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Items: 42

1.

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition.

Roepman P, Schlicker A, Tabernero J, Majewski I, Tian S, Moreno V, Snel MH, Chresta CM, Rosenberg R, Nitsche U, Macarulla T, Capella G, Salazar R, Orphanides G, Wessels LF, Bernards R, Simon IM.

Int J Cancer. 2014 Feb 1;134(3):552-62. doi: 10.1002/ijc.28387. Epub 2013 Sep 13.

2.

Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines.

Schlicker A, Beran G, Chresta CM, McWalter G, Pritchard A, Weston S, Runswick S, Davenport S, Heathcote K, Castro DA, Orphanides G, French T, Wessels LF.

BMC Med Genomics. 2012 Dec 31;5:66. doi: 10.1186/1755-8794-5-66.

3.

Subdural effusions with hydrocephalus after severe head injury: successful treatment with ventriculoperitoneal shunt placement: report of 3 adult cases.

Tzerakis N, Orphanides G, Antoniou E, Sioutos PJ, Lafazanos S, Seretis A.

Case Rep Med. 2010;2010:743784. doi: 10.1155/2010/743784. Epub 2010 Dec 12.

4.

Emerging evidence for the interrelationship of xenobiotic exposure and circadian rhythms: a review.

Lim FL, Currie RA, Orphanides G, Moggs JG.

Xenobiotica. 2006 Oct-Nov;36(10-11):1140-51. Review.

PMID:
17118921
5.

Identification of early molecular pathways affected by paraquat in rat lung.

Mainwaring G, Lim FL, Antrobus K, Swain C, Clapp M, Kimber I, Orphanides G, Moggs JG.

Toxicology. 2006 Aug 15;225(2-3):157-72. Epub 2006 Jun 6.

PMID:
16854511
6.

Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation.

Stuckey R, Aldridge T, Lim FL, Moore DJ, Tinwell H, Doherty N, Davies R, Smith AG, Kimber I, Ashby J, Orphanides G, Moggs JG.

Mol Cell Endocrinol. 2006 Jul 11;253(1-2):22-9. Epub 2006 May 8.

PMID:
16684588
7.

Proteomic analysis of suction blister fluid isolated from human skin.

Macdonald N, Cumberbatch M, Singh M, Moggs JG, Orphanides G, Dearman RJ, Griffiths CE, Kimber I.

Clin Exp Dermatol. 2006 May;31(3):445-8.

PMID:
16681597
8.

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.

Corvi R, Ahr HJ, Albertini S, Blakey DH, Clerici L, Coecke S, Douglas GR, Gribaldo L, Groten JP, Haase B, Hamernik K, Hartung T, Inoue T, Indans I, Maurici D, Orphanides G, Rembges D, Sansone SA, Snape JR, Toda E, Tong W, van Delft JH, Weis B, Schechtman LM.

Environ Health Perspect. 2006 Mar;114(3):420-9.

9.

Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3.

Macdonald N, Welburn JP, Noble ME, Nguyen A, Yaffe MB, Clynes D, Moggs JG, Orphanides G, Thomson S, Edmunds JW, Clayton AL, Endicott JA, Mahadevan LC.

Mol Cell. 2005 Oct 28;20(2):199-211.

10.

Mapping molecular responses to xenoestrogens through Gene Ontology and pathway analysis of toxicogenomic data.

Currie RA, Orphanides G, Moggs JG.

Reprod Toxicol. 2005 Sep-Oct;20(3):433-40.

PMID:
15964738
11.

Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate.

Currie RA, Bombail V, Oliver JD, Moore DJ, Lim FL, Gwilliam V, Kimber I, Chipman K, Moggs JG, Orphanides G.

Toxicol Sci. 2005 Aug;86(2):453-69. Epub 2005 May 18.

PMID:
15901911
12.

Anti-proliferative effect of estrogen in breast cancer cells that re-express ERalpha is mediated by aberrant regulation of cell cycle genes.

