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Items: 1 to 50 of 76

1.

Discovery and Lead Optimization of Atropisomer D1 Agonists with Reduced Desensitization.

Davoren JE, Nason D, Coe J, Dlugolenski K, Helal C, Harris AR, LaChapelle E, Liang S, Liu Y, O'Connor R, Orozco CC, Rai BK, Salafia M, Samas B, Xu W, Kozak R, Gray D.

J Med Chem. 2018 Dec 27;61(24):11384-11397. doi: 10.1021/acs.jmedchem.8b01622. Epub 2018 Dec 11.

PMID:
30431269
2.

Increased plasma levels of galectin-1 in pancreatic cancer: potential use as biomarker.

Martinez-Bosch N, Barranco LE, Orozco CA, Moreno M, Visa L, Iglesias M, Oldfield L, Neoptolemos JP, Greenhalf W, Earl J, Carrato A, Costello E, Navarro P.

Oncotarget. 2018 Aug 31;9(68):32984-32996. doi: 10.18632/oncotarget.26034. eCollection 2018 Aug 31.

3.

6-Chloro-5-[4-(1-Hydroxycyclobutyl)Phenyl]-1H-Indole-3-Carboxylic Acid is a Highly Selective Substrate for Glucuronidation by UGT1A1, Relative to β-Estradiol.

Lapham K, Lin J, Novak J, Orozco C, Niosi M, Di L, Goosen TC, Ryu S, Riccardi K, Eng H, Cameron KO, Kalgutkar AS.

Drug Metab Dispos. 2018 Dec;46(12):1836-1846. doi: 10.1124/dmd.118.083709. Epub 2018 Sep 7.

PMID:
30194276
4.

Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.

Humphrey JM, Movsesian M, Am Ende CW, Becker SL, Chappie TA, Jenkinson S, Liras JL, Liras S, Orozco C, Pandit J, Vajdos FF, Vandeput F, Yang E, Menniti FS.

J Med Chem. 2018 May 24;61(10):4635-4640. doi: 10.1021/acs.jmedchem.8b00374. Epub 2018 May 10.

PMID:
29718668
5.

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk.

Orozco CA, Martinez-Bosch N, Guerrero PE, Vinaixa J, Dalotto-Moreno T, Iglesias M, Moreno M, Djurec M, Poirier F, Gabius HJ, Fernandez-Zapico ME, Hwang RF, Guerra C, Rabinovich GA, Navarro P.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3769-E3778. doi: 10.1073/pnas.1722434115. Epub 2018 Apr 3.

6.

Interfacial Connection Mechanisms in Calcium-Silicate-Hydrates/Polymer Nanocomposites: A Molecular Dynamics Study.

Zhou Y, Hou D, Manzano H, Orozco CA, Geng G, Monteiro PJM, Liu J.

ACS Appl Mater Interfaces. 2017 Nov 22;9(46):41014-41025. doi: 10.1021/acsami.7b12795. Epub 2017 Nov 7.

PMID:
29076343
7.

Characterization of the Bonds Developed between Calcium Silicate Hydrate and Polycarboxylate-Based Superplasticizers with Silyl Functionalities.

Orozco CA, Chun BW, Geng G, Emwas AH, Monteiro PJ.

Langmuir. 2017 Apr 11;33(14):3404-3412. doi: 10.1021/acs.langmuir.6b04368. Epub 2017 Mar 30.

PMID:
28328229
8.

Rheumatology Informatics System for Effectiveness: A National Informatics-Enabled Registry for Quality Improvement.

Yazdany J, Bansback N, Clowse M, Collier D, Law K, Liao KP, Michaud K, Morgan EM, Oates JC, Orozco C, Reimold A, Simard JF, Myslinski R, Kazi S.

Arthritis Care Res (Hoboken). 2016 Dec;68(12):1866-1873. doi: 10.1002/acr.23089.

9.

Methods for Developing the American College of Rheumatology's Electronic Clinical Quality Measures.

Yazdany J, Myslinski R, Miller A, Francisco M, Desai S, Schmajuk G, Lacaille D, Barber CE, Orozco C, Bunyard M, Bergman MJ, Passo M, Matteson EL, Olson R, Silverman S, Warren R, Nola K, Robbins M.

Arthritis Care Res (Hoboken). 2016 Oct;68(10):1402-9. doi: 10.1002/acr.22985. Epub 2016 Sep 16. Review. No abstract available.

10.

The pancreatic niche inhibits the effectiveness of sunitinib treatment of pancreatic cancer.

Martínez-Bosch N, Guerrero PE, Moreno M, José A, Iglesias M, Munné-Collado J, Anta H, Gibert J, Orozco CA, Vinaixa J, Fillat C, Viñals F, Navarro P.

