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Items: 1 to 50 of 249

1.

Prenatal Allospecific NK Cell Tolerance Hinges on Instructive Allorecognition through the Activating Receptor during Development.

Alhajjat AM, Strong BS, Lee AE, Turner LE, Wadhwani RK, Ortaldo JR, Heusel JW, Shaaban AF.

J Immunol. 2015 Aug 15;195(4):1506-16. doi: 10.4049/jimmunol.1500463. Epub 2015 Jul 1.

2.

Natural killer activity: early days, advances, and seminal observations.

Ortaldo JR, Wiltrout RH, Reynolds CW.

Crit Rev Oncog. 2014;19(1-2):1-13. Review.

3.

IFN-gamma AU-rich element removal promotes chronic IFN-gamma expression and autoimmunity in mice.

Hodge DL, Berthet C, Coppola V, Kastenmüller W, Buschman MD, Schaughency PM, Shirota H, Scarzello AJ, Subleski JJ, Anver MR, Ortaldo JR, Lin F, Reynolds DA, Sanford ME, Kaldis P, Tessarollo L, Klinman DM, Young HA.

J Autoimmun. 2014 Sep;53:33-45. doi: 10.1016/j.jaut.2014.02.003. Epub 2014 Feb 28.

4.

Systemic IL-12 administration alters hepatic dendritic cell stimulation capabilities.

Chan T, Back TC, Subleski JJ, Weiss JM, Ortaldo JR, Wiltrout RH.

PLoS One. 2012;7(3):e33303. doi: 10.1371/journal.pone.0033303. Epub 2012 Mar 13.

5.

Hydrodynamic delivery of human IL-15 cDNA increases murine natural killer cell recovery after syngeneic bone marrow transplantation.

Barao I, Alvarez M, Redelman D, Weiss JM, Ortaldo JR, Wiltrout RH, Murphy WJ.

Biol Blood Marrow Transplant. 2011 Dec;17(12):1754-64. doi: 10.1016/j.bbmt.2011.08.023. Epub 2011 Sep 8.

6.

mTOR kinase inhibitor AZD8055 enhances the immunotherapeutic activity of an agonist CD40 antibody in cancer treatment.

Jiang Q, Weiss JM, Back T, Chan T, Ortaldo JR, Guichard S, Wiltrout RH.

Cancer Res. 2011 Jun 15;71(12):4074-84. doi: 10.1158/0008-5472.CAN-10-3968. Epub 2011 May 3.

7.

TCR-dependent and -independent activation underlie liver-specific regulation of NKT cells.

Subleski JJ, Hall VL, Wolfe TB, Scarzello AJ, Weiss JM, Chan T, Hodge DL, Back TC, Ortaldo JR, Wiltrout RH.

J Immunol. 2011 Jan 15;186(2):838-47. doi: 10.4049/jimmunol.1001735. Epub 2010 Dec 10.

8.

Editorial: NKT cells: to suppress or not to suppress, that is the question.

Subleski JJ, Ortaldo JR.

J Leukoc Biol. 2009 Oct;86(4):751-2. doi: 10.1189/jlb.0309118. No abstract available.

9.

In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses.

Winkler-Pickett R, Young HA, Cherry JM, Diehl J, Wine J, Back T, Bere WE, Mason AT, Ortaldo JR.

J Immunol. 2008 Apr 1;180(7):4495-506.

10.

Ly49 C/I-dependent NKT cell-derived IL-10 is required for corneal graft survival and peripheral tolerance.

Watte CM, Nakamura T, Lau CH, Ortaldo JR, Stein-Streilein J.

J Leukoc Biol. 2008 Apr;83(4):928-35. doi: 10.1189/jlb.0807579. Epub 2008 Jan 11.

PMID:
18192489
11.

Modulation of lymphocyte function with inhibitory CD2: loss of NK and NKT cells.

Ortaldo JR, Mason A, Willette-Brown J, Ruscetti FW, Wine J, Back T, Stull T, Bere EW, Feigenbaum L, Winkler-Pickett R, Young HA.

Cell Immunol. 2007 Sep;249(1):8-19. Epub 2007 Nov 26.

PMID:
18039542
12.

Enhanced antitumor response by divergent modulation of natural killer and natural killer T cells in the liver.

Subleski JJ, Hall VL, Back TC, Ortaldo JR, Wiltrout RH.

Cancer Res. 2006 Nov 15;66(22):11005-12.

13.

