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Items: 1 to 50 of 251

1.

Association between use of proton pump inhibitors and colorectal cancer: A nationwide population-based study.

Lei WY, Wang JH, Yi CH, Liu TT, Hung JS, Wong MW, Bair MJ, Vaezi MF, Orr WC, Chen CL.

Clin Res Hepatol Gastroenterol. 2020 Mar 26. pii: S2210-7401(20)30050-4. doi: 10.1016/j.clinre.2020.02.017. [Epub ahead of print]

PMID:
32224118
2.

Impact of concomitant dyspepsia and irritable bowel syndrome on symptom burden in patients with gastroesophageal reflux disease.

Lei WY, Chang WC, Wen SH, Wong MW, Hung JS, Yi CH, Liu TT, Hsu CS, Orr WC, Vaezi MF, Pace F, Hsieh TC, Chen CL.

J Formos Med Assoc. 2019 Apr;118(4):797-806. doi: 10.1016/j.jfma.2018.12.002. Epub 2018 Dec 21.

3.

Larks and owls and disease manifestation.

Orr WC.

Sleep Med. 2018 Dec;52:196-197. doi: 10.1016/j.sleep.2018.09.002. Epub 2018 Sep 18. No abstract available.

PMID:
30318449
4.

Overexpression of antimicrobial peptides contributes to aging through cytotoxic effects in Drosophila tissues.

Badinloo M, Nguyen E, Suh W, Alzahrani F, Castellanos J, Klichko VI, Orr WC, Radyuk SN.

Arch Insect Biochem Physiol. 2018 Aug;98(4):e21464. doi: 10.1002/arch.21464. Epub 2018 Apr 10.

5.

The Multifaceted Impact of Peroxiredoxins on Aging and Disease.

Radyuk SN, Orr WC.

Antioxid Redox Signal. 2018 Nov 1;29(13):1293-1311. doi: 10.1089/ars.2017.7452. Epub 2018 Jan 17. Review.

6.

Risk of acute myocardial infarction in patients with gastroesophageal reflux disease: A nationwide population-based study.

Lei WY, Wang JH, Wen SH, Yi CH, Hung JS, Liu TT, Orr WC, Chen CL.

PLoS One. 2017 Mar 20;12(3):e0173899. doi: 10.1371/journal.pone.0173899. eCollection 2017.

7.

Mitochondrial peroxiredoxins are essential in regulating the relationship between Drosophila immunity and aging.

Odnokoz O, Nakatsuka K, Klichko VI, Nguyen J, Solis LC, Ostling K, Badinloo M, Orr WC, Radyuk SN.

Biochim Biophys Acta Mol Basis Dis. 2017 Jan;1863(1):68-80. doi: 10.1016/j.bbadis.2016.10.017. Epub 2016 Oct 19.

8.

Tightening the connection between transposable element mobilization and aging.

Orr WC.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11069-11070. Epub 2016 Sep 23. No abstract available.

9.

Relevance of sleep disturbance to the integrity and characteristics of secondary peristalsis in patients with gastroesophageal reflux disease.

Yi CH, Lei WY, Hung JS, Liu TT, Orr WC, Chen CL.

Scand J Gastroenterol. 2017 Feb;52(2):136-142. doi: 10.1080/00365521.2016.1235225. Epub 2016 Sep 28.

PMID:
27608729
10.

Differences in the Control of Secondary Peristalsis in the Human Esophagus: Influence of the 5-HT4 Receptor versus the TRPV1 Receptor.

Yi CH, Lei WY, Hung JS, Liu TT, Orr WC, Fabio P, Chen CL.

PLoS One. 2016 Jul 20;11(7):e0159452. doi: 10.1371/journal.pone.0159452. eCollection 2016.

11.

Sleep disturbance and enhanced esophageal capsaicin sensitivity in patients with gastroesophageal reflux disease.

Yi CH, Lei WY, Hung JS, Liu TT, Orr WC, Chen CL.

J Gastroenterol Hepatol. 2016 Dec;31(12):1940-1945. doi: 10.1111/jgh.13428.

PMID:
27131333
12.

