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Items: 29

1.

Three strikes and research is out.

Orsini MJ.

Science. 2016 May 27;352(6289):1138. doi: 10.1126/science.352.6289.1138. No abstract available.

PMID:
27230382
2.

Identifying nonselective hits from a homogeneous calcium assay screen.

Cassutt KJ, Orsini MJ, Abousleiman M, Colone D, Tang W.

J Biomol Screen. 2007 Mar;12(2):285-7. Epub 2007 Feb 8.

PMID:
17289936
3.

Metastin (KiSS-1) mimetics identified from peptide structure-activity relationship-derived pharmacophores and directed small molecule database screening.

Orsini MJ, Klein MA, Beavers MP, Connolly PJ, Middleton SA, Mayo KH.

J Med Chem. 2007 Feb 8;50(3):462-71.

PMID:
17266198
4.

8-(Heteroaryl)phenalkyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-ones as opioid receptor modulators.

Jordan AD, Orsini MJ, Middleton SA, Connolly PJ, Brenneman DE, Pan K, Reitz AB.

Med Chem. 2005 Nov;1(6):601-10.

PMID:
16787343
5.

3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor.

Bignan GC, Battista K, Connolly PJ, Orsini MJ, Liu J, Middleton SA, Reitz AB.

Bioorg Med Chem Lett. 2006 Jul 1;16(13):3524-8. Epub 2006 Apr 24.

PMID:
16632355
6.

Medication safety--reliability of preference cards.

Dawson A, Orsini MJ, Cooper MR, Wollenburg K.

AORN J. 2005 Sep;82(3):399, 401-4, 406-7 passim.

PMID:
16309067
7.

Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor.

Bignan GC, Battista K, Connolly PJ, Orsini MJ, Liu J, Middleton SA, Reitz AB.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):5022-6.

PMID:
16153834
8.

The nociceptin pharmacophore site for opioid receptor binding derived from the NMR structure and bioactivity relationships.

Orsini MJ, Nesmelova I, Young HC, Hargittai B, Beavers MP, Liu J, Connolly PJ, Middleton SA, Mayo KH.

J Biol Chem. 2005 Mar 4;280(9):8134-42. Epub 2004 Dec 13.

9.

Synthesis and biological evaluation of the major metabolite of atomoxetine: elucidation of a partial kappa-opioid agonist effect.

Creighton CJ, Ramabadran K, Ciccone PE, Liu J, Orsini MJ, Reitz AB.

Bioorg Med Chem Lett. 2004 Aug 2;14(15):4083-5.

PMID:
15225731
10.

Characterization of arrestin expression and function.

Mundell SJ, Orsini MJ, Benovic JL.

Methods Enzymol. 2002;343:600-11. No abstract available.

PMID:
11665594
11.

Safe use of the CXCR4 inhibitor ALX40-4C in humans.

Doranz BJ, Filion LG, Diaz-Mitoma F, Sitar DS, Sahai J, Baribaud F, Orsini MJ, Benovic JL, Cameron W, Doms RW.

AIDS Res Hum Retroviruses. 2001 Apr 10;17(6):475-86.

PMID:
11350661
12.

Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle.

Krymskaya VP, Orsini MJ, Eszterhas AJ, Brodbeck KC, Benovic JL, Panettieri RA Jr, Penn RB.

Am J Respir Cell Mol Biol. 2000 Oct;23(4):546-54.

PMID:
11017921
13.

Trafficking of the HIV coreceptor CXCR4. Role of arrestins and identification of residues in the c-terminal tail that mediate receptor internalization.

Orsini MJ, Parent JL, Mundell SJ, Marchese A, Benovic JL.

J Biol Chem. 1999 Oct 22;274(43):31076-86. Erratum in: J Biol Chem 2000 Aug 18;275(33):25876. Marchese, Adriano [added].

14.

MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation.

Orsini MJ, Krymskaya VP, Eszterhas AJ, Benovic JL, Panettieri RA Jr, Penn RB.

Am J Physiol. 1999 Sep;277(3):L479-88. doi: 10.1152/ajplung.1999.277.3.L479.

PMID:
10484455
15.

Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation.

Krymskaya VP, Penn RB, Orsini MJ, Scott PH, Plevin RJ, Walker TR, Eszterhas AJ, Amrani Y, Chilvers ER, Panettieri RA Jr.

Am J Physiol. 1999 Jul;277(1):L65-78. doi: 10.1152/ajplung.1999.277.1.L65.

PMID:
10409232
16.

PAR1 activation initiates integrin engagement and outside-in signalling in megakaryoblastic CHRF-288 cells.

Cichowski K, Orsini MJ, Brass LF.

Biochim Biophys Acta. 1999 Jul 8;1450(3):265-76.

17.

Role of arrestins in endocytosis and signaling of alpha2-adrenergic receptor subtypes.

DeGraff JL, Gagnon AW, Benovic JL, Orsini MJ.

J Biol Chem. 1999 Apr 16;274(16):11253-9.

18.
19.

Identification of CXCR4 domains that support coreceptor and chemokine receptor functions.

Doranz BJ, Orsini MJ, Turner JD, Hoffman TL, Berson JF, Hoxie JA, Peiper SC, Brass LF, Doms RW.

J Virol. 1999 Apr;73(4):2752-61.

20.

Expression in Escherichia coli, refolding, and purification of human procathepsin K, an osteoclast-specific protease.

D'alessio KJ, McQueney MS, Brun KA, Orsini MJ, Debouck CM.

Protein Expr Purif. 1999 Mar;15(2):213-20.

PMID:
10049678
21.

The crystal structure of human procathepsin K.

LaLonde JM, Zhao B, Janson CA, D'Alessio KJ, McQueney MS, Orsini MJ, Debouck CM, Smith WW.

Biochemistry. 1999 Jan 19;38(3):862-9.

PMID:
9893980
23.

Identification and characterization of the CXCR4 chemokine receptor in human T cell lines: ligand binding, biological activity, and HIV-1 infectivity.

Hesselgesser J, Liang M, Hoxie J, Greenberg M, Brass LF, Orsini MJ, Taub D, Horuk R.

J Immunol. 1998 Jan 15;160(2):877-83.

24.

Activation of the HIV-1 long terminal repeat by cytokines and environmental stress requires an active CSBP/p38 MAP kinase.

Kumar S, Orsini MJ, Lee JC, McDonnell PC, Debouck C, Young PR.

J Biol Chem. 1996 Nov 29;271(48):30864-9.

26.

Purification and functional characterization of wild-type and mutant HIV-1 and HIV-2 Tat proteins expressed in Escherichia coli.

Orsini MJ, García-Martínez LF, Mavankal G, Gaynor RB, Debouck CM.

Protein Expr Purif. 1996 Sep;8(2):238-46.

PMID:
8812870
27.
28.

Expression and purification of the HIV type 1 Rev protein produced in Escherichia coli and its use in the generation of monoclonal antibodies.

Orsini MJ, Thakur AN, Andrews WW, Hammarskjöld ML, Rekosh D.

AIDS Res Hum Retroviruses. 1995 Aug;11(8):945-53.

PMID:
7492441
29.

An ADR surveillance program: increasing quality, number of incidence reports.

Orsini MJ, Orsini PA, Thorn DB, Gallina JN.

Formulary. 1995 Aug;30(8):454-61.

PMID:
10151733

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