NK cells use NKG2D to recognize a mouse renal cancer (Renca), yet require intercellular adhesion molecule-1 expression on the tumor cells for optimal perforin-dependent effector function.

Abdool K, Cretney E, Brooks AD, Kelly JM, Swann J, Shanker A, Bere EW Jr, Yokoyama WM, Ortaldo JR, Smyth MJ, Sayers TJ.

J Immunol. 2006 Aug 15;177(4):2575-83.

14.
15.

IL-18 as critical co-stimulatory molecules in modulating the immune response of ITAM bearing lymphocytes.

Ortaldo JR, Young HA.

Semin Immunol. 2006 Jun;18(3):193-6. Epub 2006 May 5. Review.

PMID:
16678434
16.

Pertussis toxin as an adjuvant suppresses the number and function of CD4+CD25+ T regulatory cells.

Chen X, Winkler-Pickett RT, Carbonetti NH, Ortaldo JR, Oppenheim JJ, Howard OM.

Eur J Immunol. 2006 Mar;36(3):671-80.

17.

Regulation of ITAM-positive receptors: role of IL-12 and IL-18.

Ortaldo JR, Winkler-Pickett R, Wigginton J, Horner M, Bere EW, Mason AT, Bhat N, Cherry J, Sanford M, Hodge DL, Young HA.

Blood. 2006 Feb 15;107(4):1468-75. Epub 2005 Oct 25.

18.
19.

Rapid conversion of effector mechanisms from NK to T cells during virus-induced lysis of allogeneic implants in vivo.

Brehm MA, Daniels KA, Ortaldo JR, Welsh RM.

J Immunol. 2005 Jun 1;174(11):6663-71.

20.

Mouse Ly49 NK receptors: balancing activation and inhibition.

Ortaldo JR, Young HA.

Mol Immunol. 2005 Feb;42(4):445-50. Review.

PMID:
15607796
21.

Peroxisome proliferator-activated receptor-gamma and its ligands attenuate biologic functions of human natural killer cells.

Zhang X, Rodriguez-Galán MC, Subleski JJ, Ortaldo JR, Hodge DL, Wang JM, Shimozato O, Reynolds DA, Young HA.

Blood. 2004 Nov 15;104(10):3276-84. Epub 2004 Jul 20.

PMID:
15265789
22.
23.

Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides.

Ortaldo JR, Young HA, Winkler-Pickett RT, Bere EW Jr, Murphy WJ, Wiltrout RH.

J Immunol. 2004 Jan 15;172(2):943-53.

24.

Receptor glycosylation regulates Ly-49 binding to MHC class I.

Mason LH, Willette-Brown J, Anderson SK, Alvord WG, Klabansky RL, Young HA, Ortaldo JR.

J Immunol. 2003 Oct 15;171(8):4235-42.

25.

NK-cell purging of leukemia: superior antitumor effects of NK cells H2 allogeneic to the tumor and augmentation with inhibitory receptor blockade.

Koh CY, Ortaldo JR, Blazar BR, Bennett M, Murphy WJ.

Blood. 2003 Dec 1;102(12):4067-75. Epub 2003 Jul 31.

PMID:
12893752
26.
27.

Increased bone marrow allograft rejection by depletion of NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens.

Raziuddin A, Longo DL, Bennett M, Winkler-Pickett R, Ortaldo JR, Murphy WJ.

Blood. 2002 Oct 15;100(8):3026-33.

PMID:
12351417
28.

Aberrant DAP12 signaling in the 129 strain of mice: implications for the analysis of gene-targeted mice.

McVicar DW, Winkler-Pickett R, Taylor LS, Makrigiannis A, Bennett M, Anderson SK, Ortaldo JR.

J Immunol. 2002 Aug 15;169(4):1721-8.

29.

IL-2 and IL-12 alter NK cell responsiveness to IFN-gamma-inducible protein 10 by down-regulating CXCR3 expression.

Hodge DL, Schill WB, Wang JM, Blanca I, Reynolds DA, Ortaldo JR, Young HA.

J Immunol. 2002 Jun 15;168(12):6090-8.

30.

Natural cytotoxicity uncoupled from the Syk and ZAP-70 intracellular kinases.

Colucci F, Schweighoffer E, Tomasello E, Turner M, Ortaldo JR, Vivier E, Tybulewicz VL, Di Santo JP.

Nat Immunol. 2002 Mar;3(3):288-94. Epub 2002 Feb 11.

PMID:
11836527
32.
33.

The ever-expanding Ly49 gene family: repertoire and signaling.

