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Items: 1 to 50 of 133

1.

GABA promotes β-cell proliferation, but does not overcome impaired glucose homeostasis associated with diet-induced obesity.

Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, Lai M, Batchuluun B, Wong A, Khuu N, Liu Y, Al Rijjal D, Winegarden N, Virtanen C, Orser BA, Cabrera O, Varga G, Rocheleau J, Dai FF, Wheeler MB.

FASEB J. 2018 Dec 3:fj201801397R. doi: 10.1096/fj.201801397R. [Epub ahead of print]

PMID:
30509117
2.

Anesthesiology in the 21st century: our science is our destiny.

Orser BA.

Can J Anaesth. 2019 Jan;66(1):1-13. doi: 10.1007/s12630-018-1241-9. Epub 2018 Oct 25. No abstract available.

PMID:
30362024
3.

Best Practices for Postoperative Brain Health: Recommendations From the Fifth International Perioperative Neurotoxicity Working Group.

Berger M, Schenning KJ, Brown CH 4th, Deiner SG, Whittington RA, Eckenhoff RG, Angst MS, Avramescu S, Bekker A, Brzezinski M, Crosby G, Culley DJ, Eckenhoff M, Eriksson LI, Evered L, Ibinson J, Kline RP, Kofke A, Ma D, Mathew JP, Maze M, Orser BA, Price CC, Scott DA, Silbert B, Su D, Terrando N, Wang DS, Wei H, Xie Z, Zuo Z; Perioperative Neurotoxicity Working Group.

Anesth Analg. 2018 Dec;127(6):1406-1413. doi: 10.1213/ANE.0000000000003841.

PMID:
30303868
4.

Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia.

Wang DS, Kaneshwaran K, Lei G, Mostafa F, Wang J, Lecker I, Avramescu S, Xie YF, Chan NK, Fernandez-Escobar A, Woo J, Chan D, Ramsey AJ, Sivak JM, Lee CJ, Bonin RP, Orser BA.

Anesthesiology. 2018 Sep;129(3):477-489. doi: 10.1097/ALN.0000000000002311.

PMID:
29889105
5.

SmartTots Update Regarding Anesthetic Neurotoxicity in the Developing Brain.

Orser BA, Suresh S, Evers AS.

Anesth Analg. 2018 Apr;126(4):1393-1396. doi: 10.1213/ANE.0000000000002833.

PMID:
29401076
6.

δ-Subunit Containing GABAA Receptors Modulate Respiratory Networks.

Montandon G, Wu H, Liu H, Vu MT, Orser BA, Horner RL.

Sci Rep. 2017 Dec 22;7(1):18105. doi: 10.1038/s41598-017-17379-x.

7.

Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.

Wang DS, Mazer CD, Orser BA.

N Engl J Med. 2017 May 11;376(19):1891-2. doi: 10.1056/NEJMc1703369. No abstract available.

PMID:
28492070
8.

High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors.

Lecker I, Wang DS, Kaneshwaran K, Mazer CD, Orser BA.

Anesthesiology. 2017 Jul;127(1):89-97. doi: 10.1097/ALN.0000000000001665.

PMID:
28475556
9.

Preventing delirium: beyond dexmedetomidine.

Avramescu S, Wang DS, Choi S, Orser BA.

Lancet. 2017 Mar 11;389(10073):1009. doi: 10.1016/S0140-6736(17)30661-X. No abstract available.

PMID:
28290991
10.

Ketamine Increases the Function of γ-Aminobutyric Acid Type A Receptors in Hippocampal and Cortical Neurons.

Wang DS, Penna A, Orser BA.

Anesthesiology. 2017 Apr;126(4):666-677. doi: 10.1097/ALN.0000000000001483.

PMID:
27984263
11.

Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator.

Piantadosi SC, French BJ, Poe MM, Timić T, Marković BD, Pabba M, Seney ML, Oh H, Orser BA, Savić MM, Cook JM, Sibille E.

Front Pharmacol. 2016 Nov 22;7:446. eCollection 2016.

12.

Reduced expression of α5GABAA receptors elicits autism-like alterations in EEG patterns and sleep-wake behavior.

Mesbah-Oskui L, Penna A, Orser BA, Horner RL.

