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Early genome activation in Drosophila is extensive with an initial tendency for aborted transcripts and retained introns.

Kwasnieski JC, Orr-Weaver TL, Bartel DP.

Genome Res. 2019 Jul;29(7):1188-1197. doi: 10.1101/gr.242164.118. Epub 2019 Jun 24.


Dynamic changes in ORC localization and replication fork progression during tissue differentiation.

Hua BL, Bell GW, Kashevsky H, Von Stetina JR, Orr-Weaver TL.

BMC Genomics. 2018 Aug 22;19(1):623. doi: 10.1186/s12864-018-4992-3.


Dynamic redox balance directs the oocyte-to-embryo transition via developmentally controlled reactive cysteine changes.

Petrova B, Liu K, Tian C, Kitaoka M, Freinkman E, Yang J, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E7978-E7986. doi: 10.1073/pnas.1807918115. Epub 2018 Aug 6.


Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition.

Hara M, Lourido S, Petrova B, Lou HJ, Von Stetina JR, Kashevsky H, Turk BE, Orr-Weaver TL.

Elife. 2018 Feb 26;7. pii: e33150. doi: 10.7554/eLife.33150.


Activating embryonic development in Drosophila.

Avilés-Pagán EE, Orr-Weaver TL.

Semin Cell Dev Biol. 2018 Dec;84:100-110. doi: 10.1016/j.semcdb.2018.02.019. Epub 2018 Feb 21. Review.


Variant cell cycles regulated by Notch signaling control cell size and ensure a functional blood-brain barrier.

Von Stetina JR, Frawley LE, Unhavaithaya Y, Orr-Weaver TL.

Development. 2018 Feb 13;145(3). pii: dev157115. doi: 10.1242/dev.157115.


Drosophila protein phosphatases 2A B' Wdb and Wrd regulate meiotic centromere localization and function of the MEI-S332 Shugoshin.

Pinto BS, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12988-12993. doi: 10.1073/pnas.1718450114. Epub 2017 Nov 20.


DNA Replication Control During Drosophila Development: Insights into the Onset of S Phase, Replication Initiation, and Fork Progression.

Hua BL, Orr-Weaver TL.

Genetics. 2017 Sep;207(1):29-47. doi: 10.1534/genetics.115.186627. Review.


Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation.

Hara M, Petrova B, Orr-Weaver TL.

Elife. 2017 May 30;6. pii: e22219. doi: 10.7554/eLife.22219.


Replication fork instability and the consequences of fork collisions from rereplication.

Alexander JL, Orr-Weaver TL.

Genes Dev. 2016 Oct 15;30(20):2241-2252. Review.


Multiple mechanisms contribute to double-strand break repair at rereplication forks in Drosophila follicle cells.

Alexander JL, Beagan K, Orr-Weaver TL, McVey M.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13809-13814. Epub 2016 Nov 14.


mRNA poly(A)-tail changes specified by deadenylation broadly reshape translation in Drosophila oocytes and early embryos.

Eichhorn SW, Subtelny AO, Kronja I, Kwasnieski JC, Orr-Weaver TL, Bartel DP.

Elife. 2016 Jul 30;5. pii: e16955. doi: 10.7554/eLife.16955.


Understanding replication fork progression, stability, and chromosome fragility by exploiting the Suppressor of Underreplication protein.

Nordman JT, Orr-Weaver TL.

Bioessays. 2015 Aug;37(8):856-61. doi: 10.1002/bies.201500021. Epub 2015 Jun 9.


Replication fork progression during re-replication requires the DNA damage checkpoint and double-strand break repair.

Alexander JL, Barrasa MI, Orr-Weaver TL.

Curr Biol. 2015 Jun 15;25(12):1654-60. doi: 10.1016/j.cub.2015.04.058. Epub 2015 Jun 4.



Frawley LE, Orr-Weaver TL.

Curr Biol. 2015 May 4;25(9):R353-8. doi: 10.1016/j.cub.2015.03.037.


When bigger is better: the role of polyploidy in organogenesis.

Orr-Weaver TL.

Trends Genet. 2015 Jun;31(6):307-15. doi: 10.1016/j.tig.2015.03.011. Epub 2015 Apr 25. Review.


DNA copy-number control through inhibition of replication fork progression.

Nordman JT, Kozhevnikova EN, Verrijzer CP, Pindyurin AV, Andreyeva EN, Shloma VV, Zhimulev IF, Orr-Weaver TL.

Cell Rep. 2014 Nov 6;9(3):841-9. doi: 10.1016/j.celrep.2014.10.005. Epub 2014 Oct 30.


Quantitative proteomics reveals the dynamics of protein changes during Drosophila oocyte maturation and the oocyte-to-embryo transition.

