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Methamphetamine Use and Cardiovascular Disease.

Kevil CG, Goeders NE, Woolard MD, Bhuiyan MS, Dominic P, Kolluru GK, Arnold CL, Traylor JG, Orr AW.

Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1739-1746. doi: 10.1161/ATVBAHA.119.312461. Epub 2019 Aug 21.


Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation.

Senchenkova EY, Ansari J, Becker F, Vital SA, Al-Yafeai Z, Sparkenbaugh EM, Pawlinski R, Stokes KY, Carroll JL, Dragoi AM, Qin CX, Ritchie RH, Sun H, Cuellar-Saenz HH, Rubinstein MR, Han YW, Orr AW, Perretti M, Granger DN, Gavins FNE.

Circulation. 2019 Jul 23;140(4):319-335. doi: 10.1161/CIRCULATIONAHA.118.039345. Epub 2019 Jun 3. Erratum in: Circulation. 2019 Jul 23;140(4):e172.


NFATc1-E2F1-LMCD1-Mediated IL-33 Expression by Thrombin Is Required for Injury-Induced Neointima Formation.

Govatati S, Pichavaram P, Janjanam J, Zhang B, Singh NK, Mani AM, Traylor JG Jr, Orr AW, Rao GN.

Arterioscler Thromb Vasc Biol. 2019 Jun;39(6):1212-1226. doi: 10.1161/ATVBAHA.119.312729.


Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration.

Abdullah CS, Alam S, Aishwarya R, Miriyala S, Bhuiyan MAN, Panchatcharam M, Pattillo CB, Orr AW, Sadoshima J, Hill JA, Bhuiyan MS.

Sci Rep. 2019 Feb 14;9(1):2002. doi: 10.1038/s41598-018-37862-3.


Cardiovascular disease is obNOXious: New insights into NoxA1 in smooth muscle phenotype.

Orr AW, Woolard MD.

Redox Biol. 2019 Apr;22:101081. doi: 10.1016/j.redox.2018.101081. Epub 2018 Dec 19. No abstract available.


Cardiac Dysfunction in the Sigma 1 Receptor Knockout Mouse Associated With Impaired Mitochondrial Dynamics and Bioenergetics.

Abdullah CS, Alam S, Aishwarya R, Miriyala S, Panchatcharam M, Bhuiyan MAN, Peretik JM, Orr AW, James J, Osinska H, Robbins J, Lorenz JN, Bhuiyan MS.

J Am Heart Assoc. 2018 Oct 16;7(20):e009775. doi: 10.1161/JAHA.118.009775.


Endothelial FN (Fibronectin) Deposition by α5β1 Integrins Drives Atherogenic Inflammation.

Al-Yafeai Z, Yurdagul A Jr, Peretik JM, Alfaidi M, Murphy PA, Orr AW.

Arterioscler Thromb Vasc Biol. 2018 Nov;38(11):2601-2614. doi: 10.1161/ATVBAHA.118.311705.


Guidance Molecules in Vascular Smooth Muscle.

Finney AC, Orr AW.

Front Physiol. 2018 Sep 19;9:1311. doi: 10.3389/fphys.2018.01311. eCollection 2018. Review.


Gene Transfer Induced Hypercholesterolemia in Amyloid Mice.

Grames MS, Dayton RD, Lu X, Schilke RM, Alexander JS, Orr AW, Barmada SJ, Woolard MD, Klein RL.

J Alzheimers Dis. 2018;65(4):1079-1086. doi: 10.3233/JAD-180494.


Decreases in GSH:GSSG activate vascular endothelial growth factor receptor 2 (VEGFR2) in human aortic endothelial cells.

Prasai PK, Shrestha B, Orr AW, Pattillo CB.

Redox Biol. 2018 Oct;19:22-27. doi: 10.1016/j.redox.2018.07.015. Epub 2018 Jul 25.


Cystathionine γ-Lyase Modulates Flow-Dependent Vascular Remodeling.

Yuan S, Yurdagul A Jr, Peretik JM, Alfaidi M, Al Yafeai Z, Pardue S, Kevil CG, Orr AW.

Arterioscler Thromb Vasc Biol. 2018 Sep;38(9):2126-2136. doi: 10.1161/ATVBAHA.118.311402. Erratum in: Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):e82.


De novo designed transmembrane peptides activating the α5β1 integrin.

Mravic M, Hu H, Lu Z, Bennett JS, Sanders CR, Orr AW, DeGrado WF.

Protein Eng Des Sel. 2018 May 1;31(5):181-190. doi: 10.1093/protein/gzy014.


