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Items: 1 to 50 of 64

1.

No Tissue Expression of KRAS or BRAF Mutations in 61 Adult Patients Treated for Esophageal Atresia in Early Childhood.

Dang KX, Ho T, Sistonen S, Koivusalo A, Pakarinen M, Rintala R, Stenman UH, Orpana A, Stenman J.

Eur J Pediatr Surg. 2018 Oct;28(5):413-419. doi: 10.1055/s-0037-1605346. Epub 2017 Sep 5.

PMID:
28873491
2.

EGFR gene copy number predicts response to anti-EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer.

Ålgars A, Sundström J, Lintunen M, Jokilehto T, Kytölä S, Kaare M, Vainionpää R, Orpana A, Österlund P, Ristimäki A, Carpen O, Ristamäki R.

Int J Cancer. 2017 Feb 15;140(4):922-929. doi: 10.1002/ijc.30507. Epub 2016 Nov 23.

3.

Prospective immunohistochemical analysis of BRAF V600E mutation in melanoma.

Thiel A, Moza M, Kytölä S, Orpana A, Jahkola T, Hernberg M, Virolainen S, Ristimäki A.

Hum Pathol. 2015 Feb;46(2):169-75. doi: 10.1016/j.humpath.2014.08.018. Epub 2014 Oct 30.

PMID:
25442222
4.

Automation of diagnostic genetic testing: mutation detection by cyclic minisequencing.

Alagrund K, Orpana AK.

Scand J Clin Lab Invest. 2014 Jan;74(1):44-52. doi: 10.3109/00365513.2013.857040. Epub 2013 Nov 25.

PMID:
24274319
5.

BRAF mutation in sporadic colorectal cancer and Lynch syndrome.

Thiel A, Heinonen M, Kantonen J, Gylling A, Lahtinen L, Korhonen M, Kytölä S, Mecklin JP, Orpana A, Peltomäki P, Ristimäki A.

Virchows Arch. 2013 Nov;463(5):613-21. doi: 10.1007/s00428-013-1470-9. Epub 2013 Aug 21.

PMID:
23963522
6.

Novel heat pulse extension-PCR-based method for detection of large CTG-repeat expansions in myotonic dystrophy type 1.

Orpana AK, Ho TH, Alagrund K, Ridanpää M, Aittomäki K, Stenman J.

J Mol Diagn. 2013 Jan;15(1):110-5. doi: 10.1016/j.jmoldx.2012.07.004. Epub 2012 Nov 14.

7.

Technique for strand-specific gene-expression analysis and monitoring of primer-independent cDNA synthesis in reverse transcription.

Feng L, Lintula S, Ho TH, Anastasina M, Paju A, Haglund C, Stenman UH, Hotakainen K, Orpana A, Kainov D, Stenman J.

Biotechniques. 2012 Apr;52(4):263-70. doi: 10.2144/0000113842.

8.

Multiple heat pulses during PCR extension enabling amplification of GC-rich sequences and reducing amplification bias.

Orpana AK, Ho TH, Stenman J.

Anal Chem. 2012 Feb 21;84(4):2081-7. doi: 10.1021/ac300040j. Epub 2012 Jan 30.

PMID:
22220596
9.

High serum angiogenin at diagnosis predicts for failure on long-term treatment response and for poor overall survival in non-Hodgkin lymphoma.

Fang S, Repo H, Joensuu H, Orpana A, Salven P.

Eur J Cancer. 2011 Jul;47(11):1708-16. doi: 10.1016/j.ejca.2011.02.018. Epub 2011 Mar 23.

PMID:
21439815
10.

Use of cancer-specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors.

McBride DJ, Orpana AK, Sotiriou C, Joensuu H, Stephens PJ, Mudie LJ, Hämäläinen E, Stebbings LA, Andersson LC, Flanagan AM, Durbecq V, Ignatiadis M, Kallioniemi O, Heckman CA, Alitalo K, Edgren H, Futreal PA, Stratton MR, Campbell PJ.

Genes Chromosomes Cancer. 2010 Nov;49(11):1062-9. doi: 10.1002/gcc.20815.

11.

Patients referred to an indoor air health clinic: exposure to water-damaged buildings causes an increase of lymphocytes in bronchoalveolar lavage and a decrease of CD19 leucocytes in peripheral blood.

Wolff H, Mussalo-Rauhamaa H, Raitio H, Elg P, Orpana A, Piilonen A, Haahtela T.

Scand J Clin Lab Invest. 2009;69(5):537-44. doi: 10.1080/00365510902770061.

PMID:
19347744
12.

Hemostatic gene polymorphisms in severe acute pancreatitis.

Tukiainen E, Kylänpää ML, Repo H, Orpana A, Methuen T, Salaspuro M, Kemppainen E, Puolakkainen P.

Pancreas. 2009 Mar;38(2):e43-6.

PMID:
19248219
13.

