Sort by
Items per page

Send to

Choose Destination

Search results

Items: 30


The use of site-specific suppressors to measure the relative contributions of different mitochondrial sites to skeletal muscle superoxide and hydrogen peroxide production.

Goncalves RLS, Watson MA, Wong HS, Orr AL, Brand MD.

Redox Biol. 2019 Oct 9;28:101341. doi: 10.1016/j.redox.2019.101341. [Epub ahead of print]


Neuronal Apolipoprotein E4 Expression Results in Proteome-Wide Alterations and Compromises Bioenergetic Capacity by Disrupting Mitochondrial Function.

Orr AL, Kim C, Jimenez-Morales D, Newton BW, Johnson JR, Krogan NJ, Swaney DL, Mahley RW.

J Alzheimers Dis. 2019;68(3):991-1011. doi: 10.3233/JAD-181184.


Plate-Based Measurement of Superoxide and Hydrogen Peroxide Production by Isolated Mitochondria.

Wong HS, Monternier PA, Orr AL, Brand MD.

Methods Mol Biol. 2018;1782:287-299. doi: 10.1007/978-1-4939-7831-1_16.


Loss of α-Synuclein Does Not Affect Mitochondrial Bioenergetics in Rodent Neurons.

Pathak D, Berthet A, Bendor JT, Yu K, Sellnow RC, Orr AL, Nguyen MK, Edwards RH, Manfredsson FP, Nakamura K.

eNeuro. 2017 Apr 28;4(2). pii: ENEURO.0216-16.2017. doi: 10.1523/ENEURO.0216-16.2017. eCollection 2017 Mar-Apr.


Long-term oral kinetin does not protect against α-synuclein-induced neurodegeneration in rodent models of Parkinson's disease.

Orr AL, Rutaganira FU, de Roulet D, Huang EJ, Hertz NT, Shokat KM, Nakamura K.

Neurochem Int. 2017 Oct;109:106-116. doi: 10.1016/j.neuint.2017.04.006. Epub 2017 Apr 20.


Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.

Brand MD, Goncalves RL, Orr AL, Vargas L, Gerencser AA, Borch Jensen M, Wang YT, Melov S, Turk CN, Matzen JT, Dardov VJ, Petrassi HM, Meeusen SL, Perevoshchikova IV, Jasper H, Brookes PS, Ainscow EK.

Cell Metab. 2016 Oct 11;24(4):582-592. doi: 10.1016/j.cmet.2016.08.012. Epub 2016 Sep 22.


Suppressors of superoxide production from mitochondrial complex III.

Orr AL, Vargas L, Turk CN, Baaten JE, Matzen JT, Dardov VJ, Attle SJ, Li J, Quackenbush DC, Goncalves RL, Perevoshchikova IV, Petrassi HM, Meeusen SL, Ainscow EK, Brand MD.

Nat Chem Biol. 2015 Nov;11(11):834-6. doi: 10.1038/nchembio.1910. Epub 2015 Sep 14.


β-Amyloid inhibits E-S potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition.

Orr AL, Hanson JE, Li D, Klotz A, Wright S, Schenk D, Seubert P, Madison DV.

Neuron. 2014 Jun 18;82(6):1334-45. doi: 10.1016/j.neuron.2014.04.039.


Production of superoxide/H2O2 by dihydroorotate dehydrogenase in rat skeletal muscle mitochondria.

Hey-Mogensen M, Goncalves RL, Orr AL, Brand MD.

Free Radic Biol Med. 2014 Jul;72:149-55. doi: 10.1016/j.freeradbiomed.2014.04.007. Epub 2014 Apr 16.


Novel inhibitors of mitochondrial sn-glycerol 3-phosphate dehydrogenase.

Orr AL, Ashok D, Sarantos MR, Ng R, Shi T, Gerencser AA, Hughes RE, Brand MD.

PLoS One. 2014 Feb 24;9(2):e89938. doi: 10.1371/journal.pone.0089938. eCollection 2014.


Sites of reactive oxygen species generation by mitochondria oxidizing different substrates.

Quinlan CL, Perevoshchikova IV, Hey-Mogensen M, Orr AL, Brand MD.

Redox Biol. 2013 May 23;1:304-12. doi: 10.1016/j.redox.2013.04.005. eCollection 2013.


Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.

Orr AL, Ashok D, Sarantos MR, Shi T, Hughes RE, Brand MD.

Free Radic Biol Med. 2013 Dec;65:1047-1059. doi: 10.1016/j.freeradbiomed.2013.08.170. Epub 2013 Aug 27.


The role of mitochondrial function and cellular bioenergetics in ageing and disease.

Brand MD, Orr AL, Perevoshchikova IV, Quinlan CL.

Br J Dermatol. 2013 Jul;169 Suppl 2:1-8. doi: 10.1111/bjd.12208. Review.


NF-κB activity is inversely correlated to RNF11 expression in Parkinson's disease.