Moggs JG, Murphy TC, Lim FL, Moore DJ, Stuckey R, Antrobus K, Kimber I, Orphanides G.

J Mol Endocrinol. 2005 Apr;34(2):535-51.

PMID:
15821115
13.

Phenotypic anchoring of gene expression changes during estrogen-induced uterine growth.

Moggs JG, Tinwell H, Spurway T, Chang HS, Pate I, Lim FL, Moore DJ, Soames A, Stuckey R, Currie R, Zhu T, Kimber I, Ashby J, Orphanides G.

Environ Health Perspect. 2004 Nov;112(16):1589-606.

14.

The need to decide if all estrogens are intrinsically similar.

Moggs JG, Ashby J, Tinwell H, Lim FL, Moore DJ, Kimber I, Orphanides G.

Environ Health Perspect. 2004 Aug;112(11):1137-42.

15.

The role of chromatin in molecular mechanisms of toxicity.

Moggs JG, Orphanides G.

Toxicol Sci. 2004 Aug;80(2):218-24. Epub 2004 May 12. Review.

PMID:
15141100
16.

Perturbation of epigenetic status by toxicants.

Bombail V, Moggs JG, Orphanides G.

Toxicol Lett. 2004 Apr 1;149(1-3):51-8. Review.

PMID:
15093248
17.

FACT facilitates transcription-dependent nucleosome alteration.

Belotserkovskaya R, Oh S, Bondarenko VA, Orphanides G, Studitsky VM, Reinberg D.

Science. 2003 Aug 22;301(5636):1090-3.

18.

Toxicogenetics: applications and opportunities.

Orphanides G, Kimber I.

Toxicol Sci. 2003 Sep;75(1):1-6. Epub 2003 May 2. Review.

PMID:
12730621
19.

Genomic analysis of stress response genes.

Moggs JG, Orphanides G.

Toxicol Lett. 2003 Apr 11;140-141:149-53. Review.

PMID:
12676461
20.

Toxicogenomics: challenges and opportunities.

Orphanides G.

Toxicol Lett. 2003 Apr 11;140-141:145-8. Review.

PMID:
12676460
21.

Sex steroids, ANGELS and osteoporosis.

Moggs JG, Deavall DG, Orphanides G.

Bioessays. 2003 Mar;25(3):195-9. Review.

PMID:
12596222
22.

Assessment of glycosylation-dependent cell adhesion molecule 1 as a correlate of allergen-stimulated lymph node activation.

Betts CJ, Moggs JG, Caddick HT, Cumberbatch M, Orphanides G, Dearman RJ, Ryan CA, Hulette BC, Frank Gerberick G, Kimber I.

Toxicology. 2003 Mar 14;185(1-2):103-17.

PMID:
12505449
23.

Downregulation of lactoferrin by PPARalpha ligands: role in perturbation of hepatocyte proliferation and apoptosis.

Hasmall S, Orphanides G, James N, Pennie W, Hedley K, Soames A, Kimber I, Roberts R.

Toxicol Sci. 2002 Aug;68(2):304-13.

PMID:
12151626
24.

Confirmation of uterotrophic activity of 3-(4-methylbenzylidine)camphor in the immature rat.

Tinwell H, Lefevre PA, Moffat GJ, Burns A, Odum J, Spurway TD, Orphanides G, Ashby J.

Environ Health Perspect. 2002 May;110(5):533-6.

25.

A unified theory of gene expression.

Orphanides G, Reinberg D.

Cell. 2002 Feb 22;108(4):439-51. Review.

26.

Estrogen receptors: orchestrators of pleiotropic cellular responses.

Moggs JG, Orphanides G.

EMBO Rep. 2001 Sep;2(9):775-81. Review.

27.

Application of genomics to the definition of the molecular basis for toxicity.