Aberrant Mitochondrial Fission Is Maladaptive in Desmin Mutation-Induced Cardiac Proteotoxicity.

Alam S, Abdullah CS, Aishwarya R, Miriyala S, Panchatcharam M, Peretik JM, Orr AW, James J, Robbins J, Bhuiyan MS.

J Am Heart Assoc. 2018 Jul 9;7(14). pii: e009289. doi: 10.1161/JAHA.118.009289.


Differential arterial and venous endothelial redox responses to oxidative stress.

Shrestha B, Prasai PK, Kaskas AM, Khanna A, Letchuman V, Letchuman S, Alexander JS, Orr AW, Woolard MD, Pattillo CB.

Microcirculation. 2018 Oct;25(7):e12486. doi: 10.1111/micc.12486. Epub 2018 Jul 23.


EphA2 stimulates VCAM-1 expression through calcium-dependent NFAT1 activity.

Funk SD, Finney AC, Yurdagul A Jr, Pattillo CB, Orr AW.

Cell Signal. 2018 Sep;49:30-38. doi: 10.1016/j.cellsig.2018.05.008. Epub 2018 May 21.


Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis.

Vozenilek AE, Vetkoetter M, Green JM, Shen X, Traylor JG, Klein RL, Orr AW, Woolard MD, Krzywanski DM.

J Vasc Res. 2018;55(2):98-110. doi: 10.1159/000486337. Epub 2018 Feb 16.


A critical role for both CD40 and VLA5 in angiotensin II-mediated thrombosis and inflammation.

Senchenkova EY, Russell J, Vital SA, Yildirim A, Orr AW, Granger DN, Gavins FNE.

FASEB J. 2018 Jun;32(6):3448-3456. doi: 10.1096/fj.201701068R. Epub 2018 Feb 8.


LIM and cysteine-rich domains 1 is required for thrombin-induced smooth muscle cell proliferation and promotes atherogenesis.

Janjanam J, Zhang B, Mani AM, Singh NK, Traylor JG Jr, Orr AW, Rao GN.

J Biol Chem. 2018 Mar 2;293(9):3088-3103. doi: 10.1074/jbc.RA117.000866. Epub 2018 Jan 11.


Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.

Vozenilek AE, Navratil AR, Green JM, Coleman DT, Blackburn CMR, Finney AC, Pearson BH, Chrast R, Finck BN, Klein RL, Orr AW, Woolard MD.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):324-334. doi: 10.1161/ATVBAHA.117.310455. Epub 2017 Dec 7. Erratum in: Arterioscler Thromb Vasc Biol. 2018 May;38(5):e89.


Cardiac-specific inactivation of LPP3 in mice leads to myocardial dysfunction and heart failure.

Chandra M, Escalante-Alcalde D, Bhuiyan MS, Orr AW, Kevil C, Morris AJ, Nam H, Dominic P, McCarthy KJ, Miriyala S, Panchatcharam M.

Redox Biol. 2018 Apr;14:261-271. doi: 10.1016/j.redox.2017.09.015. Epub 2017 Sep 28.


Sigmar1 regulates endoplasmic reticulum stress-induced C/EBP-homologous protein expression in cardiomyocytes.

Alam S, Abdullah CS, Aishwarya R, Orr AW, Traylor J, Miriyala S, Panchatcharam M, Pattillo CB, Bhuiyan MS.

Biosci Rep. 2017 Jul 16;37(4). pii: BSR20170898. doi: 10.1042/BSR20170898. Print 2017 Aug 31.


EphA2 Expression Regulates Inflammation and Fibroproliferative Remodeling in Atherosclerosis.

Finney AC, Funk SD, Green JM, Yurdagul A Jr, Rana MA, Pistorius R, Henry M, Yurochko A, Pattillo CB, Traylor JG, Chen J, Woolard MD, Kevil CG, Orr AW.

Circulation. 2017 Aug 8;136(6):566-582. doi: 10.1161/CIRCULATIONAHA.116.026644. Epub 2017 May 9.


New-Generation Thromboelastography: Comprehensive Evaluation of Citrated and Heparinized Blood Sample Storage Effect on Clot-Forming Variables.

Dias JD, Haney EI, Mathew BA, Lopez-Espina CG, Orr AW, Popovsky MA.

Arch Pathol Lab Med. 2017 Apr;141(4):569-577. doi: 10.5858/arpa.2016-0088-OA. Epub 2017 Feb 28.


Integrin signaling in atherosclerosis.