The role of peroxiredoxin 4 in inflammatory response and aging.

Klichko VI, Orr WC, Radyuk SN.

Biochim Biophys Acta. 2016 Feb;1862(2):265-73. doi: 10.1016/j.bbadis.2015.12.008. Epub 2015 Dec 9.

13.

Effects of esophageal capsaicin instillation on acid induced excitation of secondary peristalsis in humans.

Liu TT, Yi CH, Lei WY, Hung JS, Chen CL, Orr WC.

J Gastroenterol Hepatol. 2016 Feb;31(2):364-9. doi: 10.1111/jgh.13080.

PMID:
26250995
14.

Insomnia and Anxiety: Diagnostic and Management Implications of Complex Interactions.

Glidewell RN, McPherson Botts E, Orr WC.

Sleep Med Clin. 2015 Mar;10(1):93-9. doi: 10.1016/j.jsmc.2014.11.008. Epub 2014 Dec 24. Review.

PMID:
26055677
15.

Clinical, metabolic, and psychological characteristics in patients with gastroesophageal reflux disease overlap with irritable bowel syndrome.

Hsu CS, Liu TT, Wen SH, Wang CC, Yi CH, Chen JH, Lei WY, Orr WC, Fabio P, Chen CL.

Eur J Gastroenterol Hepatol. 2015 May;27(5):516-22. doi: 10.1097/MEG.0000000000000334.

PMID:
25822860
16.

Aging alters circadian regulation of redox in Drosophila.

Klichko VI, Chow ES, Kotwica-Rolinska J, Orr WC, Giebultowicz JM, Radyuk SN.

Front Genet. 2015 Mar 9;6:83. doi: 10.3389/fgene.2015.00083. eCollection 2015.

17.

Sleep disturbances and inflammatory bowel disease.

Ali T, Orr WC.

Inflamm Bowel Dis. 2014 Nov;20(11):1986-95. doi: 10.1097/MIB.0000000000000108. Review.

PMID:
25025716
18.

Predictors and patterns of insomnia symptoms in OSA before and after PAP therapy.

Glidewell RN, Renn BN, Roby E, Orr WC.

Sleep Med. 2014 Aug;15(8):899-905. doi: 10.1016/j.sleep.2014.05.001. Epub 2014 May 16.

PMID:
25011662
19.

Decrease in cytochrome c oxidase reserve capacity diminishes robustness of Drosophila melanogaster and shortens lifespan.

Klichko V, Sohal BH, Radyuk SN, Orr WC, Sohal RS.

Biochem J. 2014 Apr 1;459(1):127-35. doi: 10.1042/BJ20131370.

PMID:
24444354
20.

Sleep, immunity and inflammation in gastrointestinal disorders.

Ali T, Choe J, Awab A, Wagener TL, Orr WC.

World J Gastroenterol. 2013 Dec 28;19(48):9231-9. doi: 10.3748/wjg.v19.i48.9231. Review.

21.

Effects of mosapride on secondary peristalsis in patients with ineffective esophageal motility.

Chen CL, Yi CH, Liu TT, Orr WC.

Scand J Gastroenterol. 2013 Dec;48(12):1363-70. doi: 10.3109/00365521.2013.840856. Epub 2013 Oct 8.

PMID:
24099237
22.

The relationship between complaints of night-time heartburn and sleep-related gastroesophageal reflux.

Orr WC, Goodrich S, Estep ME, Shepherd K.

Dis Esophagus. 2014 May-Jun;27(4):303-10. doi: 10.1111/dote.12131. Epub 2013 Aug 29.

PMID:
24033500
23.

Novel partial 5HT3 agonist pumosetrag reduces acid reflux events in uninvestigated GERD patients after a standard refluxogenic meal: a randomized, double-blind, placebo-controlled pharmacodynamic study.

Choung RS, Locke GR 3rd, Francis DD, Katzka D, Winkle PJ, Orr WC, Crowell MD, Devault K, Harmsen WS, Zinsmeister AR, Talley NJ.

Neurogastroenterol Motil. 2014 Jan;26(1):13-20. doi: 10.1111/nmo.12214. Epub 2013 Sep 3.

