahn B, Ortega H.

J Asthma Allergy. 2019 Jan 25;12:43-58. doi: 10.2147/JAA.S189676. eCollection 2019.


The antimicrobial potential of Streptomyces from insect microbiomes.

Chevrette MG, Carlson CM, Ortega HE, Thomas C, Ananiev GE, Barns KJ, Book AJ, Cagnazzo J, Carlos C, Flanigan W, Grubbs KJ, Horn HA, Hoffmann FM, Klassen JL, Knack JJ, Lewin GR, McDonald BR, Muller L, Melo WGP, Pinto-Tomás AA, Schmitz A, Wendt-Pienkowski E, Wildman S, Zhao M, Zhang F, Bugni TS, Andes DR, Pupo MT, Currie CR.

Nat Commun. 2019 Jan 31;10(1):516. doi: 10.1038/s41467-019-08438-0.


Protein and gene expression of relevant enzymes and nuclear receptor of hepatic lipid metabolism in grazing dairy cattle during the transition period.

Angeli E, Trionfini V, Gareis NC, Matiller V, Huber E, Rey F, Salvetti NR, Ortega HH, Hein GJ.

Res Vet Sci. 2019 Apr;123:223-231. doi: 10.1016/j.rvsc.2019.01.020. Epub 2019 Jan 21.


Socioeconomic Status and Analgesia Provision at Discharge Among Children With Long-Bone Fractures Requiring Emergency Care.

Ortega HW, Velden HV, Truong W, Arms JL.

Pediatr Emerg Care. 2018 Nov 5. doi: 10.1097/PEC.0000000000001667. [Epub ahead of print]


Assessment of the long-term safety of mepolizumab and durability of clinical response in patients with severe eosinophilic asthma.

Khatri S, Moore W, Gibson PG, Leigh R, Bourdin A, Maspero J, Barros M, Buhl R, Howarth P, Albers FC, Bradford ES, Gilson M, Price RG, Yancey SW, Ortega H.

J Allergy Clin Immunol. 2019 May;143(5):1742-1751.e7. doi: 10.1016/j.jaci.2018.09.033. Epub 2018 Oct 23.


Risk Factors for Compartment Syndrome in Pediatric Trauma Patients.

Sees JA, Cutler GJ, Ortega HW.

Pediatr Emerg Care. 2018 Oct 17. doi: 10.1097/PEC.0000000000001636. [Epub ahead of print]


Fishing-Related Injuries Among Pediatric Patients Treated in United States Emergency Departments, 1997 to 2016.

Vajdic T, Bergmann KR, Zagel A, Ortega H.

Clin Pediatr (Phila). 2018 Dec;57(14):1656-1663. doi: 10.1177/0009922818803406. Epub 2018 Oct 4.


Health characteristics of patients with asthma, COPD and asthma-COPD overlap in the NHANES database.

Llanos JP, Ortega H, Germain G, Duh MS, Lafeuille MH, Tiggelaar S, Bell CF, Hahn B.

Int J Chron Obstruct Pulmon Dis. 2018 Sep 12;13:2859-2868. doi: 10.2147/COPD.S167379. eCollection 2018.


Response Rates of Medical Providers to Internet Surveys Regarding Their Adoption of Preexposure Prophylaxis for HIV: Methodological Implications.

Silverman TB, Schrimshaw EW, Franks J, Hirsch-Moverman Y, Ortega H, El-Sadr WM, Colson PW.

J Int Assoc Provid AIDS Care. 2018 Jan-Dec;17:2325958218798373. doi: 10.1177/2325958218798373.


Production and validation of a polyclonal serum against bovine FSH receptor.

Marelli BE, Leiva CJM, Flores Brun RB, Ramírez CS, Failla JI, Matiller V, Amweg AN, Rey F, Ortega HH.

Reprod Biol. 2018 Dec;18(4):432-439. doi: 10.1016/j.repbio.2018.09.001. Epub 2018 Sep 13.


Burden of disease associated with a COPD eosinophilic phenotype.

Ortega H, Llanos JP, Lafeuille MH, Germain G, Duh MS, Bell CF, Sama SR, Hahn B.

Int J Chron Obstruct Pulmon Dis. 2018 Aug 13;13:2425-2433. doi: 10.2147/COPD.S170995. eCollection 2018.


Effects of systemic corticosteroids on blood eosinophil counts in asthma: real-world data.

Ortega H, Llanos JP, Lafeuille MH, Duh MS, Germain G, Lejeune D, Sama S, Bell C, Hahn B.