Finney AC, Stokes KY, Pattillo CB, Orr AW.

Cell Mol Life Sci. 2017 Jun;74(12):2263-2282. doi: 10.1007/s00018-017-2490-4. Epub 2017 Feb 28. Review.


Fluid shear stress induces upregulation of COX-2 and PGI2 release in endothelial cells via a pathway involving PECAM-1, PI3K, FAK, and p38.

Russell-Puleri S, Dela Paz NG, Adams D, Chattopadhyay M, Cancel L, Ebong E, Orr AW, Frangos JA, Tarbell JM.

Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H485-H500. doi: 10.1152/ajpheart.00035.2016. Epub 2016 Dec 23.


Hydrogen sulfide metabolism regulates endothelial solute barrier function.

Yuan S, Pardue S, Shen X, Alexander JS, Orr AW, Kevil CG.

Redox Biol. 2016 Oct;9:157-166. doi: 10.1016/j.redox.2016.08.004. Epub 2016 Aug 11.


The arterial microenvironment: the where and why of atherosclerosis.

Yurdagul A Jr, Finney AC, Woolard MD, Orr AW.

Biochem J. 2016 May 15;473(10):1281-95. doi: 10.1042/BJ20150844. Review.


A Critical Role for Monocytes/Macrophages During Intestinal Inflammation-associated Lymphangiogenesis.

Becker F, Kurmaeva E, Gavins FN, Stevenson EV, Navratil AR, Jin L, Tsunoda I, Orr AW, Alexander JS, Ostanin DV.

Inflamm Bowel Dis. 2016 Jun;22(6):1326-45. doi: 10.1097/MIB.0000000000000731.


N-sulfation of heparan sulfate is critical for syndecan-4-mediated podocyte cell-matrix interactions.

Sugar T, Wassenhove-McCarthy DJ, Orr AW, Green J, van Kuppevelt TH, McCarthy KJ.

Am J Physiol Renal Physiol. 2016 May 15;310(10):F1123-35. doi: 10.1152/ajprenal.00603.2015. Epub 2016 Mar 2.


Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression.

Yurdagul A Jr, Sulzmaier FJ, Chen XL, Pattillo CB, Schlaepfer DD, Orr AW.

J Cell Sci. 2016 Apr 15;129(8):1580-91. doi: 10.1242/jcs.182097. Epub 2016 Feb 18.


Blood Brothers: Hemodynamics and Cell-Matrix Interactions in Endothelial Function.

Yurdagul A Jr, Orr AW.

Antioxid Redox Signal. 2016 Sep 1;25(7):415-34. doi: 10.1089/ars.2015.6525. Epub 2016 Feb 19. Review.


Lipin-1 contributes to modified low-density lipoprotein-elicited macrophage pro-inflammatory responses.

Navratil AR, Vozenilek AE, Cardelli JA, Green JM, Thomas MJ, Sorci-Thomas MG, Orr AW, Woolard MD.

Atherosclerosis. 2015 Oct;242(2):424-32. doi: 10.1016/j.atherosclerosis.2015.08.012. Epub 2015 Aug 10.


αvβ3 Integrins Mediate Flow-Induced NF-κB Activation, Proinflammatory Gene Expression, and Early Atherogenic Inflammation.

Chen J, Green J, Yurdagul A Jr, Albert P, McInnis MC, Orr AW.

Am J Pathol. 2015 Sep;185(9):2575-89. doi: 10.1016/j.ajpath.2015.05.013. Epub 2015 Jul 26.


Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment.

Holloway PM, Durrenberger PF, Trutschl M, Cvek U, Cooper D, Orr AW, Perretti M, Getting SJ, Gavins FN.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1936-44. doi: 10.1161/ATVBAHA.115.305348. Epub 2015 Jun 25.


Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice.

Singh NK, Kotla S, Dyukova E, Traylor JG Jr, Orr AW, Chernoff J, Marion TN, Rao GN.

Nat Commun. 2015 Jun 24;6:7450. doi: 10.1038/ncomms8450.


Recruitment of the adaptor protein Nck to PECAM-1 couples oxidative stress to canonical NF-κB signaling and inflammation.

Chen J, Leskov IL, Yurdagul A Jr, Thiel B, Kevil CG, Stokes KY, Orr AW.

Sci Signal. 2015 Feb 24;8(365):ra20. doi: 10.1126/scisignal.2005648.


ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation.

Kotla S, Singh NK, Traylor JG Jr, Orr AW, Rao GN.