Oncotarget. 2016 Jul 26;7(30):48265-48279. doi: 10.18632/oncotarget.10199.

11.

Evaluation of learned helplessness, self-efficacy and disease activity, functional capacity and pain in Argentinian patients with rheumatoid arthritis.

Vergara F, Rosa J, Orozco C, Bertiller E, Gallardo MA, Bravo M, Catay E, Collado V, Gómez G, Sabelli M, García MV, Rosemffet MG, Citera G, Schneeberger EE, Catoggio LJ, Soriano ER.

Scand J Rheumatol. 2017 Jan;46(1):17-21. doi: 10.3109/03009742.2016.1155643. Epub 2016 Apr 20.

PMID:
27095187
12.

Objective Sleep Assessments in Patients with Postural Tachycardia Syndrome using Overnight Polysomnograms.

Bagai K, Peltier AC, Malow BA, Diedrich A, Shibao CA, Black BK, Paranjape SY, Orozco C, Biaggioni I, Robertson D, Raj SR.

J Clin Sleep Med. 2016 May 15;12(5):727-33. doi: 10.5664/jcsm.5806.

13.

Chromatographic resolution of atropisomers for toxicity and biotransformation studies in pharmaceutical research.

Yan TQ, Riley F, Philippe L, Davoren J, Cox L, Orozco C, Rai B, Hardink M.

J Chromatogr A. 2015 Jun 12;1398:108-20. doi: 10.1016/j.chroma.2015.04.023. Epub 2015 Apr 23.

PMID:
25937130
14.

Withanolides from three species of the genus Deprea (Solanaceae). Chemotaxonomical considerations.

Casero CN, Oberti JC, Orozco CI, Cárdenas A, Brito I, Barboza GE, Nicotra VE.

Phytochemistry. 2015 Feb;110:83-90. doi: 10.1016/j.phytochem.2014.11.015. Epub 2014 Nov 27.

PMID:
25435174
15.

Positive C4d in kidney transplantation biopsy: clinical impact.

Pedraza N, Girón F, Baez Y, Niño A, Rodriguez J, Orozco C.

Transplant Proc. 2014 Nov;46(9):2966-71. doi: 10.1016/j.transproceed.2014.06.056.

PMID:
25420802
16.

Within herd transmission and evaluation of the performance of clinical and serological diagnosis of foot-and-mouth disease in partially immune cattle herds.

Gonzales JL, Barrientos MA, Quiroga JL, Ardaya D, Daza O, Martinez C, Orozco C, Crowther J, Paton DJ.

Vaccine. 2014 Oct 29;32(47):6193-8. doi: 10.1016/j.vaccine.2014.09.029. Epub 2014 Sep 26.

PMID:
25261377
17.

Generation of major human excretory and circulating drug metabolites using a hepatocyte relay method.

Ballard TE, Orozco CC, Obach RS.

Drug Metab Dispos. 2014 May;42(5):899-902. doi: 10.1124/dmd.114.057026. Epub 2014 Mar 7.

PMID:
24608634
18.

Understanding the placebo effect in clinical trials for postural tachycardia syndrome.

Nwazue VC, Arnold AC, Raj V, Black BK, Biaggioni I, Paranjape SY, Orozco C, Dupont WD, Robertson D, Raj SR.

Clin Exp Pharmacol Physiol. 2014 May;41(5):325-30. doi: 10.1111/1440-1681.12221.

19.

Assessing Restrictiveness: A Closer Look at the Foster Care Placements and Perceptions of Youth With and Without Disabilities Aging Out of Care.

Schmidt J, Cunningham M, Dalton LD, Powers LE, Geenen S, Orozco CG; other members of the Research Consortium to Increase the Success of Youth in Foster Care.

J Public Child Welf. 2013;7(5):586-609.

20.

The combined expression patterns of Ikaros isoforms characterize different hematological tumor subtypes.

Orozco CA, Acevedo A, Cortina L, Cuellar GE, Duarte M, Martín L, Mesa NM, Muñoz J, Portilla CA, Quijano SM, Quintero G, Rodriguez M, Saavedra CE, Groot H, Torres MM, López-Segura V.

PLoS One. 2013 Dec 6;8(12):e82411. doi: 10.1371/journal.pone.0082411. eCollection 2013.

21.

In vitro-in vivo correlation for low-clearance compounds using hepatocyte relay method.

Di L, Atkinson K, Orozco CC, Funk C, Zhang H, McDonald TS, Tan B, Lin J, Chang C, Obach RS.

Drug Metab Dispos. 2013 Dec;41(12):2018-23. doi: 10.1124/dmd.113.053322. Epub 2013 Jul 15.

PMID:
23857891
22.

Estimation of sleep disturbances using wrist actigraphy in patients with postural tachycardia syndrome.