J Asthma. 2019 Aug;56(8):808-815. doi: 10.1080/02770903.2018.1502301. Epub 2018 Oct 16.


Alterations in key metabolic sensors involved in bovine cystic ovarian disease.

Gareis NC, Angeli E, Huber E, Salvetti NR, Rodríguez FM, Ortega HH, Hein GJ, Rey F.

Theriogenology. 2018 Oct 15;120:138-146. doi: 10.1016/j.theriogenology.2018.07.045. Epub 2018 Aug 7.


Expression of TGFBR1, TGFBR2, TGFBR3, ACVR1B and ACVR2B is altered in ovaries of cows with cystic ovarian disease.

Matiller V, Hein GJ, Stassi AF, Angeli E, Belotti EM, Ortega HH, Rey F, Salvetti NR.

Reprod Domest Anim. 2019 Jan;54(1):46-54. doi: 10.1111/rda.13312.


Rapid and Consistent Improvements in Morning PEF in Patients with Severe Eosinophilic Asthma Treated with Mepolizumab.

Ortega H, Menzies-Gow A, Llanos JP, Forshag M, Albers F, Gunsoy N, Bradford ES, Yancey SW, Kraft M.

Adv Ther. 2018 Jul;35(7):1059-1068. doi: 10.1007/s12325-018-0727-8. Epub 2018 Jun 15.


Panax ginseng extract reduces Staphylococcus aureus internalization into bovine mammary epithelial cells but does not affect macrophages phagocytic activity.

Beccaria C, Silvestrini P, Renna MS, Ortega HH, Calvinho LF, Dallard BE, Baravalle C.

Microb Pathog. 2018 Sep;122:63-72. doi: 10.1016/j.micpath.2018.06.010. Epub 2018 Jun 7.


Long-Term Clinical Outcomes of High-Dose Mepolizumab Treatment for Hypereosinophilic Syndrome.

Kuang FL, Fay MP, Ware J, Wetzler L, Holland-Thomas N, Brown T, Ortega H, Steinfeld J, Khoury P, Klion AD.

J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1518-1527.e5. doi: 10.1016/j.jaip.2018.04.033. Epub 2018 May 8.


Revision of Gymnotus (Gymnotiformes: Gymnotidae) from the Upper Madeira Basin of Bolivia and Peru, with descriptions of two new species.

Craig JM, Correa-roldÁn V, Ortega H, Crampton WGR, Albert JS.

Zootaxa. 2018 Apr 20;4413(1):111-132. doi: 10.11646/zootaxa.4413.1.3.


Impaired insulin signaling pathways affect ovarian steroidogenesis in cows with COD.

Gareis NC, Huber E, Hein GJ, Rodríguez FM, Salvetti NR, Angeli E, Ortega HH, Rey F.

Anim Reprod Sci. 2018 May;192:298-312. doi: 10.1016/j.anireprosci.2018.03.031. Epub 2018 Mar 29.


Multiple strategies to identify HIV-positive black men who have sex with men and transgender women in New York City: a cross-sectional analysis of recruitment results.

Franks J, Mannheimer SB, Hirsch-Moverman Y, Hayes-Larson E, Colson PW, Ortega H, El-Sadr WM.

J Int AIDS Soc. 2018 Mar;21(3). doi: 10.1002/jia2.25091.


Absolute Configurations of Griseorhodins A and C.

Ortega HE, Batista JM Jr, Melo WGP, Clardy J, Pupo MT.

Tetrahedron Lett. 2017 Dec 13;58(50):4721-4723. doi: 10.1016/j.tetlet.2017.11.008. Epub 2017 Nov 7.


Altered Expression of Anti-Müllerian Hormone during the Early Stage of Bovine Persistent Ovarian Follicles.

Díaz PU, Rey F, Gareis NC, Notaro US, Matiller V, Belotti EM, Stassi AF, Salvetti NR, Ortega HH.

J Comp Pathol. 2018 Jan;158:22-31. doi: 10.1016/j.jcpa.2017.10.175. Epub 2017 Dec 1.


Fragmentation of Andes-to-Amazon connectivity by hydropower dams.

Anderson EP, Jenkins CN, Heilpern S, Maldonado-Ocampo JA, Carvajal-Vallejos FM, Encalada AC, Rivadeneira JF, Hidalgo M, Cañas CM, Ortega H, Salcedo N, Maldonado M, Tedesco PA.

Sci Adv. 2018 Jan 31;4(1):eaao1642. doi: 10.1126/sciadv.aao1642. eCollection 2018 Jan.