Anderson SK, Ortaldo JR, McVicar DW.

Immunol Rev. 2001 Jun;181:79-89. Review.

PMID:
11513154
34.

Class I MHC-binding characteristics of the 129/J Ly49 repertoire.

Makrigiannis AP, Pau AT, Saleh A, Winkler-Pickett R, Ortaldo JR, Anderson SK.

J Immunol. 2001 Apr 15;166(8):5034-43.

35.

Activating Ly-49 NK receptors: central role in cytokine and chemokine production.

Ortaldo JR, Bere EW, Hodge D, Young HA.

J Immunol. 2001 Apr 15;166(8):4994-9.

36.

Identification of the Ly49L protein: evidence for activating counterparts to inhibitory Ly49 proteins.

Makrigiannis AP, Etzler J, Winkler-Pickett R, Mason A, Ortaldo JR, Anderson SK.

J Leukoc Biol. 2000 Nov;68(5):765-71.

PMID:
11073118
37.

Activating Ly-49D NK receptors: expression and function in relation to ontogeny and Ly-49 inhibitor receptors.

Ortaldo JR, Winkler-Pickett R, Wiegand G.

J Leukoc Biol. 2000 Nov;68(5):748-56.

PMID:
11073116
38.
40.

Synergistic effects of in vivo depletion of Ly-49A and Ly-49G2 natural killer cell subsets in the rejection of H2(b) bone marrow cell allografts.

Raziuddin A, Bennett M, Winkler-Pickett R, Ortaldo JR, Longo DL, Murphy WJ.

Blood. 2000 Jun 15;95(12):3840-4.

PMID:
10845918
41.

IL-2 signaling in human monocytes involves the phosphorylation and activation of p59hck.

Bosco MC, Curiel RE, Zea AH, Malabarba MG, Ortaldo JR, Espinoza-Delgado I.

J Immunol. 2000 May 1;164(9):4575-85.

42.

Interaction of Ly-49D+ NK cells with H-2Dd target cells leads to Dap-12 phosphorylation and IFN-gamma secretion.

Mason LH, Willette-Brown J, Mason AT, McVicar D, Ortaldo JR.

J Immunol. 2000 Jan 15;164(2):603-11.

43.

Structure/function relationship of activating Ly-49D and inhibitory Ly-49G2 NK receptors.

Ortaldo JR, Winkler-Pickett R, Willette-Brown J, Wange RL, Anderson SK, Palumbo GJ, Mason LH, McVicar DW.

J Immunol. 1999 Nov 15;163(10):5269-77.

44.

Cloning and characterization of a novel activating Ly49 closely related to Ly49A.

Makrigiannis AP, Gosselin P, Mason LH, Taylor LS, McVicar DW, Ortaldo JR, Anderson SK.

J Immunol. 1999 Nov 1;163(9):4931-8.

45.

Ly-49 receptor expression and functional analysis in multiple mouse strains.

Ortaldo JR, Mason AT, Winkler-Pickett R, Raziuddin A, Murphy WJ, Mason LH.

J Leukoc Biol. 1999 Sep;66(3):512-20.

PMID:
10496323
46.

Tolerance and alloreactivity of the Ly49D subset of murine NK cells.

George TC, Ortaldo JR, Lemieux S, Kumar V, Bennett M.

J Immunol. 1999 Aug 15;163(4):1859-67.

47.

Induction of DAP12 phosphorylation, calcium mobilization, and cytokine secretion by Ly49H.

Gosselin P, Mason LH, Willette-Brown J, Ortaldo JR, McVicar DW, Anderson SK.

J Leukoc Biol. 1999 Jul;66(1):165-71.

PMID:
10411005
48.

The natural killer gene complex genetic locus Chok encodes Ly-49D, a target recognition receptor that activates natural killing.

Idris AH, Smith HR, Mason LH, Ortaldo JR, Scalzo AA, Yokoyama WM.

Proc Natl Acad Sci U S A. 1999 May 25;96(11):6330-5.

49.

Role of a STAT binding site in the regulation of the human perforin promoter.

Yu CR, Ortaldo JR, Curiel RE, Young HA, Anderson SK, Gosselin P.

J Immunol. 1999 Mar 1;162(5):2785-90.

50.

Positive recognition of MHC class I molecules by the Ly49D receptor of murine NK cells.

George TC, Mason LH, Ortaldo JR, Kumar V, Bennett M.

J Immunol. 1999 Feb 15;162(4):2035-43.

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