Kronja I, Whitfield ZJ, Yuan B, Dzeyk K, Kirkpatrick J, Krijgsveld J, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16023-8. doi: 10.1073/pnas.1418657111. Epub 2014 Oct 27.


The role of transcription in the activation of a Drosophila amplification origin.

Hua BL, Li S, Orr-Weaver TL.

G3 (Bethesda). 2014 Oct 14;4(12):2403-8. doi: 10.1534/g3.114.014050.


Regulation of centromere localization of the Drosophila Shugoshin MEI-S332 and sister-chromatid cohesion in meiosis.

Nogueira C, Kashevsky H, Pinto B, Clarke A, Orr-Weaver TL.

G3 (Bethesda). 2014 Jul 31;4(10):1849-58. doi: 10.1534/g3.114.012823.


Widespread changes in the posttranscriptional landscape at the Drosophila oocyte-to-embryo transition.

Kronja I, Yuan B, Eichhorn SW, Dzeyk K, Krijgsveld J, Bartel DP, Orr-Weaver TL.

Cell Rep. 2014 Jun 12;7(5):1495-1508. doi: 10.1016/j.celrep.2014.05.002. Epub 2014 May 29.


Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation.

Unhavaithaya Y, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2013 Dec 3;110(49):19878-83. doi: 10.1073/pnas.1320074110. Epub 2013 Nov 18.


A meiosis-specific form of the APC/C promotes the oocyte-to-embryo transition by decreasing levels of the Polo kinase inhibitor matrimony.

Whitfield ZJ, Chisholm J, Hawley RS, Orr-Weaver TL.

PLoS Biol. 2013 Sep;11(9):e1001648. doi: 10.1371/journal.pbio.1001648. Epub 2013 Sep 3.


Drosophila embryonic cell-cycle mutants.

Unhavaithaya Y, Park EA, Royzman I, Orr-Weaver TL.

G3 (Bethesda). 2013 Oct 3;3(10):1875-80. doi: 10.1534/g3.113.007880.


Fundamental differences in endoreplication in mammals and Drosophila revealed by analysis of endocycling and endomitotic cells.

Sher N, Von Stetina JR, Bell GW, Matsuura S, Ravid K, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9368-73. doi: 10.1073/pnas.1304889110. Epub 2013 Apr 23.


Regulation of DNA replication during development.

Nordman J, Orr-Weaver TL.

Development. 2012 Feb;139(3):455-64. doi: 10.1242/dev.061838. Review.


Polyploidization of glia in neural development links tissue growth to blood-brain barrier integrity.

Unhavaithaya Y, Orr-Weaver TL.

Genes Dev. 2012 Jan 1;26(1):31-6. doi: 10.1101/gad.177436.111.


Developmental control of gene copy number by repression of replication initiation and fork progression.

Sher N, Bell GW, Li S, Nordman J, Eng T, Eaton ML, Macalpine DM, Orr-Weaver TL.

Genome Res. 2012 Jan;22(1):64-75. doi: 10.1101/gr.126003.111. Epub 2011 Nov 16.


Translational regulation of the cell cycle: when, where, how and why?

Kronja I, Orr-Weaver TL.

Philos Trans R Soc Lond B Biol Sci. 2011 Dec 27;366(1584):3638-52. doi: 10.1098/rstb.2011.0084. Review.


Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins.

Kim JC, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16681-6. doi: 10.1073/pnas.1114209108. Epub 2011 Sep 20.


Drosophila Inducer of MEiosis 4 (IME4) is required for Notch signaling during oogenesis.

Hongay CF, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14855-60. doi: 10.1073/pnas.1111577108. Epub 2011 Aug 22.


Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression.

Kim JC, Nordman J, Xie F, Kashevsky H, Eng T, Li S, MacAlpine DM, Orr-Weaver TL.

Genes Dev. 2011 Jul 1;25(13):1384-98. doi: 10.1101/gad.2043111.


Developmental control of oocyte maturation and egg activation in metazoan models.

Von Stetina JR, Orr-Weaver TL.

Cold Spring Harb Perspect Biol. 2011 Oct 1;3(10):a005553. doi: 10.1101/cshperspect.a005553. Review.