Asthma Exacerbations Associated with Lung Function Decline in Patients with Severe Eosinophilic Asthma.

Ortega H, Yancey SW, Keene ON, Gunsoy NB, Albers FC, Howarth PH.

J Allergy Clin Immunol Pract. 2018 May - Jun;6(3):980-986.e1. doi: 10.1016/j.jaip.2017.12.019. Epub 2018 Feb 15.


Altered expression of IL-1β, IL-1RI, IL-1RII, IL-1RA and IL-4 could contribute to anovulation and follicular persistence in cattle.

Stassi AF, Baravalle ME, Belotti EM, Amweg AN, Angeli E, Velázquez MML, Rey F, Salvetti NR, Ortega HH.

Theriogenology. 2018 Apr 1;110:61-73. doi: 10.1016/j.theriogenology.2017.12.048. Epub 2018 Jan 3.


No genetic association detected with mepolizumab efficacy in severe asthma.

Condreay L, Chiano M, Ortega H, Buchan N, Harris E, Bleecker ER, Thompson PJ, Humbert M, Gibson P, Yancey S, Ghosh S.

Respir Med. 2017 Nov;132:178-180. doi: 10.1016/j.rmed.2017.10.019. Epub 2017 Oct 26.


Biomarkers for severe eosinophilic asthma.

Yancey SW, Keene ON, Albers FC, Ortega H, Bates S, Bleecker ER, Pavord I.

J Allergy Clin Immunol. 2017 Dec;140(6):1509-1518. doi: 10.1016/j.jaci.2017.10.005. Review.


Changes in the Proliferation/Apoptosis Balance in the Bovine Ovary: A Key Early Event in Follicular Persistence.

Belotti EM, Stassi AF, Velázquez MML, Díaz PU, Marelli BE, Rey F, Notaro US, Ortega HH, Salvetti NR.

Cells Tissues Organs. 2017;204(5-6):314-325. doi: 10.1159/000481167. Epub 2017 Nov 3.


Revealing Hidden Diversity of the Underestimated Neotropical Ichthyofauna: DNA Barcoding in the Recently Described Genus Megaleporinus (Characiformes: Anostomidae).

Ramirez JL, Birindelli JL, Carvalho DC, Affonso PRAM, Venere PC, Ortega H, Carrillo-Avila M, Rodríguez-Pulido JA, Galetti PM Jr.

Front Genet. 2017 Oct 12;8:149. doi: 10.3389/fgene.2017.00149. eCollection 2017.


Liquid chromatography tandem-mass spectrometry (LC-MS/MS) and dried blood spot sampling applied to pharmacokinetics studies in animals: Correlation of classic and block design.

Baldo MN, Angeli E, Gareis NC, Hunzicker GA, Murguía MC, Ortega HH, Hein GJ.

Lab Anim. 2018 Apr;52(2):125-134. doi: 10.1177/0023677217734235. Epub 2017 Oct 23.


Alveolar macrophages from tuberculosis patients display an altered inflammatory gene expression profile.

Lavalett L, Rodriguez H, Ortega H, Sadee W, Schlesinger LS, Barrera LF.

Tuberculosis (Edinb). 2017 Dec;107:156-167. doi: 10.1016/ Epub 2017 Sep 18.


Role of Components of the Insulin-like Growth Factor System in the Early Stages of Ovarian Follicular Persistence in Cattle.

Rodríguez FM, Gareis NC, Hein GJ, Salvetti NR, Amweg AN, Huber E, Stassi AF, Ortega HH, Rey F.

J Comp Pathol. 2017 Aug - Oct;157(2-3):201-214. doi: 10.1016/j.jcpa.2017.07.010. Epub 2017 Sep 13.


Characterization of immune response in Staphylococcus aureus chronically infected bovine mammary glands during active involution.

Andreotti CS, Baravalle C, Sacco SC, Lovato M, Pereyra EAL, Renna MS, Ortega HH, Calvinho LF, Dallard BE.

Comp Immunol Microbiol Infect Dis. 2017 Oct;54:51-60. doi: 10.1016/j.cimid.2017.08.005. Epub 2017 Sep 6.


Effect of different mini-volume colloid centrifugation configurations on flow cytometrically sorted sperm recovery efficiency and quality using a computer-assisted semen analyzer.

Ferré LB, Chitwood JL, Fresno C, Ortega HH, Kjelland ME, Ross PJ.

Reprod Domest Anim. 2018 Feb;53(1):26-33. doi: 10.1111/rda.13048. Epub 2017 Sep 11.


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