Pennie WD, Woodyatt NJ, Aldridge TC, Orphanides G.

Toxicol Lett. 2001 Mar 31;120(1-3):353-8.

PMID:
11323194
28.

Role of cytokines in non-genotoxic hepatocarcinogenesis: cause or effect?

Roberts RA, James NH, Cosulich S, Hasmall SC, Orphanides G.

Toxicol Lett. 2001 Mar 31;120(1-3):301-6. Review.

PMID:
11323188
29.

RNA polymerase II elongation through chromatin.

Orphanides G, Reinberg D.

Nature. 2000 Sep 28;407(6803):471-5. Review.

PMID:
11028991
30.

FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH.

Wada T, Orphanides G, Hasegawa J, Kim DK, Shima D, Yamaguchi Y, Fukuda A, Hisatake K, Oh S, Reinberg D, Handa H.

Mol Cell. 2000 Jun;5(6):1067-72.

31.

The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.

Orphanides G, Wu WH, Lane WS, Hampsey M, Reinberg D.

Nature. 1999 Jul 15;400(6741):284-8.

PMID:
10421373
32.

The RNA polymerase II general transcription factors: past, present, and future.

Reinberg D, Orphanides G, Ebright R, Akoulitchev S, Carcamo J, Cho H, Cortes P, Drapkin R, Flores O, Ha I, Inostroza JA, Kim S, Kim TK, Kumar P, Lagrange T, LeRoy G, Lu H, Ma DM, Maldonado E, Merino A, Mermelstein F, Olave I, Sheldon M, Shiekhattar R, Zawel L, et al.

Cold Spring Harb Symp Quant Biol. 1998;63:83-103. Review. No abstract available.

PMID:
10384273
33.

Probing the binding of coumarins and cyclothialidines to DNA gyrase.

Kampranis SC, Gormley NA, Tranter R, Orphanides G, Maxwell A.

Biochemistry. 1999 Feb 16;38(7):1967-76.

PMID:
10026280
34.

Requirement of RSF and FACT for transcription of chromatin templates in vitro.

LeRoy G, Orphanides G, Lane WS, Reinberg D.

Science. 1998 Dec 4;282(5395):1900-4.

35.

A human RNA polymerase II complex containing factors that modify chromatin structure.

Cho H, Orphanides G, Sun X, Yang XJ, Ogryzko V, Lees E, Nakatani Y, Reinberg D.

Mol Cell Biol. 1998 Sep;18(9):5355-63.

36.

FACT, a factor that facilitates transcript elongation through nucleosomes.

Orphanides G, LeRoy G, Chang CH, Luse DS, Reinberg D.

Cell. 1998 Jan 9;92(1):105-16.

37.

The general transcription factors of RNA polymerase II.

Orphanides G, Lagrange T, Reinberg D.

Genes Dev. 1996 Nov 1;10(21):2657-83. Review. No abstract available.

38.

High-resolution mapping of nucleoprotein complexes by site-specific protein-DNA photocrosslinking: organization of the human TBP-TFIIA-TFIIB-DNA quaternary complex.

Lagrange T, Kim TK, Orphanides G, Ebright YW, Ebright RH, Reinberg D.

Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10620-5.

39.

The interaction of coumarin antibiotics with fragments of DNA gyrase B protein.

Gormley NA, Orphanides G, Meyer A, Cullis PM, Maxwell A.

Biochemistry. 1996 Apr 16;35(15):5083-92.

PMID:
8664301
40.

Nucleotide binding to the 43-kilodalton N-terminal fragment of the DNA gyrase B protein.

Ali JA, Orphanides G, Maxwell A.

Biochemistry. 1995 Aug 1;34(30):9801-8.

PMID:
7626649
41.

Topoisomerases. In one gate, out the other.

Orphanides G, Maxwell A.

Curr Biol. 1994 Nov 1;4(11):1006-9. Review.

PMID:
7874480
42.

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