Polymorphisms of the TNF, CD14, and HSPA1B genes in patients with acute alcohol-induced pancreatitis.

Tukiainen E, Kylänpää ML, Puolakkainen P, Kemppainen E, Halonen K, Orpana A, Methuen T, Salaspuro M, Haapiainen R, Repo H.

Pancreas. 2008 Jul;37(1):56-61. doi: 10.1097/MPA.0b013e31815d9bad.

PMID:
18580445
14.
15.

Genome-controlled reverse transcriptase-polymerase chain reaction for targeted gene-expression analysis.

Stenman J, Räsänen J, Tenkanen T, Haglund C, Salo J, Orpana A, Paju A.

Scand J Clin Lab Invest. 2006;66(7):597-606.

PMID:
17101552
16.

Targeted gene-expression analysis by genome-controlled reverse transcription-PCR.

Stenman J, Paju A, Rissanen O, Tenkanen T, Haglund C, Räsänen J, Salo J, Stenman UH, Orpana A.

Clin Chem. 2006 Nov;52(11):1988-96. Epub 2006 Sep 21.

17.

Polymorphism at position +896 of the toll-like receptor 4 gene interferes with rapid response to treatment in rheumatoid arthritis.

Kuuliala K, Orpana A, Leirisalo-Repo M, Kautiainen H, Hurme M, Hannonen P, Korpela M, Möttönen T, Paimela L, Puolakka K, Karjalainen A, Repo H.

Ann Rheum Dis. 2006 Sep;65(9):1241-3. Epub 2006 Apr 10.

18.

Transcriptional downregulation of the lactase (LCT) gene during childhood.

Rasinperä H, Kuokkanen M, Kolho KL, Lindahl H, Enattah NS, Savilahti E, Orpana A, Järvelä I.

Gut. 2005 Nov;54(11):1660-1. No abstract available.

19.
20.

Coupling of light from an LED into a thin light guide by diffractive gratings.

Siitonen S, Laakkonen P, Vahimaa P, Jefimovs K, Kuittinen M, Parikka M, Mönkkönen K, Orpana A.

Appl Opt. 2004 Oct 20;43(30):5631-6.

PMID:
15534994
21.

Fluorescence resonance energy transfer (FRET) using ssDNA binding fluorescent dye.

Orpana AK.

Biomol Eng. 2004 Apr;21(2):45-50. Review.

PMID:
15113557
22.

Novel splice site CACNA1A mutation causing episodic ataxia type 2.

Kaunisto MA, Harno H, Kallela M, Somer H, Sallinen R, Hämäläinen E, Miettinen PJ, Vesa J, Orpana A, Palotie A, Färkkilä M, Wessman M.

Neurogenetics. 2004 Feb;5(1):69-73. Epub 2003 Oct 7.

PMID:
14530926
23.

Serum levels of mast cell tryptase, vascular endothelial growth factor and basic fibroblast growth factor in patients with acute pancreatitis.

Mentula P, Kylänpää ML, Kemppainen E, Eklund KK, Orpana A, Puolakkainen P, Haapiainen R, Repo H.

Pancreas. 2003 Aug;27(2):e29-33.

PMID:
12883276
24.

Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia.

Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Järvelä I.

Gut. 2003 May;52(5):647-52.

25.

Quantitative detection of low-copy-number mRNAs differing at single nucleotide positions.

Stenman J, Lintula S, Rissanen O, Finne P, Hedström J, Palotie A, Orpana A.

Biotechniques. 2003 Jan;34(1):172-7.

26.

CD14 and TNfa promoter polymorphisms in patients with acute arthritis. Special reference to development of chronic spondyloarthropathy.

Repo H, Anttonen K, Kilpinen SK, Palotie A, Salven P, Orpana A, Leirisalo-Repo M.

Scand J Rheumatol. 2002;31(6):355-61.

PMID:
12492251
27.

Raltitrexed treatment promotes systemic inflammatory reaction in patients with colorectal carcinoma.

Osterlund P, Orpana A, Elomaa I, Repo H, Joensuu H.

Br J Cancer. 2002 Sep 9;87(6):591-9.

28.

Angiogenic and lymphangiogenic molecules in hematological malignancies.

Orpana A, Salven P.

Leuk Lymphoma. 2002 Feb;43(2):219-24. Review.

PMID:
11999550
29.

A prospective study of inflammation markers in patients at risk of indirect acute lung injury.

Takala A, Jousela I, Takkunen O, Kautiainen H, Jansson SE, Orpana A, Karonen SL, Repo H.

Shock. 2002 Apr;17(4):252-7.

PMID:
11954822
30.

Four novel mutations in the OFD1 (Cxorf5) gene in Finnish patients with oral-facial-digital syndrome 1.

Rakkolainen A, Ala-Mello S, Kristo P, Orpana A, Järvelä I.

J Med Genet. 2002 Apr;39(4):292-6. No abstract available.

31.

Accuracy in amplification.

Stenman J, Orpana A.