Identification of functional elements and regulatory circuits by Drosophila modENCODE.

modENCODE Consortium, Roy S, Ernst J, Kharchenko PV, Kheradpour P, Negre N, Eaton ML, Landolin JM, Bristow CA, Ma L, Lin MF, Washietl S, Arshinoff BI, Ay F, Meyer PE, Robine N, Washington NL, Di Stefano L, Berezikov E, Brown CD, Candeias R, Carlson JW, Carr A, Jungreis I, Marbach D, Sealfon R, Tolstorukov MY, Will S, Alekseyenko AA, Artieri C, Booth BW, Brooks AN, Dai Q, Davis CA, Duff MO, Feng X, Gorchakov AA, Gu T, Henikoff JG, Kapranov P, Li R, MacAlpine HK, Malone J, Minoda A, Nordman J, Okamura K, Perry M, Powell SK, Riddle NC, Sakai A, Samsonova A, Sandler JE, Schwartz YB, Sher N, Spokony R, Sturgill D, van Baren M, Wan KH, Yang L, Yu C, Feingold E, Good P, Guyer M, Lowdon R, Ahmad K, Andrews J, Berger B, Brenner SE, Brent MR, Cherbas L, Elgin SC, Gingeras TR, Grossman R, Hoskins RA, Kaufman TC, Kent W, Kuroda MI, Orr-Weaver T, Perrimon N, Pirrotta V, Posakony JW, Ren B, Russell S, Cherbas P, Graveley BR, Lewis S, Micklem G, Oliver B, Park PJ, Celniker SE, Henikoff S, Karpen GH, Lai EC, MacAlpine DM, Stein LD, White KP, Kellis M.

Science. 2010 Dec 24;330(6012):1787-97. doi: 10.1126/science.1198374. Epub 2010 Dec 22.


Developmental control of the DNA replication and transcription programs.

Nordman J, Li S, Eng T, Macalpine D, Orr-Weaver TL.

Genome Res. 2011 Feb;21(2):175-81. doi: 10.1101/gr.114611.110. Epub 2010 Dec 22.


Regulation of Cyclin A protein in meiosis and early embryogenesis.

Vardy L, Pesin JA, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1838-43. doi: 10.1073/pnas.0813237106. Epub 2009 Jan 30.


Mutations in the chromosomal passenger complex and the condensin complex differentially affect synaptonemal complex disassembly and metaphase I configuration in Drosophila female meiosis.

Resnick TD, Dej KJ, Xiang Y, Hawley RS, Ahn C, Orr-Weaver TL.

Genetics. 2009 Mar;181(3):875-87. doi: 10.1534/genetics.108.097741. Epub 2008 Dec 22.


Isolation of a Drosophila amplification origin developmentally activated by transcription.

Xie F, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9651-6. doi: 10.1073/pnas.0804146105. Epub 2008 Jul 9.


Regulation of APC/C activators in mitosis and meiosis.

Pesin JA, Orr-Weaver TL.

Annu Rev Cell Dev Biol. 2008;24:475-99. doi: 10.1146/annurev.cellbio.041408.115949. Review.


Regulating translation of maternal messages: multiple repression mechanisms.

Vardy L, Orr-Weaver TL.

Trends Cell Biol. 2007 Nov;17(11):547-54. Epub 2007 Oct 29.


Drosophila follicle cell amplicons as models for metazoan DNA replication: a cyclinE mutant exhibits increased replication fork elongation.

Park EA, Macalpine DM, Orr-Weaver TL.

Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):16739-46. Epub 2007 Oct 11.


Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development.

Doroquez DB, Orr-Weaver TL, Rebay I.

Mech Dev. 2007 Sep-Oct;124(9-10):792-806. Epub 2007 May 21.


The Drosophila PNG kinase complex regulates the translation of cyclin B.

Vardy L, Orr-Weaver TL.

Dev Cell. 2007 Jan;12(1):157-66.


SMAUG is a major regulator of maternal mRNA destabilization in Drosophila and its translation is activated by the PAN GU kinase.

Tadros W, Goldman AL, Babak T, Menzies F, Vardy L, Orr-Weaver T, Hughes TR, Westwood JT, Smibert CA, Lipshitz HD.

Dev Cell. 2007 Jan;12(1):143-55.


Histone modifications and the chromatin scaffold for meiotic chromosome architecture.

Ivanovska I, Orr-Weaver TL.

Cell Cycle. 2006 Sep;5(18):2064-71. Epub 2006 Sep 15. Review.


INCENP and Aurora B promote meiotic sister chromatid cohesion through localization of the Shugoshin MEI-S332 in Drosophila.

Resnick TD, Satinover DL, MacIsaac F, Stukenberg PT, Earnshaw WC, Orr-Weaver TL, Carmena M.

Dev Cell. 2006 Jul;11(1):57-68.


New roles for model genetic organisms in understanding and treating human disease: report from the 2006 Genetics Society of America meeting.

Spradling A, Ganetsky B, Hieter P, Johnston M, Olson M, Orr-Weaver T, Rossant J, Sanchez A, Waterston R.

Genetics. 2006 Apr;172(4):2025-32.

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