Neurotoxicol Teratol. 2017 May;61:115-122. doi: 10.1016/j.ntt.2016.10.009. Epub 2016 Oct 26.

13.

α5GABAA Receptors Mediate Tonic Inhibition in the Spinal Cord Dorsal Horn and Contribute to the Resolution Of Hyperalgesia.

Perez-Sanchez J, Lorenzo LE, Lecker I, Zurek AA, Labrakakis C, Bridgwater EM, Orser BA, De Koninck Y, Bonin RP.

J Neurosci Res. 2017 Jun;95(6):1307-1318. doi: 10.1002/jnr.23981. Epub 2016 Oct 28.

PMID:
27792253
14.

δGABAA Receptors Are Necessary for Synaptic Plasticity in the Hippocampus: Implications for Memory Behavior.

Whissell PD, Avramescu S, Wang DS, Orser BA.

Anesth Analg. 2016 Nov;123(5):1247-1252.

PMID:
27464975
15.

Unlocking the Mechanisms of Anesthesia.

Roth SH, Miller KW, Orser BA, Urban BW.

Anesth Analg. 2016 Nov;123(5):1070-1071. No abstract available.

PMID:
27454067
16.

In Reply.

Avramescu S, Wang DS, Horner RL, Orser BA.

Anesthesiology. 2016 Sep;125(3):604-5. doi: 10.1097/ALN.0000000000001206. No abstract available.

PMID:
27529857
17.

Single and repeated exposures to the volatile anesthetic isoflurane do not impair operant performance in aged rats.

Walters JL, Chelonis JJ, Fogle CM, Orser BA, Paule MG.

Neurotoxicology. 2016 Sep;56:159-169. doi: 10.1016/j.neuro.2016.07.012. Epub 2016 Aug 3.

PMID:
27498192
18.

α5GABAA receptor deficiency causes autism-like behaviors.

Zurek AA, Kemp SW, Aga Z, Walker S, Milenkovic M, Ramsey AJ, Sibille E, Scherer SW, Orser BA.

Ann Clin Transl Neurol. 2016 Apr 19;3(5):392-8. doi: 10.1002/acn3.303. eCollection 2016 May.

19.

The GAS trial.

Orser BA, Evers AS, Suresh S, Hertz S.

Lancet. 2016 Apr 16;387(10028):1613-4. doi: 10.1016/S0140-6736(16)30199-4. Epub 2016 Apr 14. No abstract available.

PMID:
27116066
20.

Anesthesia research training: preparing for the future of our speciality.

Avramescu S, Orser BA.

Can J Anaesth. 2016 May;63(5):633-4. doi: 10.1007/s12630-016-0592-3. Epub 2016 Jan 20. No abstract available.

PMID:
26792281
21.

Tranexamic acid-associated seizures: Causes and treatment.

Lecker I, Wang DS, Whissell PD, Avramescu S, Mazer CD, Orser BA.

Ann Neurol. 2016 Jan;79(1):18-26. doi: 10.1002/ana.24558. Epub 2015 Dec 15. Review.

22.

Inflammation Increases Neuronal Sensitivity to General Anesthetics.

Avramescu S, Wang DS, Lecker I, To WT, Penna A, Whissell PD, Mesbah-Oskui L, Horner RL, Orser BA.

Anesthesiology. 2016 Feb;124(2):417-27. doi: 10.1097/ALN.0000000000000943.

PMID:
26566283
23.

Perioperative Medication Errors: Building Safer Systems.

Orser BA, U D, Cohen MR.

Anesthesiology. 2016 Jan;124(1):1-3. doi: 10.1097/ALN.0000000000000905. No abstract available.

PMID:
26501388
24.

Managing Ebola: Lessons Learned from the SARS Epidemic.

Nanji KC, Orser BA.

Anesth Analg. 2015 Sep;121(3):834-5. doi: 10.1213/ANE.0000000000000748. No abstract available.

PMID:
26287305
25.

α6-Containing GABAA Receptors Are the Principal Mediators of Inhibitory Synapse Strengthening by Insulin in Cerebellar Granule Cells.

Accardi MV, Brown PM, Miraucourt LS, Orser BA, Bowie D.

J Neurosci. 2015 Jul 1;35(26):9676-88. doi: 10.1523/JNEUROSCI.0513-15.2015.

