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Items: 1 to 50 of 483

1.

Role of Cell Death in Toxicology: Does It Matter How Cells Die?

Orrenius S.

Annu Rev Pharmacol Toxicol. 2018 Jul 25. doi: 10.1146/annurev-pharmtox-010818-021725. [Epub ahead of print]

PMID:
30044725
2.

Corrigendum to "Reactive oxygen species generated in different compartments induce cell death, survival, or senescence". [Free Radic. Biol. Med. 2013 Apr; 57:176-187.].

Panieri E, Gogvadze V, Norberg E, Venkatesh R, Orrenius S, Zhivotovsky B.

Free Radic Biol Med. 2017 Jan;102:287-288. doi: 10.1016/j.freeradbiomed.2016.11.051. Epub 2016 Dec 21. No abstract available.

PMID:
27989434
3.

Calcium and mitochondria in the regulation of cell death.

Orrenius S, Gogvadze V, Zhivotovsky B.

Biochem Biophys Res Commun. 2015 Apr 24;460(1):72-81. doi: 10.1016/j.bbrc.2015.01.137. Review.

PMID:
25998735
4.

Analysis of mitochondrial dysfunction during cell death.

Gogvadze V, Orrenius S, Zhivotovsky B.

Methods Mol Biol. 2015;1264:385-93. doi: 10.1007/978-1-4939-2257-4_33.

PMID:
25631030
5.

Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death.

Vakifahmetoglu-Norberg H, Norberg E, Perdomo AB, Olsson M, Ciccosanti F, Orrenius S, Fimia GM, Piacentini M, Zhivotovsky B.

Cell Death Dis. 2013 Dec 5;4:e940. doi: 10.1038/cddis.2013.463.

6.

Reactive oxygen species generated in different compartments induce cell death, survival, or senescence.

Panieri E, Gogvadze V, Norberg E, Venkatesh R, Orrenius S, Zhivotovsky B.

Free Radic Biol Med. 2013 Apr;57:176-87. doi: 10.1016/j.freeradbiomed.2012.12.024. Epub 2013 Jan 4. Erratum in: Free Radic Biol Med. 2017 Jan;102:287-288.

PMID:
23295411
7.

Autophagy in toxicology: cause or consequence?

Orrenius S, Kaminskyy VO, Zhivotovsky B.

Annu Rev Pharmacol Toxicol. 2013;53:275-97. doi: 10.1146/annurev-pharmtox-011112-140210. Epub 2012 Oct 16. Review.

PMID:
23072380
8.

Citrate kills tumor cells through activation of apical caspases.

Kruspig B, Nilchian A, Orrenius S, Zhivotovsky B, Gogvadze V.

Cell Mol Life Sci. 2012 Dec;69(24):4229-37. doi: 10.1007/s00018-012-1166-3. Epub 2012 Oct 10.

PMID:
23052210
9.

Targeting hepatoma using nitric oxide donor strategies.

González R, Ferrín G, Aguilar-Melero P, Ranchal I, Linares CI, Bello RI, De la Mata M, Gogvadze V, Bárcena JA, Alamo JM, Orrenius S, Padillo FJ, Zhivotovsky B, Muntané J.

Antioxid Redox Signal. 2013 Feb 10;18(5):491-506. doi: 10.1089/ars.2011.4476. Epub 2012 Sep 26.

PMID:
22861189
10.

Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression.

Kruspig B, Nilchian A, Bejarano I, Orrenius S, Zhivotovsky B, Gogvadze V.

Cell Mol Life Sci. 2012 Jun;69(12):2091-9. doi: 10.1007/s00018-012-0918-4.

PMID:
22286068
11.

Calcium and cell death mechanisms: a perspective from the cell death community.

Zhivotovsky B, Orrenius S.

Cell Calcium. 2011 Sep;50(3):211-21. doi: 10.1016/j.ceca.2011.03.003. Epub 2011 Apr 3. Review.

PMID:
21459443
12.

Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis.

Norberg E, Karlsson M, Korenovska O, Szydlowski S, Silberberg G, Uhlén P, Orrenius S, Zhivotovsky B.

EMBO J. 2010 Nov 17;29(22):3869-78. doi: 10.1038/emboj.2010.253. Epub 2010 Oct 29.

13.

Cell cycle and cell death in disease: past, present and future.

Zhivotovsky B, Orrenius S.

J Intern Med. 2010 Nov;268(5):395-409. doi: 10.1111/j.1365-2796.2010.02282.x.

14.

Cell death mechanisms and their implications in toxicology.

Orrenius S, Nicotera P, Zhivotovsky B.

Toxicol Sci. 2011 Jan;119(1):3-19. doi: 10.1093/toxsci/kfq268. Epub 2010 Sep 9. Review.

PMID:
20829425
15.

Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF).

