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Early genome activation in Drosophila is extensive with an initial tendency for aborted transcripts and retained introns.

Kwasnieski JC, Orr-Weaver TL, Bartel DP.

Genome Res. 2019 Jul;29(7):1188-1197. doi: 10.1101/gr.242164.118. Epub 2019 Jun 24.


Dynamic changes in ORC localization and replication fork progression during tissue differentiation.

Hua BL, Bell GW, Kashevsky H, Von Stetina JR, Orr-Weaver TL.

BMC Genomics. 2018 Aug 22;19(1):623. doi: 10.1186/s12864-018-4992-3.


Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes.

Petrova B, Liu K, Tian C, Kitaoka M, Freinkman E, Yang J, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7978-E7986. doi: 10.1073/pnas.1807918115. Epub 2018 Aug 6.


Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition.

Hara M, Lourido S, Petrova B, Lou HJ, Von Stetina JR, Kashevsky H, Turk BE, Orr-Weaver TL.

Elife. 2018 Feb 26;7. pii: e33150. doi: 10.7554/eLife.33150.


Activating embryonic development in Drosophila.

Avilés-Pagán EE, Orr-Weaver TL.

Semin Cell Dev Biol. 2018 Dec;84:100-110. doi: 10.1016/j.semcdb.2018.02.019. Epub 2018 Feb 21. Review.


Variant cell cycles regulated by Notch signaling control cell size and ensure a functional blood-brain barrier.

Von Stetina JR, Frawley LE, Unhavaithaya Y, Orr-Weaver TL.

Development. 2018 Feb 13;145(3). pii: dev157115. doi: 10.1242/dev.157115.


Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin.

Pinto BS, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12988-12993. doi: 10.1073/pnas.1718450114. Epub 2017 Nov 20.


DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression.

Hua BL, Orr-Weaver TL.

Genetics. 2017 Sep;207(1):29-47. doi: 10.1534/genetics.115.186627. Review.


Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation.

Hara M, Petrova B, Orr-Weaver TL.

Elife. 2017 May 30;6. pii: e22219. doi: 10.7554/eLife.22219.


Replication fork instability and the consequences of fork collisions from rereplication.

Alexander JL, Orr-Weaver TL.

Genes Dev. 2016 Oct 15;30(20):2241-2252. Review.


Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells.

Alexander JL, Beagan K, Orr-Weaver TL, McVey M.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13809-13814. Epub 2016 Nov 14.


mRNA poly(A)-tail changes specified by deadenylation broadly reshape translation in Drosophila oocytes and early embryos.

Eichhorn SW, Subtelny AO, Kronja I, Kwasnieski JC, Orr-Weaver TL, Bartel DP.

Elife. 2016 Jul 30;5. pii: e16955. doi: 10.7554/eLife.16955.


Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein.

Nordman JT, Orr-Weaver TL.

Bioessays. 2015 Aug;37(8):856-61. doi: 10.1002/bies.201500021. Epub 2015 Jun 9.


Replication fork progression during re-replication requires the DNA damage checkpoint and double-strand break repair.

Alexander JL, Barrasa MI, Orr-Weaver TL.

Curr Biol. 2015 Jun 15;25(12):1654-60. doi: 10.1016/j.cub.2015.04.058. Epub 2015 Jun 4.



Frawley LE, Orr-Weaver TL.

Curr Biol. 2015 May 4;25(9):R353-8. doi: 10.1016/j.cub.2015.03.037.


When bigger is better: the role of polyploidy in organogenesis.

Orr-Weaver TL.

Trends Genet. 2015 Jun;31(6):307-15. doi: 10.1016/j.tig.2015.03.011. Epub 2015 Apr 25. Review.


DNA copy-number control through inhibition of replication fork progression.

Nordman JT, Kozhevnikova EN, Verrijzer CP, Pindyurin AV, Andreyeva EN, Shloma VV, Zhimulev IF, Orr-Weaver TL.

Cell Rep. 2014 Nov 6;9(3):841-9. doi: 10.1016/j.celrep.2014.10.005. Epub 2014 Oct 30.


Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition.

Kronja I, Whitfield ZJ, Yuan B, Dzeyk K, Kirkpatrick J, Krijgsveld J, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16023-8. doi: 10.1073/pnas.1418657111. Epub 2014 Oct 27.


The role of transcription in the activation of a Drosophila amplification origin.

Hua BL, Li S, Orr-Weaver TL.

G3 (Bethesda). 2014 Oct 14;4(12):2403-8. doi: 10.1534/g3.114.014050.


Regulation of centromere localization of the Drosophila Shugoshin MEI-S332 and sister-chromatid cohesion in meiosis.

Nogueira C, Kashevsky H, Pinto B, Clarke A, Orr-Weaver TL.

G3 (Bethesda). 2014 Jul 31;4(10):1849-58. doi: 10.1534/g3.114.012823.


Widespread changes in the posttranscriptional landscape at the Drosophila oocyte-to-embryo transition.

Kronja I, Yuan B, Eichhorn SW, Dzeyk K, Krijgsveld J, Bartel DP, Orr-Weaver TL.

Cell Rep. 2014 Jun 12;7(5):1495-1508. doi: 10.1016/j.celrep.2014.05.002. Epub 2014 May 29.


Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation.

Unhavaithaya Y, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19878-83. doi: 10.1073/pnas.1320074110. Epub 2013 Nov 18.