Bagai K, Wakwe CI, Malow B, Black BK, Biaggioni I, Paranjape SY, Orozco C, Raj SR.

Auton Neurosci. 2013 Oct;177(2):260-5. doi: 10.1016/j.autneu.2013.02.021. Epub 2013 Mar 26.

23.

Safety of bisphosphonates.

Orozco C, Maalouf NM.

Rheum Dis Clin North Am. 2012 Nov;38(4):681-705. doi: 10.1016/j.rdc.2012.09.001. Review.

PMID:
23137577
24.

[Colorectal surgery in patients over 65 years of age].

Herrera-Gómez A, Orozco C, Ruíz-Molina JM, Téllez-Palacios D, Ortega-Gutiérrez C, Namendys-Silva SA.

Rev Gastroenterol Mex. 2012 Jul-Sep;77(3):119-24. doi: 10.1016/j.rgmx.2012.04.009. Epub 2012 Aug 9. Spanish.

25.

Desmopressin acutely decreases tachycardia and improves symptoms in the postural tachycardia syndrome.

Coffin ST, Black BK, Biaggioni I, Paranjape SY, Orozco C, Black PW, Dupont WD, Robertson D, Raj SR.

Heart Rhythm. 2012 Sep;9(9):1484-90. doi: 10.1016/j.hrthm.2012.05.002. Epub 2012 May 3.

26.

Hydralazine as a selective probe inactivator of aldehyde oxidase in human hepatocytes: estimation of the contribution of aldehyde oxidase to metabolic clearance.

Strelevitz TJ, Orozco CC, Obach RS.

Drug Metab Dispos. 2012 Jul;40(7):1441-8. doi: 10.1124/dmd.112.045195. Epub 2012 Apr 20.

PMID:
22522748
27.

Phosphate inhibits in vitro Fe3+ loading into transferrin by forming a soluble Fe(III)-phosphate complex: a potential non-transferrin bound iron species.

Hilton RJ, Seare MC, Andros ND, Kenealey Z, Orozco CM, Webb M, Watt RK.

J Inorg Biochem. 2012 May;110:1-7. doi: 10.1016/j.jinorgbio.2012.02.017. Epub 2012 Mar 3.

PMID:
22459167
28.

Endothelial hyperpolarizing factor increases acetylcholine-induced vasodilatation in pulmonary hypertensive broilers arterial rings.

Alvarez-Medina DI, Hernandez A, Orozco C.

Res Vet Sci. 2012 Feb;92(1):1-6. doi: 10.1016/j.rvsc.2011.02.004. Epub 2011 Mar 5.

PMID:
21382630
29.

White plague-like coral disease in remote reefs of the Western Caribbean.

Sánchez JA, Herrera S, Navas-Camacho R, Rodríguez-Ramírez A, Herron P, Pizarro V, Acosta AR, Castillo PA, Montoya P, Orozco C.

Rev Biol Trop. 2010 May;58 Suppl 1:145-54.

PMID:
20873047
30.

Recent dynamics and condition of coral reefs in the Colombian Caribbean.

Rodríguez-Ramírez A, Reyes-Nivia MC, Zea S, Navas-Camacho R, Garzón-Ferreira J, Bejarano S, Orozco C.

Rev Biol Trop. 2010 May;58 Suppl 1:107-31.

PMID:
20873044
31.

CYP1A1 and CYP1B1 gene expression and DNA adduct formation in normal human mammary epithelial cells exposed to benzo[a]pyrene in the absence or presence of chlorophyllin.

John K, Divi RL, Keshava C, Orozco CC, Schockley ME, Richardson DL, Poirier MC, Nath J, Weston A.

Cancer Lett. 2010 Jun 28;292(2):254-60. doi: 10.1016/j.canlet.2009.12.008. Epub 2010 Feb 16.

32.

Optimization of a Microfluidic Mixing Process for Gene Expression-Based Bio-dosimetry.

Shinde SM, Orozco C, Brengues M, Lenigk R, Montgomery DC, Zenhausern F.

Qual Eng. 2010;23(1):59-70.

33.

Can tumor necrosis factor inhibitors be safely used in pregnancy?

Ali YM, Kuriya B, Orozco C, Cush JJ, Keystone EC.

J Rheumatol. 2010 Jan;37(1):9-17. doi: 10.3899/jrheum.090563. Epub 2009 Dec 15. Review.

PMID:
20008917
34.

BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources.

Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J, Janes J, Huss JW 3rd, Su AI.

Genome Biol. 2009;10(11):R130. doi: 10.1186/gb-2009-10-11-r130. Epub 2009 Nov 17.

35.

[Factors related to haemolysis in the extraction of blood samples].

Agós MD, Lizarraga R, Gambra D, Marañón A, Orozco C, Díaz E.