Norberg E, Orrenius S, Zhivotovsky B.

Biochem Biophys Res Commun. 2010 May 21;396(1):95-100. doi: 10.1016/j.bbrc.2010.02.163. Review.

PMID:
20494118
16.

Cell death mechanisms: cross-talk and role in disease.

Zhivotovsky B, Orrenius S.

Exp Cell Res. 2010 May 1;316(8):1374-83. doi: 10.1016/j.yexcr.2010.02.037. Epub 2010 Mar 6. Review.

PMID:
20211164
17.

Special issue composed of minireviews written by scientists from Karolinska Institutet to celebrate its 200-year anniversary. Preface.

Jörnvall H, Orrenius S.

Biochem Biophys Res Commun. 2010 May 21;396(1):1. doi: 10.1016/j.bbrc.2010.02.052. Epub 2010 Feb 14. No abstract available.

PMID:
20159008
18.

Involvement of Ca2+ and ROS in alpha-tocopheryl succinate-induced mitochondrial permeabilization.

Gogvadze V, Norberg E, Orrenius S, Zhivotovsky B.

Int J Cancer. 2010 Oct 15;127(8):1823-32. doi: 10.1002/ijc.25204.

19.

Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing.

Norberg E, Gogvadze V, Vakifahmetoglu H, Orrenius S, Zhivotovsky B.

Free Radic Biol Med. 2010 Mar 15;48(6):791-7. doi: 10.1016/j.freeradbiomed.2009.12.020. Epub 2010 Jan 4.

PMID:
20043986
20.

The Warburg effect and mitochondrial stability in cancer cells.

Gogvadze V, Zhivotovsky B, Orrenius S.

Mol Aspects Med. 2010 Feb;31(1):60-74. doi: 10.1016/j.mam.2009.12.004. Epub 2009 Dec 6. Review.

PMID:
19995572
21.

Mitochondrial targeting of tBid/Bax: a role for the TOM complex?

Ott M, Norberg E, Zhivotovsky B, Orrenius S.

Cell Death Differ. 2009 Aug;16(8):1075-82. doi: 10.1038/cdd.2009.61. Epub 2009 Jun 12. Review.

22.

Clinical perspectives of cell death: where we are and where to go...

Zhivotovsky B, Orrenius S.

Apoptosis. 2009 Apr;14(4):333-5. doi: 10.1007/s10495-009-0326-x. Review. No abstract available.

PMID:
19238546
23.

Mitochondria as targets for chemotherapy.

Gogvadze V, Orrenius S, Zhivotovsky B.

Apoptosis. 2009 Apr;14(4):624-40. doi: 10.1007/s10495-009-0323-0. Review.

PMID:
19205885
24.

The Warburg Effect returns to the cancer stage.

Zhivotovsky B, Orrenius S.

Semin Cancer Biol. 2009 Feb;19(1):1-3. doi: 10.1016/j.semcancer.2008.12.003. Epub 2008 Dec 31. No abstract available.

PMID:
19162190
25.

Mitochondria as targets for cancer chemotherapy.

Gogvadze V, Orrenius S, Zhivotovsky B.

Semin Cancer Biol. 2009 Feb;19(1):57-66. doi: 10.1016/j.semcancer.2008.11.007. Epub 2008 Dec 3. Review.

PMID:
19101636
26.

An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death.

Norberg E, Gogvadze V, Ott M, Horn M, Uhlén P, Orrenius S, Zhivotovsky B.

Cell Death Differ. 2008 Dec;15(12):1857-64. doi: 10.1038/cdd.2008.123. Epub 2008 Sep 19.

27.

Mitochondria in cancer cells: what is so special about them?

Gogvadze V, Orrenius S, Zhivotovsky B.

Trends Cell Biol. 2008 Apr;18(4):165-73. doi: 10.1016/j.tcb.2008.01.006. Epub 2008 Mar 4. Review.

PMID:
18296052
28.

Analysis of mitochondrial dysfunction during cell death.

Gogvadze V, Orrenius S, Zhivotovsky B.

Curr Protoc Cell Biol. 2003 Aug;Chapter 18:Unit 18.5. doi: 10.1002/0471143030.cb1805s19.

PMID:
18228423
29.

Assessment of apoptosis and necrosis by DNA fragmentation and morphological criteria.

Zhivotosky B, Orrenius S.

Curr Protoc Cell Biol. 2001 Nov;Chapter 18:Unit 18.3. doi: 10.1002/0471143030.cb1803s12.

PMID:
18228342
30.

Current concepts in cell death.

Zhivotovsky B, Orrenius S.

Curr Protoc Cell Biol. 2001 Aug;Chapter 18:Unit 18.1. doi: 10.1002/0471143030.cb1801s11.

PMID:
18228340
31.