Free Radic Biol Med. 2014 Nov;76:147-62. doi: 10.1016/j.freeradbiomed.2014.08.007. Epub 2014 Aug 23.


α5β1 integrin signaling mediates oxidized low-density lipoprotein-induced inflammation and early atherosclerosis.

Yurdagul A Jr, Green J, Albert P, McInnis MC, Mazar AP, Orr AW.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1362-73. doi: 10.1161/ATVBAHA.114.303863. Epub 2014 May 15.


Flow patterns regulate hyperglycemia-induced subendothelial matrix remodeling during early atherogenesis.

Green J, Yurdagul A Jr, McInnis MC, Albert P, Orr AW.

Atherosclerosis. 2014 Feb;232(2):277-84. doi: 10.1016/j.atherosclerosis.2013.11.052. Epub 2013 Dec 8.


Resveratrol promotes endothelial cell wound healing under laminar shear stress through an estrogen receptor-α-dependent pathway.

Yurdagul A Jr, Kleinedler JJ, McInnis MC, Khandelwal AR, Spence AL, Orr AW, Dugas TR.

Am J Physiol Heart Circ Physiol. 2014 Mar;306(6):H797-806. doi: 10.1152/ajpheart.00892.2013. Epub 2014 Jan 24.


Attenuation of experimental atherosclerosis by interleukin-19.

Ellison S, Gabunia K, Kelemen SE, England RN, Scalia R, Richards JM, Orr AW, Traylor JG Jr, Rogers T, Cornwell W, Berglund LM, Goncalves I, Gomez MF, Autieri MV.

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2316-24. doi: 10.1161/ATVBAHA.113.301521. Epub 2013 Aug 15. Erratum in: Arterioscler Thromb Vasc Biol. 2014 Jan;34(1):e1. Orr, Wayne [corrected to Orr, A Wayne].


Altered nitric oxide production mediates matrix-specific PAK2 and NF-κB activation by flow.

Yurdagul A Jr, Chen J, Funk SD, Albert P, Kevil CG, Orr AW.

Mol Biol Cell. 2013 Feb;24(3):398-408. doi: 10.1091/mbc.E12-07-0513. Epub 2012 Nov 21.


Ephs and ephrins resurface in inflammation, immunity, and atherosclerosis.

Funk SD, Orr AW.

Pharmacol Res. 2013 Jan;67(1):42-52. doi: 10.1016/j.phrs.2012.10.008. Epub 2012 Oct 23. Review.


Role of endothelial N-glycan mannose residues in monocyte recruitment during atherogenesis.

Scott DW, Chen J, Chacko BK, Traylor JG Jr, Orr AW, Patel RP.

Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):e51-9. doi: 10.1161/ATVBAHA.112.253203. Epub 2012 Jun 21.


Integrins and their extracellular matrix ligands in lymphangiogenesis and lymph node metastasis.

Chen J, Alexander JS, Orr AW.

Int J Cell Biol. 2012;2012:853703. doi: 10.1155/2012/853703. Epub 2012 Feb 12.


Hyperglycemia and endothelial dysfunction in atherosclerosis: lessons from type 1 diabetes.

Funk SD, Yurdagul A Jr, Orr AW.

Int J Vasc Med. 2012;2012:569654. doi: 10.1155/2012/569654. Epub 2012 Feb 14.


Synemin promotes AKT-dependent glioblastoma cell proliferation by antagonizing PP2A.

Pitre A, Davis N, Paul M, Orr AW, Skalli O.

Mol Biol Cell. 2012 Apr;23(7):1243-53. doi: 10.1091/mbc.E11-08-0685. Epub 2012 Feb 15.


EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis.

Funk SD, Yurdagul A Jr, Albert P, Traylor JG Jr, Jin L, Chen J, Orr AW.

Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):686-95. doi: 10.1161/ATVBAHA.111.242792. Epub 2012 Jan 12.


JNK2 promotes endothelial cell alignment under flow.

Hahn C, Wang C, Orr AW, Coon BG, Schwartz MA.

PLoS One. 2011;6(8):e24338. doi: 10.1371/journal.pone.0024338. Epub 2011 Aug 31.


Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents.

Lee B, Clarke D, Al Ahmad A, Kahle M, Parham C, Auckland L, Shaw C, Fidanboylu M, Orr AW, Ogunshola O, Fertala A, Thomas SA, Bix GJ.

J Clin Invest. 2011 Aug;121(8):3005-23. doi: 10.1172/JCI46358. Epub 2011 Jul 11. Erratum in: J Clin Invest. 2012 Feb 1;122(2):777.

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