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Items: 26


Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor.

Desai AJ, Mechin I, Nagarajan K, Valant C, Wootten D, Lam PCH, Orry A, Abagyan R, Nair A, Sexton PM, Christopoulos A, Miller LJ.

Mol Pharmacol. 2019 Mar;95(3):245-259. doi: 10.1124/mol.118.114082. Epub 2018 Dec 27.


Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport.

Naschberger A, Orry A, Lechner S, Bowler MW, Nurizzo D, Novokmet M, Keller MA, Oemer G, Seppi D, Haslbeck M, Pansi K, Dieplinger H, Rupp B.

Structure. 2017 Dec 5;25(12):1907-1915.e5. doi: 10.1016/j.str.2017.10.006. Epub 2017 Nov 16.


Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor.

Dong M, Lam PC, Orry A, Sexton PM, Christopoulos A, Abagyan R, Miller LJ.

J Biol Chem. 2016 Mar 4;291(10):5172-84. doi: 10.1074/jbc.M115.706010. Epub 2016 Jan 6.


Molecular Mechanism of Action of Triazolobenzodiazepinone Agonists of the Type 1 Cholecystokinin Receptor. Possible Cooperativity across the Receptor Homodimeric Complex.

Desai AJ, Lam PC, Orry A, Abagyan R, Christopoulos A, Sexton PM, Miller LJ.

J Med Chem. 2015 Dec 24;58(24):9562-77. doi: 10.1021/acs.jmedchem.5b01110. Epub 2015 Dec 10.


Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin.

Cho KI, Orry A, Park SE, Ferreira PA.

ACS Chem Neurosci. 2015 Aug 19;6(8):1476-85. doi: 10.1021/acschemneuro.5b00134. Epub 2015 Jun 12.


Development of a highly selective allosteric antagonist radioligand for the type 1 cholecystokinin receptor and elucidation of its molecular basis of binding.

Dong M, Vattelana AM, Lam PC, Orry AJ, Abagyan R, Christopoulos A, Sexton PM, Haines DR, Miller LJ.

Mol Pharmacol. 2015 Jan;87(1):130-40. doi: 10.1124/mol.114.095430. Epub 2014 Oct 15.


Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

Cho KI, Patil H, Senda E, Wang J, Yi H, Qiu S, Yoon D, Yu M, Orry A, Peachey NS, Ferreira PA.

J Biol Chem. 2014 Feb 21;289(8):4600-25. doi: 10.1074/jbc.M113.538215. Epub 2014 Jan 8.


Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor.

Harikumar KG, Cawston EE, Lam PC, Patil A, Orry A, Henke BR, Abagyan R, Christopoulos A, Sexton PM, Miller LJ.

J Biol Chem. 2013 Jul 19;288(29):21082-95. doi: 10.1074/jbc.M113.480715. Epub 2013 Jun 10.


Structural and functional plasticity of subcellular tethering, targeting and processing of RPGRIP1 by RPGR isoforms.

Patil H, Guruju MR, Cho KI, Yi H, Orry A, Kim H, Ferreira PA.

Biol Open. 2012 Feb 15;1(2):140-60. doi: 10.1242/bio.2011489. Epub 2011 Dec 30.


Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping.

Dong M, Xu X, Ball AM, Makhoul JA, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

FASEB J. 2012 Dec;26(12):5092-105. doi: 10.1096/fj.12-212399. Epub 2012 Sep 10.


Small molecule inhibitors of Bacillus anthracis protective antigen proteolytic activation and oligomerization.

Wein AN, Williams BN, Liu S, Ermolinsky B, Provenzano D, Abagyan R, Orry A, Leppla SH, Peredelchuk M.

J Med Chem. 2012 Sep 27;55(18):7998-8006. Epub 2012 Sep 18.


Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor.

Cawston EE, Lam PC, Harikumar KG, Dong M, Ball AM, Augustine ML, Akgün E, Portoghese PS, Orry A, Abagyan R, Sexton PM, Miller LJ.

J Biol Chem. 2012 May 25;287(22):18618-35. doi: 10.1074/jbc.M111.335646. Epub 2012 Mar 30.


From Drosophila to humans: reflections on the roles of the prolyl isomerases and chaperones, cyclophilins, in cell function and disease.

Ferreira PA, Orry A.

J Neurogenet. 2012 Jun;26(2):132-43. doi: 10.3109/01677063.2011.647143. Epub 2012 Feb 14. Review.


Preparation and refinement of model protein-ligand complexes.

Orry AJ, Abagyan R.

Methods Mol Biol. 2012;857:351-73. doi: 10.1007/978-1-61779-588-6_16.


Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore.

Dong M, Lam PC, Pinon DI, Hosohata K, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2011 Jul 8;286(27):23888-99. doi: 10.1074/jbc.M111.245969. Epub 2011 May 12.


Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.

Bowers EM, Yan G, Mukherjee C, Orry A, Wang L, Holbert MA, Crump NT, Hazzalin CA, Liszczak G, Yuan H, Larocca C, Saldanha SA, Abagyan R, Sun Y, Meyers DJ, Marmorstein R, Mahadevan LC, Alani RM, Cole PA.

Chem Biol. 2010 May 28;17(5):471-82. doi: 10.1016/j.chembiol.2010.03.006.


Secretin occupies a single protomer of the homodimeric secretin receptor complex: insights from photoaffinity labeling studies using dual sites of covalent attachment.

Dong M, Lam PC, Pinon DI, Orry A, Sexton PM, Abagyan R, Miller LJ.

J Biol Chem. 2010 Mar 26;285(13):9919-31. doi: 10.1074/jbc.M109.089730. Epub 2010 Jan 25.


Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.

Cavasotto CN, Orry AJ, Murgolo NJ, Czarniecki MF, Kocsi SA, Hawes BE, O'Neill KA, Hine H, Burton MS, Voigt JH, Abagyan RA, Bayne ML, Monsma FJ Jr.

J Med Chem. 2008 Feb 14;51(3):581-8. doi: 10.1021/jm070759m. Epub 2008 Jan 17.


Ligand docking and structure-based virtual screening in drug discovery.

Cavasotto CN, Orry AJ.

Curr Top Med Chem. 2007;7(10):1006-14. Review.


Structure-based development of target-specific compound libraries.

Orry AJ, Abagyan RA, Cavasotto CN.

Drug Discov Today. 2006 Mar;11(5-6):261-6. Review.


Efficient synthetic inhibitors of anthrax lethal factor.

Forino M, Johnson S, Wong TY, Rozanov DV, Savinov AY, Li W, Fattorusso R, Becattini B, Orry AJ, Jung D, Abagyan RA, Smith JW, Alibek K, Liddington RC, Strongin AY, Pellecchia M.

Proc Natl Acad Sci U S A. 2005 Jul 5;102(27):9499-504. Epub 2005 Jun 27.


Analyses of circular dichroism spectra of membrane proteins.

Wallace BA, Lees JG, Orry AJ, Lobley A, Janes RW.

Protein Sci. 2003 Apr;12(4):875-84.


Synchrotron radiation circular dichroism spectroscopy: vacuum ultraviolet irradiation does not damage protein integrity.

Orry AJ, Janes RW, Sarra R, Hanlon MR, Wallace BA.

J Synchrotron Radiat. 2001 May 1;8(3):1027-9.


Modeling and docking the endothelin G-protein-coupled receptor.

Orry AJ, Wallace BA.

Biophys J. 2000 Dec;79(6):3083-94.

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