DNA damage induces two distinct modes of cell death in ovarian carcinomas.

Vakifahmetoglu H, Olsson M, Tamm C, Heidari N, Orrenius S, Zhivotovsky B.

Cell Death Differ. 2008 Mar;15(3):555-66. Epub 2007 Dec 7.

32.

Reactive oxygen species in mitochondria-mediated cell death.

Orrenius S.

Drug Metab Rev. 2007;39(2-3):443-55. Review.

PMID:
17786631
33.

The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release.

Ott M, Norberg E, Walter KM, Schreiner P, Kemper C, Rapaport D, Zhivotovsky B, Orrenius S.

J Biol Chem. 2007 Sep 21;282(38):27633-9. Epub 2007 Jul 16.

34.

Mitochondria, oxidative stress and cell death.

Ott M, Gogvadze V, Orrenius S, Zhivotovsky B.

Apoptosis. 2007 May;12(5):913-22. Review.

PMID:
17453160
35.

Role of cardiolipin in cytochrome c release from mitochondria.

Ott M, Zhivotovsky B, Orrenius S.

Cell Death Differ. 2007 Jul;14(7):1243-7. Epub 2007 Apr 13. Review. No abstract available.

36.

Bridge over troubled water: milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells.

Witasp E, Uthaisang W, Elenström-Magnusson C, Hanayama R, Tanaka M, Nagata S, Orrenius S, Fadeel B.

Cell Death Differ. 2007 May;14(5):1063-5. Epub 2007 Jan 26. No abstract available.

37.

HAMLET, protein folding, and tumor cell death.

Mok KH, Pettersson J, Orrenius S, Svanborg C.

Biochem Biophys Res Commun. 2007 Mar 2;354(1):1-7. Epub 2006 Dec 29. Review. No abstract available.

PMID:
17223074
38.

Mitochondrial oxidative stress: implications for cell death.

Orrenius S, Gogvadze V, Zhivotovsky B.

Annu Rev Pharmacol Toxicol. 2007;47:143-83. Review.

PMID:
17029566
39.

The future of toxicology--does it matter how cells die?

Orrenius S, Zhivotovsky B.

Chem Res Toxicol. 2006 Jun;19(6):729-33. No abstract available.

PMID:
16780349
40.

Mitochondrial regulation of apoptotic cell death.

Gogvadze V, Orrenius S.

Chem Biol Interact. 2006 Oct 27;163(1-2):4-14. Epub 2006 Apr 30. Review.

PMID:
16730343
41.

Multiple pathways of cytochrome c release from mitochondria in apoptosis.

Gogvadze V, Orrenius S, Zhivotovsky B.

Biochim Biophys Acta. 2006 May-Jun;1757(5-6):639-47. Epub 2006 Apr 19. Review.

42.

Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.

Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B.

Oncogene. 2006 Sep 14;25(41):5683-92. Epub 2006 May 1.

PMID:
16652156
43.

Carcinogenesis and apoptosis: paradigms and paradoxes.

Zhivotovsky B, Orrenius S.

Carcinogenesis. 2006 Oct;27(10):1939-45. Epub 2006 Apr 10. Review.

PMID:
16606631
44.

HAMLET triggers apoptosis but tumor cell death is independent of caspases, Bcl-2 and p53.

Hallgren O, Gustafsson L, Irjala H, Selivanova G, Orrenius S, Svanborg C.

Apoptosis. 2006 Feb;11(2):221-33.

PMID:
16502260
45.

Cardiolipin oxidation sets cytochrome c free.

Orrenius S, Zhivotovsky B.

Nat Chem Biol. 2005 Sep;1(4):188-9. No abstract available.

PMID:
16408030
46.

Early work on apoptosis, an interview with Sten Orrenius.

Orrenius S.

Cell Death Differ. 2006 Jan;13(1):1-4. No abstract available.

47.

Apoptosis: a basic biological phenomenon with wide-ranging implications in human disease.

Fadeel B, Orrenius S.

J Intern Med. 2005 Dec;258(6):479-517. Review.

48.

Serine proteases and calpains fulfill important supporting roles in the apoptotic tragedy of the cellular opera.

Vandenabeele P, Orrenius S, Zhivotovsky B.

Cell Death Differ. 2005 Sep;12(9):1219-24. No abstract available.

49.

Arsenic stimulates release of cytochrome c from isolated mitochondria via induction of mitochondrial permeability transition.

Bustamante J, Nutt L, Orrenius S, Gogvadze V.

Toxicol Appl Pharmacol. 2005 Sep 1;207(2 Suppl):110-6. Review.

PMID:
15979664
50.

Caspase-2 function in response to DNA damage.

Zhivotovsky B, Orrenius S.

Biochem Biophys Res Commun. 2005 Jun 10;331(3):859-67. Review.

PMID:
15865942

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