PMID:
24001105
24.

Assessment of the relationship between quality of sleep and disease activity in inflammatory bowel disease patients.

Ali T, Madhoun MF, Orr WC, Rubin DT.

Inflamm Bowel Dis. 2013 Oct;19(11):2440-3. doi: 10.1097/MIB.0b013e3182a0ea54.

PMID:
23945186
25.

Involvement of redox state in the aging of Drosophila melanogaster.

Orr WC, Radyuk SN, Sohal RS.

Antioxid Redox Signal. 2013 Sep 10;19(8):788-803. doi: 10.1089/ars.2012.5002. Epub 2013 Apr 6. Review.

26.

The effect of peroxiredoxin 4 on fly physiology is a complex interplay of antioxidant and signaling functions.

Radyuk SN, Klichko VI, Michalak K, Orr WC.

FASEB J. 2013 Apr;27(4):1426-38. doi: 10.1096/fj.12-214106. Epub 2012 Dec 27.

27.

Circadian regulation of glutathione levels and biosynthesis in Drosophila melanogaster.

Beaver LM, Klichko VI, Chow ES, Kotwica-Rolinska J, Williamson M, Orr WC, Radyuk SN, Giebultowicz JM.

PLoS One. 2012;7(11):e50454. doi: 10.1371/journal.pone.0050454. Epub 2012 Nov 30.

28.

Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase.

Radyuk SN, Gambini J, Borras C, Serna E, Klichko VI, ViƱa J, Orr WC.

Mech Ageing Dev. 2012 Jun;133(6):401-13. doi: 10.1016/j.mad.2012.04.006. Epub 2012 May 10.

PMID:
22579812
29.

The effect of baclofen on nocturnal gastroesophageal reflux and measures of sleep quality: a randomized, cross-over trial.

Orr WC, Goodrich S, Wright S, Shepherd K, Mellow M.

Neurogastroenterol Motil. 2012 Jun;24(6):553-9, e253. doi: 10.1111/j.1365-2982.2012.01900.x. Epub 2012 Mar 8.

PMID:
22404184
30.

Is insomnia an independent predictor of obstructive sleep apnea?

Glidewell RN, Roby EK, Orr WC.

J Am Board Fam Med. 2012 Jan-Feb;25(1):104-10. doi: 10.3122/jabfm.2012.01.110123.

31.

The redox stress hypothesis of aging.

Sohal RS, Orr WC.

Free Radic Biol Med. 2012 Feb 1;52(3):539-555. doi: 10.1016/j.freeradbiomed.2011.10.445. Epub 2011 Oct 24. Review.

32.

Evidence for altered anorectal function in irritable bowel syndrome patients with sleep disturbance.

Chen CL, Liu TT, Yi CH, Orr WC.

Digestion. 2011;84(3):247-51. doi: 10.1159/000330847. Epub 2011 Sep 22.

PMID:
21952561
33.

Impact of sleep dysfunction on anorectal motility in healthy humans.

Liu TT, Yi CH, Chen CL, Orr WC.

J Neurogastroenterol Motil. 2011 Apr;17(2):180-4. doi: 10.5056/jnm.2011.17.2.180. Epub 2011 Apr 27.

34.

Effects of mosapride on esophageal secondary peristalsis in humans.

Chen CL, Liu TT, Yi CH, Orr WC.

Neurogastroenterol Motil. 2011 Jul;23(7):606-e249. doi: 10.1111/j.1365-2982.2011.01714.x. Epub 2011 Apr 19.

PMID:
21501334
35.

The effect of dexlansoprazole MR on nocturnal heartburn and GERD-related sleep disturbances in patients with symptomatic GERD.

Fass R, Johnson DA, Orr WC, Han C, Mody R, Stern KN, Pilmer BL, Perez MC.

Am J Gastroenterol. 2011 Mar;106(3):421-31. doi: 10.1038/ajg.2010.458. Epub 2011 Jan 11.

PMID:
21224838
36.

Alterations in gastrointestinal functioning during sleep.

Orr WC.