26.

Anesthetic neurotoxicity--clinical implications of animal models.

Rappaport BA, Suresh S, Hertz S, Evers AS, Orser BA.

N Engl J Med. 2015 Feb 26;372(9):796-7. doi: 10.1056/NEJMp1414786.

PMID:
25714157
27.

Sustained increase in α5GABAA receptor function impairs memory after anesthesia.

Zurek AA, Yu J, Wang DS, Haffey SC, Bridgwater EM, Penna A, Lecker I, Lei G, Chang T, Salter EW, Orser BA.

J Clin Invest. 2014 Dec;124(12):5437-41. doi: 10.1172/JCI76669. Epub 2014 Nov 3.

28.

GABAergic signaling in health and disease.

McBain CJ, Kittler J, Luscher B, Mody I, Orser BA.

Neuropharmacology. 2015 Jan;88:1. doi: 10.1016/j.neuropharm.2014.10.001. Epub 2014 Oct 8. No abstract available.

29.
30.

Altered expression of δGABAA receptors in health and disease.

Whissell PD, Lecker I, Wang DS, Yu J, Orser BA.

Neuropharmacology. 2015 Jan;88:24-35. doi: 10.1016/j.neuropharm.2014.08.003. Epub 2014 Aug 13. Review.

PMID:
25128850
31.

Hydrogen peroxide increases GABAA receptor-mediated tonic current in hippocampal neurons.

Penna A, Wang DS, Yu J, Lecker I, Brown PM, Bowie D, Orser BA.

J Neurosci. 2014 Aug 6;34(32):10624-34. doi: 10.1523/JNEUROSCI.0335-14.2014.

32.

Repeated intermittent alcohol exposure during the third trimester-equivalent increases expression of the GABA(A) receptor δ subunit in cerebellar granule neurons and delays motor development in rats.

Diaz MR, Vollmer CC, Zamudio-Bulcock PA, Vollmer W, Blomquist SL, Morton RA, Everett JC, Zurek AA, Yu J, Orser BA, Valenzuela CF.

Neuropharmacology. 2014 Apr;79:262-74. doi: 10.1016/j.neuropharm.2013.11.020. Epub 2013 Dec 4.

33.

Acutely increasing δGABA(A) receptor activity impairs memory and inhibits synaptic plasticity in the hippocampus.

Whissell PD, Eng D, Lecker I, Martin LJ, Wang DS, Orser BA.

Front Neural Circuits. 2013 Sep 17;7:146. doi: 10.3389/fncir.2013.00146. eCollection 2013.

34.

Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar.

Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W Jr, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC Jr.

Br J Anaesth. 2013 Aug;111(2):143-51. doi: 10.1093/bja/aet177. Epub 2013 May 30.

35.

γ-aminobutyric acid type A receptors that contain the δ subunit promote memory and neurogenesis in the dentate gyrus.

Whissell PD, Rosenzweig S, Lecker I, Wang DS, Wojtowicz JM, Orser BA.

Ann Neurol. 2013 Oct;74(4):611-21. doi: 10.1002/ana.23941. Epub 2013 Jul 8.

PMID:
23686887
36.

Potentiation of GABAA receptor activity by volatile anaesthetics is reduced by α5GABAA receptor-preferring inverse agonists.

Lecker I, Yin Y, Wang DS, Orser BA.

Br J Anaesth. 2013 Jun;110 Suppl 1:i73-81. doi: 10.1093/bja/aet038. Epub 2013 Mar 27.

37.

Hyperpolarization-activated current (In) is reduced in hippocampal neurons from Gabra5-/- mice.

Bonin RP, Zurek AA, Yu J, Bayliss DA, Orser BA.

PLoS One. 2013;8(3):e58679. doi: 10.1371/journal.pone.0058679. Epub 2013 Mar 14.

38.

Isoflurane regulates atypical type-A γ-aminobutyric acid receptors in alveolar type II epithelial cells.

Xiang YY, Chen X, Li J, Wang S, Faclier G, Macdonald JF, Hogg JC, Orser BA, Lu WY.

Anesthesiology. 2013 May;118(5):1065-75. doi: 10.1097/ALN.0b013e31828e180e.