Nat Biotechnol. 2001 Nov;19(11):1011-2. No abstract available.

PMID:
11689839
32.

Endotoxins induce and interferon alpha suppresses vascular endothelial growth factor (VEGF) production in human peripheral blood mononuclear cells.

Salven P, Anttonen K, Repo H, Joensuu H, Orpana A.

FASEB J. 2001 May;15(7):1318-20. No abstract available.

PMID:
11344126
33.

Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease.

Järveläinen HA, Orpana A, Perola M, Savolainen VT, Karhunen PJ, Lindros KO.

Hepatology. 2001 May;33(5):1148-53.

PMID:
11343243
34.

Relative levels of SCCA2 and SCCA1 mRNA in primary tumors predicts recurrent disease in squamous cell cancer of the head and neck.

Stenman J, Hedström J, Grénman R, Leivo I, Finne P, Palotie A, Orpana A.

Int J Cancer. 2001 Jan 20;95(1):39-43.

35.

Procalcitonin, soluble interleukin-2 receptor, and soluble E-selectin in predicting the severity of acute pancreatitis.

Kylänpää-Bäck ML, Takala A, Kemppainen EA, Puolakkainen PA, Leppäniemi AK, Karonen SL, Orpana A, Haapiainen RK, Repo H.

Crit Care Med. 2001 Jan;29(1):63-9.

PMID:
11176162
37.

Systemic inflammation in hemorrhagic fever with renal syndrome correlates with hypotension and thrombocytopenia but not with renal injury.

Takala A, Lähdevirta J, Jansson SE, Vapalahti O, Orpana A, Karonen SL, Repo H.

J Infect Dis. 2000 Jun;181(6):1964-70. Epub 2000 May 31.

PMID:
10837176
38.

Transhepatic neutrophil and monocyte activation during clinical liver transplantation.

Pesonen EJ, Höckerstedt K, Mäkisalo H, Vuorte J, Jansson SE, Orpana A, Karonen SL, Repo H.

Transplantation. 2000 Apr 15;69(7):1458-64.

PMID:
10798771
39.

Human vascular endothelial cells produce tumor necrosis factor-alpha in response to proinflammatory cytokine stimulation.

Ranta V, Orpana A, Carpén O, Turpeinen U, Ylikorkala O, Viinikka L.

Crit Care Med. 1999 Oct;27(10):2184-7.

PMID:
10548204
40.

Markers of systemic inflammation predicting organ failure in community-acquired septic shock.

Takala A, Jousela I, Jansson SE, Olkkola KT, Takkunen O, Orpana A, Karonen SL, Repo H.

Clin Sci (Lond). 1999 Nov;97(5):529-38.

PMID:
10545303
41.

Accurate determination of relative messenger RNA levels by RT-PCR.

Stenman J, Finne P, Ståhls A, Grénman R, Stenman UH, Palotie A, Orpana A.

Nat Biotechnol. 1999 Jul;17(7):720-2. No abstract available.

PMID:
10409357
42.

Vascular endothelial growth factor is bound in amniotic fluid and maternal serum.

Vuorela-Vepsäläinen P, Alfthan H, Orpana A, Alitalo K, Stenman UH, Halmesmäki E.

Hum Reprod. 1999 May;14(5):1346-51.

PMID:
10325292
43.
44.

Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation.

Wartiovaara U, Salven P, Mikkola H, Lassila R, Kaukonen J, Joukov V, Orpana A, Ristimäki A, Heikinheimo M, Joensuu H, Alitalo K, Palotie A.

Thromb Haemost. 1998 Jul;80(1):171-5.

PMID:
9684805
45.

Reduced viability of human vascular endothelial cells cultured on Matrigel.

Ranta V, Mikkola T, Ylikorkala O, Viinikka L, Orpana A.

J Cell Physiol. 1998 Jul;176(1):92-8.

PMID:
9618149
46.

Culturing of human vascular endothelial cells strongly affects their endothelin-1 and prostacyclin production.

Ranta V, Orpana A, Mikkola T, Ylikorkala O, Viinikka L.

Mol Cell Biochem. 1997 Dec;177(1-2):251-5.

PMID:
9450670
47.

Serum vascular endothelial growth factor is often elevated in disseminated cancer.

Salven P, Mänpää H, Orpana A, Alitalo K, Joensuu H.

Clin Cancer Res. 1997 May;3(5):647-51.

48.

High endothelin-1 in the airways of preterm infants is associated with less severe respiratory distress during the early postnatal period.

Andersson S, Merritt TA, Orpana A, Viinikka L, Ylikorkala O.

Pediatrics. 1997 Apr;99(4):545-7.

PMID:
9093295
49.
50.

Different effects of oral and transdermal hormonal replacement on prostacyclin and thromboxane A2.

Viinikka L, Orpana A, Puolakka J, Pyörälä T, Ylikorkala O.

Obstet Gynecol. 1997 Jan;89(1):104-7.

PMID:
8990448

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