Handb Clin Neurol. 2011;98:347-54. doi: 10.1016/B978-0-444-52006-7.00021-6. Review. No abstract available.

PMID:
21056196
37.

Mitochondrial peroxiredoxins are critical for the maintenance of redox state and the survival of adult Drosophila.

Radyuk SN, Rebrin I, Klichko VI, Sohal BH, Michalak K, Benes J, Sohal RS, Orr WC.

Free Radic Biol Med. 2010 Dec 15;49(12):1892-902. doi: 10.1016/j.freeradbiomed.2010.09.014. Epub 2010 Oct 19.

38.

Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster.

Ren JC, Rebrin I, Klichko V, Orr WC, Sohal RS.

Biochem Biophys Res Commun. 2010 Oct 8;401(1):64-8. doi: 10.1016/j.bbrc.2010.09.009. Epub 2010 Sep 15.

39.

Effects of capsaicin-containing red pepper sauce suspension on esophageal secondary peristalsis in humans.

Chen CL, Liu TT, Yi CH, Orr WC.

Neurogastroenterol Motil. 2010 Nov;22(11):1177-82, e312-3. doi: 10.1111/j.1365-2982.2010.01561.x.

PMID:
20618832
40.

Peroxiredoxin 5 modulates immune response in Drosophila.

Radyuk SN, Michalak K, Klichko VI, Benes J, Orr WC.

Biochim Biophys Acta. 2010 Nov;1800(11):1153-63. doi: 10.1016/j.bbagen.2010.06.010. Epub 2010 Jun 28.

41.

Does sleep dysfunction affect anorectal motility in healthy adults?

Liu TT, Yi CH, Chen CL, Orr WC.

Scand J Gastroenterol. 2010 Oct;45(10):1262-3. doi: 10.3109/00365521.2010.501526. No abstract available.

PMID:
20586537
42.

Altered sensorimotor responses to esophageal acidification in older adults with GERD.

Chen CL, Yi CH, Liu TT, Orr WC.

Scand J Gastroenterol. 2010 Oct;45(10):1150-5. doi: 10.3109/00365521.2010.496493.

PMID:
20545468
43.

Gastroesophageal reflux and obstructive sleep apnea: more dangers in the night.

Orr WC.

Sleep Med. 2010 Apr;11(4):337-8. doi: 10.1016/j.sleep.2009.12.005. No abstract available.

PMID:
20223704
44.

Impaired health status, daily functioning, and work productivity in adults with excessive sleepiness.

Dean B, Aguilar D, Shapiro C, Orr WC, Isserman JA, Calimlim B, Rippon GA.

J Occup Environ Med. 2010 Feb;52(2):144-9. doi: 10.1097/JOM.0b013e3181c99505.

PMID:
20134351
45.

Does esophageal acid sensitivity alter in older adults with gastroesophageal reflux disease? A preliminary report.

Chen CL, Yi CH, Liu TT, Orr WC.

J Am Geriatr Soc. 2009 Dec;57(12):2382. doi: 10.1111/j.1532-5415.2009.02607.x. No abstract available.

PMID:
20122007
46.
47.

The relationship between the prevalence of nighttime gastroesophageal reflux disease and disease severity.

Dean BB, Aguilar D, Johnson LF, Fass R, Orr WC, McGuigan JE, Calimlim B, Yan N, Morgenstern D, Dubois RW.

Dig Dis Sci. 2010 Apr;55(4):952-9. doi: 10.1007/s10620-009-0885-2. Epub 2009 Aug 20.

PMID:
19693672
48.

Review article: sleep-related gastro-oesophageal reflux as a distinct clinical entity.

Orr WC.

Aliment Pharmacol Ther. 2010 Jan;31(1):47-56. doi: 10.1111/j.1365-2036.2009.04124.x. Review.

49.

Sleep and gastrointestinal disease: a new horizon in sleep medicine.

Orr WC.

Sleep Med. 2009 Jun;10(6):595-6. doi: 10.1016/j.sleep.2009.03.001. Epub 2009 Apr 28. No abstract available.

PMID:
19403334
50.

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