PMID:
23485993
39.

Gabapentin reduces preoperative anxiety and pain catastrophizing in highly anxious patients prior to major surgery: a blinded randomized placebo-controlled trial.

Clarke H, Kirkham KR, Orser BA, Katznelson R, Mitsakakis N, Ko R, Snyman A, Ma M, Katz J.

Can J Anaesth. 2013 May;60(5):432-43. doi: 10.1007/s12630-013-9890-1. Epub 2013 Feb 2.

PMID:
23377862
40.

Review article: improving drug safety for patients undergoing anesthesia and surgery.

Orser BA, Hyland S, U D, Sheppard I, Wilson CR.

Can J Anaesth. 2013 Feb;60(2):127-35. doi: 10.1007/s12630-012-9853-y. Epub 2012 Dec 22. Review.

PMID:
23264011
41.

Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.

Lecker I, Wang DS, Romaschin AD, Peterson M, Mazer CD, Orser BA.

J Clin Invest. 2012 Dec;122(12):4654-66. doi: 10.1172/JCI63375. Epub 2012 Nov 26.

42.

Memory deficits induced by inflammation are regulated by α5-subunit-containing GABAA receptors.

Wang DS, Zurek AA, Lecker I, Yu J, Abramian AM, Avramescu S, Davies PA, Moss SJ, Lu WY, Orser BA.

Cell Rep. 2012 Sep 27;2(3):488-96. doi: 10.1016/j.celrep.2012.08.022. Epub 2012 Sep 20.

43.

Canadian Anesthesiologists' Society 2011 Royal College lecture: anesthesiology: a profession at a crossroads.

Orser BA.

Can J Anaesth. 2012 Sep;59(9):882-8. doi: 10.1007/s12630-012-9749-x. Epub 2012 Aug 4. No abstract available.

PMID:
22865204
44.

The prevention of chronic postsurgical pain using gabapentin and pregabalin: a combined systematic review and meta-analysis.

Clarke H, Bonin RP, Orser BA, Englesakis M, Wijeysundera DN, Katz J.

Anesth Analg. 2012 Aug;115(2):428-42. doi: 10.1213/ANE.0b013e318249d36e. Epub 2012 Mar 13. Review.

PMID:
22415535
45.

Inhibition of α5 γ-Aminobutyric acid type A receptors restores recognition memory after general anesthesia.

Zurek AA, Bridgwater EM, Orser BA.

Anesth Analg. 2012 Apr;114(4):845-55. doi: 10.1213/ANE.0b013e31824720da. Epub 2012 Mar 1.

PMID:
22383672
46.

Metaplasticity gated through differential regulation of GluN2A versus GluN2B receptors by Src family kinases.

Yang K, Trepanier C, Sidhu B, Xie YF, Li H, Lei G, Salter MW, Orser BA, Nakazawa T, Yamamoto T, Jackson MF, Macdonald JF.

EMBO J. 2012 Feb 15;31(4):805-16. doi: 10.1038/emboj.2011.453. Epub 2011 Dec 20.

47.

An anti-coagulation agent Futhan preferentially targets GABA(A) receptors in lungepithelia: implication in treating asthma.

Chen X, Li M, Xiong ZG, Orser BA, Macdonald JF, Lu WY.

Int J Physiol Pathophysiol Pharmacol. 2011;3(4):249-56. Epub 2011 Nov 15.

48.

"Seizing" the opportunity to understand antifibrinolytic drugs.

Lecker I, Orser BA, Mazer CD.

Can J Anaesth. 2012 Jan;59(1):1-5. doi: 10.1007/s12630-011-9621-4. Epub 2011 Nov 4. English, French. No abstract available.

PMID:
22052288
49.

Functional modifications of acid-sensing ion channels by ligand-gated chloride channels.

Chen X, Whissell P, Orser BA, MacDonald JF.

PLoS One. 2011;6(7):e21970. doi: 10.1371/journal.pone.0021970. Epub 2011 Jul 18.

50.

Intraoperative awareness: from neurobiology to clinical practice.

Mashour GA, Orser BA, Avidan MS.

Anesthesiology. 2011 May;114(5):1218-33. doi: 10.1097/ALN.0b013e31820fc9b6. Review.

PMID:
21464699

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