An Sist Sanit Navar. 2008 May-Aug;31(2):153-8. Spanish.

36.

[Hyper IgE syndrome. Opportune diagnosis and management].

Orozco CV, Velásquez LH, Méndez NH, Augusto B, Salazar T.

Rev Alerg Mex. 2008 Jan-Feb;55(1):38-45. Review. Spanish.

PMID:
18697452
37.

A gene wiki for community annotation of gene function.

Huss JW 3rd, Orozco C, Goodale J, Wu C, Batalov S, Vickers TJ, Valafar F, Su AI.

PLoS Biol. 2008 Jul 8;6(7):e175. doi: 10.1371/journal.pbio.0060175. No abstract available.

38.

[Kidney damage caused by kidney damage].

Gutiérrrez DR, Rodríguez Pardillo C, Orozco C, Juvier L.

Nefrologia. 2007;27(4):514-5. Spanish. No abstract available.

39.

Cholinergic mechanisms of cutaneous active vasodilation during heat stress in cystic fibrosis.

Kellogg DL Jr, Hodges GJ, Orozco CR, Phillips TM, Zhao JL, Johnson JM.

J Appl Physiol (1985). 2007 Sep;103(3):963-8. Epub 2007 Jun 28.

40.

[Distribution patterns and bioerosion of the sea urchin Centrostephanus coronatus (Diadematoida: Diadematidae), at the reef of Playa Blanca, Colombian Pacific].

Toro-Farmer G, Cantera JR, Londoño-Cruz E, Orozco C, Neira R.

Rev Biol Trop. 2004 Mar;52(1):67-76. Spanish.

PMID:
17357401
41.
42.

Depolarization preconditioning produces cytoprotection against veratridine-induced chromaffin cell death.

Orozco C, García-de-Diego AM, Arias E, Hernández-Guijo JM, García AG, Villarroya M, López MG.

Eur J Pharmacol. 2006 Dec 28;553(1-3):28-38. Epub 2006 Sep 12.

PMID:
17045260
44.

Cardiac mitochondrial compromise in 1-yr-old Erythrocebus patas monkeys perinatally-exposed to nucleoside reverse transcriptase inhibitors.

Divi RL, Leonard SL, Kuo MM, Walker BL, Orozco CC, St Claire MC, Nagashima K, Harbaugh SW, Harbaugh JW, Thamire C, Sable CA, Poirier MC.

Cardiovasc Toxicol. 2005;5(3):333-46.

PMID:
16244378
45.

Low frequency of renal function impairment during one-year of therapy with tenofovir-containing regimens in the real-world: a case-control study.

Padilla S, Gutiérrez F, Masiá M, Cánovas V, Orozco C.

AIDS Patient Care STDS. 2005 Jul;19(7):421-4.

PMID:
16053398
46.

Inactivation of patS and hetN causes lethal levels of heterocyst differentiation in the filamentous cyanobacterium Anabaena sp. PCC 7120.

Borthakur PB, Orozco CC, Young-Robbins SS, Haselkorn R, Callahan SM.

Mol Microbiol. 2005 Jul;57(1):111-23.

47.

Neuropsychological functioning in methadone maintenance patients versus abstinent heroin abusers.

Verdejo A, Toribio I, Orozco C, Puente KL, Pérez-García M.

Drug Alcohol Depend. 2005 Jun 1;78(3):283-8. Epub 2004 Dec 23.

PMID:
15893159
48.

[Variation of intraabdominal pressure caused by abdominoplasty in healthy women].

Marín Valladolid JA, Saucedo Ortiz JA, Orozco CF, Pérez SL, Segura Castillo JL, Ortega AL, Hernández IM, Trabaldo SS, Ojeda AG.

Rev Gastroenterol Mex. 2004 Jul-Sep;69(3):156-61. Spanish.

PMID:
15759787
49.

[Complications of the management of secondary peritonitis with contained-open abdomen. Comparison of the Bogota's bag vs polypropylene mesh].

García Iñiguez JA, Orozco CF, Muciño Hernández MI, Ortega AL, Trabaldo SS, Cortés Flores AO, Hermosillo Sandoval JM, Ojeda AG.

Rev Gastroenterol Mex. 2004 Jul-Sep;69(3):147-55. Spanish.

PMID:
15759786
50.

ITH4012 (ethyl 5-amino-6,7,8,9-tetrahydro-2-methyl-4-phenylbenzol[1,8]naphthyridine-3-carboxylate), a novel acetylcholinesterase inhibitor with "calcium promotor" and neuroprotective properties.

Orozco C, de Los Rios C, Arias E, León R, García AG, Marco JL, Villarroya M, López MG.

J Pharmacol Exp Ther. 2004 Sep;310(3):987-94. Epub 2004 Apr 26.

PMID:
15111641

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