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Items: 19


A Subset of Exoribonucleases Serve as Degradative Enzymes for pGpG in c-di-GMP Signaling.

Orr MW, Weiss CA, Severin GB, Turdiev H, Kim SK, Turdiev A, Liu K, Tu BP, Waters CM, Winkler WC, Lee VT.

J Bacteriol. 2018 Nov 26;200(24). pii: e00300-18. doi: 10.1128/JB.00300-18. Print 2018 Dec 15.


Cyclic Di-GMP Binding by an Assembly ATPase (PilB2) and Control of Type IV Pilin Polymerization in the Gram-Positive Pathogen Clostridium perfringens.

Hendrick WA, Orr MW, Murray SR, Lee VT, Melville SB.

J Bacteriol. 2017 Apr 25;199(10). pii: e00034-17. doi: 10.1128/JB.00034-17. Print 2017 May 15.


Sustained sensing as an emerging principle in second messenger signaling systems.

Orr MW, Galperin MY, Lee VT.

Curr Opin Microbiol. 2016 Dec;34:119-126. doi: 10.1016/j.mib.2016.08.010. Epub 2016 Oct 1. Review.


Systematic Identification of Cyclic-di-GMP Binding Proteins in Vibrio cholerae Reveals a Novel Class of Cyclic-di-GMP-Binding ATPases Associated with Type II Secretion Systems.

Roelofs KG, Jones CJ, Helman SR, Shang X, Orr MW, Goodson JR, Galperin MY, Yildiz FH, Lee VT.

PLoS Pathog. 2015 Oct 27;11(10):e1005232. doi: 10.1371/journal.ppat.1005232. eCollection 2015 Oct.


Oligoribonuclease is the primary degradative enzyme for pGpG in Pseudomonas aeruginosa that is required for cyclic-di-GMP turnover.

Orr MW, Donaldson GP, Severin GB, Wang J, Sintim HO, Waters CM, Lee VT.

Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E5048-57. doi: 10.1073/pnas.1507245112. Epub 2015 Aug 24.


Catheter-associated urinary tract infection by Pseudomonas aeruginosa is mediated by exopolysaccharide-independent biofilms.

Cole SJ, Records AR, Orr MW, Linden SB, Lee VT.

Infect Immun. 2014 May;82(5):2048-58. doi: 10.1128/IAI.01652-14. Epub 2014 Mar 4.


High-throughput screening using the differential radial capillary action of ligand assay identifies ebselen as an inhibitor of diguanylate cyclases.

Lieberman OJ, Orr MW, Wang Y, Lee VT.

ACS Chem Biol. 2014 Jan 17;9(1):183-92. doi: 10.1021/cb400485k. Epub 2013 Nov 4.


Plagues and peoples, William H. McNeill.

Orr MW, McNeill WH.

Touchstone (Nashv). 1988;(12):3-5. No abstract available.


The effects of neuroleptic drugs on 5-hydroxytryptamine induced platelet aggregation in schizophrenic patients.

Orr MW, Knox JM, Allen R, Gelder MG, Grahame-Smith DG.

Br J Clin Pharmacol. 1981 Mar;11(3):255-9.


Drug-related and illness-related factors in the outcome of chlorpromazine treatment: testing a model.

Kolakowska T, Gelder MG, Orr MW.

Psychol Med. 1980 May;10(2):335-43.


Platelet aggregation and chlorpromazine therapy.

Boullin DJ, Know JM, Peters JR, Orr MW, Gelder MG, Grahame-Smith DG.

Br J Clin Pharmacol. 1978 Dec;6(6):538-40. No abstract available.


Chlorpromazine levels in plasma and milk of nursing mothers.

Wiles DH, Orr MW, Kolakowska T.

Br J Clin Pharmacol. 1978 Mar;5(3):272-3. No abstract available.


Proceedings: Cellular biochemical pharmacology in monitoring drug therapy.

Grahame-Smith DG, Aronson JK, Boulin DJ, Orr MW.

Arzneimittelforschung. 1976;26(6):1256-7. No abstract available.


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