Pranski E, Van Sanford CD, Dalal N, Orr AL, Karmali D, Cooper DS, Gearing M, Lah JJ, Levey AI, Betarbet R.

Neurosci Lett. 2013 Jun 28;547:16-20. doi: 10.1016/j.neulet.2013.04.056. Epub 2013 May 10.


Sites of superoxide and hydrogen peroxide production during fatty acid oxidation in rat skeletal muscle mitochondria.

Perevoshchikova IV, Quinlan CL, Orr AL, Gerencser AA, Brand MD.

Free Radic Biol Med. 2013 Aug;61:298-309. doi: 10.1016/j.freeradbiomed.2013.04.006. Epub 2013 Apr 11.


A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase.

Orr AL, Quinlan CL, Perevoshchikova IV, Brand MD.

J Biol Chem. 2012 Dec 14;287(51):42921-35. doi: 10.1074/jbc.M112.397828. Epub 2012 Nov 2.


Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters.

Quinlan CL, Treberg JR, Perevoshchikova IV, Orr AL, Brand MD.

Free Radic Biol Med. 2012 Nov 1;53(9):1807-17. doi: 10.1016/j.freeradbiomed.2012.08.015. Epub 2012 Aug 17.


Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions.

Quinlan CL, Orr AL, Perevoshchikova IV, Treberg JR, Ackrell BA, Brand MD.

J Biol Chem. 2012 Aug 3;287(32):27255-64. doi: 10.1074/jbc.M112.374629. Epub 2012 Jun 11.


Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain.

Pranski EL, Van Sanford CD, Dalal NV, Orr AL, Karmali D, Cooper DS, Costa N, Heilman CJ, Gearing M, Lah JJ, Levey AI, Betarbet RS.

Neurosci Lett. 2012 Jun 27;520(1):104-9. doi: 10.1016/j.neulet.2012.05.043. Epub 2012 May 23.


Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling.

Pranski EL, Dalal NV, Herskowitz JH, Orr AL, Roesch LA, Fritz JJ, Heilman C, Lah JJ, Levey AI, Betarbet RS.

J Neuroinflammation. 2012 Apr 16;9:67. doi: 10.1186/1742-2094-9-67.


A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells.

Birket MJ, Orr AL, Gerencser AA, Madden DT, Vitelli C, Swistowski A, Brand MD, Zeng X.

J Cell Sci. 2011 Feb 1;124(Pt 3):348-58. doi: 10.1242/jcs.072272.


Altered hippocampal synaptic physiology in aged parkin-deficient mice.

Hanson JE, Orr AL, Madison DV.

Neuromolecular Med. 2010 Sep;12(3):270-6. doi: 10.1007/s12017-010-8113-y. Epub 2010 Mar 16.


Impaired mitochondrial trafficking in Huntington's disease.

Li XJ, Orr AL, Li S.

Biochim Biophys Acta. 2010 Jan;1802(1):62-5. doi: 10.1016/j.bbadis.2009.06.008. Epub 2009 Jul 8. Review.


Adenosine A(2A) receptor mediates microglial process retraction.

Orr AG, Orr AL, Li XJ, Gross RE, Traynelis SF.

Nat Neurosci. 2009 Jul;12(7):872-8. doi: 10.1038/nn.2341. Epub 2009 Jun 14.


Physiological oxidative stress after arousal from hibernation in Arctic ground squirrel.

Orr AL, Lohse LA, Drew KL, Hermes-Lima M.

Comp Biochem Physiol A Mol Integr Physiol. 2009 Jun;153(2):213-21. doi: 10.1016/j.cbpa.2009.02.016. Epub 2009 Feb 20.


A FRET-based method to study protein thiol oxidation in histological preparations.

Mastroberardino PG, Orr AL, Hu X, Na HM, Greenamyre JT.

Free Radic Biol Med. 2008 Oct 1;45(7):971-81. doi: 10.1016/j.freeradbiomed.2008.06.018. Epub 2008 Jun 27.


Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.

Wang CE, Tydlacka S, Orr AL, Yang SH, Graham RK, Hayden MR, Li S, Chan AW, Li XJ.

Hum Mol Genet. 2008 Sep 1;17(17):2738-51. doi: 10.1093/hmg/ddn175. Epub 2008 Jun 16.


Sex-dependent effect of BAG1 in ameliorating motor deficits of Huntington disease transgenic mice.

Orr AL, Huang S, Roberts MA, Reed JC, Li S, Li XJ.

J Biol Chem. 2008 Jun 6;283(23):16027-36. doi: 10.1074/jbc.M710606200. Epub 2008 Apr 8.


N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.

Orr AL, Li S, Wang CE, Li H, Wang J, Rong J, Xu X, Mastroberardino PG, Greenamyre JT, Li XJ.

J Neurosci. 2008 Mar 12;28(11):2783-92. doi: 10.1523/JNEUROSCI.0106-08.2008.


The elderly visually impaired patient. What every home care provider should know.

Orr AL.

Caring. 1987 Aug;6(8):55-8. No abstract available.


Supplemental Content

Support Center