A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.

Whitfield ZJ, Chisholm J, Hawley RS, Orr-Weaver TL.

PLoS Biol. 2013 Sep;11(9):e1001648. doi: 10.1371/journal.pbio.1001648. Epub 2013 Sep 3.


Drosophila embryonic cell-cycle mutants.

Unhavaithaya Y, Park EA, Royzman I, Orr-Weaver TL.

G3 (Bethesda). 2013 Oct 3;3(10):1875-80. doi: 10.1534/g3.113.007880.


Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells.

Sher N, Von Stetina JR, Bell GW, Matsuura S, Ravid K, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9368-73. doi: 10.1073/pnas.1304889110. Epub 2013 Apr 23.


Regulation of DNA replication during development.

Nordman J, Orr-Weaver TL.

Development. 2012 Feb;139(3):455-64. doi: 10.1242/dev.061838. Review.


Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity.

Unhavaithaya Y, Orr-Weaver TL.

Genes Dev. 2012 Jan 1;26(1):31-6. doi: 10.1101/gad.177436.111.


Developmental control of gene copy number by repression of replication initiation and fork progression.

Sher N, Bell GW, Li S, Nordman J, Eng T, Eaton ML, Macalpine DM, Orr-Weaver TL.

Genome Res. 2012 Jan;22(1):64-75. doi: 10.1101/gr.126003.111. Epub 2011 Nov 16.


Translational regulation of the cell cycle: when, where, how and why?

Kronja I, Orr-Weaver TL.

Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27;366(1584):3638-52. doi: 10.1098/rstb.2011.0084. Review.


Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins.

Kim JC, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16681-6. doi: 10.1073/pnas.1114209108. Epub 2011 Sep 20.


Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis.

Hongay CF, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14855-60. doi: 10.1073/pnas.1111577108. Epub 2011 Aug 22.


Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression.

Kim JC, Nordman J, Xie F, Kashevsky H, Eng T, Li S, MacAlpine DM, Orr-Weaver TL.

Genes Dev. 2011 Jul 1;25(13):1384-98. doi: 10.1101/gad.2043111.


Developmental control of oocyte maturation and egg activation in metazoan models.

Von Stetina JR, Orr-Weaver TL.

Cold Spring Harb Perspect Biol. 2011 Oct 1;3(10):a005553. doi: 10.1101/cshperspect.a005553. Review.


Developmental control of the DNA replication and transcription programs.

Nordman J, Li S, Eng T, Macalpine D, Orr-Weaver TL.

Genome Res. 2011 Feb;21(2):175-81. doi: 10.1101/gr.114611.110. Epub 2010 Dec 22.


Regulation of Cyclin A protein in meiosis and early embryogenesis.

Vardy L, Pesin JA, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1838-43. doi: 10.1073/pnas.0813237106. Epub 2009 Jan 30.


Mutations in the chromosomal passenger complex and the condensin complex differentially affect synaptonemal complex disassembly and metaphase I configuration in Drosophila female meiosis.

Resnick TD, Dej KJ, Xiang Y, Hawley RS, Ahn C, Orr-Weaver TL.

Genetics. 2009 Mar;181(3):875-87. doi: 10.1534/genetics.108.097741. Epub 2008 Dec 22.


Isolation of a Drosophila amplification origin developmentally activated by transcription.

Xie F, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9651-6. doi: 10.1073/pnas.0804146105. Epub 2008 Jul 9.


Regulation of APC/C activators in mitosis and meiosis.

Pesin JA, Orr-Weaver TL.

Annu Rev Cell Dev Biol. 2008;24:475-99. doi: 10.1146/annurev.cellbio.041408.115949. Review.


Regulating translation of maternal messages: multiple repression mechanisms.

Vardy L, Orr-Weaver TL.

Trends Cell Biol. 2007 Nov;17(11):547-54. Epub 2007 Oct 29.


Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation.

Park EA, Macalpine DM, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16739-46. Epub 2007 Oct 11.


Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development.

Doroquez DB, Orr-Weaver TL, Rebay I.

Mech Dev. 2007 Sep-Oct;124(9-10):792-806. Epub 2007 May 21.


The Drosophila PNG kinase complex regulates the translation of cyclin B.

Vardy L, Orr-Weaver TL.

Dev Cell. 2007 Jan;12(1):157-66.


Histone modifications and the chromatin scaffold for meiotic chromosome architecture.

Ivanovska I, Orr-Weaver TL.

Cell Cycle. 2006 Sep;5(18):2064-71. Epub 2006 Sep 15. Review.


INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.

Resnick TD, Satinover DL, MacIsaac F, Stukenberg PT, Earnshaw WC, Orr-Weaver TL, Carmena M.

Dev Cell. 2006 Jul;11(1):57-68.


A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes.

Ivanovska I, Khandan T, Ito T, Orr-Weaver TL.

Genes Dev. 2005 Nov 1;19(21):2571-82. Epub 2005 Oct 17.


Replication of heterochromatin: insights into mechanisms of epigenetic inheritance.

Wallace JA, Orr-Weaver TL.

Chromosoma. 2005 Dec;114(6):389-402. Epub 2005 Nov 15. Review.


Roles and regulation of the Drosophila centromere cohesion protein MEI-S332 family.

Lee JY, Hayashi-Hagihara A, Orr-Weaver TL.

Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):543-52.

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